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Entries tagged Uniparental Disomy/genetics (71)

3007: Heijmans et al. (1999) "Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort." J. Am. Coll. Cardiol. 34(4):1176-1183 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Survival Analysis
- Cohort Studies
- Aged
- Aged, 80 and over
- Peptidyl-Dipeptidase A/genetics
- Genetic Variation
- Genetic Predisposition to Disease/genetics
- Risk
- Cause of Death
- Netherlands
- Cardiovascular Diseases/genetics/mortality
- Plasminogen Activator Inhibitor 1/genetics
1109: Lupu et al. (2001) "Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth." Dev. Biol. 229(1):141-162 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Growth Hormone/metabolism
- Mice
- Receptors, Somatotropin/genetics
- Mice, Mutant Strains
- Signal Transduction
- Organ Size
- Body Constitution
- Base Sequence
- Molecular Sequence Data
- Gene Expression Regulation
- Tissue Distribution
- Mutagenesis
- Insulin-Like Growth Factor I/genetics
- Bone Development
- Endocrine Glands/physiology
- Growth/genetics
- RNA, Messenger/isolation & purification
1115: Csoka et al. (2004) "Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis." Aging Cell 3(4):235-243 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Heterozygote
- Mutation
- Cell Line
- Child
- Adolescent
- Lamin Type A/genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors/genetics
- Fibroblasts/metabolism
- Gene Expression Profiling
- Gene Expression Regulation/genetics
- Homeodomain Proteins/genetics
- Genetic Predisposition to Disease/genetics
- Up-Regulation/genetics
- Down-Regulation/genetics
- Arteriosclerosis/complications/genetics
- Extracellular Matrix/genetics
- Mesoderm/metabolism
- Progeria/complications/genetics/pathology
- RNA/genetics/isolation & purification/metabolism
1275: Lin et al. (2004) "Cytoplasmic PML function in TGF-beta signalling." Nature 431(7005):205-211 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Carrier Proteins/genetics/metabolism
- Humans
- Mice
- DNA-Binding Proteins/genetics/metabolism
- Protein Binding
- Fibroblasts
- Tumor Suppressor Proteins
- Cell Line
- Mutation/genetics
- Cell Aging/drug effects
- Cell Division/drug effects
- Transforming Growth Factor beta/pharmacology
- Signal Transduction/drug effects
- Apoptosis/drug effects
- Protein Transport
- Transcription, Genetic/drug effects
- Trans-Activators/genetics/metabolism
- Nuclear Proteins/deficiency/genetics/metabolism
- Cell Line, Tumor
- B-Lymphocytes/cytology/drug effects
- Cytoplasm/drug effects/metabolism
- Endosomes/drug effects/metabolism
- Leukemia, Promyelocytic, Acute/metabolism/pathology
- Neoplasm Proteins/deficiency/genetics/metabolism
- Oncogene Proteins, Fusion/metabolism
- Receptors, Transforming Growth Factor beta/metabolism
- Smad2 Protein
- Smad3 Protein
- Transcription Factors/deficiency/genetics/metabolism
1402: Park et al. (2004) "Bmi1, stem cells, and senescence regulation." J. Clin. Invest. 113(2):175-179 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mutation
- Models, Biological
- Cell Line
- Cell Aging
- Gene Expression Regulation
- Repressor Proteins
- Stem Cells/metabolism
- Tumor Suppressor Protein p14ARF/metabolism
- Nuclear Proteins/genetics/metabolism/physiology
- Polycomb Repressive Complex 1
- Cyclin-Dependent Kinase Inhibitor p16/metabolism
- Proto-Oncogene Proteins/genetics/metabolism/physiology
1967: Yao et al. (2012) "SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice." J. Clin. Invest. 122(6):2032-2045 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Cell Aging
- Enzyme Activators/pharmacology
- Acetylation/drug effects
- Forkhead Transcription Factors/genetics/metabolism
- Heterocyclic Compounds with 4 or More Rings/pharmacology
- Inflammation/genetics/metabolism/pathology/therapy
- Pulmonary Disease, Chronic Obstructive/genetics/metabolism/pathology/therapy
- Pulmonary Emphysema/genetics/metabolism/pathology/therapy
- Respiratory Mucosa/metabolism/pathology
- Sirtuin 1/genetics/metabolism
4263: Carey et al. (2013) "Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells." Anticancer Res. 33(10):4271-4278 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Cell Aging/drug effects
- Doxorubicin/pharmacology
- Apoptosis/drug effects
- Cell Line, Tumor
- Tumor Suppressor Proteins/physiology
- Cadherins/metabolism
- Cyclin-Dependent Kinase Inhibitor Proteins/metabolism
- Antibiotics, Antineoplastic/pharmacology
- Prostatic Neoplasms
- Drug Resistance, Neoplasm
- Cell Shape/drug effects
- E2F1 Transcription Factor/genetics/metabolism
- Inhibitor of Differentiation Proteins/physiology
- Vimentin/metabolism
3184: Maruszak et al. (2012) "TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity." J. Alzheimers Dis. 28(2):309-322 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Chi-Square Distribution
- Age Factors
- Aged
- Aged, 80 and over
- Gene Frequency
- Apolipoproteins E/genetics
- Genetic Predisposition to Disease/genetics
- Polymorphism, Single Nucleotide/genetics
- Alzheimer Disease/genetics
- Membrane Transport Proteins/genetics
3377: Lin et al. (2011) "A novel mutation in PYCR1 causes an autosomal recessive cutis laxa with premature aging features in a family." Am. J. Med. Genet. A 155A(6):1285-1289 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Base Sequence
- Molecular Sequence Data
- Child
- Skin/pathology
- Genes, Recessive
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Analysis, DNA
- Immunoblotting
- Aging, Premature/genetics
- Fibroblasts/metabolism
- Genetic Predisposition to Disease/genetics
- Pyrroline Carboxylate Reductases/genetics/metabolism
- Cutis Laxa/genetics/pathology
- Frameshift Mutation/genetics
3400: Visel et al. (2010) "Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice." Nature 464(7287):409-412 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Cells, Cultured
- Cell Aging/genetics
- Survival Analysis
- Chromosome Deletion
- Gene Expression Regulation/genetics
- Genetic Predisposition to Disease/genetics
- Aorta/pathology
- Chromosomes, Human, Pair 9/genetics
- Cell Proliferation
- Chromosomes, Mammalian/genetics
- Coronary Artery Disease/genetics/pathology
- Cyclin-Dependent Kinase Inhibitor p15/deficiency/genetics
- Cyclin-Dependent Kinase Inhibitor p16/deficiency/genetics
- Embryo, Mammalian/embryology
- Myocytes, Smooth Muscle/pathology
3786: Li et al. (2008) "Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts." Mol. Cancer Res. 6(5):770-784 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Cell Line
- Cell Aging
- Reverse Transcriptase Polymerase Chain Reaction
- Gene Expression Regulation
- Fibroblasts/metabolism
- DNA Methylation
- Cell Proliferation
- Interferon-alpha/metabolism
- Epigenesis, Genetic
- Interferon Regulatory Factor-7/metabolism
- Interferon Regulatory Factors/metabolism
- Interferons/metabolism
- Li-Fraumeni Syndrome/metabolism
3795: Brown et al. (1997) "Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts." Science 277(5327):831-834 (PubMed)

1 citation in connected databases
- Tags:
- Gene Targeting
- Humans
- Gene Deletion
- Apoptosis
- Cyclin-Dependent Kinase Inhibitor p21
- Cells, Cultured
- DNA Damage
- Cell Division
- Fibroblasts
- Cell Aging/genetics
- Genetic Vectors
- Telomere/physiology
- G1 Phase
- Cyclins/genetics/physiology
- Aspartate Carbamoyltransferase/genetics
- Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/genetics
- Dihydroorotase/genetics
- Electroporation
- Multienzyme Complexes/genetics
3797: Jee et al. (2010) "Nek6 overexpression antagonizes p53-induced senescence in human cancer cells." Cell Cycle 9(23):4703-4710 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Reactive Oxygen Species/metabolism
- Cell Division
- Cell Aging
- Fibroblasts/cytology/metabolism
- Down-Regulation
- Cyclin B/metabolism
- Protein-Serine-Threonine Kinases/genetics/metabolism/physiology
- G1 Phase
- Cell Line, Tumor
- Cyclin-Dependent Kinases
- Neoplasms/enzymology/metabolism
- Tumor Suppressor Protein p53/antagonists & inhibitors/metabolism
3843: Dilman et al. (1979) "Increase in lifespan of rats following polypeptide pineal extract treatment." Exp Pathol (Jena) 17(9):539-545 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Cattle
- Female
- Rats
- Life Expectancy
- Pregnancy
- Peptides/pharmacology
- Estrus/drug effects
- Pineal Gland/physiology
- Neoplasms, Experimental/physiopathology
- Tissue Extracts/pharmacology
368: Wong et al. (2000) "Overexpression of epidermal growth factor induced hypospermatogenesis in transgenic mice." J. Biol. Chem. 275(24):18297-18301 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Male
- Transfection
- Mice, Transgenic
- Testis/chemistry
- Testosterone/blood
- Epidermal Growth Factor/genetics/physiology
- DNA/administration & dosage
- Microinjections
- Oligospermia/etiology
- Receptor, Epidermal Growth Factor/physiology
- Spermatogenesis/physiology
- Submandibular Gland/chemistry
- Transforming Growth Factor alpha/physiology
2565: Steinkraus et al. (2008) "Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans." Aging Cell 7(3):394-404 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Caloric Restriction
- Transcription Factors/drug effects/metabolism
- Longevity/drug effects/physiology
- Peptides/pharmacology
- Food Deprivation/physiology
- Caenorhabditis elegans/drug effects/genetics/metabolism
- Caenorhabditis elegans Proteins/drug effects/metabolism
2710: Lewis et al. (1978) "Age, thymic involution, and circulating thymic hormone activity." J. Clin. Endocrinol. Metab. 47(1):145-150 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Aging
- Adult
- Child
- Adolescent
- Child, Preschool
- Middle Aged
- Infant
- Aged
- Cardiac Surgical Procedures
- Thymic Factor, Circulating/analysis
- Thymus Gland/growth & development/pathology/physiology
- Thymus Hormones/analysis/blood
3054: Grimaldi et al. (2006) "Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population." J. Leukoc. Biol. 79(3):611-615 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Heterozygote
- Longevity/genetics
- Alleles
- DNA Mutational Analysis
- Adult
- Age Factors
- Mutation/genetics
- Middle Aged
- Risk Factors
- Aged, 80 and over
- Gene Frequency
- Genetic Testing
- Cytoskeletal Proteins/genetics
- Genetic Predisposition to Disease/genetics
- Environment
- Acute Disease/epidemiology
- Inflammation/genetics/immunology/physiopathology
- Myocardial Infarction/epidemiology/genetics/immunology
- Protein Isoforms/genetics/immunology
- Sicily/epidemiology
1018: Zappavigna et al. (1996) "HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation." EMBO J. 15(18):4981-4991 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Amino Acid Sequence
- Molecular Sequence Data
- DNA/metabolism
- Binding Sites
- Transcription Factors/metabolism
- DNA-Binding Proteins/metabolism
- Plasmids/metabolism
- Neoplasm Proteins/metabolism
- 3T3 Cells
- Transcription, Genetic/drug effects
- High Mobility Group Proteins/metabolism
- Homeodomain Proteins/metabolism
17: Eriksson et al. (2003) "Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome." Nature 423(6937):293-298 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Homozygote
- Aging/genetics/physiology
- Exons/genetics
- Base Sequence
- DNA Mutational Analysis
- Adult
- Cell Membrane/metabolism/pathology
- Child
- Chromosomes, Human, Pair 1/genetics
- Fibroblasts/metabolism/pathology
- Fluorescent Antibody Technique
- In Situ Hybridization, Fluorescence
- Lamin Type A/analysis/genetics
- Pedigree
- Point Mutation/genetics
- Progeria/genetics/pathology
- RNA Splice Sites/genetics
- Syndrome
- Uniparental Disomy/genetics