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Entries tagged Mice, Mutant Strains/physiology (45)

1618: Garau et al. (2006) "Age related changes in the activity-rest circadian rhythms and c-fos expression of ring doves with aging. Effects of tryptophan intake." Exp. Gerontol. 41(4):430-438 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Aging/genetics/physiology
- Models, Animal
- Circadian Rhythm
- Immunohistochemistry/methods
- Gene Expression/drug effects
- Activity Cycles/drug effects
- Body Temperature Regulation
- Columbidae
- Jet Lag Syndrome/metabolism
- Melatonin/administration & dosage/metabolism
- Proto-Oncogene Proteins c-fos/analysis/metabolism
- Receptors, Melatonin/metabolism
- Sleep/drug effects
- Tryptophan/administration & dosage/metabolism
1807: Salehi et al. (2006) "Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration." Neuron 51(1):29-42 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Knockout
- Female
- Male
- Mice, Transgenic
- Up-Regulation/genetics
- Amyloid beta-Protein Precursor/genetics/metabolism
- Down Syndrome/genetics/metabolism/physiopathology
- Alzheimer Disease/genetics/metabolism/physiopathology
- Amyloid beta-Peptides/biosynthesis
- Protein Transport/genetics
- Plaque, Amyloid/genetics/metabolism/pathology
- Axonal Transport/genetics
- Basal Nucleus of Meynert/metabolism/pathology/physiopathology
- Cholinergic Fibers/metabolism/pathology
- Endosomes/genetics/metabolism/pathology
- Nerve Degeneration/genetics/metabolism/physiopathology
- Nerve Growth Factor/genetics/metabolism
1850: Gates et al. (2007) "Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease." Cell Metab. 6(6):497-505 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Female
- Mice, Inbred C57BL
- Mice, Transgenic
- Aging/genetics/metabolism
- Longevity/genetics/physiology
- Muscle, Skeletal/metabolism
- Mice, Inbred CBA
- Apolipoproteins E/deficiency/genetics
- Diet, Atherogenic
- Uncoupling Agents/metabolism
- Atherosclerosis/genetics/metabolism/prevention & control
- Electron Transport/physiology
- Ion Channels/deficiency/genetics/metabolism
- Mitochondrial Proteins/deficiency/genetics/metabolism
2138: Moghadasian et al. (2001) "Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans." FASEB J. 15(14):2623-2630 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Body Weight/physiology
- Genotype
- Male
- Mice, Inbred C57BL
- Immunohistochemistry
- Lipids/blood
- Brain/metabolism
- Antioxidants/metabolism
- Survival Analysis
- Time Factors
- Tissue Distribution
- Kidney/metabolism
- Liver/metabolism
- Cholesterol/metabolism
- Blood Glucose/metabolism
- Receptors, LDL/physiology
- Neurofilament Proteins/analysis
- Apolipoproteins E/deficiency/genetics
- Lipoproteins, HDL/metabolism
- Homocysteine/blood
- Esterification
- Glial Fibrillary Acidic Protein/analysis
- Hydroxymethylglutaryl CoA Reductases/metabolism
- Hyperlipidemias/blood/physiopathology
- Lipase/blood
2347: Li et al. (2007) "RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination." Dev. Cell 12(2):235-246 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Transcription Factors/genetics/metabolism
- Protein Binding
- Phenotype
- RNA, Messenger/genetics/metabolism
- Transcription, Genetic
- Catalysis
- Aging/metabolism
- Mutation/genetics
- Cell Nucleus/metabolism
- Substrate Specificity
- Caenorhabditis elegans Proteins/genetics/metabolism
- Protein Transport
- Larva
- Protein Processing, Post-Translational
- Heat-Shock Response
- Transcriptional Activation/genetics
- Thermodynamics
- Ubiquitin-Protein Ligases/metabolism
- Caenorhabditis elegans/enzymology/physiology
- Hyperthermia, Induced
- Polyubiquitin/metabolism
3223: Koropatnick et al. (2008) "A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men." J. Gerontol. A Biol. Sci. Med. Sci. 63(11):1235-1240 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Longevity/physiology
- Male
- Aged
- Aged, 80 and over
- Cholesterol Ester Transfer Proteins/genetics
- Cardiovascular Diseases/mortality
- Lipoproteins, HDL/blood
- Hawaii
- Japan/ethnology
3349: Florian et al. (2012) "Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation." Cell Stem Cell 10(5):520-530 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Cells, Cultured
- Cell Aging
- Aging, Premature/genetics
- Acetylation
- Histones/metabolism
- Hematopoiesis/genetics
- Protein Transport/genetics
- Tubulin/metabolism
- Cell Polarity/genetics
- GTPase-Activating Proteins/genetics
- Hematopoietic Stem Cells/drug effects/physiology
- Myeloid Cells/physiology
- Rejuvenation
- cdc42 GTP-Binding Protein/metabolism/pharmacology
389: Mecklenbräuker et al. (2002) "Protein kinase Cdelta controls self-antigen-induced B-cell tolerance." Nature 416(6883):860-865 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Gene Deletion
- Mice, Inbred C57BL
- Signal Transduction
- Cell Differentiation
- Flow Cytometry
- Lymphocyte Activation
- Antigens, CD/metabolism
- B-Lymphocytes/cytology/immunology
- Mitogen-Activated Protein Kinases/metabolism
- JNK Mitogen-Activated Protein Kinases
- Calcium/metabolism
- Membrane Glycoproteins/metabolism
- Enzyme-Linked Immunosorbent Assay
- Protein Kinase C-delta
- Antibodies, Antinuclear/blood/immunology
- Antigens, CD86
- Autoantigens/immunology
- Calcium Signaling
- Clonal Anergy/immunology
- Immune Tolerance/immunology
- Isoenzymes/deficiency/genetics/immunology/metabolism
- Lymph Nodes/cytology/immunology
- Protein Kinase C/deficiency/genetics/immunology/metabolism
- Spleen/cytology/immunology
2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (PubMed)

276 citations in connected databases
- Tags:
- Humans
- Female
- Aging/physiology
- Adult
- Cell Cycle Proteins/genetics
- Aged
- Cyclin-Dependent Kinase Inhibitor p27
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Histone Deacetylases/genetics
- Muscle, Skeletal/metabolism
- Energy Metabolism/genetics
- Myosin Heavy Chains/genetics
- Tumor Suppressor Proteins/genetics
2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (PubMed)

272 citations in connected databases
- Tags:
- Humans
- Male
- Aging/genetics
- Adult
- Aged
- RNA, Messenger/biosynthesis/genetics
- Gene Expression Regulation/genetics
- Genes/genetics
- Gene Expression Profiling/methods
- Oligonucleotide Array Sequence Analysis/methods
- Myosin Heavy Chains/genetics
- Muscle, Skeletal/chemistry/physiology
- Muscular Atrophy/genetics
3775: Zhang et al. (2005) "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA." Dev. Cell 8(1):19-30 (PubMed)

1 citation in connected databases
- Tags:
- Tumor Suppressor Proteins
- Amino Acid Sequence
- Cell Line
- Recombinant Fusion Proteins/metabolism
- Cell Aging/physiology
- Transcription Factors/metabolism
- Blotting, Western/methods
- Repressor Proteins
- Cell Cycle/physiology
- Time Factors
- Gene Expression Regulation/physiology
- Nuclear Proteins/metabolism
- Neoplasm Proteins/metabolism
- ras Proteins/metabolism
- Cell Cycle Proteins/physiology
- Histones/metabolism
- Dosage Compensation, Genetic
- Immunohistochemistry/methods
- Heterochromatin/metabolism
- Cell Count/methods
- Chromosomal Proteins, Non-Histone/metabolism
- Immunoprecipitation/methods
- Transfection/methods
- Indoles
3837: Fuxe et al. (2000) "Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A." Cell Growth Differ. 11(7):373-384 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Protein-Serine-Threonine Kinases/metabolism
- Tumor Suppressor Protein p53/genetics/metabolism
- Mutation
- Transfection
- Cell Cycle Proteins
- Cell Division
- Tumor Suppressor Proteins
- Cell Line
- Tumor Cells, Cultured
- Cell Aging
- Recombinant Proteins/metabolism
- Immunoblotting
- Enzyme Induction
- Cyclin-Dependent Kinase 4
- Proto-Oncogene Proteins
- Retinoblastoma Protein/genetics/metabolism
- Cell Size
- Telomerase/antagonists & inhibitors/metabolism
- Cyclin D1/genetics/metabolism
- Cyclin-Dependent Kinase 6
- Cyclin-Dependent Kinase Inhibitor p15
- Adenoviridae/genetics/metabolism
- Carrier Proteins/genetics/immunology/metabolism
- Cyclin-Dependent Kinase Inhibitor p16/genetics/immunology/metabolism
- Cyclin-Dependent Kinases/antagonists & inhibitors/genetics/metabolism
- Glioma
697: Poch et al. (2004) "Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice." FASEB J. 18(2):418-420 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Gene Deletion
- Male
- Cell Division
- RNA/genetics
- Telomere/metabolism
- Telomerase/deficiency/genetics
- Sex Characteristics
- Diet
- Apolipoproteins E/deficiency/genetics
- Arteriosclerosis/chemically induced/genetics/metabolism/pathology
- Cholesterol, Dietary/pharmacology
- Leukocytes/cytology/enzymology/metabolism
1719: Dell'Era et al. (2003) "Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development." Circ. Res. 93(5):414-420 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Mutant Strains
- Cells, Cultured
- Transcription Factors
- Gene Expression
- Enzyme Inhibitors/pharmacology
- Tetradecanoylphorbol Acetate/pharmacology
- Embryo, Mammalian/cytology
- Homeodomain Proteins/genetics
- Signal Transduction/drug effects
- Protein-Tyrosine Kinases/antagonists & inhibitors
- Cell Size/physiology
- Butadienes/pharmacology
- Nitriles/pharmacology
- Receptor, Fibroblast Growth Factor, Type 1
- Myosin Heavy Chains/genetics
- Receptor Protein-Tyrosine Kinases/genetics/physiology
- Cell Differentiation/drug effects/genetics/physiology
- Epidermal Growth Factor/physiology
- Mesoderm/cytology/metabolism
- Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors
- Myocytes, Cardiac/cytology/drug effects/physiology
- Pyrroles/pharmacology
- Receptors, Fibroblast Growth Factor/genetics/physiology
- Stem Cells/cytology/drug effects/metabolism
- Xenopus Proteins/genetics
2011: Ranieri et al. (2010) "Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance." Proc. Natl. Acad. Sci. U.S.A. 107(30):13420-13425 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Mice, Inbred C57BL
- Longevity/genetics
- Phosphorylation
- Cells, Cultured
- Mice, Inbred Strains
- Flow Cytometry
- Immunoblotting
- Insulin/pharmacology
- RNA Interference
- Insulin Resistance/physiology
- Hypoglycemic Agents/pharmacology
- Mice, Obese
- Ribosomal Protein S6 Kinases, 70-kDa/metabolism
- Adipose Tissue/cytology/metabolism
- 3T3-L1 Cells
- Leptin/genetics/metabolism
- Adipocytes/cytology/drug effects/metabolism
- Glucose Intolerance/genetics/physiopathology
- Hyperinsulinism/genetics/physiopathology
- Obesity/genetics/metabolism/physiopathology
- Shc Signaling Adaptor Proteins/genetics/metabolism
1142: Fabrizio et al. (2004) "Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae." J. Cell Biol. 166(7):1055-1067 (PubMed)

1 citation in connected databases
- Tags:
- Hydrogen Peroxide/pharmacology
- Cells, Cultured
- Oxidative Stress/genetics
- Aging/genetics/metabolism
- Species Specificity
- Starvation
- Environment
- Adaptation, Physiological/genetics
- Aging, Premature/genetics/metabolism
- Apoptosis/drug effects/genetics
- Cell Survival/drug effects/genetics
- Culture Media/pharmacology
- Mutation/drug effects/genetics
- Saccharomyces cerevisiae/drug effects/genetics/metabolism
- Superoxides/metabolism
1206: Fernández-Galaz et al. (2001) "Decreased leptin uptake in hypothalamic nuclei with ageing in Wistar rats." J. Endocrinol. 171(1):23-32 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Rats
- Brain/metabolism
- Recombinant Proteins/metabolism
- RNA, Messenger/analysis
- Aging/metabolism
- Blotting, Western/methods
- Reverse Transcriptase Polymerase Chain Reaction
- Rats, Wistar
- Receptors, Cell Surface
- Receptors, Leptin
- Immunohistochemistry/methods
- Carrier Proteins/analysis/genetics/metabolism
- Hypothalamus, Middle/metabolism
- Image Processing, Computer-Assisted
- Leptin/analysis/genetics/pharmacokinetics
1233: Kida et al. (1995) "Deposition of apolipoproteins E and J in senile plaques is topographically determined in both Alzheimer's disease and Down's syndrome brain." Brain Res. 685(1-2):211-216 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Immunohistochemistry
- Adult
- Child
- Aging/metabolism
- Adolescent
- Middle Aged
- Aged
- Aged, 80 and over
- Clusterin
- Case-Control Studies
- Brain Chemistry/physiology
- Alzheimer Disease/metabolism
- Apolipoproteins E/analysis
- Down Syndrome/metabolism
- Molecular Chaperones
- Glycoproteins/analysis
- Brain Mapping/methods
- Cerebellum/chemistry
- Cerebral Cortex/chemistry
- Corpus Striatum/chemistry
- Nerve Tissue Proteins/analysis
3394: Botto et al. (1998) "Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies." Nat. Genet. 19(1):56-59 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Homozygote
- Crosses, Genetic
- Microscopy, Electron
- Autoantigens/immunology
- Kidney Glomerulus/metabolism/pathology/ultrastructure
- Antibodies, Antinuclear/immunology
- Complement C1q/deficiency/genetics
- Glomerulonephritis/genetics/immunology
2996: Commo et al. (2004) "Human hair greying is linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath." Br. J. Dermatol. 150(3):435-443 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Aging/physiology
- Adult
- Cell Division/physiology
- Middle Aged
- Aged
- Immunohistochemistry/methods
- Melanocytes/physiology
- Keratinocytes/physiology
- Proteins/analysis
- Membrane Glycoproteins
- Hair Color/physiology
- Hair Follicle/cytology/enzymology
- Melanins/analysis
- Monophenol Monooxygenase/analysis
- Oxidoreductases
- Sebaceous Glands/cytology