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Entries tagged Cachexia/etiology (161)

3101: Anselmi et al. (2009) "Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study." Rejuvenation Res 12(2):95-9104 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Adult
- Adolescent
- Middle Aged
- Aged, 80 and over
- Case-Control Studies
- Age Distribution
- Haplotypes
- Italy
- Forkhead Transcription Factors/genetics
- Meta-Analysis as Topic
- Linkage Disequilibrium/genetics
- Population Dynamics
3120: Laplana et al. (2010) "Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes." Biogerontology 11(4):437-446 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Alleles
- Adult
- Adolescent
- Polymorphism, Genetic
- Aged, 80 and over
- Genetic Markers
- Haplotypes
- Young Adult
- Receptors, Calcitriol/genetics
3132: Conneely et al. (2012) "Human longevity and common variations in the LMNA gene: a meta-analysis." Aging Cell 11(3):475-481 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Age Factors
- Lamin Type A/genetics
- Progeria/genetics
- Linkage Disequilibrium
- Aged, 80 and over
- Case-Control Studies
- Polymorphism, Single Nucleotide
- Haplotypes
3161: Zhao et al. (2012) "Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity." Aging Cell 11(6):1094-1101 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Transfection
- Aging/genetics/metabolism
- Linkage Disequilibrium
- Aged, 80 and over
- Genes, Reporter
- Case-Control Studies
- Protein Biosynthesis
- Asian Continental Ancestry Group/genetics
- Polymorphism, Single Nucleotide
- Follow-Up Studies
- Haplotypes
- Questionnaires
- HEK293 Cells
- Mitogen-Activated Protein Kinase 1/genetics/metabolism
- Adenylate Cyclase/genetics/metabolism
- Luciferases, Renilla
- Receptors, Adrenergic, beta-1/genetics/metabolism
- Receptors, Adrenergic, beta-2/genetics/metabolism
3166: Dato et al. (2012) "UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts." Mech. Ageing Dev. 133(8):530-537 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Longevity/physiology
- Male
- Middle Aged
- Cohort Studies
- Aged, 80 and over
- Polymorphism, Single Nucleotide
- Haplotypes
- Hand Strength/physiology
- Denmark
- Endopeptidases/genetics/metabolism
- Ubiquitin-Specific Proteases
3206: Soerensen et al. (2010) "Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data." Aging Cell 9(6):1010-1017 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Genotype
- Male
- Longevity/genetics
- Aged, 80 and over
- Gene Frequency
- Case-Control Studies
- Polymorphism, Single Nucleotide
- Genetic Variation/genetics
- Haplotypes
- Longitudinal Studies
- Forkhead Transcription Factors/genetics/metabolism
3213: Neville et al. (2007) "Absence of relationship between MTTP haplotypes and longevity." J. Gerontol. A Biol. Sci. Med. Sci. 62(2):202-205 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Carrier Proteins/genetics
- Longevity/genetics
- Phenotype
- Adult
- Middle Aged
- Linkage Disequilibrium
- Cohort Studies
- Aged
- Polymorphism, Single Nucleotide
- Risk
- Haplotypes
- Cardiovascular Diseases/genetics
- Great Britain
- Genetic Markers/genetics
- Sample Size
3217: Lio et al. (2002) "Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population." Genes Immun. 3(1):20-24 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Alleles
- Adult
- Middle Aged
- Polymorphism, Genetic
- Aged
- Aged, 80 and over
- Gene Frequency
- Haplotypes
- Membrane Proteins
- HLA Antigens/genetics
- Histocompatibility Antigens Class I/genetics
- Sicily
- Genes, MHC Class I
3303: Titus et al. (2013) "Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans." Sci Transl Med 5(172):172ra21 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Mutation
- Mice, Transgenic
- DNA Repair
- Fertility
- Adult
- Child
- Cell Aging
- Age Factors
- Adolescent
- Child, Preschool
- Gene Expression Regulation
- Aging/genetics/metabolism/pathology
- RNA Interference
- BRCA2 Protein/genetics/metabolism
- BRCA1 Protein/genetics/metabolism
- DNA Breaks, Double-Stranded
- Young Adult
- Anti-Mullerian Hormone/blood
- Oocytes/metabolism/pathology
- Ovary/metabolism/pathology/physiopathology
1071: Motta et al. (2004) "Mammalian SIRT1 represses forkhead transcription factors." Cell 116(4):551-563 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Apoptosis
- Up-Regulation
- Forkhead Transcription Factors
- Protein Binding
- Tumor Suppressor Protein p53/metabolism
- Transcription, Genetic
- Cell Line
- HeLa Cells
- Blotting, Northern
- Cell Cycle Proteins/metabolism
- Dose-Response Relationship, Drug
- Transcription Factors/metabolism
- Blotting, Western
- Gene Expression Regulation
- DNA-Binding Proteins/metabolism
- Stem Cells/metabolism
- Embryo, Mammalian/cytology
- Plasmids/metabolism
- Genes, Reporter
- Precipitin Tests
- Acetylation
- Down-Regulation
- Sirtuin 1
- PTEN Phosphohydrolase
- Histone Acetyltransferases
- Acetyltransferases/metabolism
- p300-CBP Transcription Factors
- Phosphoric Monoester Hydrolases/metabolism
- Histone Deacetylases/metabolism/physiology
- Sirtuins/metabolism/physiology
- Tumor Suppressor Proteins/metabolism
1079: Kauffmann-Zeh et al. (1997) "Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB." Nature 385(6616):544-548 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Signal Transduction
- Proto-Oncogene Proteins c-akt
- Rats
- Fibroblasts
- Point Mutation
- Cell Line
- Androstadienes/pharmacology
- Enzyme Inhibitors/pharmacology
- ras Proteins/metabolism
- Phosphatidylinositol 3-Kinases
- Apoptosis/drug effects
- Chromones/pharmacology
- Morpholines/pharmacology
- Ribosomal Protein S6 Kinases
- Tamoxifen/analogs & derivatives/pharmacology
- Phosphotransferases (Alcohol Group Acceptor)/genetics/metabolism
- Polyenes/pharmacology
- Protein-Serine-Threonine Kinases/antagonists & inhibitors/genetics/metabolism
- Proto-Oncogene Proteins/antagonists & inhibitors/genetics/metabolism
- Proto-Oncogene Proteins c-myc/antagonists & inhibitors/physiology
- Sirolimus
1176: Neubauer et al. (1998) "Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis." Cell 93(3):397-409 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Phenotype
- Fibroblasts
- RNA, Messenger/analysis
- DNA-Binding Proteins/genetics
- B-Lymphocytes/cytology
- Proto-Oncogene Proteins
- Protein-Tyrosine Kinases/genetics/physiology
- Janus Kinase 2
- Hematopoietic Stem Cells/cytology
- Hematopoiesis/genetics
- Liver/cytology/embryology
- Phosphoproteins/genetics
- Cytokines/pharmacology
- Interferon Regulatory Factor-1
- Receptors, Cytokine/physiology
- Anemia
- Erythrocytes
- Erythroid Precursor Cells/cytology
- Leukopoiesis
- Receptors, Erythropoietin/physiology
1297: Stefansson et al. (2002) "Neuregulin 1 and susceptibility to schizophrenia." Am. J. Hum. Genet. 71(4):877-892 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Chromosome Mapping
- Molecular Sequence Data
- Genetic Predisposition to Disease
- Chromosomes, Human, Pair 8
- Receptor, Epidermal Growth Factor/genetics
- Haplotypes
- Neuregulin-1/genetics
- Schizophrenia/genetics
1328: Cohen et al. (2004) "Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase." Science 305(5682):390-392 (PubMed)

6 citations in connected databases
- Tags:
- Animals
- Humans
- Male
- Apoptosis
- Mutation
- Proto-Oncogene Proteins/metabolism
- Rats
- Alleles
- Cell Line
- Cell Survival
- DNA-Binding Proteins/metabolism
- Mitochondria/metabolism
- Rats, Inbred F344
- Acetylation
- Adipose Tissue/metabolism
- Sirtuin 1
- Sirtuins/genetics/metabolism
- Caloric Restriction
- Histone Deacetylases/genetics/metabolism
- Kidney/metabolism
- Liver/metabolism
- Proto-Oncogene Proteins c-bcl-2
- bcl-2-Associated X Protein
- Insulin/metabolism/pharmacology
- RNA, Small Interfering
- Antigens, Nuclear/metabolism
- Insulin-Like Growth Factor I/metabolism/pharmacology
1453: Son et al. (2004) "Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle." Diabetologia 47(1):47-54 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Carrier Proteins/genetics/metabolism
- Mice
- Male
- Aging
- Mice, Transgenic
- Base Sequence
- Glucose Tolerance Test
- Kinetics
- Oxygen Consumption
- DNA Primers
- Obesity/genetics
- Diet
- Diet, Reducing
- Muscle, Skeletal/metabolism
- Weight Loss
- Mitochondria, Muscle/metabolism
- Mitochondrial Proteins
- Ion Channels
- Animal Feed
1480: Chua et al. (2005) "Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress." Cell Metab. 2(1):67-76 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Hydrogen Peroxide/pharmacology
- Fibroblasts
- Cell Aging/drug effects
- Sirtuin 1
- Doxorubicin/pharmacology
- Cyclin-Dependent Kinase Inhibitor p16
- Genes, ras/genetics
- Tumor Suppressor Protein p14ARF/metabolism
- DNA Damage/drug effects
- Oxidative Stress/drug effects
- Sirtuins/deficiency/genetics/metabolism
- Cell Proliferation/drug effects
- NIH 3T3 Cells
- S Phase/drug effects
1675: Howell et al. (2005) "VEGF polymorphisms and severity of atherosclerosis." J. Med. Genet. 42(6):485-490 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Genetic Predisposition to Disease
- Middle Aged
- Disease Progression
- Gene Frequency
- Polymorphism, Single Nucleotide
- Haplotypes
- Coronary Artery Disease/genetics/radiography
- Vascular Endothelial Growth Factor A/genetics
1705: Kim et al. (2006) "Association between the MLH1 gene and longevity." Hum. Genet. 119(3):353-354 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Carrier Proteins/genetics
- Longevity/genetics
- Adaptor Proteins, Signal Transducing
- Nuclear Proteins/genetics
- Middle Aged
- Aged
- Aged, 80 and over
- Gene Frequency
- Polymorphism, Single Nucleotide
- Haplotypes
- Genetic Testing/methods
1725: Thomas et al. (2001) "Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia." Hum. Mol. Genet. 10(1):39-45 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Heterozygote
- Mutation
- Alleles
- Phenotype
- DNA/metabolism
- Child
- Pedigree
- Repressor Proteins
- Infant
- Homeodomain Proteins/genetics
- Mutation, Missense
- Family Health
- Haplotypes
- Chromosomes, Artificial, Yeast
- Basic Helix-Loop-Helix Transcription Factors
- Optic Nerve/abnormalities
- Pituitary Gland/abnormalities
1776: Qin et al. (2006) "Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction." J. Biol. Chem. 281(31):21745-21754 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Mice, Transgenic
- Enzyme Activation
- Mice, Inbred Strains
- Sirtuin 1
- Caloric Restriction
- Sirtuins/metabolism
- Endopeptidases/metabolism
- Amyloid Precursor Protein Secretases
- Aspartic Acid Endopeptidases
- Intracellular Signaling Peptides and Proteins/genetics/physiology
- Protein-Serine-Threonine Kinases/genetics/physiology
- Alzheimer Disease/diet therapy/prevention & control
- Amyloid/analysis
- Neurons/enzymology/pathology
- rho-Associated Kinases