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Entries tagged Neoplasms/etiology/genetics (52)

1939: Hu et al. (2007) "Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase." Neurobiol Learn Mem 87(3):372-384 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Longevity/physiology
- Mice, Transgenic
- Analysis of Variance
- Superoxide Dismutase/metabolism
- Memory/physiology
- Mitochondria/enzymology
- Hippocampus/enzymology
- Long-Term Potentiation/physiology
2206: Albayram et al. (2011) "Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging." Proc. Natl. Acad. Sci. U.S.A. 108(27):11256-11261 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Mice, Inbred C57BL
- Aging/physiology
- Gene Expression
- Cell Count
- Memory/physiology
- Maze Learning/physiology
- Neurons/cytology/physiology
- Neuroglia/cytology/physiology
- Hippocampus/cytology/physiology
- Brain/cytology/physiology
- Interleukin-6/genetics/physiology
- Neurogenesis/physiology
- Receptor, Cannabinoid, CB1/deficiency/genetics/physiology
- Seizures/pathology/physiopathology
- gamma-Aminobutyric Acid/physiology
2794: Pelvig et al. (2008) "Neocortical glial cell numbers in human brains." Neurobiol. Aging 29(11):1754-1762 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Aging/pathology
- Middle Aged
- Aged
- Aged, 80 and over
- Cell Count
- Brain/cytology
- Young Adult
- Neocortex/cytology
- Neuroglia/cytology
3223: Koropatnick et al. (2008) "A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men." J. Gerontol. A Biol. Sci. Med. Sci. 63(11):1235-1240 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Longevity/physiology
- Male
- Aged
- Aged, 80 and over
- Cholesterol Ester Transfer Proteins/genetics
- Cardiovascular Diseases/mortality
- Lipoproteins, HDL/blood
- Hawaii
- Japan/ethnology
3724: Maehara et al. (2010) "CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses." Mol. Cell. Biol. 30(9):2090-2104 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cells, Cultured
- Tumor Suppressor Protein p53/metabolism
- Phenotype
- Transcription, Genetic
- Cell Line
- Cell Aging
- Gene Expression Regulation
- Retinoblastoma Protein/metabolism
- Mitosis
- Fibroblasts/cytology/metabolism
- Protein Biosynthesis
- Protein Processing, Post-Translational
- Cyclin-Dependent Kinase Inhibitor p16/metabolism
- RNA, Small Interfering/metabolism
- Cell Proliferation
- Heterochromatin/metabolism
- Receptors, Retinoic Acid/metabolism
- Autoantigens/metabolism
- Chromosomal Proteins, Non-Histone/deficiency/metabolism
- Cytoprotection
3725: Calabrese et al. (2009) "SOCS1 links cytokine signaling to p53 and senescence." Mol. Cell 36(5):754-767 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Phosphorylation
- Protein-Serine-Threonine Kinases/metabolism
- Signal Transduction
- DNA Damage
- Tumor Suppressor Protein p53/metabolism
- Cell Aging
- Cell Cycle Proteins/metabolism
- DNA-Binding Proteins/metabolism
- Cell Nucleus/metabolism
- RNA Interference
- Cell Line, Tumor
- Tumor Suppressor Proteins/metabolism
- Ataxia Telangiectasia Mutated Proteins
- STAT5 Transcription Factor/metabolism
- Suppressor of Cytokine Signaling Proteins/analysis/metabolism/physiology
3726: Squillaro et al. (2010) "Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA." FASEB J. 24(5):1593-1603 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cells, Cultured
- DNA Damage
- Tumor Suppressor Protein p53/metabolism
- Cell Aging/genetics
- DNA Repair/genetics
- Retinoblastoma Protein/metabolism
- Cell Cycle/genetics
- Down-Regulation
- Gene Silencing
- DNA Methylation
- Mesenchymal Stromal Cells/physiology
- Cytosine/metabolism
- Methyl-CpG-Binding Protein 2/genetics/metabolism
3779: Morris et al. (2002) "Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function." Oncogene 21(27):4277-4288 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Apoptosis
- Cyclin-Dependent Kinase Inhibitor p21
- Protein Binding
- Models, Biological
- Genes, p53
- Cell Aging/genetics
- Papillomavirus E7 Proteins
- Repressor Proteins
- Cell Division/genetics
- Cell Cycle/genetics
- Genes, Retinoblastoma
- Fibroblasts/cytology/metabolism
- Cyclin-Dependent Kinase 4
- Proto-Oncogene Proteins
- Retinoblastoma Protein/physiology
- Recombinant Fusion Proteins/physiology
- Cyclins/biosynthesis/genetics
- Genes, p16
- Clone Cells/cytology/metabolism
- Protein-Serine-Threonine Kinases/genetics/physiology
- Tumor Suppressor Protein p53/deficiency/physiology
- Cyclin-Dependent Kinases/genetics/physiology
- Cyclin-Dependent Kinase Inhibitor p16/biosynthesis
- Cell Transformation, Viral/genetics
- Cyclin-Dependent Kinase 6
- Genetic Vectors/genetics/pharmacology
- Oncogene Proteins, Viral/genetics/physiology
1669: Tomita et al. (2003) "Defective brain development in mice lacking the Hif-1alpha gene in neural cells." Mol. Cell. Biol. 23(19):6739-6749 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Gene Deletion
- DNA-Binding Proteins/genetics/physiology
- Cells, Cultured
- Apoptosis/genetics
- Transcription Factors
- Animals, Genetically Modified
- Gene Expression Regulation, Developmental
- Behavior, Animal
- Nuclear Proteins/genetics/physiology
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Hypoxia-Inducible Factor 1
- Cell Hypoxia/genetics
- Hypoxia-Inducible Factor 1, alpha Subunit
- Glucose Transporter Type 1
- Monosaccharide Transport Proteins/metabolism
- Fibroblasts/metabolism/ultrastructure
- Brain/blood supply/embryology/pathology
- Endothelial Growth Factors/metabolism
- Hydrocephalus/embryology/pathology
- Intercellular Signaling Peptides and Proteins/metabolism
- Lymphokines/metabolism
- Neurons/physiology/ultrastructure
336: Fischer et al. (1991) "NGF improves spatial memory in aged rodents as a function of age." J. Neurosci. 11(7):1889-1906 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Aging/physiology
- Rats
- Cell Count
- Nerve Growth Factors/pharmacology
- Rats, Inbred Strains
- Receptors, Nerve Growth Factor
- Brain/cytology
- Choline O-Acetyltransferase/analysis
- Learning
- Memory/physiology
- Neurons/chemistry/cytology
- Receptors, Cell Surface/analysis
- Swimming
337: Alberch et al. (1991) "Involvement of nerve growth factor and its receptor in the regulation of the cholinergic function in aged rats." J. Neurochem. 57(5):1483-1487 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Aging
- Rats
- Organ Specificity
- Kinetics
- Cell Membrane/metabolism
- Choline O-Acetyltransferase/metabolism
- Nerve Growth Factors/physiology
- Rats, Inbred Strains
- Receptors, Nerve Growth Factor
- Brain/growth & development/metabolism
- Receptors, Cell Surface/physiology
1190: Toran-Allerand et al. (1992) "Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain." Proc. Natl. Acad. Sci. U.S.A. 89(10):4668-4672 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Rats
- Nerve Growth Factors/metabolism
- Rats, Inbred Strains
- Receptors, Nerve Growth Factor
- Neurons/metabolism
- Prosencephalon/metabolism
- Autoradiography
- Ovariectomy
- Estradiol/metabolism
- Choline O-Acetyltransferase/genetics/metabolism
- Iodine Radioisotopes
- RNA, Messenger/analysis/genetics/metabolism
- Receptors, Cell Surface/analysis/genetics/metabolism
- Receptors, Estrogen/analysis/metabolism
1407: Genoux et al. (2002) "Protein phosphatase 1 is a molecular constraint on learning and memory." Nature 418(6901):970-975 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Phosphorylation
- Mutation
- Aging/genetics/physiology
- Mice, Transgenic
- Protein Subunits
- Gene Expression Regulation
- Time Factors
- Cyclic AMP Response Element-Binding Protein/metabolism
- Calcium-Calmodulin-Dependent Protein Kinases/metabolism
- Memory/physiology
- Protein Phosphatase 1
- Cognition/physiology
- Space Perception/physiology
- Discrimination (Psychology)/physiology
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Hippocampus/enzymology/physiology
- Learning/physiology
- Phosphoprotein Phosphatases/antagonists & inhibitors/genetics/metabolism
- Receptors, AMPA/metabolism
3813: Bailet et al. (2009) "Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest." Cancer Res. 69(7):2748-2756 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Signal Transduction
- Up-Regulation
- Transfection
- Tumor Suppressor Protein p53/metabolism
- Cell Aging/physiology
- Promoter Regions, Genetic
- DNA Methylation
- src Homology Domains
- RNA, Small Interfering/genetics
- Cell Growth Processes/physiology
- Chemotaxis
- Cyclin-Dependent Kinase Inhibitor p21/biosynthesis/genetics
- Intracellular Signaling Peptides and Proteins/genetics/metabolism/physiology
- Melanoma/enzymology/genetics/pathology
- Neoplastic Stem Cells/pathology
- Protein-Tyrosine Kinases/biosynthesis/genetics/metabolism/physiology
- Spheroids, Cellular
3837: Fuxe et al. (2000) "Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A." Cell Growth Differ. 11(7):373-384 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Protein-Serine-Threonine Kinases/metabolism
- Tumor Suppressor Protein p53/genetics/metabolism
- Mutation
- Transfection
- Cell Cycle Proteins
- Cell Division
- Tumor Suppressor Proteins
- Cell Line
- Tumor Cells, Cultured
- Cell Aging
- Recombinant Proteins/metabolism
- Immunoblotting
- Enzyme Induction
- Cyclin-Dependent Kinase 4
- Proto-Oncogene Proteins
- Retinoblastoma Protein/genetics/metabolism
- Cell Size
- Telomerase/antagonists & inhibitors/metabolism
- Cyclin D1/genetics/metabolism
- Cyclin-Dependent Kinase 6
- Cyclin-Dependent Kinase Inhibitor p15
- Adenoviridae/genetics/metabolism
- Carrier Proteins/genetics/immunology/metabolism
- Cyclin-Dependent Kinase Inhibitor p16/genetics/immunology/metabolism
- Cyclin-Dependent Kinases/antagonists & inhibitors/genetics/metabolism
- Glioma
4253: Rajarajacholan et al. (2013) "The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway." PLoS Biol. 11(3):e1001502 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cell Line
- Immunoblotting
- Signal Transduction/genetics/physiology
- Retinoblastoma Protein/genetics/metabolism
- Tumor Suppressor Proteins/genetics/metabolism
- Cell Aging/genetics/physiology
- Nuclear Proteins/genetics/metabolism
- beta-Galactosidase/genetics/metabolism
- Immunoprecipitation
- Intracellular Signaling Peptides and Proteins/genetics/metabolism
- Real-Time Polymerase Chain Reaction
- E2F Transcription Factors/genetics/metabolism
- Adaptor Proteins, Vesicular Transport/genetics/metabolism
- Endocytosis/genetics/physiology
1368: Shen et al. (1997) "Skeletal and CNS defects in Presenilin-1-deficient mice." Cell 89(4):629-639 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Mutation
- Phenotype
- Base Sequence
- DNA Primers/genetics
- Gestational Age
- Nerve Degeneration/genetics
- Presenilin-1
- Membrane Proteins/deficiency/genetics/physiology
- Bone and Bones/abnormalities/embryology
- Alzheimer Disease/etiology/genetics
- Central Nervous System/abnormalities/embryology
- Cerebral Hemorrhage/genetics
1373: Handler et al. (2000) "Presenilin-1 regulates neuronal differentiation during neurogenesis." Development 127(12):2593-2606 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Apoptosis
- Reference Values
- Cell Differentiation
- In Situ Hybridization
- Embryonic and Fetal Development
- Cell Movement
- Neurons/cytology/physiology
- Presenilin-1
- Membrane Proteins/deficiency/genetics/physiology
- Brain/cytology/embryology
3708: Morris et al. (2015) "Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry." J. Gerontol. A Biol. Sci. Med. Sci. 70(2):133-142 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Genotype
- Male
- Carrier Proteins/genetics
- Longevity/genetics
- Aged
- Aged, 80 and over
- Gene Frequency
- Case-Control Studies
- Adaptor Proteins, Signal Transducing/genetics
- Polymorphism, Single Nucleotide
- Longitudinal Studies
- Asian Americans/genetics
- Hawaii
- Japan/ethnology
- Ribosomal Protein S6 Kinases, 90-kDa/genetics
- TOR Serine-Threonine Kinases/genetics
3728: Humbert et al. (2010) "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." EMBO J. 29(2):376-386 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Phosphorylation
- Cell Line
- Cell Aging
- Gene Expression Regulation
- Fibroblasts/cytology/metabolism
- Protein-Serine-Threonine Kinases/genetics/metabolism
- Protein Kinases/genetics/metabolism
- Repressor Proteins/genetics/metabolism
- Ploidies