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Entries tagged Receptors, Somatotropin/genetics (827)

4172: Baberschke et al. (2015) "Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans." Chemosphere 124:122-128 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Dose-Response Relationship, Drug
- Caenorhabditis elegans/drug effects/physiology
- Longevity/drug effects
- Energy Metabolism/drug effects
- Environmental Pollutants/toxicity
- Body Size/drug effects
- Acetates/toxicity
- Dimethylnitrosamine/toxicity
4235: Cho et al. (2012) "POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway." Cell Death Differ. 19(4):703-712 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Tumor Suppressor Protein p53/genetics/metabolism
- Reactive Oxygen Species/metabolism
- Cell Aging
- Aging/genetics/metabolism/pathology
- Repressor Proteins/genetics/metabolism
- Cyclin-Dependent Kinase Inhibitor p16/genetics/metabolism
- Gene Knockdown Techniques
- Kruppel-Like Transcription Factors/genetics/metabolism
- Arteries/metabolism/pathology
- Atherosclerosis/genetics/metabolism/pathology
- Cell Cycle Checkpoints/genetics
- Endothelial Cells/metabolism/pathology
4236: Lentini et al. (2012) "MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation." J. Cell. Physiol. 227(9):3324-3332 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Signal Transduction
- Tumor Suppressor Protein p53/genetics/metabolism
- Cells, Cultured
- Aneuploidy
- Cell Aging/genetics
- Gene Expression Regulation
- Fibroblasts/metabolism
- Cell Cycle Proteins/genetics/metabolism
- Gene Silencing
- Repressor Proteins/genetics/metabolism
- Calcium-Binding Proteins/genetics/metabolism
- Tumor Suppressor Protein p14ARF/genetics/metabolism
- beta-Galactosidase/genetics/metabolism
- Cell Proliferation
- Chromosomal Instability/genetics
- RNA, Small Interfering/genetics
- Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism
- Cell Cycle Checkpoints/genetics
- M Phase Cell Cycle Checkpoints/genetics
- Mad2 Proteins
4239: Ren et al. (2013) "Overexpression of reptin in renal cell carcinoma contributes to tumor malignancies and its inhibition triggers senescence of cancer cells." Urol. Oncol. 31(7):1358-1366 (PubMed)

1 citation in connected databases
- Tags:
- Carrier Proteins/genetics/metabolism
- Humans
- Female
- Male
- Immunohistochemistry
- Cell Aging/genetics
- DNA Helicases/genetics/metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Middle Aged
- Gene Expression Regulation, Neoplastic
- Cell Cycle/genetics
- RNA Interference
- Cell Movement/drug effects
- Cell Line, Tumor
- Cell Proliferation
- Kaplan-Meier Estimate
- Neoplasm Invasiveness
- Kidney Neoplasms/genetics/metabolism/pathology
- Carcinoma, Renal Cell/genetics/metabolism/pathology
4268: Park et al. (2014) "PPM1B depletion induces premature senescence in human IMR-90 fibroblasts." Mech. Ageing Dev. 138:45-52 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cells, Cultured
- Tumor Suppressor Protein p53/metabolism
- Models, Biological
- Fibroblasts
- Transcription Factors
- Cell Aging/genetics
- Gene Expression Regulation
- NF-kappa B/metabolism
- p38 Mitogen-Activated Protein Kinases/metabolism
- Cell Proliferation/physiology
- Phosphoprotein Phosphatases/genetics
4404: Kumar et al. (2016) "Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span." PLoS Genet. 12(2):e1005866 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Longevity
- Mutation
- Animals, Genetically Modified
- Phosphatidylinositol 3-Kinases/genetics
- RNA Interference
- Stress, Physiological/genetics
- Sirtuins/genetics
- Caenorhabditis elegans/drug effects/physiology
- Receptor, Insulin/genetics
- Forkhead Transcription Factors/genetics
- Aging/drug effects/genetics
- Electron Transport Complex III/genetics
- Angiotensin-Converting Enzyme Inhibitors/pharmacology
- Caenorhabditis elegans Proteins/antagonists & inhibitors/genetics
- Captopril/pharmacology
4567: Saharia et al. (2016) "Reserpine requires the D2-type receptor, " J. Biosci. 41(4):689-695 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mutation
- Signal Transduction/drug effects
- Transcription Factors/biosynthesis/genetics
- Behavior, Animal/drug effects
- Longevity/drug effects/genetics
- Neurons/drug effects
- Caenorhabditis elegans Proteins/biosynthesis/genetics
- Caenorhabditis elegans/drug effects/genetics/growth & development
- Exoribonucleases/biosynthesis/genetics
- GTP-Binding Protein alpha Subunits, Gi-Go/biosynthesis/genetics
- Multidrug Resistance-Associated Proteins/biosynthesis/genetics
- Receptors, Dopamine D2/biosynthesis/genetics
- Reserpine/administration & dosage
4580: Zhang et al. (2016) "NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice." Science 352(6292):1436-1443 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Mice
- Mice, Inbred C57BL
- Oxidative Stress
- Longevity/drug effects/physiology
- Mitochondria/drug effects/physiology
- Unfolded Protein Response/drug effects
- Cellular Reprogramming
- Cellular Senescence/drug effects/physiology
- Melanocytes/cytology/drug effects/physiology
- Mice, Inbred mdx
- Muscular Dystrophies/therapy
- Myoblasts, Skeletal/cytology/drug effects/physiology
- NAD/metabolism/pharmacology
- Neural Stem Cells/cytology/drug effects/physiology
- Niacinamide/analogs & derivatives/metabolism
- Repressor Proteins/biosynthesis
4648: Wang et al. (2015) "The longevity effect of echinacoside in Caenorhabditis elegans mediated through daf-16." Biosci. Biotechnol. Biochem. 79(10):1676-1683 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Antioxidants/pharmacology
- Reproduction
- Transcription, Genetic
- Dose-Response Relationship, Drug
- Gene Expression Regulation
- Hot Temperature
- Molecular Structure
- Oxidative Stress/drug effects
- Longevity/drug effects/genetics
- Heat-Shock Response/drug effects
- Caenorhabditis elegans/drug effects/genetics/growth & development/metabolism
- Caenorhabditis elegans Proteins/agonists/genetics/metabolism
- Protective Agents/pharmacology
- Glycosides/pharmacology
- Forkhead Transcription Factors/agonists/genetics/metabolism
- Larva/drug effects/genetics/growth & development/metabolism
- Paraquat/antagonists & inhibitors/pharmacology
- RNA, Messenger/agonists/genetics/metabolism
4685: Urban et al. (2017) "Non-linear impact of glutathione depletion on C. elegans life span and stress resistance." Redox Biol 11:502-515 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Oxidation-Reduction
- Oxidative Stress/genetics
- Caenorhabditis elegans/genetics/physiology
- DNA-Binding Proteins/genetics
- Tumor Suppressor Protein p53/genetics
- Transcription Factors/genetics
- Gene Expression Regulation, Developmental
- Repressor Proteins/genetics
- Dipeptides/metabolism
- Cell Death/genetics
- Glutamate-Cysteine Ligase/genetics
- Caenorhabditis elegans Proteins/genetics
- Forkhead Transcription Factors/genetics
- Gene Knockdown Techniques
- Glutathione/biosynthesis/genetics
- Maleates/metabolism
- Sulfhydryl Compounds/metabolism
4746: Zhou et al. (2018) "Stress resistance and lifespan extension of Caenorhabditis elegans enhanced by peptides from mussel (Mytilus edulis) protein hydrolyzate." Food Funct 9(6):3313-3320 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Reactive Oxygen Species/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Longevity/drug effects
- Oxidative Stress/drug effects
- Caenorhabditis elegans/drug effects/genetics/growth & development/metabolism
- Mytilus edulis/chemistry
- Peptides/chemistry/isolation & purification/pharmacology
- Protein Hydrolysates/chemistry/pharmacology
4772: Wood et al. (2018) "Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster." Proc. Natl. Acad. Sci. U.S.A. 115(7):1564-1569 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Longevity
- Homeostasis
- Sirtuins/genetics/metabolism
- Drosophila melanogaster/genetics/growth & development/metabolism
- Fertility/physiology
- Mitochondria/genetics/metabolism
- Fasting/physiology
- Mitochondrial Proteins/genetics/metabolism
- Glycolysis
- Animals, Genetically Modified/genetics/growth & development/metabolism
- Metabolomics
517: Bischof et al. (2002) "Deconstructing PML-induced premature senescence." EMBO J. 21(13):3358-3369 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Adaptor Proteins, Signal Transducing
- Phosphorylation
- Reactive Oxygen Species
- DNA-Binding Proteins
- Tumor Suppressor Proteins
- Fibroblasts/cytology
- Intracellular Signaling Peptides and Proteins
- Antigens, Nuclear
- Cell Aging/genetics/physiology
- Transcription Factors/deficiency/genetics/physiology
- Acetylation
- Macromolecular Substances
- Recombinant Fusion Proteins/physiology
- Protein Processing, Post-Translational
- Tumor Suppressor Protein p53/chemistry/metabolism
- Structure-Activity Relationship
- Autoantigens/physiology
- Carrier Proteins/physiology
- Cell Nucleus/ultrastructure
- Neoplasm Proteins/deficiency/genetics/physiology
- Nuclear Proteins/physiology
- Organelles/physiology
- Protein Isoforms/deficiency/genetics/physiology
- Proto-Oncogene Proteins p21(ras)/physiology
- SUMO-1 Protein/physiology
- Telomerase/physiology
521: Wang et al. (1998) "Role of PML in cell growth and the retinoic acid pathway." Science 279(5356):1547-1551 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Female
- Male
- Transcription Factors/genetics/physiology
- Apoptosis
- Cyclin-Dependent Kinase Inhibitor p21
- Cells, Cultured
- Transcriptional Activation
- Cell Transformation, Neoplastic
- Cell Division
- Tumor Suppressor Proteins
- Fibroblasts/cytology
- Nuclear Proteins
- Monocytes/cytology
- Cyclins/genetics
- Hematopoiesis
- Cell Differentiation/drug effects
- Hematopoietic Stem Cells/cytology
- Neoplasm Proteins/genetics/physiology
- Granulocytes/cytology
- Leukemia, Promyelocytic, Acute/pathology
- Neoplasms, Experimental/etiology
- Oncogene Proteins, Fusion/physiology
- Tretinoin/pharmacology/physiology
528: Duyao et al. (1995) "Inactivation of the mouse Huntington's disease gene homolog Hdh." Science 269(5222):407-410 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Humans
- Mice
- Female
- Genotype
- Male
- Mice, Inbred C57BL
- Heterozygote
- Homozygote
- Phenotype
- Base Sequence
- Cell Line
- Molecular Sequence Data
- Mesoderm/cytology
- Stem Cells/metabolism
- Nuclear Proteins/genetics/physiology
- Embryonic and Fetal Development
- Ectoderm/cytology
- Huntington Disease/genetics
- Nerve Tissue Proteins/genetics/physiology
529: Zeitlin et al. (1995) "Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue." Nat. Genet. 11(2):155-163 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Genotype
- Apoptosis
- Polymerase Chain Reaction
- Reference Values
- Base Sequence
- Molecular Sequence Data
- HeLa Cells
- Stem Cells/physiology
- Nuclear Proteins/genetics
- Repetitive Sequences, Nucleic Acid
- Genes, Dominant
- Fetal Death/genetics
- DNA Primers
- Genes, Lethal
- Restriction Mapping
- Protein Biosynthesis
- Kidney/metabolism
- Nerve Tissue Proteins/genetics
- Chimera
- Huntington Disease/genetics
- Blastocyst/cytology/physiology
- Embryo, Mammalian/pathology/physiology
539: Kimura et al. (1997) "daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans." Science 277(5328):942-946 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Longevity/genetics
- Phosphorylation
- Signal Transduction
- Mutation
- Amino Acid Sequence
- Chromosome Mapping
- Molecular Sequence Data
- Conserved Sequence
- Genes, Helminth
- Glucose/metabolism
- Insulin/metabolism
- Adipose Tissue/metabolism
- Caenorhabditis elegans Proteins
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates/metabolism
- Energy Intake
- Phosphotransferases (Alcohol Group Acceptor)/metabolism
- Larva/genetics/growth & development/metabolism
- Caenorhabditis elegans/chemistry/genetics/growth & development/metabolism
- Receptor, IGF Type 1/chemistry/genetics
- Receptor, Insulin/chemistry/genetics/metabolism
547: Weeda et al. (1990) "A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome." Cell 62(4):777-791 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Polymerase Chain Reaction
- DNA Repair
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Molecular Sequence Data
- Blotting, Northern
- DNA/genetics
- DNA Helicases/genetics
- Genes
- Blotting, Southern
- RNA Splicing
- Restriction Mapping
- Microinjections
- Cockayne Syndrome/enzymology/genetics
- Dwarfism/enzymology
- Xeroderma Pigmentosum/enzymology/genetics
578: Tuteja et al. (1994) "Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen." EMBO J. 13(20):4991-5001 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- HeLa Cells
- Blotting, Western
- Antigens, Nuclear
- Substrate Specificity
- DNA Helicases
- Adenosine Triphosphatases/chemistry/immunology/isolation & purification
- DNA-Binding Proteins/chemistry/immunology/isolation & purification
- Neutralization Tests
- Nuclear Proteins/chemistry/immunology/isolation & purification
663: Jaarsma et al. (2000) "Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1." Neurobiol. Dis. 7(6 Pt B):623-643 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Transgenic
- Crosses, Genetic
- Cell Death
- Gene Dosage
- Mice, Inbred Strains
- Aging/metabolism
- Disease Progression
- Mitogen-Activated Protein Kinases/metabolism
- JNK Mitogen-Activated Protein Kinases
- Neurofilament Proteins/metabolism
- Amyotrophic Lateral Sclerosis/enzymology/genetics/pathology
- Axons/pathology/ultrastructure
- Brain Stem/enzymology/pathology
- Electron Transport Complex IV/metabolism
- Hippocampus/enzymology/pathology
- Mitochondria/enzymology/pathology/ultrastructure
- Motor Neurons/enzymology/pathology/ultrastructure
- Spinal Cord/enzymology/pathology
- Spinocerebellar Tracts/enzymology/pathology
- Superoxide Dismutase/biosynthesis/genetics