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Entries tagged Telomerase/deficiency/genetics/physiology (36)

3285: Lu et al. (2011) "Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction." Cell 146(6):969-979 (PubMed)

1 citation in connected databases
- Tags:
- Protein-Serine-Threonine Kinases/metabolism
- Cell Division
- Protein Kinases/metabolism
- Transcription Factors/metabolism
- Trans-Activators/metabolism
- Acetylation
- Histone Deacetylases/metabolism
- Caloric Restriction
- Saccharomyces cerevisiae Proteins/metabolism
- Histone Acetyltransferases/metabolism
- AMP-Activated Protein Kinases/metabolism
- Saccharomyces cerevisiae/cytology/enzymology/physiology
1128: Wang et al. (1995) "Impaired energy homeostasis in C/EBP alpha knockout mice." Science 269(5227):1108-1112 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Female
- Male
- Carrier Proteins/genetics
- DNA-Binding Proteins/genetics/physiology
- RNA, Messenger/metabolism
- Homeostasis
- Animals, Newborn
- Gene Expression Regulation
- Membrane Proteins/genetics
- Adipose Tissue/metabolism
- Nuclear Proteins/genetics/physiology
- Liver/metabolism
- Blood Glucose/metabolism
- Energy Metabolism
- CCAAT-Enhancer-Binding Proteins
- Lipid Metabolism
- Mitochondrial Proteins
- Adipose Tissue, Brown/metabolism
- Glucose-6-Phosphatase/genetics
- Glycogen Synthase/genetics/metabolism
- Ion Channels
- Liver Glycogen/metabolism
- Phosphoenolpyruvate Carboxykinase (GTP)/genetics
- Serum Albumin/genetics
1253: Espejel et al. (2004) "Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs." J. Cell Biol. 167(4):627-638 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Longevity/genetics
- Aging, Premature/genetics/metabolism/pathology
- Protein-Serine-Threonine Kinases/deficiency/genetics
- Telomere/genetics
- Telomerase/deficiency/genetics/physiology
- DNA-Activated Protein Kinase
- DNA Repair/genetics
- Neoplasms/genetics/metabolism
- Cell Division/genetics
- Cell Transformation, Neoplastic/genetics/metabolism
- Poly(ADP-ribose) Polymerases/deficiency/genetics
- DNA-Binding Proteins/deficiency/genetics
- Antigens, Nuclear/genetics
- Chromosomal Instability/genetics
2062: Jaskelioff et al. (2011) "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice." Nature 469(7328):102-106 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Cells, Cultured
- Phenotype
- Models, Animal
- Enzyme Activation/drug effects
- Recombinant Fusion Proteins/genetics/metabolism
- Cell Differentiation/drug effects
- Avoidance Learning/drug effects
- DNA Damage/drug effects
- Myelin Sheath/metabolism
- Tamoxifen/analogs & derivatives/pharmacology
- Receptors, Estrogen/genetics/metabolism
- Organ Size/drug effects
- Cell Proliferation/drug effects
- Aging/drug effects/metabolism/pathology
- Brain/anatomy & histology/cytology/drug effects/pathology
- Enzyme Reactivators/pharmacology
- Neural Stem Cells/cytology/drug effects/enzymology/pathology
- Regenerative Medicine
- Smell/drug effects/physiology
- Telomerase/deficiency/genetics/metabolism
- Telomere/drug effects/metabolism/pathology
4265: Liesenfeld et al. (2013) "SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes." BMC Cancer 13:507 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Cell Line
- Chromosome Mapping
- Cell Aging/genetics
- Gene Expression Regulation
- Gene Expression Profiling
- Chromosomes, Human, Pair 10
- Homeodomain Proteins/genetics/metabolism
- Chromosomes, Human, Pair 4
- Fibroblasts/metabolism/pathology/virology
- Keratinocytes/metabolism/pathology/virology
- Papillomaviridae/genetics/metabolism
- Toll-Like Receptor 3/genetics/metabolism
- Uterine Cervical Neoplasms/genetics/pathology
4312: Lee et al. (2015) "ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway." FEBS J. 282(2):361-371 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Rats
- Neoplasms/genetics/pathology
- Cell Aging/genetics
- Signal Transduction/genetics
- Tumor Suppressor Protein p53/biosynthesis
- Gene Expression Regulation, Enzymologic
- HEK293 Cells
- Gene Knockdown Techniques
- Acetyl Coenzyme A/metabolism
- ATP Citrate (pro-S)-Lyase/genetics/metabolism
- AMP-Activated Protein Kinases/genetics
- Carcinogenesis/genetics
- Cytosol/metabolism/pathology
2716: Baloh et al. (1995) "Posturography and balance problems in older people." J Am Geriatr Soc 43(6):638-644 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Aging/physiology
- Aged
- Aged, 80 and over
- Case-Control Studies
- Prospective Studies
- Fear
- Neurologic Examination
- Accidental Falls
- Dizziness/physiopathology
- Gait/physiology
- Hearing Disorders/diagnosis/physiopathology
- Postural Balance/physiology
- Posture/physiology
- Sensation Disorders/diagnosis/physiopathology
- Vestibular Diseases/diagnosis/physiopathology
- Vibration
589: Huggins et al. (2002) "Flap endonuclease 1 efficiently cleaves base excision repair and DNA replication intermediates assembled into nucleosomes." Mol. Cell 10(5):1201-1211 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Protein Binding
- DNA Repair
- Base Sequence
- Molecular Sequence Data
- DNA/chemistry/metabolism
- Kinetics
- Dose-Response Relationship, Drug
- Protein Structure, Tertiary
- Time Factors
- Substrate Specificity
- Chromatin/metabolism
- Nucleosomes/metabolism
- Xenopus
- DNA Ligases/metabolism
- Flap Endonucleases
- Base Pair Mismatch
- Endodeoxyribonucleases/metabolism/physiology
- Hydroxyl Radical
380: Klinghoffer et al. (2001) "The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions." Mol. Cell 7(2):343-354 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Gene Deletion
- Genotype
- Phosphorylation
- Signal Transduction
- Cells, Cultured
- Mice, Transgenic
- Genetic Complementation Test
- Protein Structure, Tertiary
- Time Factors
- Mitogen-Activated Protein Kinases/metabolism
- Recombinant Fusion Proteins/genetics/metabolism
- Gene Targeting/methods
- Glomerulonephritis/genetics/pathology
- Heart Defects, Congenital/genetics/pathology
- Histocytochemistry
- Kidney/abnormalities/embryology/pathology
- Protein Isoforms/genetics/metabolism
- Receptor, Platelet-Derived Growth Factor alpha/genetics/metabolism
- Receptor, Platelet-Derived Growth Factor beta/genetics/metabolism
- Retina/abnormalities/embryology/pathology
- Thrombosis/genetics/pathology
827: Croll et al. (1998) "Expression of BDNF and trkB as a function of age and cognitive performance." Brain Res. 812(1-2):200-208 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Rats
- RNA, Messenger/analysis
- In Situ Hybridization
- Rats, Sprague-Dawley
- Enzyme-Linked Immunosorbent Assay
- Cognition/physiology
- Maze Learning/physiology
- Regression Analysis
- Receptor Protein-Tyrosine Kinases/genetics
- Aging/metabolism/psychology
- Brain-Derived Neurotrophic Factor/analysis/genetics
- Neuroprotective Agents/analysis
- Receptor, Ciliary Neurotrophic Factor
- Receptors, Nerve Growth Factor/genetics
850: Intano et al. (2002) "Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice." Mol. Cell. Biol. 22(7):2410-2418 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Aging/genetics/physiology
- DNA Repair/genetics
- Blotting, Western
- Time Factors
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Spermatogenesis/genetics
- N-Glycosyl Hydrolases/metabolism
- DNA Ligases/metabolism
- Carbon-Oxygen Lyases/metabolism
- Cell Extracts/chemistry
- DNA Glycosylases
- Spermatozoa/chemistry/cytology/metabolism
- Testis/cytology
- Uracil-DNA Glycosidase
1419: Li et al. (1998) "Novel arterial pathology in mice and humans hemizygous for elastin." J. Clin. Invest. 102(10):1783-1787 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Blotting, Northern
- Microscopy, Electron
- Aorta/pathology/physiology
- Arterial Occlusive Diseases/genetics/pathology/physiopathology
- Compliance
- Elastin/genetics
- Tunica Media/pathology
1602: Presse et al. (1992) "Rat melanin-concentrating hormone messenger ribonucleic acid expression: marked changes during development and after stress and glucocorticoid stimuli." Endocrinology 131(3):1241-1250 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Aging/physiology
- Rats
- Blotting, Northern
- Nucleic Acid Hybridization
- Animals, Newborn
- Pregnancy
- Polymerase Chain Reaction/methods
- Oligodeoxyribonucleotides
- RNA, Messenger/biosynthesis/genetics
- DNA Probes
- Gene Expression Regulation/drug effects
- Gestational Age
- Dexamethasone/pharmacology
- Rats, Inbred Strains
- Embryonic and Fetal Development
- Electroshock
- Adrenalectomy
- Hypothalamus/drug effects/physiology
- Melanins/biosynthesis/genetics
- Pituitary Hormones/biosynthesis/genetics
- Brain/drug effects/growth & development/physiology
- Hypothalamic Hormones
- Stress, Psychological/physiopathology
1666: Calon et al. (2004) "Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model." Neuron 43(5):633-645 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Female
- Male
- Mice, Transgenic
- Phosphatidylinositol 3-Kinases/metabolism
- Microscopy, Electron
- Nerve Tissue Proteins/metabolism
- Phosphorylation/drug effects
- Brain/drug effects/metabolism/pathology
- Down-Regulation/genetics
- bcl-Associated Death Protein
- Apoptosis/drug effects/genetics
- Neuropeptides/metabolism
- Actins/metabolism
- Alzheimer Disease/metabolism/pathology/prevention & control
- Carrier Proteins/drug effects/metabolism
- Dendrites/drug effects/metabolism/pathology
- Dietary Fats, Unsaturated/metabolism/pharmacology
- Docosahexaenoic Acids/metabolism/pharmacology/therapeutic use
- Food, Formulated
- Oxidative Stress/drug effects/genetics
- Protein Subunits/metabolism
- Synapses/drug effects/metabolism/pathology
1817: Gong et al. (2006) "Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory." Cell 126(4):775-788 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Cyclic AMP Response Element-Binding Protein/metabolism
- Recombinant Fusion Proteins/genetics/metabolism
- Membrane Proteins/genetics/metabolism
- Memory/physiology
- Amyloid beta-Protein Precursor/genetics/metabolism
- Fear
- Hippocampus/cytology/metabolism
- Presenilin-1
- Cyclic AMP-Dependent Protein Kinases/metabolism
- Synaptic Transmission/physiology
- Alzheimer Disease/enzymology/physiopathology
- Avoidance Learning
- Excitatory Postsynaptic Potentials/physiology
- Gene Products, tat/genetics/metabolism
- Long-Term Potentiation/physiology
- Ubiquitin Thiolesterase/genetics/metabolism
1997: Kilpeläinen et al. (2011) "Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile." Nat. Genet. 43(8):753-760 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Body Weight
- Alleles
- Obesity/genetics
- Polymorphism, Single Nucleotide/genetics
- Body Mass Index
- Genetic Variation/genetics
- Intracellular Signaling Peptides and Proteins/genetics
- Genome-Wide Association Study
- Insulin Receptor Substrate Proteins/genetics
- Adiponectin/blood
- Adiposity/genetics
- Body Fat Distribution
- Meta-Analysis as Topic
- Metabolome/genetics
- Subcutaneous Fat
4267: Yang et al. (2013) "Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage." PLoS ONE 8(11):e79434 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Signal Transduction
- Cells, Cultured
- DNA Damage
- Adult
- Gene Expression
- Middle Aged
- Cell Aging/drug effects
- Receptors, Androgen/genetics/metabolism
- Young Adult
- Gene Knockdown Techniques
- Hair Follicle/cytology/drug effects/metabolism
- Alopecia/genetics/metabolism
- Androgens/pharmacology
4280: Succoio et al. (2015) "Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence." J Proteomics 128:18-29 (PubMed)

4 citations in connected databases
- Tags:
- Humans
- Cell Line
- Cell Aging/physiology
- Cell Differentiation/physiology
- Gene Expression Regulation/physiology
- Fibroblasts/cytology/physiology
- Gene Expression Profiling/methods
- Proteomics/methods
- Stress, Physiological/physiology
- Cell Proliferation/physiology
- Proteome/metabolism
3426: Phiel et al. (2003) "GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides." Nature 423(6938):435-439 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Cells, Cultured
- Cricetinae
- CHO Cells
- Membrane Proteins/metabolism
- Phosphorylation/drug effects
- Peptide Fragments/metabolism
- Endopeptidases/metabolism
- Neurons/drug effects/metabolism/pathology
- Amyloid beta-Peptides/metabolism
- Alzheimer Disease/metabolism/pathology
- Lithium/pharmacology
- Brain/drug effects/metabolism/pathology
- Amyloid Precursor Protein Secretases
- Aspartic Acid Endopeptidases
- Receptors, Notch
- Glycogen Synthase Kinase 3/antagonists & inhibitors/metabolism
1032: Nichols et al. (2001) "Do glucocorticoids contribute to brain aging?" Brain Res. Brain Res. Rev. 37(1-3):273-286 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Apoptosis
- Rats
- Aging/metabolism/pathology
- Brain/drug effects/metabolism/pathology
- Hippocampus/drug effects/metabolism/pathology
- Glial Fibrillary Acidic Protein/metabolism
- Receptors, Glucocorticoid/metabolism
- Adrenalectomy
- Glucocorticoids/metabolism/pharmacology