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Entries tagged Mammary Neoplasms, Experimental/chemically induced/enzymology/genetics/pathology (61)

1592: Liszt et al. (2005) "Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase." J. Biol. Chem. 280(22):21313-21320 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- RNA, Messenger/metabolism
- Amino Acid Sequence
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Catalysis
- Blotting, Northern
- Catalytic Domain
- Dose-Response Relationship, Drug
- Blotting, Western
- Protein Structure, Tertiary
- Time Factors
- Tissue Distribution
- Fluorescent Antibody Technique, Indirect
- Plasmids/metabolism
- RNA/metabolism
- Serine/chemistry
- Microscopy, Fluorescence
- Sirtuin 2
- Gene Silencing
- Sirtuins/metabolism
- Recombinant Proteins/chemistry
- Cytoplasm/metabolism
- Phylogeny
- Cell Nucleus/enzymology/metabolism
- Actins/metabolism
- NIH 3T3 Cells
- ADP Ribose Transferases/chemistry/physiology
- Adenosine Diphosphate/chemistry
- Adenosine Diphosphate Ribose/chemistry
- Epitopes/chemistry
- Green Fluorescent Proteins/chemistry/metabolism
- Recombinant Fusion Proteins/chemistry
- Ribose/chemistry
734: Langley et al. (2002) "Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence." EMBO J. 21(10):2383-2396 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Male
- Transfection
- Tumor Suppressor Protein p53/metabolism
- Tumor Suppressor Proteins
- Cell Line
- HeLa Cells
- Recombinant Proteins/metabolism
- Cell Aging/physiology
- Transcription Factors/metabolism
- Transcriptional Activation/physiology
- Nuclear Proteins/metabolism
- Neoplasm Proteins/metabolism
- Trans-Activators/metabolism
- Histone Deacetylases/metabolism
- Sirtuin 1
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Sirtuin 2
- Sirtuins
- Fibroblasts/cytology/physiology
- Testis/cytology/enzymology
944: Eagle et al. (1995) "Mutation of the MXI1 gene in prostate cancer." Nat. Genet. 9(3):249-255 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- DNA-Binding Proteins/genetics/metabolism
- Mutation
- Alleles
- Tumor Suppressor Proteins
- Transcription Factors
- Base Sequence
- Chromosome Mapping
- DNA Primers/genetics
- Molecular Sequence Data
- In Situ Hybridization, Fluorescence
- Chromosome Aberrations
- Genes, Tumor Suppressor
- Sequence Deletion
- Chromosomes, Human, Pair 10
- DNA, Neoplasm/genetics/metabolism
- Basic Helix-Loop-Helix Transcription Factors
- Prostatic Neoplasms/genetics/metabolism
203: Kim et al. (1999) "Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae." Mol. Biol. Cell 10(10):3125-3136 (PubMed)

5 citations in connected databases
- Tags:
- Gene Deletion
- Genotype
- Aging
- Mutation
- RNA, Messenger/metabolism
- Fungal Proteins/genetics
- Gene Expression Regulation, Fungal
- Saccharomyces cerevisiae Proteins
- Genes, Fungal
- DNA-Binding Proteins/genetics
- Transcription Factors/genetics
- Cell Division/genetics
- Time Factors
- Trans-Activators/genetics
- Histone Deacetylases/genetics
- DNA, Ribosomal/genetics
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Sirtuin 2
- Sirtuins
- Gene Silencing
- Genes, Mating Type, Fungal
- Heterochromatin/genetics
- Saccharomyces cerevisiae/enzymology/genetics
4543: Mendler et al. (2017) "Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan." J. Diabetes Complicat. 31(2):304-310 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity
- Oxidative Stress
- Mutation
- Reactive Oxygen Species/metabolism
- Survival Analysis
- Gene Expression Regulation, Developmental
- RNA Interference
- Behavior, Animal
- Osmolar Concentration
- Feedback, Physiological
- Gene Knockdown Techniques
- Gene Knockout Techniques
- Caenorhabditis elegans/enzymology/growth & development/metabolism
- Caenorhabditis elegans Proteins/agonists/antagonists & inhibitors/genetics/metabolism
- Glucose/poisoning
- Glycation End Products, Advanced/metabolism
- Lactoylglutathione Lyase/antagonists & inhibitors/genetics/metabolism
- Neuroprotection
- Peptide Hormones/agonists/antagonists & inhibitors/genetics/metabolism
- Superoxide Dismutase/antagonists & inhibitors/genetics/metabolism
4551: Xiong et al. (2018) "Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans." Redox Biol 14:305-315 (PubMed)

7 citations in connected databases
- Tags:
- Animals
- Reactive Oxygen Species/metabolism
- Aging/drug effects
- Caenorhabditis elegans/drug effects/physiology
- Longevity/drug effects
- Mitochondria/drug effects/metabolism
- Tea/chemistry
- Catechin/analogs & derivatives/chemistry/pharmacology
- Organelle Biogenesis
3074: Da Cruz et al. (2003) "Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age." J. Gerontol. A Biol. Sci. Med. Sci. 58(9):M851-M856 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Polymerase Chain Reaction
- Aging/genetics
- Base Sequence
- Molecular Sequence Data
- Adult
- Child
- Age Factors
- Adolescent
- Middle Aged
- Cohort Studies
- Polymorphism, Genetic
- Aged
- Aged, 80 and over
- Gene Frequency
- Peptidyl-Dipeptidase A/genetics
- Genetics, Population
- Asian Continental Ancestry Group/genetics
- European Continental Ancestry Group/genetics
- Multivariate Analysis
- Logistic Models
- Rural Population
- Brazil
1131: Croniger et al. (2001) "Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism." J. Biol. Chem. 276(1):629-638 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Gene Deletion
- Phenotype
- RNA, Messenger/genetics/metabolism
- Phosphoenolpyruvate Carboxykinase (ATP)/genetics
- Cyclic AMP-Dependent Protein Kinases/metabolism
- Hypoglycemia/genetics
- Food Deprivation
- Glucose-6-Phosphatase/genetics
- 3-Hydroxybutyric Acid/blood
- Adenylate Cyclase/metabolism
- Ammonia/blood
- CCAAT-Enhancer-Binding Protein-beta/deficiency/genetics/metabolism
- Carbohydrate Metabolism
- Cyclic AMP/metabolism/pharmacology
- Glucagon/pharmacology
- Glucose/biosynthesis/metabolism
- Liver/drug effects/enzymology/metabolism
- Nitrogen/blood
- Phosphoric Diester Hydrolases/genetics/metabolism
- Urea/blood
1429: Avila et al. (2004) "Role of tau protein in both physiological and pathological conditions." Physiol. Rev. 84(2):361-384 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Genotype
- Mutation
- Phenotype
- Dementia/genetics
- Neurons/pathology/physiology
- tau Proteins/genetics
- Frontal Lobe/pathology
- Temporal Lobe/pathology
- Microtubules/physiology
- Protein Processing, Post-Translational/physiology
- Tauopathies/pathology/physiopathology
- tau Proteins/chemistry/genetics/physiology
1431: Martin et al. (2001) "Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease." JAMA 286(18):2245-2250 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Genetic Predisposition to Disease
- Middle Aged
- Linkage Disequilibrium
- Aged
- Polymorphism, Single Nucleotide
- Age of Onset
- Chromosomes, Human, Pair 17
- Haplotypes
- Parkinson Disease/genetics
- Microsatellite Repeats
- tau Proteins/genetics
2524: Gallo et al. (2004) "Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity." Mol. Cell. Biol. 24(3):1301-1312 (PubMed)

1 citation in connected databases
- Tags:
- Telomere/metabolism
- Time Factors
- Histone Deacetylases/metabolism
- Sirtuin 2
- Sirtuins/metabolism
- DNA, Ribosomal/metabolism
- Saccharomyces cerevisiae/metabolism
- Saccharomyces cerevisiae Proteins/metabolism
- Niacinamide/metabolism
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/metabolism
- Gene Silencing/physiology
- Nicotinamidase/metabolism
2002: Gareus et al. (2008) "Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis." Cell Metab. 8(5):372-383 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Signal Transduction
- Cells, Cultured
- Apolipoproteins E/genetics
- NF-kappa B/antagonists & inhibitors/metabolism
- Intracellular Signaling Peptides and Proteins/metabolism
- I-kappa B Proteins/metabolism
- Atherosclerosis/metabolism/pathology
- Cholesterol, Dietary/administration & dosage
- Endothelial Cells/metabolism
- Endothelium, Vascular/metabolism/pathology
- I-kappa B Kinase/biosynthesis/genetics/metabolism
- Macrophages/pathology
4238: Zuo et al. (2012) "IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells." J. Cancer Res. Clin. Oncol. 138(6):1045-1055 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Signal Transduction
- Cell Aging/physiology
- Genes, Tumor Suppressor
- Gene Expression Regulation, Neoplastic
- Retinoblastoma Protein/genetics/metabolism
- Recombinant Fusion Proteins/genetics/metabolism
- Cell Cycle Proteins/genetics/metabolism
- G1 Phase/physiology
- Cell Line, Tumor
- Cell Growth Processes/physiology
- Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism
- Transfection/methods
- Breast Neoplasms/genetics/metabolism/pathology
- Insulin-Like Growth Factor Binding Proteins/genetics/metabolism
- Gene Knockdown Techniques/methods
- G0 Phase
- Cell Cycle Checkpoints/physiology
- Tumor Suppressor Protein p53/biosynthesis/genetics/metabolism
3881: Howitz et al. (2003) "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan." Nature 425(6954):191-196 (PubMed)

6 citations in connected databases
- Tags:
- Humans
- Tumor Suppressor Protein p53/metabolism
- Cell Line
- Kinetics
- Cell Survival/drug effects
- Cell Aging/drug effects
- Sirtuin 1
- Caloric Restriction
- Sirtuin 2
- Histone Deacetylases/genetics/metabolism
- Longevity/drug effects
- Stilbenes/pharmacology
- Phenols/pharmacology
- Polyphenols
- Acetylation/drug effects
- Recombination, Genetic/drug effects
- Saccharomyces cerevisiae/cytology/drug effects/genetics/metabolism
- Wine
- Catalysis/drug effects
- Flavonoids
- Polymers/pharmacology
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/agonists/genetics/metabolism
- Sirtuins/agonists/genetics/metabolism
3926: Kaeberlein et al. (2002) "High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction." Mol. Cell. Biol. 22(22):8056-8066 (PubMed)

5 citations in connected databases
- Tags:
- Animals
- Gene Expression Regulation, Fungal
- Life Expectancy
- NAD/metabolism
- Oligonucleotide Array Sequence Analysis
- Sirtuins/genetics/metabolism
- Caloric Restriction
- Sirtuin 2
- Histone Deacetylases/genetics/metabolism
- Osmolar Concentration
- Molecular Structure
- Glucose/chemistry/metabolism
- Glycerol/chemistry/metabolism
- Nucleotidyltransferases/genetics/metabolism
- Saccharomyces cerevisiae/metabolism/physiology
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/genetics/metabolism
- Sorbitol/chemistry/metabolism
- Xylitol/chemistry/metabolism
200: Kaeberlein et al. (1999) "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms." Genes Dev. 13(19):2570-2580 (PubMed)

8 citations in connected databases
- Tags:
- DNA-Binding Proteins/genetics/physiology
- Phenotype
- Saccharomyces cerevisiae Proteins
- Peptides
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Mutagenesis
- Sirtuin 2
- Sirtuins
- DNA, Fungal
- DNA, Ribosomal
- Fungal Proteins/genetics/physiology
- Histone Deacetylases
- Saccharomyces cerevisiae/genetics/physiology
- Trans-Activators/genetics/physiology
875: Xiao et al. (1999) "Induction of G(1) checkpoint in the gastric mucosa of aged rats." Am. J. Physiol. 277(5 Pt 1):G929-G934 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Aging/physiology
- Cyclin-Dependent Kinase Inhibitor p21
- Rats
- Tumor Suppressor Protein p53/metabolism
- Enzyme Activation/physiology
- Blotting, Western
- Rats, Inbred F344
- CDC2-CDC28 Kinases
- Cyclin-Dependent Kinase 2
- G1 Phase/physiology
- Cyclin D1/analysis/metabolism
- Cyclin E/analysis/metabolism
- Cyclin-Dependent Kinases/analysis/metabolism
- Cyclins/analysis/metabolism
- Gastric Mucosa/cytology/enzymology
- Protein-Serine-Threonine Kinases/analysis/metabolism
- Retinoblastoma Protein/analysis/metabolism
- S Phase/physiology
972: Medema et al. (2000) "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1." Nature 404(6779):782-787 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Signal Transduction
- Forkhead Transcription Factors
- Mutation
- Protein-Serine-Threonine Kinases
- Proto-Oncogene Proteins/metabolism
- Proto-Oncogene Proteins c-akt
- Cell Transformation, Neoplastic
- Cell Cycle Proteins
- Cell Division
- Tumor Suppressor Proteins
- Cell Line
- Tumor Cells, Cultured
- Enzyme Activation
- Gene Expression Regulation
- DNA-Binding Proteins/metabolism
- Cell Cycle/physiology
- Cyclin-Dependent Kinase Inhibitor p27
- ras Proteins/metabolism
- PTEN Phosphohydrolase
- 3T3 Cells
- Transcription Factors/genetics/metabolism/physiology
- G1 Phase/physiology
- Caenorhabditis elegans
- Blood Proteins/genetics/physiology
- Microtubule-Associated Proteins/genetics/metabolism
- Phosphoric Monoester Hydrolases/genetics/metabolism
31: Artandi et al. (2002) "Constitutive telomerase expression promotes mammary carcinomas in aging mice." Proc. Natl. Acad. Sci. U.S.A. 99(12):8191-8196 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Aging
- Mice, Transgenic
- DNA-Binding Proteins
- Telomerase/genetics
- Cloning, Molecular
- Telomere/genetics
- Catalytic Domain
- 9,10-Dimethyl-1,2-benzanthracene
- Gene Expression
- Kinetics
- Mammary Neoplasms, Experimental/chemically induced/enzymology/genetics/pathology
- Open Reading Frames
384: Muller et al. (2002) "GH-related and extra-endocrine actions of GH secretagogues in aging." Neurobiol. Aging 23(5):907-919 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Aging/metabolism
- Aged
- Growth Hormone-Releasing Hormone/metabolism
- Endocrine System/metabolism
- Ghrelin
- Human Growth Hormone/metabolism
- Peptide Hormones/metabolism