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Entries tagged Protein Kinases/chemistry/metabolism (64)

3909: Anisimov et al. (2001) "Melatonin increases both life span and tumor incidence in female CBA mice." J. Gerontol. A Biol. Sci. Med. Sci. 56(7):B311-B323 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Brain/metabolism
- Longevity/drug effects
- Liver/metabolism
- Neoplasms/chemically induced
- Aging/drug effects/physiology
- Incidence
- Mice, Inbred CBA
- Body Weight/drug effects
- Estrus/drug effects
- Locomotion/drug effects
- Free Radicals/blood/metabolism
- Melatonin/adverse effects/pharmacology/physiology
- Models, Theoretical
4102: Zhang et al. (2014) "Rapamycin extends life and health in C57BL/6 mice." J. Gerontol. A Biol. Sci. Med. Sci. 69(2):119-130 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Myocardium/pathology
- Brain/pathology
- Sex Factors
- Longevity/drug effects
- Body Composition/drug effects
- Kidney/pathology
- Liver/pathology
- Sirolimus/pharmacology
- Energy Metabolism/drug effects
- Motor Activity/drug effects
- Sleep/drug effects
- Rotarod Performance Test
- Autophagy/drug effects
- Immunosuppressive Agents/pharmacology
- TOR Serine-Threonine Kinases/drug effects/metabolism
2148: Benigni et al. (2009) "Disruption of the Ang II type 1 receptor promotes longevity in mice." J. Clin. Invest. 119(3):524-530 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Blood Glucose
- Longevity/genetics
- Body Weight
- Up-Regulation
- Phenotype
- Oxidative Stress/genetics
- Down-Regulation
- Sirtuins/genetics
- Cytokines/genetics
- Adaptor Proteins, Signal Transducing/genetics
- Energy Intake
- Mice, Knockout/genetics
- Mitochondrial Proteins/genetics
- Rotarod Performance Test
- Heart Diseases/genetics/prevention & control
- Nicotinamide Phosphoribosyltransferase/genetics
- Sirtuin 3
- Vascular Diseases/genetics/prevention & control
2339: Zhao et al. (2007) "Cancer resistance in transgenic mice expressing the SAC module of Par-4." Cancer Res. 67(19):9276-9285 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Apoptosis/genetics
- Mice, Transgenic
- Genetic Predisposition to Disease
- Protein Structure, Tertiary
- Cell Transformation, Neoplastic/genetics/metabolism
- Recombinant Fusion Proteins/biosynthesis/genetics
- Neoplasms, Experimental/genetics/prevention & control
- Green Fluorescent Proteins/biosynthesis/genetics
- Receptors, Proteinase-Activated/biosynthesis/genetics/metabolism
639: Heydari et al. (1996) "Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1." Dev. Genet. 18(2):114-124 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Cells, Cultured
- DNA-Binding Proteins/genetics/metabolism
- Rats
- Transcription Factors/genetics/metabolism
- Base Sequence
- Molecular Sequence Data
- Gene Expression
- Age Factors
- DNA Primers
- Rats, Inbred F344
- Heat-Shock Proteins/genetics
- Transcription, Genetic/genetics
- Liver/cytology/metabolism
- Energy Intake/physiology
642: Heydari et al. (1994) "Hsp70 and aging." Experientia 50(11-12):1092-1098 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Transcription Factors
- Transcription, Genetic
- Aging/metabolism
- DNA-Binding Proteins/metabolism
- Liver/metabolism
- HSP70 Heat-Shock Proteins/biosynthesis
740: de Haan et al. (1995) "Cu/Zn-superoxide dismutase and glutathione peroxidase during aging." Biochem. Mol. Biol. Int. 35(6):1281-1297 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Reactive Oxygen Species
- Superoxide Dismutase/metabolism
- Aging/metabolism
- NF-kappa B/metabolism
- Catalase/metabolism
- Glutathione Peroxidase/metabolism
- Mice, Inbred CBA
- Down Syndrome/metabolism
979: Donehower et al. (1992) "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours." Nature 356(6366):215-221 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Heterozygote
- Homozygote
- Mutation
- Polymerase Chain Reaction
- Alleles
- Genes, p53/genetics
- Mice, Transgenic
- Base Sequence
- Molecular Sequence Data
- Genetic Vectors
- RNA, Messenger/analysis/biosynthesis
- Exons
- Stem Cells/metabolism
- Blotting, Southern
- Neoplasms, Experimental/genetics/pathology
- DNA/chemistry
- Mice, Inbred CBA
- Blastocyst
- Tumor Suppressor Protein p53/deficiency/genetics
4387: Mendias et al. (2015) "Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice." Aging Cell 14(4):704-706 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Heterozygote
- Homozygote
- Longevity/genetics
- Aging/genetics/pathology
- Gene Expression
- Life Expectancy
- Muscle, Skeletal/metabolism/pathology
- Haploinsufficiency
- Muscle Contraction/genetics
- Muscular Atrophy/genetics/metabolism/pathology
- Myostatin/deficiency/genetics
4613: Chen et al. (2016) "Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans." Food Funct 7(2):943-952 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Reactive Oxygen Species/metabolism
- Superoxide Dismutase/metabolism
- Aging/drug effects
- Caenorhabditis elegans/drug effects/physiology
- Oxidative Stress/drug effects
- Malondialdehyde/metabolism
- Anthocyanins/analysis/pharmacology
- Antioxidants/analysis/pharmacology
- Brassica/chemistry
- Phenols/analysis/pharmacology
- Plant Extracts/analysis/pharmacology
4616: Qi et al. (2017) "The ω-3 fatty acid α-linolenic acid extends Caenorhabditis elegans lifespan via NHR-49/PPARα and oxidation to oxylipins." Aging Cell 16(5):1125-1135 (PubMed)

5 citations in connected databases
- Tags:
- Animals
- Signal Transduction
- DNA-Binding Proteins/genetics/metabolism
- Oxidation-Reduction
- Transcription Factors/genetics/metabolism
- Dose-Response Relationship, Drug
- Gene Expression Regulation, Developmental
- Caenorhabditis elegans Proteins/genetics/metabolism
- Lipid Metabolism
- Receptors, Cytoplasmic and Nuclear/genetics/metabolism
- PPAR alpha/genetics/metabolism
- Longevity/drug effects/genetics
- NF-E2-Related Factor 2/genetics/metabolism
- Caenorhabditis elegans/drug effects/genetics/growth & development/metabolism
- Biotransformation
- Oxylipins/metabolism
- alpha-Linolenic Acid/metabolism/pharmacology
2686: Fox et al. (1973) "Body temperatures in the elderly: a national study of physiological, social, and environmental conditions." Br Med J 1(5847):200-206 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Age Factors
- Middle Aged
- Aged
- Heating
- Body Temperature
- Body Temperature Regulation
- Great Britain
- Family Characteristics
- Hypothermia
- Marriage
- Seasons
- Skin Temperature
- Socioeconomic Factors
- Weather
1310: Sun et al. (1997) "Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome." Nature 389(6653):809-815 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Inbred C57BL
- Transcriptional Activation
- Mice, Transgenic
- Phenotype
- Cell Line
- Gene Expression Regulation, Developmental
- Repressor Proteins/metabolism
- Embryonic and Fetal Development/genetics
- Stem Cells
- Animals, Newborn/growth & development
- DNA Methylation
- Genomic Imprinting
- Insulin-Like Growth Factor II/genetics
- Chimera
- Mice, Inbred CBA
- Beckwith-Wiedemann Syndrome/embryology/genetics/pathology
1499: Sreekumar et al. (2002) "Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle." Am. J. Physiol. Endocrinol. Metab. 283(1):E38-E43 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Body Weight/physiology
- Male
- Carrier Proteins/genetics
- Rats
- Polymerase Chain Reaction
- Proteins/genetics
- RNA, Messenger/genetics/metabolism
- Blotting, Northern
- Superoxide Dismutase/genetics
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Rats, Sprague-Dawley
- Muscle, Skeletal/metabolism
- Adenosine Triphosphate/metabolism
- Energy Intake/physiology
- Electron Transport Complex IV/genetics
- Mitochondrial Proteins
- Ion Channels
- Mitochondria/genetics/metabolism
- Membrane Transport Proteins
- Citrate (si)-Synthase/metabolism
1826: Eller et al. (2006) "A role for WRN in telomere-based DNA damage responses." Proc. Natl. Acad. Sci. U.S.A. 103(41):15073-15078 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Cells, Cultured
- DNA Damage
- DNA Repair
- Exodeoxyribonucleases
- Telomere/genetics
- Cell Aging/genetics
- Werner Syndrome/genetics/pathology
- Infant, Newborn
- Oligodeoxyribonucleotides/pharmacology
- RecQ Helicases/genetics/physiology
4614: Levitt et al. (1978) "Detection of neoplastic involvement of the mesentery and omentum by computed tomography." AJR Am J Roentgenol 131(5):835-838 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Aged
- Tomography, X-Ray Computed
- Abdominal Neoplasms/diagnostic imaging
- Barium Sulfate
- Diagnostic Errors
- Evaluation Studies as Topic
- Mesentery/diagnostic imaging
- Omentum/diagnostic imaging
- Peritoneal Neoplasms/diagnostic imaging
3314: Keipert et al. (2013) "Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system." Am. J. Physiol. Endocrinol. Metab. 304(5):E495-E506 (PubMed)

6 citations in connected databases
- Tags:
- Animals
- Mice
- Longevity/physiology
- Mice, Inbred C57BL
- Oxidation-Reduction
- Biological Markers
- Antioxidants/metabolism
- Superoxide Dismutase/metabolism
- Aconitate Hydratase/metabolism
- Mitogen-Activated Protein Kinases/metabolism
- Insulin Resistance/physiology
- Fatty Acids/metabolism
- Catalase/blood
- Mice, Inbred CBA
- Triglycerides/blood
- Muscle, Skeletal/metabolism/physiology
- Dietary Fats/adverse effects
- Muscle Proteins/biosynthesis/genetics
- Oxidative Stress/drug effects/physiology
- Real-Time Polymerase Chain Reaction
- Body Composition/drug effects/genetics/physiology
3408: Bernhagen et al. (1993) "MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia." Nature 365(6448):756-759 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Cloning, Molecular
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Mice, Nude
- DNA Primers
- Recombinant Proteins/pharmacology
- Hypophysectomy
- Acute-Phase Reaction/blood
- Antibodies/immunology/pharmacology
- Endotoxins
- Lipopolysaccharides
- Macrophage Migration-Inhibitory Factors/blood/immunology/metabolism/physiology
- Pituitary Gland, Anterior/metabolism
- Shock, Septic/metabolism
- Toxemia/etiology/metabolism
3541: Doze et al. (2011) "Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity." Mol. Pharmacol. 80(4):747-758 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Mice, Inbred C57BL
- Mice, Transgenic
- Longevity/drug effects/physiology
- Organ Culture Techniques
- Hippocampus/drug effects/metabolism
- Mice, Inbred CBA
- Cognition/drug effects/physiology
- Neuronal Plasticity/drug effects/physiology
- Adrenergic alpha-1 Receptor Agonists/pharmacology
- Affect/drug effects/physiology
- Long-Term Potentiation/drug effects/physiology
- Receptors, Adrenergic, alpha-1/metabolism/physiology
- Synapses/drug effects/physiology
201: McBurney et al. (2003) "The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis." Mol. Cell. Biol. 23(1):38-54 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Mice, Mutant Strains
- Telomere/genetics
- Mice, Inbred Strains
- Animals, Newborn
- Mammals
- Fetal Death/genetics
- Gene Expression Regulation, Developmental
- Sirtuin 1
- Sirtuins/genetics/metabolism
- Animals, Outbred Strains
- Embryo, Mammalian/physiology
- Euchromatin/genetics/metabolism
- Gene Silencing
- Germ Cells/physiology
- Infertility, Female/genetics
- Infertility, Male/genetics
- Testis/abnormalities/physiology