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Entries tagged Connective Tissue Diseases/pathology (64)

682: Ackerman and Clapham (1997) "Ion channels--basic science and clinical disease." N. Engl. J. Med. 336(22):1575-1586 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Mutation
- Cloning, Molecular
- Receptors, Purinergic P2/metabolism
- Receptors, Cell Surface/metabolism
- GTP-Binding Proteins/metabolism
- Cystic Fibrosis/genetics
- Ion Channels/drug effects/genetics/physiology
- Long QT Syndrome/congenital/genetics
- Potassium Channels/drug effects
3029: Agúndez et al. (1997) "CYP2D6, NAT2 and CYP2E1 genetic polymorphisms in nonagenarians." Age Ageing 26(2):147-151 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Polymerase Chain Reaction
- Alleles
- Reference Values
- Aged
- Gene Expression Regulation, Enzymologic/physiology
- Aged, 80 and over/physiology
- Polymorphism, Genetic/genetics
- Arylamine N-Acetyltransferase/genetics
- Cytochrome P-450 CYP2D6/genetics
- Cytochrome P-450 CYP2E1/genetics
- Metabolic Detoxication, Drug/genetics
3357: Dawson et al. (2003) "Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene." Proc. Natl. Acad. Sci. U.S.A. 100(23):13704-13709 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Mice, Inbred C57BL
- Body Weight
- Fertility
- Genetic Vectors
- Time Factors
- Exons
- Models, Genetic
- Mutagenesis, Site-Directed
- Blotting, Southern
- RNA/metabolism
- DNA, Complementary/metabolism
- Cytosol/metabolism
- Kidney/metabolism
- Cell Membrane/metabolism
- Liver/metabolism
- Biological Transport
- Intestines/metabolism
- Growth Disorders/etiology
- Symporters/genetics/physiology
- Bile Acids and Salts/blood
- Cation Transport Proteins
- Seizures/etiology
- Sulfates/blood/urine
- Sulfotransferases/metabolism
3519: Yizhak et al. (2013) "Model-based identification of drug targets that revert disrupted metabolism and its application to ageing." Nat Commun 4:2632 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Gene Expression Regulation, Fungal
- Computer Simulation
- Genome, Human
- Caloric Restriction
- Saccharomyces cerevisiae/genetics/metabolism
- Saccharomyces cerevisiae Proteins/genetics
- Algorithms
- Sirolimus/pharmacology
- Stilbenes/pharmacology
- Longevity/drug effects/genetics
- Aging/drug effects/genetics/metabolism
- Genome, Fungal
- Metabolic Networks and Pathways
- Alcohol Dehydrogenase/deficiency/genetics
- Alcohol Oxidoreductases/deficiency/genetics
- Eicosanoids/metabolism
- Hormesis
- Molecular Targeted Therapy
- Reactive Oxygen Species/antagonists & inhibitors/metabolism
3573: Robida-Stubbs et al. (2012) "TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO." Cell Metab. 15(5):713-724 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Male
- DNA-Binding Proteins/genetics/metabolism
- Transcription Factors/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Insulin-Like Growth Factor I/genetics/metabolism
- Signal Transduction/drug effects
- Transcription, Genetic/drug effects
- Trans-Activators/genetics/metabolism
- Caenorhabditis elegans
- Sirolimus/pharmacology
- Longevity/drug effects/genetics
- TOR Serine-Threonine Kinases/antagonists & inhibitors/genetics/metabolism
3871: Morselli et al. (2010) "Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy." Cell Death Dis 1:e10 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- RNA Interference
- Caloric Restriction
- Longevity/drug effects
- Cell Line, Tumor
- Caenorhabditis elegans/metabolism
- RNA, Small Interfering/metabolism
- Sirolimus/pharmacology
- Stilbenes/pharmacology
- Apoptosis Regulatory Proteins/metabolism
- Autophagy
- Sirtuin 1/genetics/metabolism
- Tumor Suppressor Protein p53/antagonists & inhibitors/metabolism
- Antineoplastic Agents, Phytogenic/pharmacology
3955: Wanke et al. (2008) "Caffeine extends yeast lifespan by targeting TORC1." Mol. Microbiol. 69(1):277-285 (PubMed)

1 citation in connected databases
- Tags:
- Signal Transduction
- Protein-Serine-Threonine Kinases/genetics/metabolism
- Protein Kinases/genetics/metabolism
- Saccharomyces cerevisiae Proteins/genetics/metabolism
- Sirolimus/pharmacology
- Saccharomyces cerevisiae/drug effects/genetics/physiology
- Gene Expression Regulation, Fungal/drug effects
- Caffeine/pharmacology
4102: Zhang et al. (2014) "Rapamycin extends life and health in C57BL/6 mice." J. Gerontol. A Biol. Sci. Med. Sci. 69(2):119-130 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Myocardium/pathology
- Brain/pathology
- Sex Factors
- Longevity/drug effects
- Body Composition/drug effects
- Kidney/pathology
- Liver/pathology
- Sirolimus/pharmacology
- Energy Metabolism/drug effects
- Motor Activity/drug effects
- Sleep/drug effects
- Rotarod Performance Test
- Autophagy/drug effects
- Immunosuppressive Agents/pharmacology
- TOR Serine-Threonine Kinases/drug effects/metabolism
4112: Neff et al. (2013) "Rapamycin extends murine lifespan but has limited effects on aging." J. Clin. Invest. 123(8):3272-3291 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Mice, Inbred C57BL
- Phenotype
- Survival Analysis
- Cell Transformation, Neoplastic/drug effects
- Aging/drug effects
- Longevity/drug effects
- Leukocyte Count
- Immunoglobulins/blood
- Maze Learning/drug effects
- Sirolimus/pharmacology
- Platelet Count
- Oxygen Consumption/drug effects
- Drug Evaluation, Preclinical
- Granuloma/prevention & control
- Liver/drug effects/pathology
- Liver Cirrhosis/prevention & control
- Muscle Strength/drug effects
- Psychomotor Performance/drug effects
- T-Lymphocytes/drug effects/immunology
- TOR Serine-Threonine Kinases/antagonists & inhibitors
- Thyroid Gland/drug effects/pathology
1043: Treins et al. (2002) "Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway." J. Biol. Chem. 277(31):27975-27981 (PubMed)

5 citations in connected databases
- Tags:
- Animals
- Protein-Serine-Threonine Kinases
- Proto-Oncogene Proteins/metabolism
- Proto-Oncogene Proteins c-akt
- Transcription Factors/genetics/metabolism
- Transfection
- Cell Line
- Kinetics
- Phosphatidylinositol 3-Kinases/metabolism
- Plasmids
- DNA-Binding Proteins/metabolism
- Cell Nucleus/metabolism
- Nuclear Proteins/metabolism
- Mitogen-Activated Protein Kinases/metabolism
- Insulin/pharmacology
- Gene Expression Regulation/drug effects
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Protein Biosynthesis/drug effects
- Transcription, Genetic/drug effects
- Hypoxia-Inducible Factor 1
- Hypoxia-Inducible Factor 1, alpha Subunit
- Cobalt/pharmacology
- Endothelial Growth Factors/genetics
- Lymphokines/genetics
- Pigment Epithelium of Eye
- Signal Transduction/drug effects/physiology
- Sirolimus/pharmacology
1176: Neubauer et al. (1998) "Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis." Cell 93(3):397-409 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Phenotype
- Fibroblasts
- RNA, Messenger/analysis
- DNA-Binding Proteins/genetics
- B-Lymphocytes/cytology
- Proto-Oncogene Proteins
- Protein-Tyrosine Kinases/genetics/physiology
- Janus Kinase 2
- Hematopoietic Stem Cells/cytology
- Hematopoiesis/genetics
- Liver/cytology/embryology
- Phosphoproteins/genetics
- Cytokines/pharmacology
- Interferon Regulatory Factor-1
- Receptors, Cytokine/physiology
- Anemia
- Erythrocytes
- Erythroid Precursor Cells/cytology
- Leukopoiesis
- Receptors, Erythropoietin/physiology
1320: Cornu et al. (2013) "mTOR in aging, metabolism, and cancer." Curr. Opin. Genet. Dev. 23(1):53-62 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Gene Deletion
- Signal Transduction
- Models, Biological
- Cell Cycle Proteins
- Cell Division
- Saccharomyces cerevisiae Proteins
- Fungal Proteins/metabolism
- Aging/genetics/metabolism
- Neoplasms/genetics/metabolism
- Gene Expression Regulation
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)/metabolism
- Obesity/genetics/metabolism
- Sirolimus/pharmacology
- Cell Proliferation
- Protein Kinases
- TOR Serine-Threonine Kinases
- Diabetes Mellitus, Type 2/genetics/metabolism
- Multiprotein Complexes/genetics/metabolism
- TOR Serine-Threonine Kinases/genetics/metabolism
1744: Wauters et al. (2001) "Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance." J. Clin. Endocrinol. Metab. 86(7):3227-3232 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Insulin/blood
- Carrier Proteins/genetics
- Polymerase Chain Reaction
- Adult
- Adolescent
- Middle Aged
- Polymorphism, Genetic
- Gene Frequency
- Obesity/genetics
- Polymorphism, Restriction Fragment Length
- Receptors, Cell Surface
- Receptors, Leptin
- Postmenopause
- Premenopause
- Blood Glucose/metabolism
- Glucose Intolerance
2031: Castilho et al. (2009) "mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging." Cell Stem Cell 5(3):279-289 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Protein Kinases/metabolism
- Cell Aging/drug effects
- Signal Transduction/drug effects
- Sirolimus/pharmacology
- TOR Serine-Threonine Kinases
- Cell Separation
- Cell Proliferation/drug effects
- Stem Cells/cytology/drug effects/metabolism
- beta Catenin/metabolism
- Antigens, CD34/metabolism
- Doxycycline/pharmacology
- Epidermis/cytology
- Epithelial Cells/cytology/drug effects/metabolism
- Hair Follicle/cytology/drug effects/metabolism
- Keratinocytes/cytology/drug effects/metabolism
- Regeneration/drug effects
- Wnt Proteins/metabolism
622: Matuoka et al. (1993) "Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF." EMBO J. 12(9):3467-3473 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Adaptor Proteins, Signal Transducing
- Epidermal Growth Factor/pharmacology
- Signal Transduction
- Rats
- Cell Line
- Tumor Cells, Cultured
- Recombinant Fusion Proteins/metabolism
- Platelet-Derived Growth Factor/pharmacology
- Kidney
- GRB2 Adaptor Protein
- Cell Division/drug effects/physiology
- Proto-Oncogene Proteins c-sis
- Microinjections
- Antibodies/pharmacology
- Carcinoma, Squamous Cell
- Cytoskeleton/drug effects/ultrastructure
- GTP-Binding Proteins/metabolism
- Proteins/immunology/physiology
- Recombinant Proteins/pharmacology
229: Khorram et al. (2001) "The influence of aging and sex hormones on expression of growth hormone-releasing hormone in the human immune system." J. Clin. Endocrinol. Metab. 86(7):3157-3161 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Aging/physiology
- Adult
- Tumor Cells, Cultured
- Gene Expression
- Reverse Transcriptase Polymerase Chain Reaction
- Middle Aged
- Flow Cytometry
- Aged
- B-Lymphocytes/chemistry
- Estrogen Replacement Therapy
- Gonadal Steroid Hormones/physiology
- Granulocytes/chemistry
- Growth Hormone-Releasing Hormone/blood/genetics
- Hematologic Neoplasms/metabolism
- Immune System/chemistry
- Monocytes/chemistry
- Postmenopause
- Premenopause
- RNA, Messenger/blood
- T-Lymphocytes/chemistry
4576: Arriola Apelo et al. (2016) "Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice." J. Gerontol. A Biol. Sci. Med. Sci. 71(7):876-881 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Mice, Inbred C57BL
- Treatment Outcome
- Aging/drug effects/physiology
- Longevity/drug effects/physiology
- Signal Transduction/drug effects/physiology
- Drug Administration Schedule
- TOR Serine-Threonine Kinases/metabolism
- Drug Chronotherapy
- Glucose Metabolism Disorders/etiology/prevention & control
- Immune System/drug effects
- Immunosuppressive Agents/administration & dosage/adverse effects/metabolism
- Sirolimus/administration & dosage/adverse effects/metabolism
3010: Blanché et al. (2001) "A study of French centenarians: are ACE and APOE associated with longevity?" C. R. Acad. Sci. III, Sci. Vie 324(2):129-135 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Alleles
- Reference Values
- Polymorphism, Genetic
- Aged
- Gene Frequency
- Apolipoproteins E/genetics
- Peptidyl-Dipeptidase A/genetics
- Geography
- Lymphocytes
- Aged, 80 and over/physiology
- France
- DNA/blood
1253: Espejel et al. (2004) "Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs." J. Cell Biol. 167(4):627-638 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Longevity/genetics
- Aging, Premature/genetics/metabolism/pathology
- Protein-Serine-Threonine Kinases/deficiency/genetics
- Telomere/genetics
- Telomerase/deficiency/genetics/physiology
- DNA-Activated Protein Kinase
- DNA Repair/genetics
- Neoplasms/genetics/metabolism
- Cell Division/genetics
- Cell Transformation, Neoplastic/genetics/metabolism
- Poly(ADP-ribose) Polymerases/deficiency/genetics
- DNA-Binding Proteins/deficiency/genetics
- Antigens, Nuclear/genetics
- Chromosomal Instability/genetics
1754: Araki et al. (2004) "Impaired lipid metabolism in aged mice as revealed by fasting-induced expression of apolipoprotein mRNAs in the liver and changes in serum lipids." Gerontology 50(4):206-215 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Mice, Inbred C57BL
- RNA, Messenger/metabolism
- Gene Expression
- Aging/metabolism
- Liver/metabolism
- Carrier Proteins/metabolism
- Fasting/metabolism
- Cholesterol/blood
- Triglycerides/blood
- Fatty Acid-Binding Proteins
- Mice, Inbred DBA
- Apolipoprotein C-III
- Apolipoprotein A-I/metabolism
- Apolipoprotein C-II
- Apolipoproteins/genetics/metabolism
- Apolipoproteins A/metabolism
- Apolipoproteins C/metabolism
- Lipid Mobilization/physiology