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Entries tagged Cell Transformation, Neoplastic/drug effects (31)

3519: Yizhak et al. (2013) "Model-based identification of drug targets that revert disrupted metabolism and its application to ageing." Nat Commun 4:2632 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Gene Expression Regulation, Fungal
- Computer Simulation
- Genome, Human
- Caloric Restriction
- Saccharomyces cerevisiae/genetics/metabolism
- Saccharomyces cerevisiae Proteins/genetics
- Algorithms
- Sirolimus/pharmacology
- Stilbenes/pharmacology
- Longevity/drug effects/genetics
- Aging/drug effects/genetics/metabolism
- Genome, Fungal
- Metabolic Networks and Pathways
- Alcohol Dehydrogenase/deficiency/genetics
- Alcohol Oxidoreductases/deficiency/genetics
- Eicosanoids/metabolism
- Hormesis
- Molecular Targeted Therapy
- Reactive Oxygen Species/antagonists & inhibitors/metabolism
4112: Neff et al. (2013) "Rapamycin extends murine lifespan but has limited effects on aging." J. Clin. Invest. 123(8):3272-3291 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Mice, Inbred C57BL
- Phenotype
- Survival Analysis
- Cell Transformation, Neoplastic/drug effects
- Aging/drug effects
- Longevity/drug effects
- Leukocyte Count
- Immunoglobulins/blood
- Maze Learning/drug effects
- Sirolimus/pharmacology
- Platelet Count
- Oxygen Consumption/drug effects
- Drug Evaluation, Preclinical
- Granuloma/prevention & control
- Liver/drug effects/pathology
- Liver Cirrhosis/prevention & control
- Muscle Strength/drug effects
- Psychomotor Performance/drug effects
- T-Lymphocytes/drug effects/immunology
- TOR Serine-Threonine Kinases/antagonists & inhibitors
- Thyroid Gland/drug effects/pathology
1588: Harrigan et al. (2006) "The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta." Nucleic Acids Res. 34(2):745-754 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- DNA Damage
- DNA Repair
- Cell Line
- RecQ Helicases
- RNA Interference
- Methyl Methanesulfonate/toxicity
- DNA Polymerase beta/metabolism
- Base Pair Mismatch
- Alkylating Agents/toxicity
- DNA Helicases/antagonists & inhibitors/physiology
- Exodeoxyribonucleases/antagonists & inhibitors/physiology
2327: Goddeeris et al. (2003) "Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants." Aging Cell 2(5):257-264 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Apoptosis
- Paraquat/pharmacology
- Cell Aging/genetics
- Behavior, Animal
- Mutation, Missense
- Drosophila Proteins/genetics/metabolism/physiology
- Starvation/genetics
- Desiccation
- Drosophila/cytology/genetics/physiology
- Integrin alpha Chains
- Integrins/genetics/metabolism/physiology
994: Watters et al. (1999) "Localization of a portion of extranuclear ATM to peroxisomes." J. Biol. Chem. 274(48):34277-34282 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Male
- Immunohistochemistry
- Cell Cycle Proteins
- DNA-Binding Proteins
- Tumor Suppressor Proteins
- Amino Acid Sequence
- Cell Line
- Molecular Sequence Data
- Sequence Alignment
- Two-Hybrid System Techniques
- Ataxia Telangiectasia/enzymology/metabolism/pathology
- Catalase/analysis/genetics/metabolism
- Cell Nucleus/chemistry
- Fibroblasts/chemistry/cytology/metabolism
- Lipid Peroxides/metabolism
- Peroxisomal Disorders/metabolism/pathology
- Peroxisomes/chemistry
- Protein-Serine-Threonine Kinases/analysis/genetics/metabolism
- Recombinant Fusion Proteins/analysis/genetics/metabolism
- Ataxia Telangiectasia Mutated Proteins
484: Yang et al. (2000) "DNA topoisomerase IIbeta and neural development." Science 287(5450):131-134 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Mice, Knockout
- DNA-Binding Proteins
- DNA Repair
- Embryonic and Fetal Development
- Axons/physiology/ultrastructure
- Cell Lineage
- Cues
- DNA Topoisomerases, Type II/genetics/metabolism
- Diaphragm/chemistry/embryology/innervation
- Intercostal Muscles/innervation
- Motor Neurons/physiology/ultrastructure
- Muscle, Skeletal/embryology/innervation
- Neuromuscular Junction/embryology/growth & development
- Neurons, Afferent/physiology/ultrastructure
- Presynaptic Terminals/ultrastructure
- Receptors, Cholinergic/analysis
- Skin/innervation
- Spinal Cord/embryology/ultrastructure
2180: Haffner et al. (2007) "Favorable prognostic value of SOCS2 and IGF-I in breast cancer." BMC Cancer 7:136 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Female
- Transfection
- Adult
- Survival Analysis
- Middle Aged
- Cohort Studies
- Aged
- Aged, 80 and over
- Insulin-Like Growth Factor I/analysis
- COS Cells
- Cercopithecus aethiops
- Prognosis
- Retrospective Studies
- Breast Neoplasms/diagnosis/mortality/pathology
- Carcinoma, Ductal/diagnosis/mortality/pathology
- Carcinoma, Lobular/diagnosis/mortality/pathology
- Suppressor of Cytokine Signaling Proteins/analysis/genetics
2251: Sánchez-Blanco et al. (2006) "Involvement of Drosophila uncoupling protein 5 in metabolism and aging." Genetics 172(3):1699-1710 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Mutation
- Aging/genetics/physiology
- Animals, Genetically Modified
- Infertility, Female/genetics
- Neurons/metabolism
- Drosophila Proteins/genetics/physiology
- Mitochondria/genetics/metabolism
- Weight Gain/genetics
- Homeostasis/genetics/physiology
- Mitochondrial Proteins/genetics/physiology
- Drosophila/genetics/metabolism
- Adenosine Triphosphate/genetics/metabolism
- Starvation/genetics
- Triglycerides/genetics/metabolism
2255: Zhang et al. (2007) "Caspase-2 deficiency enhances aging-related traits in mice." Mech. Ageing Dev. 128(2):213-221 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Longevity/physiology
- Oxidative Stress
- Proteins/metabolism
- Aging/genetics/physiology
- Survival Rate
- Bone Density/genetics
- Liver/metabolism
- Apoptosis/genetics/physiology
- Adipose Tissue/physiology
- Cysteine/metabolism
- Bone Resorption
- Caspase 2/genetics/metabolism
- Hair/growth & development/physiology
- Neoplasms/epidemiology/genetics
1874: Turek et al. (2005) "Obesity and metabolic syndrome in circadian Clock mutant mice." Science 308(5724):1043-1045 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Insulin/blood
- Mice, Inbred C57BL
- Body Weight
- Leptin/blood
- Mutation
- Dietary Fats/administration & dosage
- Brain/metabolism
- Feeding Behavior
- Trans-Activators/genetics/physiology
- Circadian Rhythm
- Energy Intake
- Energy Metabolism
- Motor Activity
- CLOCK Proteins
- Obesity/genetics/physiopathology
- Hyperglycemia
- Neuropeptides/genetics/metabolism
- Adipocytes/pathology
- Hepatocytes/pathology
- Hyperlipidemias
- Metabolic Syndrome X/genetics/physiopathology
- Weight Gain
997: Yaffe et al. (1997) "The structural basis for 14-3-3:phosphopeptide binding specificity." Cell 91(7):961-971 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Phosphorylation
- Protein Binding
- Molecular Sequence Data
- Protein Conformation
- Phosphoserine/metabolism
- Models, Molecular
- Substrate Specificity
- Crystallography, X-Ray
- 14-3-3 Proteins
- Tyrosine 3-Monooxygenase
- Proteins/chemistry/metabolism
- Enzyme Inhibitors/chemistry/metabolism
- Peptide Library
- Phosphopeptides/metabolism
1866: Kondratov et al. (2006) "Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation." FASEB J. 20(3):530-532 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Mice, Inbred C57BL
- Cell Cycle Proteins
- Crosses, Genetic
- Promoter Regions, Genetic
- Models, Genetic
- Genes, Reporter
- Gene Expression Profiling
- Nuclear Proteins/genetics/physiology
- Trans-Activators/deficiency/genetics/physiology
- Recombinant Fusion Proteins/physiology
- Flavoproteins/genetics/physiology
- ARNTL Transcription Factors
- CLOCK Proteins
- Cryptochromes
- Period Circadian Proteins
- Gene Expression Regulation/genetics/physiology
- Circadian Rhythm/genetics/physiology
- Basic Helix-Loop-Helix Transcription Factors/deficiency/genetics/physiology
- Multiprotein Complexes
- Proto-Oncogene Proteins c-ets/physiology
- Proto-Oncogene Proteins c-myc/physiology
- Stress, Physiological/genetics/metabolism
- Transcriptional Activation/genetics/physiology
2250: Meléndez et al. (2003) "Autophagy genes are essential for dauer development and life-span extension in C. elegans." Science 301(5638):1387-1391 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Longevity
- Signal Transduction
- Mutation
- Phenotype
- Genes, Fungal
- Recombinant Fusion Proteins/metabolism
- Animals, Genetically Modified
- Genes, Helminth
- RNA Interference
- Receptor, Insulin/genetics/metabolism
- Saccharomyces cerevisiae/genetics/physiology
- Morphogenesis
- Vesicular Transport Proteins
- Membrane Proteins
- Apoptosis Regulatory Proteins
- Autophagy/genetics
- Caenorhabditis elegans/genetics/growth & development/metabolism/ultrastructure
- Caenorhabditis elegans Proteins/chemistry/genetics/metabolism/physiology
- Phagosomes/ultrastructure
- Proteins/chemistry/genetics/physiology
2587: Molin et al. (2011) "Life span extension and H(2)O(2) resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae." Mol. Cell 43(5):823-833 (PubMed)

2 citations in connected databases
- Tags:
- Hydrogen Peroxide/metabolism
- Caloric Restriction
- Saccharomyces cerevisiae Proteins/genetics/metabolism
- Saccharomyces cerevisiae/metabolism/physiology
- Oxidoreductases Acting on Sulfur Group Donors/genetics/metabolism
- Peroxidases/genetics/metabolism
3779: Morris et al. (2002) "Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function." Oncogene 21(27):4277-4288 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Apoptosis
- Cyclin-Dependent Kinase Inhibitor p21
- Protein Binding
- Models, Biological
- Genes, p53
- Cell Aging/genetics
- Papillomavirus E7 Proteins
- Repressor Proteins
- Cell Division/genetics
- Cell Cycle/genetics
- Genes, Retinoblastoma
- Fibroblasts/cytology/metabolism
- Cyclin-Dependent Kinase 4
- Proto-Oncogene Proteins
- Retinoblastoma Protein/physiology
- Recombinant Fusion Proteins/physiology
- Cyclins/biosynthesis/genetics
- Genes, p16
- Clone Cells/cytology/metabolism
- Protein-Serine-Threonine Kinases/genetics/physiology
- Tumor Suppressor Protein p53/deficiency/physiology
- Cyclin-Dependent Kinases/genetics/physiology
- Cyclin-Dependent Kinase Inhibitor p16/biosynthesis
- Cell Transformation, Viral/genetics
- Cyclin-Dependent Kinase 6
- Genetic Vectors/genetics/pharmacology
- Oncogene Proteins, Viral/genetics/physiology
4100: Schmeisser et al. (2013) "Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension." Aging Cell 12(3):508-517 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Forkhead Transcription Factors
- Reactive Oxygen Species
- Transcription, Genetic
- Cell Line
- Transcription Factors/metabolism
- Superoxide Dismutase/metabolism
- DNA-Binding Proteins/metabolism
- Longevity/drug effects
- 3T3 Cells
- Oxidative Stress/drug effects
- Caenorhabditis elegans Proteins/metabolism
- Mitochondria/drug effects/metabolism
- Arsenites/pharmacology
- Hormesis
- Hep G2 Cells
- Caenorhabditis elegans/drug effects/metabolism
- Metallothionein/metabolism
- Teratogens/pharmacology
4600: Anisimov et al. (2016) "Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice." Aging (Albany NY) 8(9):1866-1875 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Cell Transformation, Neoplastic/drug effects
- Aging/drug effects
- Longevity/drug effects
- Body Weight/drug effects
- Body Temperature/drug effects
- Carcinogenesis/drug effects
- Estrous Cycle/drug effects
- Polyphenols/administration & dosage
125: Katakura et al. (1999) "Transforming growth factor beta triggers two independent-senescence programs in cancer cells." Biochem. Biophys. Res. Commun. 255(1):110-115 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Telomerase/metabolism
- Tumor Cells, Cultured
- Enzyme Activation
- Cell Aging/drug effects
- Cell Division/drug effects
- Cell Transformation, Neoplastic/drug effects
- Gene Expression Regulation, Neoplastic/drug effects
- Neoplasms/metabolism/pathology
- Transforming Growth Factor beta/metabolism/pharmacology
2254: Simonsen et al. (2007) "Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles." Genetics 176(2):1283-1297 (PubMed)

9 citations in connected databases
- Tags:
- Animals
- Mutation
- Life Expectancy
- Gene Expression Regulation, Developmental
- Drosophila Proteins/genetics/metabolism
- Nerve Tissue Proteins/genetics/metabolism
- Protein Transport
- Larva
- Ubiquitin/metabolism
- Microscopy, Confocal
- Nerve Degeneration/genetics
- DNA Transposable Elements
- Drosophila/genetics/growth & development
- Pupa
2307: Morrow et al. (2004) "Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress." FASEB J. 18(3):598-599 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Longevity/genetics
- Reactive Oxygen Species
- Aging/genetics
- Hot Temperature
- Recombinant Fusion Proteins/physiology
- Paraquat/toxicity
- Mitochondria/physiology
- Genetic Vectors/genetics
- Motor Activity/genetics
- Oxidative Stress/drug effects/genetics
- Stress, Physiological/genetics/metabolism
- Drosophila Proteins/biosynthesis/genetics/physiology
- Drosophila melanogaster/drug effects/genetics/metabolism
- Heat-Shock Proteins/biosynthesis/genetics/physiology
- Motor Neurons/metabolism
- Nerve Tissue Proteins/biosynthesis/genetics/physiology