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Entries tagged Transforming Growth Factor beta/metabolism/pharmacology (33)

3750: Fujikawa et al. (2007) "ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence." Cancer Sci. 98(9):1468-1475 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cell Line
- Promoter Regions, Genetic
- Oligonucleotide Array Sequence Analysis
- Cell Aging/genetics/physiology
- Alternative Splicing
- Transcription Factors/biosynthesis/genetics/physiology
- Trans-Activators/physiology
- Cyclin-Dependent Kinase Inhibitor p16/genetics/metabolism
- MAP Kinase Kinase 6/biosynthesis/genetics
- Protein Isoforms/biosynthesis/genetics/physiology
- Up-Regulation/genetics/physiology
- p38 Mitogen-Activated Protein Kinases/genetics/physiology
3789: Ohtani et al. (2001) "Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence." Nature 409(6823):1067-1070 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Protein-Serine-Threonine Kinases/metabolism
- Protein Binding
- Fibroblasts
- Cell Line
- Cell Aging/genetics
- Gene Expression Regulation
- Repressor Proteins
- Promoter Regions, Genetic
- Transcription Factors/physiology
- DNA-Binding Proteins/physiology
- MAP Kinase Signaling System
- ras Proteins/metabolism
- Proto-Oncogene Proteins/physiology
- MAP Kinase Kinase Kinase 1
- Trans-Activators/physiology
- Cyclin-Dependent Kinase Inhibitor p16/biosynthesis/genetics
- Inhibitor of Differentiation Protein 1
- Proto-Oncogene Protein c-ets-1
- Proto-Oncogene Protein c-ets-2
- Proto-Oncogene Proteins c-ets
- Proto-Oncogene Proteins c-raf/metabolism
1589: Varga et al. (2006) "Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome." Proc. Natl. Acad. Sci. U.S.A. 103(9):3250-3255 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Disease Progression
- Blood Pressure
- Transgenes/genetics
- Lamin Type A/metabolism
- Microscopy, Electron, Transmission
- Chromosomes, Artificial, Bacterial/genetics
- Muscle, Smooth, Vascular/abnormalities/blood supply/metabolism/pathology
- Myocytes, Smooth Muscle/metabolism/pathology/ultrastructure
- Progeria/genetics/metabolism/pathology/ultrastructure
1946: Suh et al. (2006) "p63 protects the female germ line during meiotic arrest." Nature 444(7119):624-628 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Male
- Mice, Inbred BALB C
- Phosphorylation
- DNA Damage
- Transcription Factors
- Amino Acid Sequence
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Cell Death
- Tumor Suppressor Protein p53/physiology
- DNA-Binding Proteins/physiology
- Trans-Activators/physiology
- Tumor Suppressor Proteins/physiology
- Oocytes/physiology
- Meiosis/physiology
- Oogenesis/genetics/physiology
2357: Ashrafi et al. (2000) "Sip2p and its partner snf1p kinase affect aging in S. cerevisiae." Genes Dev. 14(15):1872-1885 (PubMed)

5 citations in connected databases
- Tags:
- Mutation
- Gene Expression Regulation, Fungal
- Saccharomyces cerevisiae Proteins
- Telomere/genetics
- Glucose/metabolism
- DNA-Binding Proteins/metabolism
- Protein-Serine-Threonine Kinases/genetics/metabolism
- Saccharomyces cerevisiae/physiology
- Repressor Proteins/metabolism
- Trans-Activators
- Fungal Proteins/genetics/metabolism
- DNA, Ribosomal/genetics/metabolism
- Carbon/metabolism
- Myristic Acid/metabolism
484: Yang et al. (2000) "DNA topoisomerase IIbeta and neural development." Science 287(5450):131-134 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Mice, Knockout
- DNA-Binding Proteins
- DNA Repair
- Embryonic and Fetal Development
- Axons/physiology/ultrastructure
- Cell Lineage
- Cues
- DNA Topoisomerases, Type II/genetics/metabolism
- Diaphragm/chemistry/embryology/innervation
- Intercostal Muscles/innervation
- Motor Neurons/physiology/ultrastructure
- Muscle, Skeletal/embryology/innervation
- Neuromuscular Junction/embryology/growth & development
- Neurons, Afferent/physiology/ultrastructure
- Presynaptic Terminals/ultrastructure
- Receptors, Cholinergic/analysis
- Skin/innervation
- Spinal Cord/embryology/ultrastructure
2181: Liu et al. (2008) "Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling." Pigment Cell Melanoma Res 21(5):545-558 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Base Sequence
- Molecular Sequence Data
- Tumor Cells, Cultured
- Sequence Analysis, DNA
- Gene Expression Regulation, Neoplastic
- Disease Progression
- Gene Expression Profiling
- Promoter Regions, Genetic/genetics
- Gene Silencing
- DNA Methylation
- Epigenesis, Genetic
- CpG Islands
- Melanocytes/cytology/physiology
- Melanoma/genetics/metabolism/pathology
- Skin Neoplasms/genetics/metabolism/pathology
2262: Connell-Crowley et al. (2007) "Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan." Mech. Dev. 124(5):341-349 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Longevity
- Mutation
- Alleles
- Animals, Genetically Modified
- Genes, Insect
- Age Factors
- Behavior, Animal
- Drosophila Proteins/genetics/metabolism
- Nerve Tissue Proteins/genetics/metabolism
- Motor Neurons/physiology
- Axons/ultrastructure
- Cyclin-Dependent Kinase 5/genetics/metabolism
- Drosophila melanogaster/genetics/growth & development/metabolism/physiology
2419: Yun et al. (2008) "Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans." Proc. Natl. Acad. Sci. U.S.A. 105(19):7094-7099 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Phenotype
- Cell Line
- Sequence Homology, Amino Acid
- Caenorhabditis elegans/drug effects/physiology
- Environment
- Longevity/drug effects/physiology
- Protein Folding
- RNA-Binding Proteins/metabolism
- Proteasome Endopeptidase Complex/metabolism
- Protein Binding/drug effects
- Adaptation, Physiological/drug effects
- Arsenites/toxicity
- Caenorhabditis elegans Proteins/chemistry/metabolism
- Endoplasmic Reticulum/drug effects/metabolism
- Intracellular Membranes/drug effects/metabolism
2530: Shcheprova et al. (2008) "A mechanism for asymmetric segregation of age during yeast budding." Nature 454(7205):728-734 (PubMed)

1 citation in connected databases
- Tags:
- Anaphase
- Cell Division
- Cell Aging/physiology
- Mitosis
- Diffusion
- Nuclear Envelope/metabolism
- Saccharomyces cerevisiae Proteins/metabolism
- Cytoskeletal Proteins/metabolism
- Saccharomyces cerevisiae/cytology/genetics
- Chromosome Segregation
- DNA, Fungal/genetics/metabolism
- Microfilament Proteins/metabolism
- Cell Polarity/physiology
- Chromosomes, Fungal/genetics/metabolism
- Fluorescence Recovery After Photobleaching
- Plasmids/genetics/metabolism
2535: Piper et al. (2002) "The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells." Aging Cell 1(2):149-157 (PubMed)

2 citations in connected databases
- Tags:
- Longevity/genetics
- Proteins/genetics/metabolism
- Cell Aging/genetics
- Electron Transport/genetics
- Mutation/genetics
- Repressor Proteins
- Cell Division/genetics
- Saccharomyces cerevisiae/genetics/metabolism
- Cell Respiration/genetics
- DNA, Ribosomal/genetics/metabolism
- Mitochondria/genetics/metabolism/pathology
3234: Meister et al. (2011) "Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism." Genome Biol. 12(12):R123 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Longevity/genetics
- Signal Transduction
- Mutation
- Gene Expression Regulation, Developmental
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Receptor, Insulin/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Caenorhabditis elegans/genetics/growth & development/metabolism
- Heterochromatin/genetics
- Environment
- Repressor Proteins/genetics/metabolism
- Transforming Growth Factor beta/genetics/metabolism
- Chromosomal Proteins, Non-Histone/genetics/metabolism
- Germ Cells/growth & development/metabolism
- Hermaphroditic Organisms
- Lipid Metabolism/genetics
2541: Unal et al. (2011) "Gametogenesis eliminates age-induced cellular damage and resets life span in yeast." Science 332(6037):1554-1557 (PubMed)

1 citation in connected databases
- Tags:
- Aging
- DNA-Binding Proteins/genetics/metabolism
- Transcription Factors/genetics/metabolism
- Cell Division
- Recombinant Fusion Proteins/metabolism
- Heat-Shock Proteins/metabolism
- Nuclear Proteins/genetics/metabolism
- Saccharomyces cerevisiae Proteins/genetics/metabolism
- Meiosis
- DNA, Circular/genetics/metabolism
- DNA, Fungal/genetics/metabolism
- DNA, Ribosomal/genetics/metabolism
- Cell Nucleolus/physiology/ultrastructure
- Saccharomyces cerevisiae/genetics/growth & development/physiology/ultrastructure
- Spores, Fungal/physiology
3054: Grimaldi et al. (2006) "Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population." J. Leukoc. Biol. 79(3):611-615 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Heterozygote
- Longevity/genetics
- Alleles
- DNA Mutational Analysis
- Adult
- Age Factors
- Mutation/genetics
- Middle Aged
- Risk Factors
- Aged, 80 and over
- Gene Frequency
- Genetic Testing
- Cytoskeletal Proteins/genetics
- Genetic Predisposition to Disease/genetics
- Environment
- Acute Disease/epidemiology
- Inflammation/genetics/immunology/physiopathology
- Myocardial Infarction/epidemiology/genetics/immunology
- Protein Isoforms/genetics/immunology
- Sicily/epidemiology
995: Lin et al. (1993) "Molecular basis of the little mouse phenotype and implications for cell type-specific growth." Nature 364(6434):208-213 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Transcription Factor Pit-1
- Mutation
- Phenotype
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- DNA Mutational Analysis
- Molecular Sequence Data
- Transcription Factors/metabolism
- Signal Transduction/genetics
- DNA-Binding Proteins/metabolism
- Promoter Regions, Genetic
- Cell Division/genetics
- Oligodeoxyribonucleotides
- Binding Sites/genetics
- Dwarfism, Pituitary/genetics
- Cell Differentiation/genetics
- Receptors, Neuropeptide
- Receptors, Pituitary Hormone-Regulating Hormone
- Growth Hormone-Releasing Hormone/physiology
- Pituitary Gland, Anterior/cytology/pathology
- Receptors, Neurotransmitter/genetics/physiology
461: Queitsch et al. (2002) "Hsp90 as a capacitor of phenotypic variation." Nature 417(6889):618-624 (PubMed)

1 citation in connected databases
- Tags:
- Genotype
- Phenotype
- Crosses, Genetic
- Environment
- Biological Evolution
- Light
- Arabidopsis/drug effects/genetics/growth & development/metabolism
- Arabidopsis Proteins/antagonists & inhibitors/genetics/metabolism
- Darkness
- Genes, Plant/genetics
- Genetic Engineering
- Genetic Variation/genetics
- HSP90 Heat-Shock Proteins/antagonists & inhibitors/genetics/metabolism
- Plants, Genetically Modified
- Stochastic Processes
4074: Palermo et al. (2012) "Apple can act as anti-aging on yeast cells." Oxid Med Cell Longev 2012:491759 (PubMed)

3 citations in connected databases
- Tags:
- Reactive Oxygen Species/metabolism
- Cell Survival/drug effects
- Cell Aging/drug effects
- Oxidative Stress/drug effects
- Malus/chemistry
- Fruit/chemistry
- Ascorbic Acid/chemistry/pharmacology
- Polyphenols/chemistry/pharmacology
- Saccharomyces cerevisiae/drug effects
1875: Roybal et al. (2007) "Mania-like behavior induced by disruption of CLOCK." Proc. Natl. Acad. Sci. U.S.A. 104(15):6406-6411 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Immunohistochemistry
- Analysis of Variance
- Mutation/genetics
- Gene Expression Regulation/genetics
- Mutagenesis
- Gene Transfer Techniques
- Electric Stimulation
- CLOCK Proteins
- Genetic Therapy/methods
- Circadian Rhythm/genetics
- Behavioral Symptoms/genetics
- Bipolar Disorder/drug therapy/genetics/pathology/therapy
- Glycogen Synthase Kinase 3/genetics
- Lithium/pharmacology/therapeutic use
- Lithium Compounds/pharmacology/therapeutic use
- Locomotion/drug effects
- Trans-Activators/genetics/therapeutic use
- Ventral Tegmental Area/drug effects
125: Katakura et al. (1999) "Transforming growth factor beta triggers two independent-senescence programs in cancer cells." Biochem. Biophys. Res. Commun. 255(1):110-115 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Telomerase/metabolism
- Tumor Cells, Cultured
- Enzyme Activation
- Cell Aging/drug effects
- Cell Division/drug effects
- Cell Transformation, Neoplastic/drug effects
- Gene Expression Regulation, Neoplastic/drug effects
- Neoplasms/metabolism/pathology
- Transforming Growth Factor beta/metabolism/pharmacology
3520: Feng et al. (2013) "FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways." Biochem. J. 456(2):219-229 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Aging
- Cells, Cultured
- Amino Acid Sequence
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Glucose/metabolism
- Caenorhabditis elegans/physiology
- Xenopus
- Biological Transport
- Caenorhabditis elegans Proteins/chemistry/metabolism
- Glucose Transport Proteins, Facilitative/chemistry/metabolism