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Entries tagged Leukemia, Myeloid/enzymology/genetics/pathology (54)

3564: Okuyama et al. (2010) "The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans." J. Biol. Chem. 285(39):30274-30281 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Longevity/physiology
- DNA-Binding Proteins/genetics/metabolism
- Transcription Factors/genetics/metabolism
- Receptor, Insulin/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- MAP Kinase Signaling System/physiology
- Caenorhabditis elegans/genetics/metabolism
- Active Transport, Cell Nucleus/physiology
- Cell Nucleus/genetics/metabolism
- Phosphorylation/physiology
- Mitogen-Activated Protein Kinase 1/genetics/metabolism
- Epistasis, Genetic/physiology
- Insulin/genetics/metabolism
- raf Kinases/genetics/metabolism
3909: Anisimov et al. (2001) "Melatonin increases both life span and tumor incidence in female CBA mice." J. Gerontol. A Biol. Sci. Med. Sci. 56(7):B311-B323 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Brain/metabolism
- Longevity/drug effects
- Liver/metabolism
- Neoplasms/chemically induced
- Aging/drug effects/physiology
- Incidence
- Mice, Inbred CBA
- Body Weight/drug effects
- Estrus/drug effects
- Locomotion/drug effects
- Free Radicals/blood/metabolism
- Melatonin/adverse effects/pharmacology/physiology
- Models, Theoretical
4034: Luciani et al. (2011) "Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans." Nat. Chem. Biol. 7(12):891-893 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Enzyme Activation/drug effects
- Longevity/drug effects
- Structure-Activity Relationship
- Molecular Structure
- Cytochrome P-450 Enzyme System/metabolism
- Larva/drug effects
- Caenorhabditis elegans Proteins/antagonists & inhibitors/metabolism
- Caenorhabditis elegans/drug effects/growth & development/metabolism
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors/chemistry/pharmacology
- Isoxazoles/chemistry/pharmacology
- Piperidines/chemistry/pharmacology
- Pyridines/chemistry/pharmacology
- Stereoisomerism
1724: Vergnes et al. (2004) "Lamin B1 is required for mouse development and nuclear integrity." Proc. Natl. Acad. Sci. U.S.A. 101(28):10428-10433 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Cells, Cultured
- Mutagenesis, Insertional
- Fibroblasts/cytology
- Embryonic and Fetal Development/physiology
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Bone and Bones/abnormalities
- Stem Cells/cytology
- Lung/abnormalities
- Lamin Type B/genetics/metabolism
- Nuclear Lamina/pathology/physiology
- Ossification, Heterotopic/physiopathology
1757: Di Cristofano et al. (1998) "Pten is essential for embryonic development and tumour suppression." Nat. Genet. 19(4):348-355 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Cells, Cultured
- Tumor Suppressor Proteins
- RNA, Messenger/analysis
- Germ-Line Mutation
- Genes, Lethal
- PTEN Phosphohydrolase
- Embryonic and Fetal Development/genetics
- Cell Adhesion
- Neoplasms, Experimental/genetics/pathology
- Genes, Tumor Suppressor/physiology
- Stem Cells/cytology
- Protein Tyrosine Phosphatases/genetics/physiology
- Hamartoma Syndrome, Multiple/genetics
- Phosphoric Monoester Hydrolases
- Adenocarcinoma/pathology
- Colonic Neoplasms/pathology
- Teratocarcinoma/pathology
- Testicular Neoplasms/pathology
- Thyroid Neoplasms/pathology
2009: Tomilov et al. (2010) "Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice." J. Biol. Chem. 285(2):1153-1165 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Longevity
- Oxidative Stress
- Shc Signaling Adaptor Proteins
- Cell Line
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Gene Expression Regulation/genetics
- Enzyme Activation/genetics
- Superoxides/metabolism
- Gene Knockdown Techniques
- Proto-Oncogene Proteins c-akt/genetics/metabolism
- Extracellular Signal-Regulated MAP Kinases/genetics/metabolism
- NADPH Oxidase/genetics/metabolism
- Protein Kinase C-delta/genetics/metabolism
2074: Min et al. (2010) "Acetylation of tau inhibits its degradation and contributes to tauopathy." Neuron 67(6):953-966 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Cells, Cultured
- Rats
- Models, Biological
- Mice, Transgenic
- Enzyme Inhibitors/pharmacology
- Analysis of Variance
- Animals, Newborn
- Mutation/genetics
- Time Factors
- Cycloheximide/pharmacology
- Rats, Sprague-Dawley
- Gene Expression Regulation/drug effects
- Protein Synthesis Inhibitors/pharmacology
- tau Proteins/genetics/metabolism
- Acetylation/drug effects
- Cerebral Cortex/cytology
- Sirtuin 1/genetics/metabolism
- Phosphorylation/drug effects/physiology
- Neurons/drug effects/metabolism
- Carbazoles/pharmacology
- Immunoprecipitation/methods
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
- Tauopathies/etiology/genetics/metabolism
- Transfection/methods
- Ubiquitination/drug effects
- p300-CBP Transcription Factors/physiology
2161: Yap et al. (2009) "Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation." Oncogene 28(27):2524-2534 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Adaptor Proteins, Signal Transducing
- Up-Regulation
- Cells, Cultured
- Immunohistochemistry
- Reverse Transcriptase Polymerase Chain Reaction
- Blotting, Western
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- RNA Interference
- Cell Membrane/metabolism
- Cell Movement
- Cell Line, Tumor
- Intracellular Signaling Peptides and Proteins/genetics/metabolism
- Keratinocytes/cytology/metabolism
- Carcinoma, Squamous Cell/genetics/metabolism/pathology
- Antigens, Neoplasm/metabolism
- Integrins/metabolism
- Mouth Mucosa/cytology/metabolism
- Mouth Neoplasms/genetics/metabolism/pathology
- Neoplasm Invasiveness
- Receptors, Vitronectin/metabolism
- rac1 GTP-Binding Protein/genetics/metabolism
2212: Kapeta et al. (2010) "Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts." J. Biol. Chem. 285(11):8171-8184 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Reactive Oxygen Species/metabolism
- Cell Line
- Cell Aging/physiology
- Cell Division/physiology
- Enzyme Activation/physiology
- Fibroblasts/cytology/metabolism
- RNA Interference
- Down-Regulation/physiology
- Luciferases/genetics
- Proteasome Endopeptidase Complex/metabolism
- Oxidative Stress/drug effects/physiology
- Glycyrrhetinic Acid/analogs & derivatives/pharmacology
- NF-E2-Related Factor 2/genetics/metabolism
782: Shalaby et al. (1995) "Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice." Nature 376(6535):62-66 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Base Sequence
- Cell Line
- Molecular Sequence Data
- Genetic Vectors
- DNA Primers
- Genes, Lethal
- Mutagenesis
- Restriction Mapping
- Hematopoiesis
- Stem Cells
- Receptors, Vascular Endothelial Growth Factor
- Lac Operon
- Blood Vessels/embryology
- Receptor Protein-Tyrosine Kinases/deficiency/genetics/physiology
- Receptors, Growth Factor/deficiency/genetics/physiology
- Yolk Sac/blood supply/embryology
470: Ferrara et al. (1996) "Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene." Nature 380(6573):439-442 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Female
- Gene Deletion
- Male
- Mice, Inbred C57BL
- Heterozygote
- Alleles
- Mice, Nude
- Receptor Protein-Tyrosine Kinases/genetics/metabolism
- Fetal Death/genetics
- Proto-Oncogene Proteins/genetics/metabolism
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Stem Cells
- Receptors, Vascular Endothelial Growth Factor
- Chimera
- Embryo, Mammalian/abnormalities/blood supply
- Embryonic and Fetal Development/genetics/physiology
- Endothelial Growth Factors/genetics/physiology
- Lymphokines/genetics/physiology
- Neoplasms, Experimental/genetics/pathology
- Neovascularization, Physiologic/genetics
- Receptors, Growth Factor/genetics/metabolism
- Vascular Endothelial Growth Factor Receptor-1
4577: Chen et al. (2013) "Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans." Cell Rep 5(6):1600-1610 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity/genetics
- Signal Transduction
- Forkhead Transcription Factors
- Transcription Factors/genetics/metabolism
- Germ-Line Mutation
- Receptor, Insulin/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Caenorhabditis elegans/genetics/growth & development/metabolism
- Feedback, Physiological
- Germ Cells/metabolism
- Ribosomal Protein S6 Kinases, 70-kDa/genetics/metabolism
- AMP-Activated Protein Kinases/metabolism
- Intestinal Mucosa/metabolism
4682: Basso et al. (2007) "Protective effect of long-term angiotensin II inhibition." Am. J. Physiol. Heart Circ. Physiol. 293(3):H1351-H1358 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Rats
- Myocardium/pathology
- Rats, Wistar
- Aorta/pathology
- Aging/drug effects/physiology
- Random Allocation
- Oxidative Stress/drug effects/physiology
- Body Weight/drug effects/physiology
- Angiotensin-Converting Enzyme Inhibitors/pharmacology
- Angiotensin II/antagonists & inhibitors
- Angiotensin II Type 1 Receptor Blockers/pharmacology
- Blood Pressure/drug effects/physiology
- Cardiovascular System/drug effects/physiopathology
- Enalapril/pharmacology
- Losartan/pharmacology
- Renin-Angiotensin System/drug effects/physiology
2540: Selman et al. (2009) "Ribosomal protein S6 kinase 1 signaling regulates mammalian life span." Science 326(5949):140-144 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Gene Deletion
- Longevity/physiology
- Male
- Mice, Inbred C57BL
- Aging/physiology
- Signal Transduction
- Bone Density
- Transcription, Genetic
- Gene Expression
- Protein Kinases/metabolism
- Gene Expression Regulation
- Insulin/metabolism
- Caloric Restriction
- Liver/metabolism
- Muscle, Skeletal/metabolism
- T-Lymphocyte Subsets/immunology
- Motor Activity
- TOR Serine-Threonine Kinases
- Adipose Tissue, White/metabolism
- AMP-Activated Protein Kinases/metabolism
- Ribosomal Protein S6 Kinases, 90-kDa/genetics/metabolism
1565: Chehab et al. (1997) "Early onset of reproductive function in normal female mice treated with leptin." Science 275(5296):88-90 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Mice, Inbred C57BL
- Recombinant Proteins/pharmacology
- Luteinizing Hormone/blood
- Body Weight/drug effects
- Estradiol/blood
- Eating/drug effects
- Leptin
- Organ Size/drug effects
- Estrus/drug effects
- Genitalia, Female/drug effects
- Proteins/analysis/pharmacology
- Reproduction/drug effects
- Sexual Maturation/drug effects
1846: Gerhart-Hines et al. (2007) "Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha." EMBO J. 26(7):1913-1923 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Cells, Cultured
- Models, Biological
- Cell Cycle Proteins/metabolism
- Transcription Factors/metabolism
- Fibroblasts/drug effects/metabolism
- Sirtuin 1
- Sirtuins/metabolism
- p300-CBP Transcription Factors
- Trans-Activators/genetics/metabolism
- Niacinamide/pharmacology
- Glucose/pharmacology
- 3-Hydroxyacyl CoA Dehydrogenases/genetics/metabolism
- Acetyl-CoA C-Acyltransferase/genetics/metabolism
- Acetylation/drug effects
- Carbon-Carbon Double Bond Isomerases/genetics/metabolism
- Down-Regulation/drug effects
- Enoyl-CoA Hydratase/genetics/metabolism
- Histone Acetyltransferases/metabolism
- Mitochondria, Muscle/drug effects/metabolism
- Muscle, Skeletal/cytology/drug effects/metabolism
- Racemases and Epimerases/genetics/metabolism
1985: Qiang et al. (2010) "Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization." J. Biol. Chem. 285(35):27396-27401 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Hydrogen Peroxide/pharmacology
- Cell Line
- Oxidants/pharmacology
- Insulin/metabolism
- Cell Nucleus/genetics/metabolism
- Acetylation/drug effects
- Forkhead Transcription Factors/genetics/metabolism
- Sirtuin 1/genetics/metabolism
- Active Transport, Cell Nucleus/drug effects/physiology
- Oxidative Stress/drug effects/physiology
- Phosphorylation/drug effects/physiology
- Proto-Oncogene Proteins c-akt/genetics/metabolism
3314: Keipert et al. (2013) "Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system." Am. J. Physiol. Endocrinol. Metab. 304(5):E495-E506 (PubMed)

6 citations in connected databases
- Tags:
- Animals
- Mice
- Longevity/physiology
- Mice, Inbred C57BL
- Oxidation-Reduction
- Biological Markers
- Antioxidants/metabolism
- Superoxide Dismutase/metabolism
- Aconitate Hydratase/metabolism
- Mitogen-Activated Protein Kinases/metabolism
- Insulin Resistance/physiology
- Fatty Acids/metabolism
- Catalase/blood
- Mice, Inbred CBA
- Triglycerides/blood
- Muscle, Skeletal/metabolism/physiology
- Dietary Fats/adverse effects
- Muscle Proteins/biosynthesis/genetics
- Oxidative Stress/drug effects/physiology
- Real-Time Polymerase Chain Reaction
- Body Composition/drug effects/genetics/physiology
3390: Kennedy et al. (2011) "Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis." Mol. Cell 42(1):36-49 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Knockout
- Female
- Male
- Signal Transduction
- Mutation
- Mice, Transgenic
- Enzyme Activation
- Cell Line, Transformed
- Middle Aged
- Gene Expression Regulation, Neoplastic
- Aged
- Genes, ras
- Cell Aging/genetics/physiology
- Phosphatidylinositol 3-Kinases/genetics/metabolism
- Cell Proliferation
- Proto-Oncogene Proteins c-akt/genetics/metabolism
- Neoplasms/enzymology/genetics/pathology
- PTEN Phosphohydrolase/antagonists & inhibitors/genetics/metabolism
- Pancreatic Neoplasms/genetics/metabolism/pathology
3843: Dilman et al. (1979) "Increase in lifespan of rats following polypeptide pineal extract treatment." Exp Pathol (Jena) 17(9):539-545 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Cattle
- Female
- Rats
- Life Expectancy
- Pregnancy
- Peptides/pharmacology
- Estrus/drug effects
- Pineal Gland/physiology
- Neoplasms, Experimental/physiopathology
- Tissue Extracts/pharmacology