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Entries tagged RNA Splice Sites/genetics (71)

3436: Li et al. (1999) "Severe liver degeneration in mice lacking the IkappaB kinase 2 gene." Science 284(5412):321-325 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Apoptosis
- Phosphorylation
- Signal Transduction
- Polymerase Chain Reaction
- Cell Line
- Recombinant Fusion Proteins/metabolism
- Transcription Factors/metabolism
- DNA-Binding Proteins/metabolism
- Sequence Deletion
- NF-kappa B/metabolism
- Tumor Necrosis Factor-alpha/pharmacology
- I-kappa B Proteins
- Interleukin-1/pharmacology
- Protein-Serine-Threonine Kinases/genetics/metabolism
- Transcription Factor RelA
- I-kappa B Kinase
- Embryonic and Fetal Development
- Liver/cytology/embryology
- Receptors, Tumor Necrosis Factor/genetics/metabolism
3786: Li et al. (2008) "Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts." Mol. Cancer Res. 6(5):770-784 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Cell Line
- Cell Aging
- Reverse Transcriptase Polymerase Chain Reaction
- Gene Expression Regulation
- Fibroblasts/metabolism
- DNA Methylation
- Cell Proliferation
- Interferon-alpha/metabolism
- Epigenesis, Genetic
- Interferon Regulatory Factor-7/metabolism
- Interferon Regulatory Factors/metabolism
- Interferons/metabolism
- Li-Fraumeni Syndrome/metabolism
463: Sollars et al. (2003) "Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution." Nat. Genet. 33(1):70-74 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Selection, Genetic
- Mutation
- Phenotype
- Gene Expression Regulation, Developmental
- Genetic Variation
- Proto-Oncogene Proteins/analysis/genetics
- Biological Evolution
- HSP90 Heat-Shock Proteins/genetics
- Chromatin/genetics/metabolism
- Drosophila Proteins/analysis/genetics/metabolism
- Drosophila melanogaster/anatomy & histology/drug effects/genetics/growth & development
- Eye Abnormalities/genetics
- Heat-Shock Proteins/genetics/metabolism
- Wing/growth & development
- Wnt1 Protein
2710: Lewis et al. (1978) "Age, thymic involution, and circulating thymic hormone activity." J. Clin. Endocrinol. Metab. 47(1):145-150 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Aging
- Adult
- Child
- Adolescent
- Child, Preschool
- Middle Aged
- Infant
- Aged
- Cardiac Surgical Procedures
- Thymic Factor, Circulating/analysis
- Thymus Gland/growth & development/pathology/physiology
- Thymus Hormones/analysis/blood
17: Eriksson et al. (2003) "Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome." Nature 423(6937):293-298 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Homozygote
- Aging/genetics/physiology
- Exons/genetics
- Base Sequence
- DNA Mutational Analysis
- Adult
- Cell Membrane/metabolism/pathology
- Child
- Chromosomes, Human, Pair 1/genetics
- Fibroblasts/metabolism/pathology
- Fluorescent Antibody Technique
- In Situ Hybridization, Fluorescence
- Lamin Type A/analysis/genetics
- Pedigree
- Point Mutation/genetics
- Progeria/genetics/pathology
- RNA Splice Sites/genetics
- Syndrome
- Uniparental Disomy/genetics
461: Queitsch et al. (2002) "Hsp90 as a capacitor of phenotypic variation." Nature 417(6889):618-624 (PubMed)

1 citation in connected databases
- Tags:
- Genotype
- Phenotype
- Crosses, Genetic
- Environment
- Biological Evolution
- Light
- Arabidopsis/drug effects/genetics/growth & development/metabolism
- Arabidopsis Proteins/antagonists & inhibitors/genetics/metabolism
- Darkness
- Genes, Plant/genetics
- Genetic Engineering
- Genetic Variation/genetics
- HSP90 Heat-Shock Proteins/antagonists & inhibitors/genetics/metabolism
- Plants, Genetically Modified
- Stochastic Processes
895: Wilda et al. (2000) "Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development." Hum. Mol. Genet. 9(12):1739-1744 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Mice, Inbred C57BL
- Syndrome
- Abnormalities, Multiple/genetics
- Nuclear Proteins/genetics
- Gene Expression Profiling
- Embryonic and Fetal Development
- Blotting, Northern/methods
- In Situ Hybridization/methods
1020: Stelnicki et al. (1998) "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development." J. Invest. Dermatol. 110(2):110-115 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Aging/physiology
- Polymerase Chain Reaction
- Transcription, Genetic
- Adult
- Time Factors
- Infant, Newborn
- Fetus/physiology
- Gestational Age
- Gene Expression/physiology
- Embryonic and Fetal Development
- Genes, Homeobox/physiology
- Hair Follicle/embryology/physiology
- Sebaceous Glands/embryology/physiology
- Skin/embryology
- Sweat Glands/embryology/physiology
1415: Gong et al. (1999) "Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis." Nat. Genet. 21(3):302-304 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Male
- Heterozygote
- Mutation
- Proteins/genetics
- Chromosome Mapping
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
- Carrier Proteins
- Abnormalities, Multiple/genetics
- Adolescent
- Gene Expression Regulation, Developmental
- Swine
- Morphogenesis
- Xenopus laevis
- Genetic Markers
- Sequence Analysis
- Chickens
- Gorilla gorilla
- Cats
- Finger Joint/abnormalities
- Joints/abnormalities/physiology
- Synostosis/genetics
- Zebrafish
1602: Presse et al. (1992) "Rat melanin-concentrating hormone messenger ribonucleic acid expression: marked changes during development and after stress and glucocorticoid stimuli." Endocrinology 131(3):1241-1250 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Aging/physiology
- Rats
- Blotting, Northern
- Nucleic Acid Hybridization
- Animals, Newborn
- Pregnancy
- Polymerase Chain Reaction/methods
- Oligodeoxyribonucleotides
- RNA, Messenger/biosynthesis/genetics
- DNA Probes
- Gene Expression Regulation/drug effects
- Gestational Age
- Dexamethasone/pharmacology
- Rats, Inbred Strains
- Embryonic and Fetal Development
- Electroshock
- Adrenalectomy
- Hypothalamus/drug effects/physiology
- Melanins/biosynthesis/genetics
- Pituitary Hormones/biosynthesis/genetics
- Brain/drug effects/growth & development/physiology
- Hypothalamic Hormones
- Stress, Psychological/physiopathology
1651: Li et al. (1998) "Elastin is an essential determinant of arterial morphogenesis." Nature 393(6682):276-280 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Cell Line
- Mutagenesis
- Stem Cells
- Embryonic and Fetal Development
- Organ Culture Techniques
- Muscle Development
- Neovascularization, Physiologic/physiology
- Hemodynamics
- Morphogenesis/physiology
- Aorta/embryology
- Arterial Occlusive Diseases/embryology/genetics/physiopathology
- Arteries/anatomy & histology/embryology/pathology
- Arteritis/pathology
- Elastin/deficiency/physiology
- Muscle, Smooth, Vascular/growth & development
1821: Alkuraya et al. (2006) "SUMO1 haploinsufficiency leads to cleft lip and palate." Science 313(5794):1751 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Inbred C57BL
- Cell Line
- Adult
- Karyotyping
- Gene Dosage
- Child, Preschool
- Translocation, Genetic
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Stem Cells/metabolism
- Protein Tyrosine Phosphatases/genetics/metabolism
- Morphogenesis
- Nuclear Proteins/genetics/metabolism
- Intracellular Signaling Peptides and Proteins/genetics/metabolism
- Embryo, Mammalian/cytology/metabolism
- Cleft Lip/genetics
- Cleft Palate/genetics
- Palate/embryology/metabolism
- SUMO-1 Protein/genetics/physiology
- Small Ubiquitin-Related Modifier Proteins/genetics/physiology
2149: Cassis et al. (2010) "Angiotensin receptors as determinants of life span." Pflugers Arch. 459(2):325-332 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Longevity/physiology
- Oxidative Stress/physiology
- Aging/drug effects/physiology
- Mitochondria/physiology
- Sirtuins/physiology
- Renin-Angiotensin System/physiology
- Angiotensin II/physiology
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors/therapeutic use
- Receptors, Angiotensin/physiology
- Sirtuin 3/physiology
2250: Meléndez et al. (2003) "Autophagy genes are essential for dauer development and life-span extension in C. elegans." Science 301(5638):1387-1391 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Longevity
- Signal Transduction
- Mutation
- Phenotype
- Genes, Fungal
- Recombinant Fusion Proteins/metabolism
- Animals, Genetically Modified
- Genes, Helminth
- RNA Interference
- Receptor, Insulin/genetics/metabolism
- Saccharomyces cerevisiae/genetics/physiology
- Morphogenesis
- Vesicular Transport Proteins
- Membrane Proteins
- Apoptosis Regulatory Proteins
- Autophagy/genetics
- Caenorhabditis elegans/genetics/growth & development/metabolism/ultrastructure
- Caenorhabditis elegans Proteins/chemistry/genetics/metabolism/physiology
- Phagosomes/ultrastructure
- Proteins/chemistry/genetics/physiology
2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (PubMed)

48 citations in connected databases
- Tags:
- Gene Deletion
- Transcription Factors/physiology
- DNA-Binding Proteins/physiology
- Saccharomyces cerevisiae/physiology
- Sirtuin 2
- Histone Deacetylases/physiology
- Basic-Leucine Zipper Transcription Factors
- Sirtuins/physiology
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/physiology
- Ribosomal Proteins/physiology
- Ribosome Subunits, Large, Eukaryotic/physiology
- Saccharomyces cerevisiae Proteins/physiology
3231: Ren et al. (2012) "Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans." PLoS ONE 7(1):e29666 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- RNA, Messenger/genetics/metabolism
- Amino Acid Sequence
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Sequence Alignment
- Reverse Transcriptase Polymerase Chain Reaction
- Reproducibility of Results
- Paraquat/toxicity
- Caenorhabditis elegans Proteins/chemistry/genetics/metabolism
- Saccharomyces cerevisiae/drug effects/metabolism
- Gene Expression Regulation, Developmental/drug effects
- Biological Assay
- Body Size/drug effects
- Caenorhabditis elegans/anatomy & histology/drug effects/genetics/growth & development
- Cation Transport Proteins/chemistry/genetics/metabolism
- Gonads/abnormalities/drug effects/pathology
- Locomotion/drug effects/physiology
- Longevity/drug effects/genetics/physiology
- RNA Interference/drug effects
3577: Magwire et al. (2010) "Quantitative and molecular genetic analyses of mutations increasing Drosophila life span." PLoS Genet. 6(7):e1001037 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Female
- Male
- Longevity/genetics
- Mutation
- Aging/genetics
- Drosophila/genetics
- Gene Expression Profiling
- Sex Factors
- Biological Evolution
- Epigenesis, Genetic
3790: Ho et al. (2000) "Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts." Free Radic. Biol. Med. 29(2):156-169 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Oxidative Stress
- Cells, Cultured
- Reactive Oxygen Species/metabolism
- Transfection
- Cell Division
- Reference Values
- Telomere/genetics
- Cell Aging
- beta-Galactosidase/metabolism
- Kinetics
- Cell Cycle
- Infant, Newborn
- Fibroblasts/cytology/physiology
- Skin Physiological Phenomena
- Glucosephosphate Dehydrogenase/metabolism
- Glucosephosphate Dehydrogenase Deficiency/pathology/physiopathology
- Skin/cytology/pathology/physiopathology
3791: Lin et al. (1998) "Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling." Genes Dev. 12(19):3008-3019 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Protein-Serine-Threonine Kinases/metabolism
- Signal Transduction
- Cells, Cultured
- Cell Transformation, Neoplastic
- Cell Aging
- Tumor Suppressor Protein p53/physiology
- Cell Cycle
- Calcium-Calmodulin-Dependent Protein Kinases/metabolism
- ras Proteins/metabolism
- Protein-Tyrosine Kinases/metabolism
- MAP Kinase Kinase 1
- Microinjections
- Cyclin-Dependent Kinase Inhibitor p16/physiology
- Fibroblasts/physiology
- Mitogen-Activated Protein Kinase Kinases
- MAP Kinase Kinase 2
1897: Pfluger et al. (2008) "Sirt1 protects against high-fat diet-induced metabolic damage." Proc. Natl. Acad. Sci. U.S.A. 105(28):9793-9798 (PubMed)

9 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Transgenic
- Superoxide Dismutase/genetics
- Gene Expression Regulation
- Sirtuin 1
- Diet
- Insulin Resistance
- Sirtuins/physiology
- Inflammation
- Dietary Fats/adverse effects
- Fatty Liver
- Metabolism
- Nuclear Respiratory Factor 1/genetics
- Protective Agents