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Entries tagged Neoplasms, Experimental/pathology (72)

3275: Rana et al. (2013) "Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan." Proc. Natl. Acad. Sci. U.S.A. 110(21):8638-8643 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity/physiology
- Gene Expression Regulation/physiology
- Drosophila melanogaster
- Membrane Proteins/genetics/metabolism
- Neurons/cytology/metabolism
- Organ Specificity/genetics
- Mitochondria/genetics/metabolism
- Drosophila Proteins/biosynthesis/genetics/metabolism
- Neurodegenerative Diseases/genetics/metabolism
- Polyubiquitin/genetics/metabolism
- Ubiquitin-Protein Ligases/biosynthesis/genetics
1176: Neubauer et al. (1998) "Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis." Cell 93(3):397-409 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Phenotype
- Fibroblasts
- RNA, Messenger/analysis
- DNA-Binding Proteins/genetics
- B-Lymphocytes/cytology
- Proto-Oncogene Proteins
- Protein-Tyrosine Kinases/genetics/physiology
- Janus Kinase 2
- Hematopoietic Stem Cells/cytology
- Hematopoiesis/genetics
- Liver/cytology/embryology
- Phosphoproteins/genetics
- Cytokines/pharmacology
- Interferon Regulatory Factor-1
- Receptors, Cytokine/physiology
- Anemia
- Erythrocytes
- Erythroid Precursor Cells/cytology
- Leukopoiesis
- Receptors, Erythropoietin/physiology
1417: Brunet et al. (1998) "Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton." Science 280(5368):1455-1457 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Proteins/genetics/physiology
- Up-Regulation
- Mutation
- Gene Expression
- Carrier Proteins
- Homeodomain Proteins/genetics
- Morphogenesis
- Embryo, Mammalian/metabolism
- Mesoderm/metabolism
- Chondrocytes/metabolism
- Bone Morphogenetic Proteins/genetics/metabolism
- Cartilage/embryology/metabolism
- Extremities/embryology
- Growth Differentiation Factor 5
- Growth Substances/genetics
- Joints/abnormalities/embryology
2538: Lorenz et al. (2009) "A network biology approach to aging in yeast." Proc. Natl. Acad. Sci. U.S.A. 106(4):1145-1150 (PubMed)

1 citation in connected databases
- Tags:
- RNA, Messenger/genetics/metabolism
- Transcription, Genetic
- Gene Expression Regulation, Fungal
- Time Factors
- Models, Genetic
- Gene Expression Profiling
- Protein-Serine-Threonine Kinases/genetics/metabolism
- Reproducibility of Results
- Regression Analysis
- Saccharomyces cerevisiae/genetics/growth & development
- Gene Regulatory Networks
4216: Rathor et al. (2015) "Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans." Age (Dordr) 37(6):113 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Insulin-Like Growth Factor I/metabolism
- Signal Transduction
- Oxidation-Reduction
- Transcription Factors/metabolism
- Superoxide Dismutase/metabolism
- DNA-Binding Proteins/metabolism
- Insulin/metabolism
- Models, Animal
- Microscopy, Fluorescence
- Sirtuins/metabolism
- Aging/drug effects
- Longevity/drug effects
- Glutathione Transferase/metabolism
- Oxidative Stress/drug effects
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins/metabolism
- Forkhead Transcription Factors/metabolism
- TOR Serine-Threonine Kinases/metabolism
- Real-Time Polymerase Chain Reaction
- Folic Acid/administration & dosage/pharmacology
4564: Castillo-Quan et al. (2016) "Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis." Cell Rep 15(3):638-650 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Female
- Male
- Models, Biological
- Survival Analysis
- Caloric Restriction
- Longevity/drug effects
- Transcription, Genetic/drug effects
- Lithium/pharmacology
- Drosophila Proteins/metabolism
- Autophagy/drug effects
- Stress, Physiological/drug effects
- NF-E2-Related Factor 2/metabolism
- Xenobiotics/pharmacology
- Glycogen Synthase Kinase 3/antagonists & inhibitors/metabolism
- Lipid Metabolism/drug effects
- Hormesis/drug effects
- Drosophila melanogaster/drug effects/metabolism/physiology
- Dietary Carbohydrates
4603: Kim et al. (2017) "Selenocysteine modulates resistance to environmental stress and confers anti-aging effects in C. elegans." Clinics (Sao Paulo) 72(8):491-498 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Antioxidants/pharmacology
- Age Factors
- Time Factors
- Aging/drug effects
- Fertility/drug effects
- Longevity/drug effects
- Reproducibility of Results
- Oxidative Stress/drug effects
- Reproduction/drug effects
- Locomotion/drug effects
- Stress, Physiological/drug effects
- Caenorhabditis elegans/drug effects/physiology/radiation effects
- Selenocysteine/pharmacology
2685: Baehr et al. (2000) "Individual differences in the phase and amplitude of the human circadian temperature rhythm: with an emphasis on morningness-eveningness." J Sleep Res 9(2):117-127 (PubMed)

4 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Adolescent
- Reproducibility of Results
- Sleep/physiology
- Body Temperature/physiology
- Circadian Rhythm/physiology
- MMPI
- Personality
2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (PubMed)

11 citations in connected databases
- Tags:
- Animals
- Humans
- Female
- Male
- Aging/genetics
- Base Sequence
- Molecular Sequence Data
- Adult
- HeLa Cells
- Reverse Transcriptase Polymerase Chain Reaction
- Middle Aged
- Signal Transduction/genetics
- Gene Expression Regulation, Developmental
- Gene Expression Profiling
- Up-Regulation/genetics
- Caenorhabditis elegans/genetics/growth & development
- Phosphatidylinositol 3-Kinases/genetics/metabolism
- Reproducibility of Results
- Down-Regulation/genetics
- MicroRNAs/genetics/metabolism
2325: Wei et al. (2003) "Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility." Genes Dev. 17(5):603-614 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Female
- Male
- Cell Line
- Genetic Predisposition to Disease
- Neoplasms/genetics
- Exodeoxyribonucleases/genetics/metabolism
- DNA Repair/genetics/physiology
- Blastocyst
- Microsatellite Repeats
- Base Pair Mismatch/genetics
- Meiosis/physiology
- Infertility/etiology/genetics
- Metaphase/physiology
- Mice/embryology
1892: Teglund et al. (1998) "Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses." Cell 93(5):841-850 (PubMed)

5 citations in connected databases
- Tags:
- Animals
- Growth Hormone/metabolism
- Mice
- Female
- Gene Deletion
- Mice, Mutant Strains
- DNA-Binding Proteins/genetics/metabolism
- Body Constitution
- Infertility, Female/genetics
- Milk Proteins
- STAT5 Transcription Factor
- Hematopoiesis/genetics
- Erythropoietin/pharmacology
- Trans-Activators/genetics/metabolism
- Cytokines/pharmacology
- Mammary Glands, Animal/growth & development
- Ovary/growth & development
- Prolactin/pharmacology
2014: Kawahara et al. (2011) "Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks." PLoS Genet. 7(6):e1002153 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Aging/genetics
- Cell Line
- Gene Expression Regulation
- Models, Genetic
- Gene Expression Profiling
- Chromatin/metabolism
- Stress, Physiological/genetics
- Sirtuins/metabolism
- Reproducibility of Results
- Protein Transport/genetics
- Gene Regulatory Networks/genetics
- Intracellular Space/metabolism
- Transcription Factor RelA/metabolism
4221: Kang et al. (2011) "Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation." Free Radic. Biol. Med. 50(6):680-688 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Apoptosis
- Cells, Cultured
- Reactive Oxygen Species/metabolism
- Mice, Transgenic
- Cell Aging
- Gene Expression
- Mitochondria/metabolism
- MAP Kinase Signaling System
- Fibroblasts/metabolism
- Gene Silencing
- Proto-Oncogene Proteins c-bcl-2/metabolism
- Ultraviolet Rays/adverse effects
- Aldehydes/metabolism
- Thiobarbituric Acid Reactive Substances/metabolism
- bcl-2-Associated X Protein/metabolism
- Gene Knockdown Techniques
- Epidermis/metabolism
- RNA, Small Interfering/genetics/pharmacology
- Aldehyde Reductase/genetics/metabolism
- Keratinocytes/cytology/metabolism/radiation effects
- Phosphatidylinositol 3-Kinase/genetics/metabolism
- Sunburn/metabolism/pathology
4306: Bolesta et al. (2012) "Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance." Mol. Cell. Biol. 32(10):1879-1892 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Nude
- Genes, p53
- Cell Aging/genetics
- Gene Expression Regulation, Neoplastic
- Neoplasm Transplantation
- Cell Line, Tumor
- Proto-Oncogene Proteins c-bcl-2/genetics
- Drug Resistance, Neoplasm/genetics
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasms/drug therapy/genetics/pathology
4690: Xu et al. (2017) "Feeding recombinant E. coli with GST-mBmKTX fusion protein increases the fecundity and lifespan of Caenorhabditis elegans." Peptides 89:1-8 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Recombinant Fusion Proteins/genetics/pharmacology
- Escherichia coli/genetics
- Amino Acid Sequence/genetics
- Gene Expression/drug effects
- Longevity/drug effects/genetics
- Microarray Analysis
- Fertility/drug effects/genetics
- Caenorhabditis elegans/drug effects/genetics
- Caenorhabditis elegans Proteins/biosynthesis
- Glutathione Transferase/genetics/pharmacology
- Mutant Proteins/genetics/pharmacology
- Peptides/genetics/pharmacology
- Scorpion Venoms/genetics/pharmacology
3203: Huffman et al. (2012) "Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene." J. Gerontol. A Biol. Sci. Med. Sci. 67(11):1153-1160 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Carrier Proteins/genetics
- Longevity/genetics
- Aging/genetics
- Alleles
- Survival Rate
- Pedigree
- Middle Aged
- Gene Expression Regulation
- Cohort Studies
- Aged
- Aged, 80 and over
- Genetics, Population
- Polymorphism, Single Nucleotide
- Reproducibility of Results
- Jews/genetics
3255: Houtkooper et al. (2013) "Mitonuclear protein imbalance as a conserved longevity mechanism." Nature 497(7450):451-457 (PubMed)

15 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Evolution, Molecular
- Aging/genetics/metabolism
- Mice, Inbred Strains
- RNA Interference
- Caenorhabditis elegans Proteins/genetics/metabolism
- Anti-Bacterial Agents/pharmacology
- Reproducibility of Results
- Sirolimus/pharmacology
- Mitochondrial Proteins/genetics/metabolism
- Doxycycline/pharmacology
- Quantitative Trait Loci
- Caenorhabditis elegans/drug effects/genetics/physiology
- Ribosomal Proteins/genetics/metabolism
- Longevity/drug effects/genetics/physiology
- Mitochondria/drug effects/genetics/metabolism
- Unfolded Protein Response/genetics/physiology
3301: Wijshake et al. (2012) "Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation." PLoS Genet. 8(12):e1003138 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Longevity/genetics
- Mutation
- Aging/genetics
- Alleles
- Mice, Transgenic
- Phenotype
- Mosaicism
- Protein-Serine-Threonine Kinases/genetics/physiology
- Chromosome Disorders/genetics/physiopathology
3311: de la Rosa et al. (2013) "Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion." Nat Commun 4:2268 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Male
- Phenotype
- Aging/pathology
- Neoplasms/metabolism/pathology
- Nuclear Proteins/metabolism
- Mosaicism
- Progeria/metabolism/pathology
- Protein Precursors/metabolism
- Biological Markers/metabolism
- Neoplasm Invasiveness
- Carcinogenesis/pathology
- Membrane Proteins/deficiency/metabolism
- Metalloendopeptidases/deficiency/metabolism
28: Blasco et al. (1997) "Telomere shortening and tumor formation by mouse cells lacking telomerase RNA." Cell 91(1):25-34 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Cells, Cultured
- Cell Transformation, Neoplastic
- Fibroblasts
- Telomere/metabolism
- Aneuploidy
- Cell Survival
- Chromosome Aberrations
- DNA, Neoplasm/metabolism
- Mice, Nude
- Neoplasms, Experimental/pathology
- Organ Specificity
- RNA/genetics/physiology
- Telomerase/genetics/physiology