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Entries tagged Intracellular Membranes/drug effects/enzymology (83)

3794: Watanabe et al. (1997) "Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells." Oncogene 14(17):2025-2032 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Cells, Cultured
- Cell Aging/drug effects
- Cell Division/drug effects
- Cell Size
- Gene Expression Regulation/drug effects
- Endothelial Growth Factors/pharmacology
- Lymphokines/pharmacology
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Nerve Tissue Proteins/pharmacology
- Recombinant Proteins/pharmacology
- Brain-Derived Neurotrophic Factor
- Skin/blood supply
- Capillaries/cytology
- Depression, Chemical
- Endothelium, Vascular/cytology/drug effects/metabolism
4032: Zhang et al. (2012) "Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans." Biochem. J. 441(1):417-424 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Transcription Factors/genetics/metabolism
- Cell Survival
- Caenorhabditis elegans Proteins/genetics/metabolism
- Gene Expression Regulation/drug effects
- Oxidative Stress/drug effects
- Neurons/drug effects
- Forkhead Transcription Factors/genetics/metabolism
- Peptides/metabolism
- Astragalus membranaceus/chemistry
- Endoplasmic Reticulum
- Polysaccharides/chemistry/pharmacology
4081: Kayashima et al. (2012) "Freeze-dried royal jelly maintains its developmental and physiological bioactivity in Drosophila melanogaster." Biosci. Biotechnol. Biochem. 76(11):2107-2111 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Insulin/metabolism
- Somatomedins/metabolism
- Longevity/drug effects
- Gene Expression Regulation/drug effects
- Signal Transduction/drug effects
- TOR Serine-Threonine Kinases/genetics
- Oviposition/drug effects
- Bees
- Drosophila melanogaster/drug effects/genetics/growth & development/physiology
- Fatty Acids/administration & dosage/pharmacology
- Freeze Drying
4143: Fok et al. (2014) "Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome." PLoS ONE 9(1):e83988 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Longevity/genetics
- Signal Transduction
- Gene Expression Profiling
- Sex Factors
- Gene Expression Regulation/drug effects
- Diet
- Cluster Analysis
- Liver/drug effects/metabolism
- Transcriptome
- Sirolimus/administration & dosage/pharmacokinetics/pharmacology
1749: McLaughlin et al. (2000) "Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis." J. Clin. Invest. 106(9):1105-1113 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Base Sequence
- DNA Primers/genetics
- Clusterin
- T-Lymphocytes/immunology
- Receptors, Tumor Necrosis Factor, Type I
- Molecular Chaperones
- Antigens, CD/biosynthesis
- Autoantibodies/biosynthesis
- Autoimmune Diseases/etiology/immunology/pathology
- Glycoproteins/deficiency/genetics/physiology
- Histocompatibility Antigens Class II/biosynthesis
- Myocarditis/etiology/immunology/pathology
- Myosins/immunology
- Receptors, Tumor Necrosis Factor/biosynthesis
1814: Komatsu et al. (2006) "Effect of leptin on hypothalamic gene expression in calorie-restricted rats." J. Gerontol. A Biol. Sci. Med. Sci. 61(9):890-898 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Insulin/blood
- Male
- Up-Regulation
- Rats
- Blood Glucose/analysis
- RNA, Messenger/metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Rats, Inbred F344
- Caloric Restriction
- Gene Expression Regulation/drug effects
- Ghrelin
- Eating/drug effects
- Leptin/blood/pharmacology
- Peptide Hormones/blood
- Agouti Signaling Protein
- Agouti-Related Protein
- Arcuate Nucleus/metabolism
- Intercellular Signaling Peptides and Proteins/genetics/metabolism
- Neuropeptide Y/genetics/metabolism
1875: Roybal et al. (2007) "Mania-like behavior induced by disruption of CLOCK." Proc. Natl. Acad. Sci. U.S.A. 104(15):6406-6411 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Immunohistochemistry
- Analysis of Variance
- Mutation/genetics
- Gene Expression Regulation/genetics
- Mutagenesis
- Gene Transfer Techniques
- Electric Stimulation
- CLOCK Proteins
- Genetic Therapy/methods
- Circadian Rhythm/genetics
- Behavioral Symptoms/genetics
- Bipolar Disorder/drug therapy/genetics/pathology/therapy
- Glycogen Synthase Kinase 3/genetics
- Lithium/pharmacology/therapeutic use
- Lithium Compounds/pharmacology/therapeutic use
- Locomotion/drug effects
- Trans-Activators/genetics/therapeutic use
- Ventral Tegmental Area/drug effects
1955: Tilstra et al. (2012) "NF-κB inhibition delays DNA damage-induced senescence and aging in mice." J. Clin. Invest. 122(7):2601-2612 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Mice
- Oxidative Stress
- Phosphorylation
- Signal Transduction
- Cells, Cultured
- DNA-Binding Proteins/genetics/metabolism
- DNA Damage
- Protein Binding
- Transcriptional Activation
- Mice, Transgenic
- Cell Aging
- Cell Nucleus/metabolism
- Gene Expression Regulation/drug effects
- Peptides/pharmacology
- Cyclin-Dependent Kinase Inhibitor p16/genetics/metabolism
- Aging/drug effects/genetics
- Endonucleases/genetics/metabolism
- Hepatocytes/drug effects/metabolism/physiology
- I-kappa B Kinase/antagonists & inhibitors/metabolism
- Progeria/drug therapy/pathology
- Transcription Factor RelA/genetics/metabolism
3421: Gerhardt et al. (2011) "Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice." PLoS ONE 6(12):e28855 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Cell Count
- Longevity/drug effects
- Gene Expression Regulation/drug effects
- Signal Transduction/drug effects
- Oxidative Stress/drug effects
- Stilbenes/pharmacology
- Motor Activity/drug effects
- Gene Knockout Techniques
- Serine Endopeptidases/deficiency/genetics
- Mitochondrial Proteins/deficiency/genetics
- Neostriatum/cytology/drug effects/metabolism/physiology
- Transcription Factor CHOP/genetics/metabolism
- Ubiquinone/analogs & derivatives/pharmacology
2194: Bellizzi et al. (2005) "A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages." Genomics 85(2):258-263 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Base Sequence
- Molecular Sequence Data
- Adult
- Middle Aged
- Polymorphism, Genetic
- Aged
- Aged, 80 and over
- Histone Deacetylases/genetics
- Sirtuins
- Mitochondrial Proteins/genetics
- Enhancer Elements, Genetic/genetics
- Sirtuin 3
- Minisatellite Repeats
2309: Lamming et al. (2005) "HST2 mediates SIR2-independent life-span extension by calorie restriction." Science 309(5742):1861-1864 (PubMed)

3 citations in connected databases
- Tags:
- Gene Deletion
- Longevity
- Mutation
- DNA, Fungal/genetics
- Genes, Fungal
- Recombination, Genetic
- Caloric Restriction
- DNA, Ribosomal/genetics
- Sirtuin 2
- Saccharomyces cerevisiae/genetics/physiology
- Gene Silencing
- Sirtuins/genetics/physiology
- Histone Deacetylases/genetics/physiology
- Niacinamide/pharmacology
- Saccharomyces cerevisiae Proteins/genetics/physiology
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/physiology
2554: Kaeberlein et al. (2004) "Sir2-independent life span extension by calorie restriction in yeast." PLoS Biol. 2(9):E296 (PubMed)

1 citation in connected databases
- Tags:
- Gene Deletion
- DNA-Binding Proteins/genetics/physiology
- Mutation
- Models, Biological
- Phenotype
- Gene Expression Regulation, Fungal
- Species Specificity
- Time Factors
- Plasmids/metabolism
- Caloric Restriction
- Sirtuin 2
- Saccharomyces cerevisiae/genetics/physiology
- Culture Media/metabolism
- Sirtuins/genetics/physiology
- Histone Deacetylases/genetics/physiology
- Databases, Genetic
- Genetic Techniques
- Saccharomyces cerevisiae Proteins/genetics/physiology
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/genetics/physiology
- DNA, Ribosomal/chemistry
1160: Torella et al. (2004) "Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression." Circ. Res. 94(4):514-524 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Male
- Apoptosis
- Cyclin-Dependent Kinase Inhibitor p21
- Oxidative Stress
- Phosphorylation
- Protein-Serine-Threonine Kinases
- Proto-Oncogene Proteins/metabolism
- Proto-Oncogene Proteins c-akt
- Tumor Suppressor Protein p53/metabolism
- Mice, Transgenic
- Cell Division
- Telomerase/metabolism
- Biological Markers
- Cell Aging
- Cell Differentiation
- Telomere/ultrastructure
- Cell Cycle Proteins/metabolism
- Aging/pathology
- Cyclin-Dependent Kinase Inhibitor p27
- Cell Count
- Recombinant Fusion Proteins/physiology
- Tumor Suppressor Protein p14ARF/metabolism
- Cyclins/metabolism
- Protein Processing, Post-Translational
- Cell Lineage
- Cyclin-Dependent Kinase Inhibitor p16/metabolism
- Insulin-Like Growth Factor I/genetics/physiology
- Tumor Suppressor Proteins/metabolism
- Multipotent Stem Cells/cytology
- Myocytes, Cardiac/cytology
1201: Pérez et al. (2004) "Leptin impairs insulin signaling in rat adipocytes." Diabetes 53(2):347-353 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Aging
- Phosphorylation
- Rats
- Transcription Factors/genetics
- Mitogen-Activated Protein Kinases/drug effects/metabolism
- Insulin/pharmacology
- Rats, Wistar
- Gene Expression Regulation/drug effects
- Diet, Reducing
- Suppressor of Cytokine Signaling Proteins
- Repressor Proteins/genetics
- Signal Transduction/drug effects/physiology
- Adipocytes/drug effects/physiology
- Leptin/pharmacology
4006: Wang et al. (2010) "Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16." Biochem. Biophys. Res. Commun. 400(4):613-618 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Transcription Factors/genetics/physiology
- Forkhead Transcription Factors
- Gene Expression
- Caenorhabditis elegans Proteins/genetics/physiology
- Sirtuins/genetics/physiology
- Longevity/drug effects/genetics
- Caenorhabditis elegans/drug effects/genetics/physiology
- Dimethyl Sulfoxide/pharmacology
- Solvents/pharmacology
4154: Pant et al. (2014) "Beta-caryophyllene modulates expression of stress response genes and mediates longevity in Caenorhabditis elegans." Exp. Gerontol. 57:81-95 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Reactive Oxygen Species/metabolism
- Transcription Factors/metabolism
- Superoxide Dismutase/metabolism
- DNA-Binding Proteins/metabolism
- Longevity/drug effects
- Gene Expression Regulation/drug effects
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins/metabolism
- Lipofuscin/metabolism
- Reproduction/drug effects
- Stress, Physiological/drug effects
- Body Size/drug effects
- Plant Extracts/administration & dosage
- Feeding Behavior/drug effects
- Phytotherapy
- Molecular Docking Simulation
- Sesquiterpenes/administration & dosage
4226: Yun et al. (2011) "p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb." Exp. Mol. Med. 43(7):389-392 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cell Aging
- Cell Cycle Proteins/metabolism
- Cell Nucleus/metabolism
- Recombinant Proteins/genetics/metabolism
- Fibroblasts/physiology
- Cell Line, Tumor
- Tumor Suppressor Protein p53/deficiency/genetics
- Actin Cytoskeleton/metabolism
- Actin-Related Protein 2-3 Complex/metabolism
- Retinoblastoma Protein/deficiency/genetics
4567: Saharia et al. (2016) "Reserpine requires the D2-type receptor, " J. Biosci. 41(4):689-695 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mutation
- Signal Transduction/drug effects
- Transcription Factors/biosynthesis/genetics
- Behavior, Animal/drug effects
- Longevity/drug effects/genetics
- Neurons/drug effects
- Caenorhabditis elegans Proteins/biosynthesis/genetics
- Caenorhabditis elegans/drug effects/genetics/growth & development
- Exoribonucleases/biosynthesis/genetics
- GTP-Binding Protein alpha Subunits, Gi-Go/biosynthesis/genetics
- Multidrug Resistance-Associated Proteins/biosynthesis/genetics
- Receptors, Dopamine D2/biosynthesis/genetics
- Reserpine/administration & dosage
4709: Pinto et al. (2018) "Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis." Redox Biol 18:84-92 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Caenorhabditis elegans/drug effects/physiology
- Longevity/drug effects
- Gene Expression Regulation/drug effects
- Oxidative Stress/drug effects
- Oxidation-Reduction/drug effects
- MicroRNAs/genetics
- Topoisomerase II Inhibitors/pharmacology
- Cytochrome P-450 CYP1A2 Inhibitors/pharmacology
- Enoxacin/pharmacology
980: Cheng et al. (2003) "Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice." Proc. Natl. Acad. Sci. U.S.A. 100(19):10794-10799 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- DNA Damage
- Tumor Suppressor Protein p53/metabolism
- Apoptosis/physiology
- Cell Cycle/physiology
- Sirtuin 2
- Congenital Abnormalities/genetics
- Infrared Rays
- Sirtuins/genetics/physiology