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Entries tagged Pituitary Gland/transplantation (705)

5: Flurkey et al. (2001) "Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production." Proc. Natl. Acad. Sci. U.S.A. 98(12):6736-6741 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Aging
- Body Weight
- Collagen/chemistry
- DNA-Binding Proteins/genetics/physiology
- Growth Hormone/physiology
- Insulin-Like Growth Factor I/physiology
- Leptin/blood
- Longevity
- Mice, Inbred C3H
- Mice, Mutant Strains
- Pituitary Gland/transplantation
- T-Lymphocyte Subsets
- T-Lymphocytes/physiology
- Transcription Factor Pit-1
- Transcription Factors/genetics/physiology
74: van Steensel et al. (1998) "TRF2 protects human telomeres from end-to-end fusions." Cell 92(3):401-413 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Anaphase
- Cell Division
- DNA/metabolism
- Telomerase/metabolism
- HeLa Cells
- Tumor Cells, Cultured
- Telomere/genetics
- Cell Aging
- DNA-Binding Proteins/analysis/genetics/metabolism
- Chromosome Aberrations/genetics
- Telomeric Repeat Binding Protein 2
- Fibrosarcoma
- Guanosine/analysis
- Metaphase
- Recombinant Fusion Proteins
- Repetitive Sequences, Nucleic Acid
78: Karlseder et al. (1999) "p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2." Science 283(5406):1321-1325 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Apoptosis
- Phosphorylation
- Cells, Cultured
- Protein-Serine-Threonine Kinases
- DNA Damage
- Proteins/metabolism
- Tumor Suppressor Protein p53/metabolism
- Cell Cycle Proteins
- Tumor Suppressor Proteins
- Cell Line
- Cloning, Molecular
- Tumor Cells, Cultured
- Genetic Vectors
- Telomeric Repeat Binding Protein 2
- Adenoviridae/genetics/physiology
- Ataxia Telangiectasia/pathology
- B-Lymphocytes/cytology
- DNA-Binding Proteins/chemistry/genetics/physiology
- In Situ Nick-End Labeling
- Mitosis
- T-Lymphocytes/cytology
- Telomere/physiology
- Ataxia Telangiectasia Mutated Proteins
147: Chen et al. (2003) "WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair." Aging Cell 2(4):191-199 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- RecQ Helicases
- Cell Aging/genetics
- DNA Repair/genetics
- DNA Damage/genetics
- Cell Line, Transformed
- Mutation/genetics
- Adenosine Triphosphatases/genetics/metabolism
- DNA/genetics/metabolism
- DNA Helicases/deficiency/genetics/metabolism
- Exodeoxyribonucleases/genetics/metabolism
- Fibroblasts/metabolism
- Recombination, Genetic/genetics
- Werner Syndrome/enzymology/genetics/physiopathology
165: Lagger et al. (2003) "The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene." Mol. Cell. Biol. 23(8):2669-2679 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Cyclin-Dependent Kinase Inhibitor p21
- Signal Transduction
- Transfection
- DNA Damage
- Protein Binding
- Tumor Suppressor Protein p53/metabolism
- Cell Line
- Binding Sites
- Enzyme Inhibitors/pharmacology
- Gene Expression Regulation
- Promoter Regions, Genetic
- Cyclins/genetics
- Acetylation
- Antineoplastic Agents/pharmacology
- Binding, Competitive
- Down-Regulation
- Histone Deacetylase 1
- Histone Deacetylase Inhibitors
- Histone Deacetylases/metabolism
- Pregnancy Proteins/metabolism
- Recombinant Proteins/genetics/metabolism
- Repressor Proteins/metabolism
- Sp1 Transcription Factor/metabolism
213: Xu et al. (1995) "Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age." Endocrinology 136(10):4551-4557 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Mice, Inbred C57BL
- Phosphorylation
- Signal Transduction
- Aging/metabolism
- Gene Expression Regulation
- Proto-Oncogene Proteins
- Calcium-Calmodulin-Dependent Protein Kinases/metabolism
- Immunologic Techniques
- Lymphoma/classification/diagnosis
- Protein-Tyrosine Kinases/metabolism
- Growth Hormone/pharmacology
- Janus Kinase 2
- Insulin-Like Growth Factor I/genetics
- Receptors, Somatotropin/analysis/metabolism
315: Murphy et al. (2003) "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans." Nature 424(6946):277-283 (PubMed)

26 citations in connected databases
- Tags:
- Animals
- Insulin-Like Growth Factor I/metabolism
- Signal Transduction
- Transcription Factors/genetics/metabolism
- Aging/genetics/physiology
- Longevity/genetics/physiology
- Time Factors
- Gene Expression Regulation, Developmental
- Insulin/metabolism
- Oligonucleotide Array Sequence Analysis
- RNA Interference
- Caenorhabditis elegans Proteins/genetics/metabolism
- Caenorhabditis elegans/genetics/immunology/physiology
- Cluster Analysis
- Feedback, Physiological
- Genes, Helminth/genetics/physiology
- RNA, Helminth/analysis/genetics
- Receptor, Insulin/agonists/genetics/metabolism
- Response Elements/genetics
- Stress, Physiological/genetics/physiopathology
- Transcription, Genetic/genetics
353: Jepsen et al. (2000) "Combinatorial roles of the nuclear receptor corepressor in transcription and development." Cell 102(6):753-763 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Gene Deletion
- Male
- Mice, Inbred C57BL
- Nuclear Proteins/genetics
- T-Lymphocytes/cytology
- Gene Expression Regulation, Developmental
- Transcription, Genetic/physiology
- Hematocrit
- Nuclear Receptor Co-Repressor 1
- Diencephalon/embryology
- Erythropoiesis/physiology
- Fibroblasts/cytology/physiology
- Repressor Proteins/genetics
- Thymus Gland/cytology/embryology
- Yolk Sac/blood supply/physiology
391: Djouadi et al. (1998) "A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice." J. Clin. Invest. 102(6):1083-1091 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Oxidation-Reduction
- Myocardium/metabolism
- Glucose/metabolism
- Feedback
- Mitochondria/metabolism
- Sex Factors
- Liver/metabolism
- Carbohydrate Metabolism, Inborn Errors/physiopathology
- Carnitine O-Palmitoyltransferase/antagonists & inhibitors
- Epoxy Compounds/pharmacology
- Estradiol/pharmacology
- Fatty Acids/metabolism
- Glycogen/metabolism
- Hypoglycemia
- Lipid Metabolism, Inborn Errors/physiopathology
- Receptors, Cytoplasmic and Nuclear/deficiency
- Transcription Factors/deficiency
420: Lu et al. (1996) "A human peptidyl-prolyl isomerase essential for regulation of mitosis." Nature 380(6574):544-547 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Protein-Serine-Threonine Kinases/metabolism
- Protein Binding
- Cell Cycle Proteins
- Amino Acid Sequence
- Cloning, Molecular
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- HeLa Cells
- Recombinant Fusion Proteins/genetics
- Amino Acid Isomerases/chemistry/genetics/physiology
- Aspergillus/genetics
- Carrier Proteins/chemistry/genetics/physiology
- Fungal Proteins/chemistry
- Mitosis/physiology
- Nuclear Proteins/chemistry/genetics/physiology
- Peptidylprolyl Isomerase
457: Waters et al. (2003) "Serum Sex Hormones, IGF-1, and IGFBP3 Exert a Sexually Dimorphic Effect on Lean Body Mass in Aging." J. Gerontol. A Biol. Sci. Med. Sci. 58(7):648-652 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Aging/physiology
- Organ Size
- Sex Characteristics
- Aged
- Aged, 80 and over
- Gonadal Steroid Hormones/blood
- Estrogen Replacement Therapy
- Insulin-Like Growth Factor I/analysis
- Body Composition/physiology
- Testosterone/blood
- Insulin-Like Growth Factor Binding Protein 3/blood
- Adipose Tissue/anatomy & histology
472: Schwartzberg et al. (1991) "Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations." Cell 65(7):1165-1175 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Homozygote
- Mice, Mutant Strains
- Phosphorylation
- Polymerase Chain Reaction
- Phenotype
- Flow Cytometry
- Antigens, Differentiation, B-Lymphocyte/analysis
- Bone Marrow Cells
- Oligonucleotides/chemistry
- Hematopoiesis
- Protein-Tyrosine Kinases/metabolism
- Bone Marrow Transplantation
- Eye Abnormalities/genetics
- Antigens, Differentiation, T-Lymphocyte/analysis
- B-Lymphocyte Subsets/cytology
- Lymphocytes/cytology
- Proto-Oncogene Proteins c-abl/genetics
- Spleen/cytology/pathology
- T-Lymphocyte Subsets/cytology
511: Blander et al. (2002) "DNA damage-induced translocation of the Werner helicase is regulated by acetylation." J. Biol. Chem. 277(52):50934-50940 (PubMed)

2 citations in connected databases
- Tags:
- Transfection
- DNA Damage
- Cell Line
- Exodeoxyribonucleases
- RecQ Helicases
- Werner Syndrome/genetics
- Recombinant Proteins/metabolism
- Enzyme Activation
- Cell Nucleus/enzymology
- DNA Helicases/genetics/metabolism
- Active Transport, Cell Nucleus
- Translocation, Genetic
- Acetylation
- Fibroblasts/cytology/pathology/physiology
4171: Schriner et al. (2014) "Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico." Exp. Gerontol. 60:220-230 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Female
- Male
- Drosophila melanogaster/genetics/physiology
- Sex Characteristics
- Insulin/metabolism
- Fertility/drug effects
- Signal Transduction/drug effects
- Stress, Physiological
- HSP70 Heat-Shock Proteins/metabolism
- Mitochondria/drug effects/metabolism
- Motor Activity/drug effects
- Drosophila Proteins/metabolism
- Insulin Receptor Substrate Proteins/metabolism
- Coumarins/pharmacology
- Longevity/drug effects/genetics/physiology
- Acrolein/analogs & derivatives/pharmacology
- Cinnamomum zeylanicum
- Spices
4219: Watsky et al. (1990) "Corneal endothelial junctions and the effect of ouabain." Invest. Ophthalmol. Vis. Sci. 31(5):933-941 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Permeability/drug effects
- Perfusion
- Rabbits
- Ouabain/pharmacology
- In Vitro Techniques
- Corneal Stroma/metabolism
- Endothelium, Corneal/drug effects/metabolism/ultrastructure
- Freeze Fracturing
- Intercellular Junctions/drug effects/metabolism/ultrastructure
4389: Kaushik et al. (2015) "Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart." Sci Transl Med 7(292):292ra99 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Genotype
- Male
- Aging/physiology
- Rats
- Organ Specificity
- Drosophila melanogaster/physiology
- Macaca mulatta
- Ventricular Remodeling
- Actin Cytoskeleton/metabolism
- Cytoskeleton/metabolism
- Heart Ventricles/pathology/physiopathology
- Myocytes, Cardiac/metabolism/pathology
- Myocardial Contraction
- Biomarkers/metabolism
- Proteome/metabolism
- Cardiomegaly/pathology/physiopathology
- Vinculin/metabolism
4594: Wang et al. (2017) "Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan." Nat Commun 8(1):2270 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- HeLa Cells
- Enzyme Inhibitors/pharmacology
- Starvation
- Caloric Restriction
- Calcium/metabolism
- Longevity/drug effects
- Biguanides/pharmacology
- Liver/drug effects/metabolism
- Mitochondria/drug effects/metabolism
- Autophagy/drug effects
- Fatty Liver/metabolism
- High-Throughput Screening Assays
- Caenorhabditis elegans/drug effects/metabolism
- Lipid Metabolism/drug effects
- Lactams/pharmacology
- Diet, High-Fat
- Autophagosomes/drug effects/metabolism
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/agonists
- Digoxin/pharmacology
- Lysosomes/drug effects/metabolism
- Metabolic Syndrome/metabolism
4699: Mills et al. (2016) "Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice." Cell Metab. 24(6):795-806 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Mice, Inbred C57BL
- Lipids/blood
- Time Factors
- NAD/metabolism
- Insulin/pharmacology
- Gene Expression Regulation/drug effects
- Bone Density/drug effects
- Darkness
- Mitochondria/drug effects/metabolism
- Eating/drug effects
- Drinking/drug effects
- Energy Metabolism/drug effects
- Physical Conditioning, Animal
- Food
- Aging/drug effects/genetics/physiology
- Administration, Oral
- Cell Respiration/drug effects
- Weight Gain/drug effects
- Muscle, Skeletal/drug effects/metabolism
- Lymphocytes/drug effects/metabolism
- Myeloid Cells/drug effects/metabolism
- Nicotinamide Mononucleotide/administration & dosage/blood/pharmacology
540: Parrado et al. (1999) "Effects of aging on the various steps of protein synthesis: fragmentation of elongation factor 2." Free Radic. Biol. Med. 26(3-4):362-370 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Rats
- Amino Acid Sequence
- Molecular Sequence Data
- Oxidative Stress/physiology
- Aging/metabolism
- Free Radicals
- Phosphoproteins/biosynthesis/metabolism
- Rats, Wistar
- Liver/metabolism
- Isoelectric Focusing
- Peptide Chain Termination, Translational
- Peptide Elongation Factor 2
- Peptide Elongation Factors/metabolism
610: Lee et al. (1987) "Human retinoblastoma susceptibility gene: cloning, identification, and sequence." Science 235(4794):1394-1399 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Homozygote
- Transcription, Genetic
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- Nucleic Acid Hybridization
- DNA/genetics
- Pregnancy
- RNA, Messenger/genetics
- Eye Neoplasms/genetics
- Retinoblastoma/genetics
- Carboxylesterase
- Carboxylic Ester Hydrolases/genetics
- Chromosomes, Human, Pair 13
- Placenta/analysis
- Retina/analysis/embryology