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Entries tagged Nucleic Acid Synthesis Inhibitors/pharmacology (36)

3740: Kim et al. (2009) "Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells." Mech. Ageing Dev. 130(3):179-188 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Phosphorylation
- Tumor Suppressor Protein p53/genetics/metabolism
- Acetylcysteine/pharmacology
- Cells, Cultured
- Reactive Oxygen Species/metabolism
- Antioxidants/pharmacology
- DNA Damage
- Phosphoproteins/metabolism
- Recombinant Proteins/metabolism
- Cell Aging/drug effects/genetics
- Time Factors
- Nuclear Proteins/metabolism
- Fibroblasts/metabolism
- Histones/metabolism
- Signal Transduction/drug effects
- Protein Processing, Post-Translational
- Cyclin-Dependent Kinase Inhibitor p16/metabolism
- Cell Proliferation
- Interferon-alpha/metabolism
- Cyclin-Dependent Kinase Inhibitor p21/metabolism
- Endothelial Cells/drug effects/metabolism
- Interferon-gamma/metabolism
1192: MacLusky et al. (1979) "The development of estrogen receptor systems in the rat brain: perinatal development." Brain Res. 178(1):129-142 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Aging
- Rats
- Animals, Newborn
- Pregnancy
- Tissue Distribution
- Sex Factors
- Cytosol/metabolism
- Fetus
- Adrenalectomy
- Estradiol/metabolism
- Receptors, Estrogen/physiology
- Brain/growth & development/physiology
- Castration
1768: van der Horst et al. (1997) "Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition." Cell 89(3):425-435 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Alleles
- Amino Acid Sequence
- DNA Repair Enzymes
- Transcription Factors/genetics
- Repressor Proteins/genetics
- Cockayne Syndrome/genetics/physiopathology
- Ultraviolet Rays/adverse effects
- Viral Proteins/genetics
- DNA Helicases/deficiency/genetics
- Mutagenesis/physiology
- DNA Repair/physiology/radiation effects
- Photosensitivity Disorders/genetics/physiopathology
- Skin Neoplasms/genetics/physiopathology
- Transcription, Genetic/physiology/radiation effects
- Viral Regulatory and Accessory Proteins
740: de Haan et al. (1995) "Cu/Zn-superoxide dismutase and glutathione peroxidase during aging." Biochem. Mol. Biol. Int. 35(6):1281-1297 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Reactive Oxygen Species
- Superoxide Dismutase/metabolism
- Aging/metabolism
- NF-kappa B/metabolism
- Catalase/metabolism
- Glutathione Peroxidase/metabolism
- Mice, Inbred CBA
- Down Syndrome/metabolism
243: Cho et al. (2003) "Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process." Exp. Gerontol. 38(5):539-548 (PubMed)

7 citations in connected databases
- Tags:
- Animals
- Male
- Aging/physiology
- Oxidation-Reduction
- Rats
- Transcription Factors
- Gene Expression
- Glutathione/metabolism
- Thioredoxins/metabolism
- Blotting, Western/methods
- DNA-Binding Proteins/genetics
- Translocation, Genetic
- Rats, Inbred F344
- Drosophila Proteins
- Caloric Restriction/methods
- Carbon-Oxygen Lyases/genetics
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Glutathione Peroxidase/metabolism
- Glutathione Reductase/metabolism
- Glutathione Transferase/metabolism
- Kidney/metabolism
418: Liou et al. (2003) "Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration." Nature 424(6948):556-561 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Gene Deletion
- Aging/physiology
- Phosphorylation
- Gene Expression
- Phosphoserine/metabolism
- Microscopy, Electron
- Behavior, Animal/physiology
- Alzheimer Disease/enzymology/pathology/physiopathology/prevention & control
- Amino Acid Motifs
- Motor Activity/physiology
- Neurofibrillary Tangles/metabolism/pathology
- Neurons/metabolism/pathology
- Neuroprotective Agents/metabolism
- Peptidylprolyl Isomerase/genetics/metabolism
- Phosphoproteins/chemistry/metabolism
- Phosphothreonine/metabolism
- Plaque, Amyloid/metabolism/pathology
- Tauopathies/enzymology/pathology/physiopathology/prevention & control
2686: Fox et al. (1973) "Body temperatures in the elderly: a national study of physiological, social, and environmental conditions." Br Med J 1(5847):200-206 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Age Factors
- Middle Aged
- Aged
- Heating
- Body Temperature
- Body Temperature Regulation
- Great Britain
- Family Characteristics
- Hypothermia
- Marriage
- Seasons
- Skin Temperature
- Socioeconomic Factors
- Weather
2978: Burt et al. (1995) "Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991." Hypertension 25(3):305-313 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Adolescent
- Middle Aged
- Aged
- Aged, 80 and over
- Blood Pressure
- European Continental Ancestry Group
- Prevalence
- United States/epidemiology
- Health Surveys
- Antihypertensive Agents/therapeutic use
- African Continental Ancestry Group
- Hispanic Americans
- Hypertension/epidemiology/physiopathology/therapy
- Nutrition Surveys
1186: Dubal et al. (2001) "Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury." Proc. Natl. Acad. Sci. U.S.A. 98(4):1952-1957 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Mice, Inbred C57BL
- Hormone Replacement Therapy
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Brain/blood supply/pathology
- Brain Injuries/pathology/prevention & control
- Brain Ischemia/pathology/prevention & control
- Cerebral Infarction/pathology/prevention & control
- Cerebrovascular Circulation
- Estradiol/blood/physiology
- Receptors, Estrogen/physiology
- Stroke/pathology/prevention & control
1439: Tatebayashi et al. (2002) "Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau." Proc. Natl. Acad. Sci. U.S.A. 99(21):13896-13901 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Transgenic
- Phenotype
- Point Mutation
- Gene Expression
- Neurofibrillary Tangles/metabolism/pathology
- Recombinant Proteins/chemistry/genetics/metabolism
- Association Learning/physiology
- Aging/genetics/metabolism/psychology
- Alzheimer Disease/genetics/metabolism/psychology
- Inclusion Bodies/metabolism/pathology
- Memory Disorders/genetics/metabolism/psychology
- Prosencephalon/metabolism/pathology
- tau Proteins/chemistry/genetics/metabolism
2062: Jaskelioff et al. (2011) "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice." Nature 469(7328):102-106 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Cells, Cultured
- Phenotype
- Models, Animal
- Enzyme Activation/drug effects
- Recombinant Fusion Proteins/genetics/metabolism
- Cell Differentiation/drug effects
- Avoidance Learning/drug effects
- DNA Damage/drug effects
- Myelin Sheath/metabolism
- Tamoxifen/analogs & derivatives/pharmacology
- Receptors, Estrogen/genetics/metabolism
- Organ Size/drug effects
- Cell Proliferation/drug effects
- Aging/drug effects/metabolism/pathology
- Brain/anatomy & histology/cytology/drug effects/pathology
- Enzyme Reactivators/pharmacology
- Neural Stem Cells/cytology/drug effects/enzymology/pathology
- Regenerative Medicine
- Smell/drug effects/physiology
- Telomerase/deficiency/genetics/metabolism
- Telomere/drug effects/metabolism/pathology
2420: Uccelletti et al. (2008) "APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses." Mol. Biol. Cell 19(4):1337-1345 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Signal Transduction
- Mutation
- Base Sequence
- Animals, Genetically Modified
- DNA, Helminth/genetics
- Genes, Helminth
- Gene Expression Regulation
- Recombinant Fusion Proteins/genetics/metabolism
- RNA Interference
- Caenorhabditis elegans/genetics/growth & development/metabolism
- Endoplasmic Reticulum/metabolism
- Protein Folding
- Caenorhabditis elegans Proteins/chemistry/genetics/metabolism
- Glycosylation
- Green Fluorescent Proteins/genetics/metabolism
- Apyrase/antagonists & inhibitors/genetics/metabolism
- Pharynx/enzymology/growth & development
- Pyrophosphatases/antagonists & inhibitors/genetics/metabolism
4614: Levitt et al. (1978) "Detection of neoplastic involvement of the mesentery and omentum by computed tomography." AJR Am J Roentgenol 131(5):835-838 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Aged
- Tomography, X-Ray Computed
- Abdominal Neoplasms/diagnostic imaging
- Barium Sulfate
- Diagnostic Errors
- Evaluation Studies as Topic
- Mesentery/diagnostic imaging
- Omentum/diagnostic imaging
- Peritoneal Neoplasms/diagnostic imaging
3786: Li et al. (2008) "Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts." Mol. Cancer Res. 6(5):770-784 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Cell Line
- Cell Aging
- Reverse Transcriptase Polymerase Chain Reaction
- Gene Expression Regulation
- Fibroblasts/metabolism
- DNA Methylation
- Cell Proliferation
- Interferon-alpha/metabolism
- Epigenesis, Genetic
- Interferon Regulatory Factor-7/metabolism
- Interferon Regulatory Factors/metabolism
- Interferons/metabolism
- Li-Fraumeni Syndrome/metabolism
637: Jurivich et al. (1997) "Attenuated stress responses in young and old human lymphocytes." Mech. Ageing Dev. 94(1-3):233-249 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Transcription Factors
- DNA/metabolism
- Adult
- HeLa Cells
- Middle Aged
- DNA-Binding Proteins/metabolism
- Aged
- Aged, 80 and over
- Cell Extracts
- Heating
- Protease Inhibitors
655: Van Remmen et al. (2003) "Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging." Physiol. Genomics 16(1):29-37 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Heterozygote
- Oxidative Stress
- Oxidation-Reduction
- DNA Damage
- Aging/genetics/physiology
- Cell Division
- Biological Markers
- Longevity/genetics/physiology
- Superoxide Dismutase/deficiency/genetics/metabolism
- Catalase/metabolism
- Glutathione Peroxidase/metabolism
- DNA, Mitochondrial/analysis/genetics
- Neoplasms/enzymology/genetics/metabolism/pathology
879: Ikeyama et al. (2003) "Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury." J. Biol. Chem. 278(19):16726-16731 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Rats
- Apoptosis/genetics
- Oxidative Stress/genetics
- Gene Expression Regulation
- Rats, Inbred F344
- Aging/genetics/metabolism/pathology
- Liver/metabolism/pathology
- Transcription Factors/biosynthesis/genetics
- CCAAT-Enhancer-Binding Proteins/biosynthesis/genetics
- Transcription Factor CHOP
61: Pichierri et al. (2000) "Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle." Mutat. Res. 459(2):123-133 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- DNA Damage
- Exodeoxyribonucleases
- RecQ Helicases
- Enzyme Inhibitors/pharmacology
- Amsacrine/pharmacology
- Cell Line, Transformed
- DNA Helicases/genetics/metabolism/physiology
- DNA Topoisomerases, Type II/metabolism
- Etoposide/pharmacology
- G2 Phase
- Nucleic Acid Synthesis Inhibitors/pharmacology
- Topoisomerase II Inhibitors
- Werner Syndrome/enzymology
1485: Kurosu et al. (2005) "Suppression of aging in mice by the hormone Klotho." Science 309(5742):1829-1833 (PubMed)

10 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Phosphorylation
- Signal Transduction
- Aging/genetics/physiology
- Mice, Transgenic
- Blood Glucose/analysis
- Eating
- Cell Line
- Ligands
- Oxygen Consumption
- Longevity/genetics/physiology
- Glucuronidase
- Receptor, Insulin/metabolism
- Insulin Resistance
- Receptors, Cell Surface/metabolism
- Cell Line, Tumor
- Insulin-Like Growth Factor I/metabolism/pharmacology
- Insulin/blood/metabolism
- Membrane Proteins/chemistry/genetics/pharmacology/physiology
- Myoblasts/metabolism
- Peptide Fragments/chemistry/pharmacology
- Receptor, IGF Type 1/metabolism
- Recombinant Proteins/chemistry/isolation & purification/metabolism
2777: Collins et al. (1977) "Accidental hypothermia and impaired temperature homoeostasis in the elderly." Br Med J 1(6057):353-356 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Aged
- Heating
- Body Temperature
- Vasomotor System/physiopathology
- Body Temperature Regulation
- Hypothermia/physiopathology