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Entries tagged Topoisomerase II Inhibitors (51)

2168: Abdul and Hoosein (2006) "Reduced Kv1.3 potassium channel expression in human prostate cancer." J. Membr. Biol. 214(2):99-9102 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Male
- Rats
- Adult
- Middle Aged
- Gene Expression Regulation, Neoplastic
- Aged
- Prognosis
- Neoplasm Staging
- Kv1.3 Potassium Channel/biosynthesis
- Neoplasms/diagnosis/metabolism/pathology
- Prostate-Specific Antigen/biosynthesis
- Prostatic Hyperplasia/diagnosis/metabolism/pathology
- Prostatic Neoplasms/diagnosis/metabolism/pathology
1179: Li et al. (2004) "Age-dependent methylation of ESR1 gene in prostate cancer." Biochem. Biophys. Res. Commun. 321(2):455-461 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Aging/physiology
- Base Sequence
- Middle Aged
- Aged
- DNA Methylation
- Estrogen Receptor alpha
- Neoplasm Staging
- Prostatic Neoplasms/classification/genetics/pathology
- Receptors, Estrogen/genetics
1184: Wilson et al. (2002) "Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain." Mech. Ageing Dev. 123(6):593-601 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Rats
- Brain/metabolism
- RNA, Messenger/metabolism
- Gene Expression
- Aging/genetics/metabolism
- Rats, Sprague-Dawley
- Cerebral Cortex/metabolism
- Estrogen Receptor alpha
- Receptors, Estrogen/genetics
- Estrogen Receptor beta
- Ovariectomy
- Estradiol/metabolism
- Suprachiasmatic Nucleus/metabolism
- Supraoptic Nucleus/metabolism
1196: Davis et al. (2002) "An estrogen receptor repressor induces cataract formation in transgenic mice." Proc. Natl. Acad. Sci. U.S.A. 99(14):9427-9432 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Male
- Models, Biological
- Mice, Transgenic
- Animals, Newborn
- Repressor Proteins/genetics/metabolism
- Sexual Maturation
- Estrogen Receptor alpha
- Ovariectomy
- Cataract/etiology/genetics/metabolism/pathology
- Diethylstilbestrol/toxicity
- Receptors, Estrogen/antagonists & inhibitors/genetics
1682: Lucas et al. (2001) "Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice." EMBO J. 20(1-2):27-39 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Male
- Phosphorylation
- Transfection
- Mice, Transgenic
- Crosses, Genetic
- Cell Death
- Recombinant Proteins/metabolism
- beta Catenin
- COS Cells
- tau Proteins/metabolism
- Glycogen Synthase Kinase 3
- Trans-Activators
- Brain/metabolism/pathology
- Neurons/metabolism/pathology
- Glycogen Synthase Kinases
- Cercopithecus aethiops
- Gliosis
- Hippocampus/pathology
- Calcium-Calmodulin-Dependent Protein Kinases/genetics/metabolism
- Microtubule-Associated Proteins/genetics/metabolism
- Cytoskeletal Proteins/metabolism
- Nerve Degeneration/genetics/pathology/physiopathology
1768: van der Horst et al. (1997) "Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition." Cell 89(3):425-435 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Alleles
- Amino Acid Sequence
- DNA Repair Enzymes
- Transcription Factors/genetics
- Repressor Proteins/genetics
- Cockayne Syndrome/genetics/physiopathology
- Ultraviolet Rays/adverse effects
- Viral Proteins/genetics
- DNA Helicases/deficiency/genetics
- Mutagenesis/physiology
- DNA Repair/physiology/radiation effects
- Photosensitivity Disorders/genetics/physiopathology
- Skin Neoplasms/genetics/physiopathology
- Transcription, Genetic/physiology/radiation effects
- Viral Regulatory and Accessory Proteins
2214: Ramsey et al. (2007) "Expression of Nrf2 in neurodegenerative diseases." J. Neuropathol. Exp. Neurol. 66(1):75-85 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Middle Aged
- Cell Nucleus/metabolism
- Aged
- Aged, 80 and over
- Case-Control Studies
- Cytoplasm/metabolism
- Gene Expression/physiology
- Neurons/metabolism/pathology
- Immunohistochemistry/methods
- Glial Fibrillary Acidic Protein/metabolism
- Postmortem Changes
- Hippocampus/metabolism/pathology
- Microscopy, Confocal/methods
- NF-E2-Related Factor 2/metabolism
- Neurodegenerative Diseases/metabolism/pathology/physiopathology
- Substantia Nigra/metabolism/pathology
2421: Oliveira et al. (2009) "Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf." Aging Cell 8(5):524-541 (PubMed)

20 citations in connected databases
- Tags:
- Animals
- Longevity/genetics
- Reactive Oxygen Species/metabolism
- tert-Butylhydroperoxide/pharmacology
- DNA, Helminth/genetics
- RNA, Messenger/genetics
- Reverse Transcriptase Polymerase Chain Reaction
- DNA-Binding Proteins/genetics
- Transcription Factors/genetics
- Oligonucleotide Array Sequence Analysis
- RNA Interference
- Gene Expression Regulation/drug effects
- Transcription, Genetic/drug effects
- Caenorhabditis elegans Proteins/genetics
- Down-Regulation/drug effects
- Arsenites/pharmacology
- Caenorhabditis elegans/drug effects/genetics/growth & development
- NF-E2-Related Factor 1/genetics
243: Cho et al. (2003) "Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process." Exp. Gerontol. 38(5):539-548 (PubMed)

7 citations in connected databases
- Tags:
- Animals
- Male
- Aging/physiology
- Oxidation-Reduction
- Rats
- Transcription Factors
- Gene Expression
- Glutathione/metabolism
- Thioredoxins/metabolism
- Blotting, Western/methods
- DNA-Binding Proteins/genetics
- Translocation, Genetic
- Rats, Inbred F344
- Drosophila Proteins
- Caloric Restriction/methods
- Carbon-Oxygen Lyases/genetics
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Glutathione Peroxidase/metabolism
- Glutathione Reductase/metabolism
- Glutathione Transferase/metabolism
- Kidney/metabolism
418: Liou et al. (2003) "Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration." Nature 424(6948):556-561 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Gene Deletion
- Aging/physiology
- Phosphorylation
- Gene Expression
- Phosphoserine/metabolism
- Microscopy, Electron
- Behavior, Animal/physiology
- Alzheimer Disease/enzymology/pathology/physiopathology/prevention & control
- Amino Acid Motifs
- Motor Activity/physiology
- Neurofibrillary Tangles/metabolism/pathology
- Neurons/metabolism/pathology
- Neuroprotective Agents/metabolism
- Peptidylprolyl Isomerase/genetics/metabolism
- Phosphoproteins/chemistry/metabolism
- Phosphothreonine/metabolism
- Plaque, Amyloid/metabolism/pathology
- Tauopathies/enzymology/pathology/physiopathology/prevention & control
1186: Dubal et al. (2001) "Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury." Proc. Natl. Acad. Sci. U.S.A. 98(4):1952-1957 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Mice, Inbred C57BL
- Hormone Replacement Therapy
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Brain/blood supply/pathology
- Brain Injuries/pathology/prevention & control
- Brain Ischemia/pathology/prevention & control
- Cerebral Infarction/pathology/prevention & control
- Cerebrovascular Circulation
- Estradiol/blood/physiology
- Receptors, Estrogen/physiology
- Stroke/pathology/prevention & control
2062: Jaskelioff et al. (2011) "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice." Nature 469(7328):102-106 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Cells, Cultured
- Phenotype
- Models, Animal
- Enzyme Activation/drug effects
- Recombinant Fusion Proteins/genetics/metabolism
- Cell Differentiation/drug effects
- Avoidance Learning/drug effects
- DNA Damage/drug effects
- Myelin Sheath/metabolism
- Tamoxifen/analogs & derivatives/pharmacology
- Receptors, Estrogen/genetics/metabolism
- Organ Size/drug effects
- Cell Proliferation/drug effects
- Aging/drug effects/metabolism/pathology
- Brain/anatomy & histology/cytology/drug effects/pathology
- Enzyme Reactivators/pharmacology
- Neural Stem Cells/cytology/drug effects/enzymology/pathology
- Regenerative Medicine
- Smell/drug effects/physiology
- Telomerase/deficiency/genetics/metabolism
- Telomere/drug effects/metabolism/pathology
2160: Chen et al. (2010) "Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis." Cancer Res. 70(23):9979-9990 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Immunohistochemistry
- Adult
- Mice, Nude
- Middle Aged
- Blotting, Western
- Aged
- RNA Interference
- Cell Movement/drug effects
- Cell Line, Tumor
- Transplantation, Heterologous
- Neoplasm Staging
- Cytoskeletal Proteins/genetics/metabolism
- Intracellular Signaling Peptides and Proteins/genetics/metabolism
- Adaptor Proteins, Signal Transducing/genetics/metabolism
- Young Adult
- Multiprotein Complexes/genetics/metabolism
- Lysophospholipids/pharmacology
- Neoplasm Metastasis
- Neoplasms, Experimental/genetics/metabolism/pathology
- Ovarian Neoplasms/genetics/metabolism/pathology
- Receptors, Lysophosphatidic Acid/genetics/metabolism
- SOS1 Protein/genetics/metabolism
1728: Gauthier et al. (2004) "Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules." Cell 118(1):127-138 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Cells, Cultured
- Models, Biological
- Cell Survival
- DNA-Binding Proteins/metabolism
- Nuclear Proteins/metabolism
- Brain/pathology
- Nerve Tissue Proteins/metabolism
- Neurons/metabolism/pathology
- Microtubules/metabolism
- Brain-Derived Neurotrophic Factor/metabolism
- Biological Transport
- Microtubule-Associated Proteins/metabolism
- Cytoplasmic Vesicles/chemistry/metabolism
4614: Levitt et al. (1978) "Detection of neoplastic involvement of the mesentery and omentum by computed tomography." AJR Am J Roentgenol 131(5):835-838 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Aged
- Tomography, X-Ray Computed
- Abdominal Neoplasms/diagnostic imaging
- Barium Sulfate
- Diagnostic Errors
- Evaluation Studies as Topic
- Mesentery/diagnostic imaging
- Omentum/diagnostic imaging
- Peritoneal Neoplasms/diagnostic imaging
3865: Bains et al. (1996) "Gender specific alterations in antioxidant status of aging Zaprionus paravittiger fed on propyl gallate." Biochem. Mol. Biol. Int. 40(4):731-740 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Female
- Male
- Aging
- Antioxidants/metabolism
- Glutathione/metabolism
- Catalase/metabolism
- Glutathione Reductase/metabolism
- Lipid Peroxides/metabolism
- Peroxidase/metabolism
- Drosophilidae
- Propyl Gallate/pharmacology
637: Jurivich et al. (1997) "Attenuated stress responses in young and old human lymphocytes." Mech. Ageing Dev. 94(1-3):233-249 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Transcription Factors
- DNA/metabolism
- Adult
- HeLa Cells
- Middle Aged
- DNA-Binding Proteins/metabolism
- Aged
- Aged, 80 and over
- Cell Extracts
- Heating
- Protease Inhibitors
879: Ikeyama et al. (2003) "Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury." J. Biol. Chem. 278(19):16726-16731 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Rats
- Apoptosis/genetics
- Oxidative Stress/genetics
- Gene Expression Regulation
- Rats, Inbred F344
- Aging/genetics/metabolism/pathology
- Liver/metabolism/pathology
- Transcription Factors/biosynthesis/genetics
- CCAAT-Enhancer-Binding Proteins/biosynthesis/genetics
- Transcription Factor CHOP
61: Pichierri et al. (2000) "Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle." Mutat. Res. 459(2):123-133 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- DNA Damage
- Exodeoxyribonucleases
- RecQ Helicases
- Enzyme Inhibitors/pharmacology
- Amsacrine/pharmacology
- Cell Line, Transformed
- DNA Helicases/genetics/metabolism/physiology
- DNA Topoisomerases, Type II/metabolism
- Etoposide/pharmacology
- G2 Phase
- Nucleic Acid Synthesis Inhibitors/pharmacology
- Topoisomerase II Inhibitors
- Werner Syndrome/enzymology
1166: Shapiro et al. (2004) "Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome." Brain Res. 1010(1-2):17-21 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Immunohistochemistry
- Mice, Transgenic
- Aging/genetics/metabolism
- Clusterin
- Glycoproteins/metabolism
- Molecular Chaperones/metabolism
- Up-Regulation/genetics
- Nerve Growth Factors
- Neurons/metabolism/pathology
- Chromosomes, Human, Pair 21/genetics
- Brain/metabolism/pathology/physiopathology
- Down Syndrome/genetics/metabolism/physiopathology
- S100 Proteins/genetics/metabolism
- S100 Calcium Binding Protein beta Subunit