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Entries tagged Aging, Premature/etiology (87)

1077: Dorszewska and Adamczewska-Goncerzewicz (2004) "Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain." Respir Physiol Neurobiol 139(3):227-236 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Aging/physiology
- Tumor Suppressor Protein p53/genetics/metabolism
- Rats
- DNA/metabolism
- Oxidative Stress/physiology
- Blotting, Western/methods
- Polymerase Chain Reaction/methods
- RNA/metabolism
- Rats, Wistar
- Brain Chemistry/physiology
- Gene Expression/physiology
- Brain/anatomy & histology/metabolism
- Chromatography, High Pressure Liquid/methods
- Deoxyadenosines/analysis
- Statistics, Nonparametric
2376: Ailion et al. (1999) "Neurosecretory control of aging in Caenorhabditis elegans." Proc. Natl. Acad. Sci. U.S.A. 96(13):7394-7397 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Aging/physiology
- Mutation
- Gene Expression Regulation
- Transcription Factors/genetics
- Caenorhabditis elegans/physiology
- Caenorhabditis elegans Proteins
- Calcium-Binding Proteins
- Nerve Tissue Proteins/genetics
- Receptor, Insulin/physiology
- Helminth Proteins/genetics
- Antigens, Surface/genetics
- Neurosecretory Systems/physiology
- Syntaxin 1
3137: Kolovou et al. (2014) "The frequency of 4 common gene polymorphisms in nonagenarians, centenarians, and average life span individuals." Angiology 65(3):210-215 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Genotype
- Aging/physiology
- Alleles
- Adult
- Adolescent
- Middle Aged
- Aged
- Aged, 80 and over
- Gene Frequency
- Peptidyl-Dipeptidase A/genetics
- Polymorphism, Single Nucleotide
- NF-kappa B/genetics
- Cholesterol Ester Transfer Proteins/genetics
3304: Bojesen et al. (2013) "Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer." Nat. Genet. 45(4):371-84, 384e1 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Luciferases/metabolism
- Telomerase/genetics
- Telomere/genetics
- Genetic Predisposition to Disease
- RNA, Messenger/genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Risk Factors
- Case-Control Studies
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide/genetics
- DNA Methylation
- Alternative Splicing
- Genome-Wide Association Study
- Chromatin/genetics
- Genetic Loci/genetics
- Real-Time Polymerase Chain Reaction
- Breast Neoplasms/etiology/pathology
- Ovarian Neoplasms/etiology/pathology
- Tumor Markers, Biological/genetics
3739: Ghosh et al. (2008) "Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence." PLoS ONE 3(10):e3384 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- DNA-Binding Proteins/genetics/physiology
- Cells, Cultured
- Tumor Suppressor Protein p53/metabolism
- Cell Aging
- Fibroblasts/cytology/metabolism
- RNA Interference
- RNA, Small Interfering/pharmacology
- G1 Phase
- Cell Proliferation
- Cyclin-Dependent Kinase Inhibitor p21/metabolism
- Foreskin/cytology
3750: Fujikawa et al. (2007) "ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence." Cancer Sci. 98(9):1468-1475 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cell Line
- Promoter Regions, Genetic
- Oligonucleotide Array Sequence Analysis
- Cell Aging/genetics/physiology
- Alternative Splicing
- Transcription Factors/biosynthesis/genetics/physiology
- Trans-Activators/physiology
- Cyclin-Dependent Kinase Inhibitor p16/genetics/metabolism
- MAP Kinase Kinase 6/biosynthesis/genetics
- Protein Isoforms/biosynthesis/genetics/physiology
- Up-Regulation/genetics/physiology
- p38 Mitogen-Activated Protein Kinases/genetics/physiology
1388: Kusumi et al. (1998) "The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries." Nat. Genet. 19(3):274-278 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mutation
- Proteins/metabolism
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Molecular Sequence Data
- Membrane Proteins/genetics/physiology
- Intracellular Signaling Peptides and Proteins
- DNA, Complementary
- Alternative Splicing
- Glycosyltransferases
- Somites/physiology
1664: Saito et al. (2005) "Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation." Nat. Med. 11(4):434-439 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Aging
- Cells, Cultured
- Transfection
- Brain/metabolism
- Hippocampus/metabolism
- Alzheimer Disease/metabolism
- Amyloid beta-Peptides/metabolism
- Neprilysin/metabolism
- Somatostatin/pharmacology
1764: Utsugi et al. (2000) "Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging." Metab. Clin. Exp. 49(9):1118-1123 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Aging/physiology
- Mice, Mutant Strains
- Models, Biological
- Blood Glucose/analysis
- Glucose Tolerance Test
- Gene Expression
- RNA, Messenger/analysis
- Growth Hormone/blood
- Muscle, Skeletal/metabolism
- Thyrotropin/blood
- Glucose Transporter Type 4
- Muscle Proteins
- Adrenocorticotropic Hormone/blood
- Hypoglycemia/metabolism
- Insulin/blood/pharmacology
- Islets of Langerhans/anatomy & histology/metabolism
- Monosaccharide Transport Proteins/genetics/metabolism
2141: Zhang et al. (2008) "Klotho is a target gene of PPAR-gamma." Kidney Int. 74(6):732-739 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Inbred C57BL
- Transcription, Genetic
- Cell Line
- RNA, Small Interfering/pharmacology
- Gene Expression Regulation/drug effects
- Kidney/metabolism
- Response Elements
- Glucuronidase/genetics
- PPAR gamma/agonists/antagonists & inhibitors/physiology
- Thiazolidinediones/pharmacology
2162: Welsch et al. (2007) "Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization." Cancer Lett. 255(2):205-218 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Adaptor Proteins, Signal Transducing
- Up-Regulation
- RNA, Small Interfering/pharmacology
- Cell Movement/drug effects
- Cell Line, Tumor
- Actins/analysis/metabolism/ultrastructure
- Cell Surface Extensions/chemistry/metabolism/ultrastructure
- Cytoskeleton/ultrastructure
- Intracellular Signaling Peptides and Proteins/analysis/antagonists & inhibitors/physiology
- Pancreas/chemistry/ultrastructure
- Pancreatic Neoplasms/chemistry/metabolism/ultrastructure
- Pseudopodia/chemistry/metabolism/ultrastructure
2322: Loo et al. (2005) "The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster." Mol. Cell. Biol. 25(16):7078-7091 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity
- DNA-Binding Proteins/genetics/metabolism
- Mutation
- Transcription Factors/genetics/metabolism
- Protein Binding
- Immunohistochemistry
- Alleles
- Phenotype
- Transcription, Genetic
- DNA/metabolism
- Recombinant Fusion Proteins/metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Flow Cytometry
- Protein Structure, Tertiary
- Time Factors
- Models, Genetic
- Insulin/metabolism
- Dimerization
- Drosophila Proteins/genetics/metabolism
- Glutathione Transferase/metabolism
- Two-Hybrid System Techniques
- Alternative Splicing
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Phylogeny
- Cell Proliferation
- Body Size
- Cell Separation
- Green Fluorescent Proteins/metabolism
- Drosophila melanogaster/growth & development/physiology
- Repressor Proteins/metabolism/physiology
538: Miki et al. (1994) "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1." Science 266(5182):66-71 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Female
- Male
- Mutation
- Alleles
- Phenotype
- Amino Acid Sequence
- Molecular Sequence Data
- Pedigree
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Breast Neoplasms/genetics
- BRCA1 Protein
- Zinc Fingers
- Alternative Splicing
- Chromosomes, Human, Pair 17
- Haplotypes
- Lod Score
- Neoplasm Proteins/chemistry/genetics/physiology
- Ovarian Neoplasms/genetics
- Transcription Factors/chemistry/genetics/physiology
4231: Cao et al. (2011) "WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts." J. Biol. Chem. 286(38):33447-33456 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Protein Binding
- Amino Acid Sequence
- Molecular Sequence Data
- HeLa Cells
- Cell Aging
- Protein Structure, Tertiary
- Fibroblasts/cytology/metabolism
- Gene Silencing
- Protein Processing, Post-Translational
- Amino Acid Motifs
- Diploidy
- Cyclin-Dependent Kinase Inhibitor p21/metabolism
- Ubiquitination
- Polyubiquitin/metabolism
- Cyclin-Dependent Kinase Inhibitor p27/chemistry/metabolism
- Ubiquitin-Protein Ligases/chemistry/metabolism
4515: Tabrez et al. (2017) "Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity." Nat Commun 8(1):306 (PubMed)

18 citations in connected databases
- Tags:
- Animals
- Mice
- Longevity/genetics
- Mutation
- Exons/genetics
- RNA, Messenger/genetics/metabolism
- Animals, Genetically Modified
- Caenorhabditis elegans/genetics
- Caloric Restriction
- Diet
- Alternative Splicing
- Introns/genetics
- Gene Expression Profiling/methods
- 3' Untranslated Regions/genetics
- Nonsense Mediated mRNA Decay
2974: Encinas et al. (2011) "Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus." Cell Stem Cell 8(5):566-579 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Aging/physiology
- Mice, Transgenic
- Cell Division
- Cell Line
- Cell Differentiation
- Cell Survival
- Nerve Tissue Proteins/genetics
- Hippocampus/pathology
- Green Fluorescent Proteins/genetics
- Astrocytes/metabolism/pathology
- Cognition Disorders/pathology/physiopathology
- Computational Biology
- Intermediate Filament Proteins/genetics
- Neural Stem Cells/metabolism/pathology
- Stem Cell Niche
- Nestin
1098: Sano et al. (2004) "Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein." Ann. Neurol. 55(2):241-249 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Immunohistochemistry
- Reverse Transcriptase Polymerase Chain Reaction
- Blotting, Western
- DNA-Binding Proteins/chemistry/genetics/metabolism
- DNA Repair/physiology
- COS Cells
- RNA, Messenger
- Nuclear Proteins/chemistry/genetics/metabolism
- Two-Hybrid System Techniques
- Alternative Splicing
- Cercopithecus aethiops
- Protein Isoforms
- Apraxias/genetics
- Hypoalbuminemia/genetics
- Nuclear Localization Signals/metabolism
2072: Guan et al. (2009) "HDAC2 negatively regulates memory formation and synaptic plasticity." Nature 459(7243):55-60 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Mice, Inbred C57BL
- Gene Expression Regulation
- Promoter Regions, Genetic/genetics
- Histone Deacetylase 1
- Histone Deacetylase Inhibitors
- Hydroxamic Acids/pharmacology
- Hippocampus/metabolism
- Butyrates/pharmacology
- Neurons/metabolism
- Histone Deacetylases/deficiency/genetics/metabolism
- Memory/drug effects/physiology
- Dendritic Spines/physiology
- Electrical Synapses/physiology
- Histone Deacetylase 2
- Learning/drug effects
- Repressor Proteins/antagonists & inhibitors/genetics/metabolism
- Sodium/pharmacology
2189: Iwabuchi et al. (2008) "Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1." Biochem. Biophys. Res. Commun. 376(3):509-513 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Chromosome Aberrations
- DNA Repair/genetics
- Cell Cycle/genetics
- Exons
- Alternative Splicing
- Cell Line, Tumor
- Intracellular Signaling Peptides and Proteins/genetics/physiology
- X-Rays
- DNA Breaks, Double-Stranded
- Colonic Neoplasms/genetics/pathology
2283: Shen et al. (2007) "Involvement of genes required for synaptic function in aging control in C. elegans." Neurosci Bull 23(1):21-29 (PubMed)

10 citations in connected databases
- Tags:
- Animals
- Longevity/genetics
- Aging/genetics
- DNA Mutational Analysis
- Mutation/genetics
- Signal Transduction/genetics
- Insulin/metabolism
- Gene Expression Regulation/genetics
- Nerve Tissue Proteins/genetics
- Caenorhabditis elegans/genetics/metabolism
- Nervous System/metabolism
- Synaptic Transmission/genetics
- Lipofuscin/metabolism
- Caenorhabditis elegans Proteins/genetics
- Neurosecretion/genetics
- Synapses/genetics/metabolism