You can search for any reference by title, author, date, editor, journal and publisher. Searching is case insensitive, and allows for only partial terms (e.g. seq with pickup both RNA-Seq and sequencing) matching. You can also use advanced queries that are detailed here.

Entries tagged Peroxidases/deficiency/genetics/metabolism (50)

4553: Abergel et al. (2017) "Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans." Aging Cell 16(2):401-413 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Reactive Oxygen Species/metabolism
- Oxygen/metabolism
- Mutation/genetics
- Temperature
- Gene Expression Regulation/drug effects
- Signal Transduction/drug effects
- Longevity/drug effects/physiology
- Transcription, Genetic/drug effects
- Paraquat/toxicity
- Caenorhabditis elegans Proteins/metabolism
- Neuropeptides/metabolism
- Oxidation-Reduction/drug effects
- Guanylate Cyclase/metabolism
- Food
- Stress, Physiological/drug effects
- Caenorhabditis elegans/drug effects/genetics/physiology
- Neurotransmitter Agents/metabolism
- Immunity, Innate/drug effects/genetics
- Interneurons/drug effects/metabolism
- Receptors, Neuropeptide Y/metabolism
3446: Kaeberlein et al. (2006) "Lifespan extension in Caenorhabditis elegans by complete removal of food." Aging Cell 5(6):487-494 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Insulin-Like Growth Factor I/metabolism
- Longevity/physiology
- Aging/physiology
- Mutation/genetics
- Immunity, Innate/genetics
- Insulin/metabolism
- Models, Animal
- Sirtuins/genetics/metabolism
- Caloric Restriction
- Caenorhabditis elegans Proteins/genetics/metabolism
- Fertility/physiology
- Food Deprivation/physiology
- Caenorhabditis elegans/metabolism
- Stress, Physiological/genetics/metabolism
- Bacteria/metabolism
- Receptors, Nicotinic/genetics
3579: Wang et al. (2008) "Fat metabolism links germline stem cells and longevity in C. elegans." Science 322(5903):957-960 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Aging
- Longevity
- Signal Transduction
- Stem Cells/cytology/metabolism
- Reproduction
- Cell Differentiation
- Transcription Factors/metabolism
- Genes, Helminth
- Models, Animal
- Caenorhabditis elegans Proteins/genetics/metabolism
- Receptor, Insulin/metabolism
- Caenorhabditis elegans/genetics/metabolism/physiology
- Temperature
- Hydrolysis
- Lipid Metabolism
- Cell Proliferation
- Intracellular Signaling Peptides and Proteins/metabolism
- Intestines/cytology/metabolism
- Germ Cells/cytology/metabolism
- Lipase/genetics/metabolism
3886: Saito et al. (1998) "A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice." Biosci. Biotechnol. Biochem. 62(4):792-794 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Mice, Inbred C57BL
- Longevity/drug effects
- Body Weight/drug effects
- Drinking/drug effects
- Cyclic N-Oxides
- Nitrogen Oxides/pharmacology
- Spin Labels
1461: Hesselink et al. (2003) "Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo." J. Clin. Invest. 111(4):479-486 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Dietary Fats/administration & dosage
- Adult
- Carrier Proteins/metabolism
- Muscle, Skeletal/metabolism
- Fatty Acids/metabolism
- Mitochondria, Muscle/metabolism
- Oxidative Phosphorylation
- Mitochondrial Proteins
- Muscle Contraction/physiology
- Ion Channels
- Lactic Acid/metabolism
- Uncoupling Agents/metabolism
- Creatine/metabolism
- Phosphocreatine/biosynthesis
- Proton-Translocating ATPases/metabolism
2148: Benigni et al. (2009) "Disruption of the Ang II type 1 receptor promotes longevity in mice." J. Clin. Invest. 119(3):524-530 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Blood Glucose
- Longevity/genetics
- Body Weight
- Up-Regulation
- Phenotype
- Oxidative Stress/genetics
- Down-Regulation
- Sirtuins/genetics
- Cytokines/genetics
- Adaptor Proteins, Signal Transducing/genetics
- Energy Intake
- Mice, Knockout/genetics
- Mitochondrial Proteins/genetics
- Rotarod Performance Test
- Heart Diseases/genetics/prevention & control
- Nicotinamide Phosphoribosyltransferase/genetics
- Sirtuin 3
- Vascular Diseases/genetics/prevention & control
865: Oshima et al. (1996) "Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)." Cell 87(5):803-809 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Mice
- Mice, Knockout
- Female
- Male
- Mice, Inbred C57BL
- Enzyme Inhibitors/pharmacology
- Dose-Response Relationship, Drug
- Gene Dosage
- Time Factors
- Gene Expression Regulation, Enzymologic/physiology
- Cytoskeletal Proteins/genetics
- Cyclooxygenase 2
- Adenomatous Polyposis Coli/drug therapy/enzymology/genetics
- Adenomatous Polyposis Coli Protein
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors/pharmacology
- Extracellular Space/physiology
- Furans/pharmacology
- Gene Expression Regulation, Neoplastic/physiology
- Genes, APC/physiology
- Intestinal Mucosa/enzymology/pathology
- Isoenzymes/drug effects/genetics/metabolism
- Mutagenesis/physiology
- Prostaglandin-Endoperoxide Synthases/drug effects/genetics/metabolism
- Sulindac/pharmacology
4633: Lucanic et al. (2016) "Chemical activation of a food deprivation signal extends lifespan." Aging Cell 15(5):832-841 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Models, Biological
- Mutation/genetics
- Caenorhabditis elegans/physiology
- Caloric Restriction
- Signal Transduction/drug effects
- Longevity/drug effects/physiology
- Food Deprivation/physiology
- Caenorhabditis elegans Proteins/metabolism
- Muscle Contraction/drug effects
- Pharynx/drug effects/physiology
- Feeding Behavior/drug effects
- Chloride Channels/metabolism
- Glutamates/metabolism
- Receptors, Muscarinic/genetics/metabolism
- Small Molecule Libraries/analysis/chemistry/pharmacology
2810: Campbell et al. (2012) "Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels." PLoS ONE 7(11):e49813 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Aging
- Adult
- Middle Aged
- Aged
- Collagen/metabolism
- Echocardiography
- Hemodynamics
- Myocardium/metabolism/pathology
- Blood Chemical Analysis
- Diastole
- Coronary Artery Disease/complications
- Glycosylation End Products, Advanced/blood
- Lysine/analogs & derivatives/blood/metabolism
- Receptors, Immunologic/blood/metabolism
- Ventricular Dysfunction, Left/blood/etiology/pathology
1254: Carrieri et al. (2004) "The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians." Aging Cell 3(6):443-448 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Alleles
- Adult
- Adolescent
- Middle Aged
- Sex Characteristics
- Polymorphism, Genetic
- Aged
- Aged, 80 and over
- Transforming Growth Factor beta1
- Aging/genetics/immunology
- Longevity/genetics/immunology
- Cytokines/genetics
- Italy
- Transforming Growth Factor beta/blood/genetics
2211: Tanaka et al. (2008) "NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet." J. Pharmacol. Exp. Ther. 325(2):655-664 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Male
- Mice, Inbred C57BL
- Body Weight
- Oxidative Stress
- Organ Size
- RNA, Messenger/metabolism
- Liver/drug effects/growth & development/metabolism
- Malondialdehyde/metabolism
- Triglycerides/blood/metabolism
- Cholesterol/blood/metabolism
- Dietary Fats/pharmacology
- Fatty Acids, Nonesterified/blood/metabolism
- NF-E2-Related Factor 2/genetics
1743: Altomonte et al. (2004) "Foxo1 mediates insulin action on apoC-III and triglyceride metabolism." J. Clin. Invest. 114(10):1493-1503 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Inbred C57BL
- Cells, Cultured
- Rats
- Transcription Factors/genetics/metabolism
- Luciferases/metabolism
- Alleles
- Mice, Transgenic
- Cell Line
- Dose-Response Relationship, Drug
- Mice, Inbred Strains
- Adenoviridae/genetics
- Promoter Regions, Genetic
- Genes, Reporter
- Hepatocytes/metabolism
- Binding Sites/genetics
- Insulin/metabolism/pharmacology
- Caco-2 Cells
- Mice, Inbred NOD
- Apolipoproteins C/blood/drug effects/genetics/metabolism
- Enterocytes/metabolism
- Hypertriglyceridemia/genetics
- Triglycerides/blood/metabolism
3240: Vilchez et al. (2012) "RPN-6 determines C. elegans longevity under proteotoxic stress conditions." Nature 489(7415):263-268 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Ultraviolet Rays
- Animals, Genetically Modified
- Oxidative Stress/physiology
- Transcription Factors/metabolism
- Mutation/genetics
- Gene Expression Regulation
- Caenorhabditis elegans Proteins/genetics/metabolism
- Cell Separation
- Heat-Shock Response/genetics
- Germ Cells/cytology/metabolism
- Peptides/metabolism
- Caenorhabditis elegans/cytology/genetics/metabolism/physiology
- Homeostasis/radiation effects
- Longevity/genetics/physiology/radiation effects
- Proteasome Endopeptidase Complex/chemistry/genetics/metabolism
- Stress, Physiological/physiology/radiation effects
4095: Wan et al. (2013) "Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway." Exp. Gerontol. 48(5):499-506 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Forkhead Transcription Factors
- Mutation
- Phenotype
- Dose-Response Relationship, Drug
- Caenorhabditis elegans Proteins/genetics/physiology
- Transcription Factors/physiology
- Signal Transduction/physiology
- Hot Temperature
- Telomere-Binding Proteins/genetics
- Food Deprivation/physiology
- Protein Kinases/physiology
- Stress, Physiological/drug effects
- Caenorhabditis elegans/drug effects/genetics/physiology
- Longevity/drug effects/genetics/physiology
- Electron Transport Complex III/genetics
- Aspirin/administration & dosage/pharmacology
- Receptors, Nicotinic/genetics
- Movement/drug effects
- Drug Evaluation, Preclinical/methods
50: Neumann et al. (2003) "Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression." Nature 424(6948):561-565 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Gene Deletion
- Longevity/genetics
- Oxidative Stress
- Reactive Oxygen Species/metabolism
- DNA Damage
- Cell Survival
- Cell Cycle
- Antioxidants/metabolism
- Aging/metabolism
- Anemia, Hemolytic/genetics/metabolism/pathology
- Erythrocytes/metabolism/pathology
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Guanosine/analogs & derivatives/analysis
- Hemoglobins/metabolism
- Killer Cells, Natural/immunology/metabolism/pathology
- Lymphoma/genetics/metabolism
- Neoplasms/genetics/metabolism
- Peroxidases/deficiency/genetics/metabolism
- Peroxiredoxins
- Sarcoma/genetics/metabolism
- Survival Analysis
2565: Steinkraus et al. (2008) "Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans." Aging Cell 7(3):394-404 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Caloric Restriction
- Transcription Factors/drug effects/metabolism
- Longevity/drug effects/physiology
- Peptides/pharmacology
- Food Deprivation/physiology
- Caenorhabditis elegans/drug effects/genetics/metabolism
- Caenorhabditis elegans Proteins/drug effects/metabolism
3047: Okayama et al. (2005) "Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging." J. Gerontol. A Biol. Sci. Med. Sci. 60(12):1525-1529 (PubMed)

8 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Aging/genetics
- Adult
- Middle Aged
- Aged
- Aged, 80 and over
- Interleukin-10/genetics
- Cytokines/genetics
- Polymorphism, Single Nucleotide
- Matrix Metalloproteinase 3/genetics
937: Potestio et al. (1999) "Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes." Exp. Gerontol. 34(5):659-673 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Child
- Age Factors
- Adolescent
- Child, Preschool
- Middle Aged
- Aged
- Aged, 80 and over
- Infant, Newborn
- Lymphocyte Count
- Lymphocytes/immunology
- T-Lymphocytes/immunology
- Leukocyte Count
- Antigens, CD/genetics
- Antigens, CD95/genetics
- Aging/blood/genetics/immunology
- Fetal Blood
- Gene Expression Regulation, Developmental/immunology
- Lymphocyte Subsets/immunology
938: Razzaque et al. (1999) "Life-long caloric restriction suppresses age-associated Fas expression in the Fischer 344 rat kidney." Mol. Cell Biol. Res. Commun. 1(1):82-85 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Rats
- Immunohistochemistry
- RNA, Messenger/genetics/metabolism
- Gene Expression
- Rats, Inbred F344
- Energy Intake
- Kidney/immunology/pathology
- Antigens, CD95/genetics/metabolism
- Aging/genetics/immunology/pathology
- Food Deprivation/physiology
616: Zhang et al. (1999) "Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition." Cell 97(1):53-61 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- DNA-Binding Proteins
- Tumor Cells, Cultured
- Carrier Proteins
- Promoter Regions, Genetic
- E2F Transcription Factors
- Retinoblastoma-Binding Protein 1
- Transcription Factor DP1
- Transforming Growth Factor beta/physiology
- Cell Cycle Proteins/physiology
- Repressor Proteins/physiology
- Cell Communication/genetics/physiology
- Cyclin-Dependent Kinase Inhibitor p16/physiology
- G1 Phase/genetics/physiology
- Growth Inhibitors/physiology
- Retinoblastoma Protein/biosynthesis/metabolism/physiology
- Transcription Factors/biosynthesis/genetics/physiology