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Entries tagged Nervous System/pathology (64)

3967: Abbas and Wink (2009) "Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans." Planta Med. 75(3):216-221 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity
- Free Radical Scavengers/pharmacology
- Antioxidants/pharmacology
- Oxidative Stress/drug effects
- Tea
- Catechin/analogs & derivatives/pharmacology
- Camellia sinensis
- Plant Extracts/pharmacology
- Caenorhabditis/drug effects/growth & development/metabolism
- Caenorhabditis elegans Proteins/antagonists & inhibitors/metabolism
- Genes, Reporter/physiology
- Heat-Shock Proteins/antagonists & inhibitors/metabolism
- Hydrogen Peroxide/antagonists & inhibitors/metabolism
- Superoxides/antagonists & inhibitors
3446: Kaeberlein et al. (2006) "Lifespan extension in Caenorhabditis elegans by complete removal of food." Aging Cell 5(6):487-494 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Insulin-Like Growth Factor I/metabolism
- Longevity/physiology
- Aging/physiology
- Mutation/genetics
- Immunity, Innate/genetics
- Insulin/metabolism
- Models, Animal
- Sirtuins/genetics/metabolism
- Caloric Restriction
- Caenorhabditis elegans Proteins/genetics/metabolism
- Fertility/physiology
- Food Deprivation/physiology
- Caenorhabditis elegans/metabolism
- Stress, Physiological/genetics/metabolism
- Bacteria/metabolism
- Receptors, Nicotinic/genetics
4013: Zarse et al. (2011) "The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans." Horm. Metab. Res. 43(4):241-243 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mitochondria/metabolism
- Models, Animal
- Longevity/drug effects
- Adipose Tissue/drug effects/metabolism
- Oxygen Consumption/drug effects
- Plant Extracts/pharmacology
- Caenorhabditis elegans/drug effects/growth & development/metabolism
- Glaucarubin/analogs & derivatives/pharmacology
- Simaroubaceae/chemistry
4094: Liu et al. (2013) "Lifespan extension by n-butanol extract from seed of Platycladus orientalis in Caenorhabditis elegans." J Ethnopharmacol 147(2):366-372 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Reactive Oxygen Species/metabolism
- Longevity/drug effects
- Heat-Shock Proteins/genetics
- Aging/drug effects/physiology
- Glutathione Transferase/genetics
- Lipofuscin/metabolism
- Caenorhabditis elegans Proteins/genetics
- Caenorhabditis elegans/drug effects/metabolism
- Plant Extracts/pharmacology
- 1-Butanol/chemistry
- Solvents/chemistry
- Seeds/chemistry
- Cupressaceae
1067: Goldman et al. (2004) "Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome." Proc. Natl. Acad. Sci. U.S.A. 101(24):8963-8968 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Aging/physiology
- Cell Aging/physiology
- Sequence Deletion
- Cell Cycle/genetics
- Infant
- Aged
- Aged, 80 and over
- Fibroblasts/cytology/metabolism
- Mitosis/genetics
- Cell Nucleus/metabolism/ultrastructure
- Cell Nucleus Structures/ultrastructure
- Lamin Type A/genetics/metabolism
- Nuclear Envelope/ultrastructure
- Progeria/genetics/metabolism/pathology
1071: Motta et al. (2004) "Mammalian SIRT1 represses forkhead transcription factors." Cell 116(4):551-563 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Apoptosis
- Up-Regulation
- Forkhead Transcription Factors
- Protein Binding
- Tumor Suppressor Protein p53/metabolism
- Transcription, Genetic
- Cell Line
- HeLa Cells
- Blotting, Northern
- Cell Cycle Proteins/metabolism
- Dose-Response Relationship, Drug
- Transcription Factors/metabolism
- Blotting, Western
- Gene Expression Regulation
- DNA-Binding Proteins/metabolism
- Stem Cells/metabolism
- Embryo, Mammalian/cytology
- Plasmids/metabolism
- Genes, Reporter
- Precipitin Tests
- Acetylation
- Down-Regulation
- Sirtuin 1
- PTEN Phosphohydrolase
- Histone Acetyltransferases
- Acetyltransferases/metabolism
- p300-CBP Transcription Factors
- Phosphoric Monoester Hydrolases/metabolism
- Histone Deacetylases/metabolism/physiology
- Sirtuins/metabolism/physiology
- Tumor Suppressor Proteins/metabolism
1757: Di Cristofano et al. (1998) "Pten is essential for embryonic development and tumour suppression." Nat. Genet. 19(4):348-355 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Cells, Cultured
- Tumor Suppressor Proteins
- RNA, Messenger/analysis
- Germ-Line Mutation
- Genes, Lethal
- PTEN Phosphohydrolase
- Embryonic and Fetal Development/genetics
- Cell Adhesion
- Neoplasms, Experimental/genetics/pathology
- Genes, Tumor Suppressor/physiology
- Stem Cells/cytology
- Protein Tyrosine Phosphatases/genetics/physiology
- Hamartoma Syndrome, Multiple/genetics
- Phosphoric Monoester Hydrolases
- Adenocarcinoma/pathology
- Colonic Neoplasms/pathology
- Teratocarcinoma/pathology
- Testicular Neoplasms/pathology
- Thyroid Neoplasms/pathology
1927: Perez et al. (2007) "Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice." Proc. Natl. Acad. Sci. U.S.A. 104(12):5229-5234 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Aging/physiology
- Behavior, Animal
- Cognition
- Fertility/physiology
- Body Composition
- Ovariectomy
- Ovary/pathology
- Bone and Bones/physiology
- Perception
- bcl-2-Associated X Protein/deficiency
4728: Wang et al. (2018) "Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans." Food Funct 9(10):5273-5282 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Reactive Oxygen Species/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Longevity/drug effects
- Signal Transduction/drug effects
- Forkhead Transcription Factors/genetics/metabolism
- Stress, Physiological/drug effects
- Plant Extracts/pharmacology
- Caenorhabditis elegans/drug effects/genetics/growth & development/metabolism
- Blueberry Plants/chemistry
2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (PubMed)

19 citations in connected databases
- Tags:
- Humans
- Male
- Adult
- Analysis of Variance
- RNA, Messenger/genetics
- Middle Aged
- Aged
- Algorithms
- Computational Biology/methods/statistics & numerical data
- Gene Expression Profiling/methods/standards/statistics & numerical data
- Muscle, Skeletal/chemistry/metabolism
- Oligonucleotide Array Sequence Analysis/methods/standards/statistics & numerical data
- RNA Probes/genetics
- Thigh
3003: Paulson et al. (2001) "The lack of influence of age on male fertility." Am. J. Obstet. Gynecol. 184(5):818-22; discussion 822 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Age Factors
- Pregnancy
- Middle Aged
- Fertility/physiology
- Logistic Models
- Retrospective Studies
- Spermatozoa/physiology
- Oocyte Donation
- Sperm Count
- Semen/physiology
- Embryo Transfer
- Fertilization in Vitro
- Pregnancy Outcome
- Sperm Motility/physiology
1070: Luo et al. (2001) "Negative control of p53 by Sir2alpha promotes cell survival under stress." Cell 107(2):137-148 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Apoptosis
- Oxidative Stress
- DNA Damage
- Polymerase Chain Reaction
- Protein Binding
- Transcriptional Activation
- Point Mutation
- Cell Line
- Cell Death
- Cell Survival
- Dose-Response Relationship, Drug
- Electrophoresis, Polyacrylamide Gel
- Blotting, Western
- Poly(ADP-ribose) Polymerases/metabolism
- Protein Structure, Tertiary
- Tumor Suppressor Protein p53/biosynthesis
- Antigens, CD95/metabolism
- NAD/metabolism
- Mutagenesis, Site-Directed
- Trans-Activators/metabolism
- DNA, Complementary/metabolism
- Histone Deacetylases/metabolism
- Sirtuin 1
- Sirtuins/metabolism
- Neoplasms/metabolism/therapy
- Niacinamide/pharmacology
1253: Espejel et al. (2004) "Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs." J. Cell Biol. 167(4):627-638 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Longevity/genetics
- Aging, Premature/genetics/metabolism/pathology
- Protein-Serine-Threonine Kinases/deficiency/genetics
- Telomere/genetics
- Telomerase/deficiency/genetics/physiology
- DNA-Activated Protein Kinase
- DNA Repair/genetics
- Neoplasms/genetics/metabolism
- Cell Division/genetics
- Cell Transformation, Neoplastic/genetics/metabolism
- Poly(ADP-ribose) Polymerases/deficiency/genetics
- DNA-Binding Proteins/deficiency/genetics
- Antigens, Nuclear/genetics
- Chromosomal Instability/genetics
1567: Bauer et al. (2005) "Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span." Curr. Biol. 15(22):2063-2068 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Tumor Suppressor Protein p53/metabolism
- Longevity/genetics/physiology
- Oxidative Stress/physiology
- Neurons/metabolism
- Fertility/physiology
- Energy Metabolism/physiology
- Drosophila Proteins/metabolism
- Drosophila melanogaster/metabolism/physiology
1846: Gerhart-Hines et al. (2007) "Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha." EMBO J. 26(7):1913-1923 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Cells, Cultured
- Models, Biological
- Cell Cycle Proteins/metabolism
- Transcription Factors/metabolism
- Fibroblasts/drug effects/metabolism
- Sirtuin 1
- Sirtuins/metabolism
- p300-CBP Transcription Factors
- Trans-Activators/genetics/metabolism
- Niacinamide/pharmacology
- Glucose/pharmacology
- 3-Hydroxyacyl CoA Dehydrogenases/genetics/metabolism
- Acetyl-CoA C-Acyltransferase/genetics/metabolism
- Acetylation/drug effects
- Carbon-Carbon Double Bond Isomerases/genetics/metabolism
- Down-Regulation/drug effects
- Enoyl-CoA Hydratase/genetics/metabolism
- Histone Acetyltransferases/metabolism
- Mitochondria, Muscle/drug effects/metabolism
- Muscle, Skeletal/cytology/drug effects/metabolism
- Racemases and Epimerases/genetics/metabolism
4196: Huang et al. (2015) "Analysis of lifespan-promoting effect of garlic extract by an integrated metabolo-proteomics approach." J. Nutr. Biochem. 26(8):808-817 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Signal Transduction
- Up-Regulation
- Amino Acid Sequence
- Cloning, Molecular
- Molecular Sequence Data
- Evolution, Molecular
- Caenorhabditis elegans/genetics
- Down-Regulation
- Caenorhabditis elegans Proteins/genetics/metabolism
- Longevity/drug effects
- Proteomics/methods
- Forkhead Transcription Factors/genetics/metabolism
- Acetylcysteine/metabolism
- Metabolomics/methods
- Chromatography, Liquid
- Tandem Mass Spectrometry
- Plant Extracts/pharmacology
- Garlic/chemistry
- Mannose-Binding Lectin/metabolism
- Vitellogenins/genetics/metabolism
4535: Lee et al. (2016) "Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol." Exp. Biol. Med. (Maywood) 241(16):1757-1763 (PubMed)

6 citations in connected databases
- Tags:
- Animals
- Dose-Response Relationship, Drug
- Blotting, Western
- Longevity/drug effects
- Stilbenes/pharmacology
- Caenorhabditis elegans/drug effects/growth & development
- Plant Extracts/pharmacology
- Resveratrol
- Caenorhabditis elegans Proteins/drug effects/physiology
- Sirtuins/drug effects/physiology
4538: Pannakal et al. (2017) "Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae." PLoS ONE 12(7):e0179813 (PubMed)

7 citations in connected databases
- Tags:
- Animals
- Aging
- Dose-Response Relationship, Drug
- Longevity/drug effects
- Cell Proliferation/drug effects
- Polysaccharides/pharmacology
- Plant Extracts/pharmacology
- Caenorhabditis elegans/drug effects
- Saccharomyces cerevisiae/drug effects
- Asparagaceae
- Keratinocytes/drug effects
- Medicine, Ayurvedic
3969: Pun et al. (2010) "Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?" Biogerontology 11(1):17-30 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Dose-Response Relationship, Drug
- Life Expectancy
- Caenorhabditis elegans/drug effects/physiology
- Longevity/drug effects/physiology
- Aging/drug effects/metabolism
- Antioxidants/administration & dosage
- Plant Extracts/pharmacology
4017: Zou et al. (2012) "Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age." Age (Dordr) 34(2):269-279 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Caloric Restriction
- Longevity/drug effects
- Aging/drug effects/physiology
- Follow-Up Studies
- Dietary Supplements
- Tephritidae
- Plant Extracts/pharmacology
- Origanum
- Vaccinium macrocarpon