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Entries tagged Recombinant Proteins/isolation & purification/metabolism (45)

1476: Agarwal et al. (2003) "Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia." Hum. Mol. Genet. 12(16):1995-2001 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Phenotype
- Pedigree
- Lamin Type A/genetics
- Nuclear Proteins/metabolism
- Lipodystrophy/genetics
- Mutation, Missense
- Membrane Proteins/genetics/metabolism
- Sequence Analysis
- Saccharomyces cerevisiae Proteins/genetics
- Atrophy/genetics
- Protein Precursors/metabolism
- Abnormalities, Multiple/etiology/genetics
- Acro-Osteolysis/genetics
- Clavicle/abnormalities
- Lipoproteins/genetics/metabolism
- Mandible/abnormalities
- Metalloendopeptidases/genetics
- Metalloproteases/genetics/metabolism
3740: Kim et al. (2009) "Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells." Mech. Ageing Dev. 130(3):179-188 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Knockout
- Phosphorylation
- Tumor Suppressor Protein p53/genetics/metabolism
- Acetylcysteine/pharmacology
- Cells, Cultured
- Reactive Oxygen Species/metabolism
- Antioxidants/pharmacology
- DNA Damage
- Phosphoproteins/metabolism
- Recombinant Proteins/metabolism
- Cell Aging/drug effects/genetics
- Time Factors
- Nuclear Proteins/metabolism
- Fibroblasts/metabolism
- Histones/metabolism
- Signal Transduction/drug effects
- Protein Processing, Post-Translational
- Cyclin-Dependent Kinase Inhibitor p16/metabolism
- Cell Proliferation
- Interferon-alpha/metabolism
- Cyclin-Dependent Kinase Inhibitor p21/metabolism
- Endothelial Cells/drug effects/metabolism
- Interferon-gamma/metabolism
3904: Hunt et al. (2011) "Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms." PLoS ONE 6(7):e21922 (PubMed)

45 citations in connected databases
- Tags:
- Animals
- Humans
- Transcription Factors/metabolism
- Survival Analysis
- Mutation/genetics
- Genes, Reporter
- Caenorhabditis elegans Proteins/genetics/metabolism
- Aging/drug effects
- Longevity/drug effects
- Gene Expression Regulation/drug effects
- Transcription, Genetic/drug effects
- Green Fluorescent Proteins/metabolism
- Stress, Physiological/drug effects
- Caenorhabditis elegans/drug effects/genetics/physiology
- Hep G2 Cells
- Biosensing Techniques
- Naphthoquinones/chemistry/pharmacology
- Tetrahydronaphthalenes/chemistry/pharmacology
- Toxins, Biological/chemistry/pharmacology
- Vitamin K 3/chemistry/pharmacology
4112: Neff et al. (2013) "Rapamycin extends murine lifespan but has limited effects on aging." J. Clin. Invest. 123(8):3272-3291 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Mice, Inbred C57BL
- Phenotype
- Survival Analysis
- Cell Transformation, Neoplastic/drug effects
- Aging/drug effects
- Longevity/drug effects
- Leukocyte Count
- Immunoglobulins/blood
- Maze Learning/drug effects
- Sirolimus/pharmacology
- Platelet Count
- Oxygen Consumption/drug effects
- Drug Evaluation, Preclinical
- Granuloma/prevention & control
- Liver/drug effects/pathology
- Liver Cirrhosis/prevention & control
- Muscle Strength/drug effects
- Psychomotor Performance/drug effects
- T-Lymphocytes/drug effects/immunology
- TOR Serine-Threonine Kinases/antagonists & inhibitors
- Thyroid Gland/drug effects/pathology
1079: Kauffmann-Zeh et al. (1997) "Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB." Nature 385(6616):544-548 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Signal Transduction
- Proto-Oncogene Proteins c-akt
- Rats
- Fibroblasts
- Point Mutation
- Cell Line
- Androstadienes/pharmacology
- Enzyme Inhibitors/pharmacology
- ras Proteins/metabolism
- Phosphatidylinositol 3-Kinases
- Apoptosis/drug effects
- Chromones/pharmacology
- Morpholines/pharmacology
- Ribosomal Protein S6 Kinases
- Tamoxifen/analogs & derivatives/pharmacology
- Phosphotransferases (Alcohol Group Acceptor)/genetics/metabolism
- Polyenes/pharmacology
- Protein-Serine-Threonine Kinases/antagonists & inhibitors/genetics/metabolism
- Proto-Oncogene Proteins/antagonists & inhibitors/genetics/metabolism
- Proto-Oncogene Proteins c-myc/antagonists & inhibitors/physiology
- Sirolimus
1081: Wang et al. (2004) "BUBR1 deficiency results in abnormal megakaryopoiesis." Blood 103(4):1278-1285 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Genotype
- Cells, Cultured
- Protein-Serine-Threonine Kinases
- Cell Cycle Proteins
- Pregnancy
- Protein Kinases/genetics/metabolism
- Erythropoiesis/physiology
- Bone Marrow/embryology
- Hematopoiesis, Extramedullary/physiology
- Hematopoietic Stem Cells/cytology/physiology
- Megakaryocytes/cytology/physiology
- Platelet Count
- Splenomegaly/physiopathology
1325: Brown et al. (1994) "A mammalian protein targeted by G1-arresting rapamycin-receptor complex." Nature 369(6483):756-758 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Cattle
- Cell Cycle Proteins
- Amino Acid Sequence
- Cell Line
- Cloning, Molecular
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Fungal Proteins/genetics
- Saccharomyces cerevisiae/genetics
- Saccharomyces cerevisiae Proteins
- DNA, Complementary
- Heat-Shock Proteins/metabolism
- Phosphatidylinositol 3-Kinases
- Recombinant Fusion Proteins/genetics
- G1 Phase/drug effects
- Sirolimus
- TOR Serine-Threonine Kinases
- Carrier Proteins/analysis/chemistry/genetics/metabolism
- Immunophilins
- Phosphotransferases (Alcohol Group Acceptor)/genetics
- Polyenes/metabolism/pharmacology
- Proteins/analysis/chemistry/genetics
- Tacrolimus Binding Proteins
1424: Sharma et al. (2005) "Mice severely deficient in growth hormone have normal hematopoiesis." Exp. Hematol. 33(7):776-783 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Reference Values
- Flow Cytometry
- Hematopoiesis/physiology
- Antigens, CD34/analysis
- Growth Hormone/deficiency/genetics
- Colony-Forming Units Assay
- Hematopoietic Stem Cells/cytology/physiology
- Blood Cell Count
1757: Di Cristofano et al. (1998) "Pten is essential for embryonic development and tumour suppression." Nat. Genet. 19(4):348-355 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Cells, Cultured
- Tumor Suppressor Proteins
- RNA, Messenger/analysis
- Germ-Line Mutation
- Genes, Lethal
- PTEN Phosphohydrolase
- Embryonic and Fetal Development/genetics
- Cell Adhesion
- Neoplasms, Experimental/genetics/pathology
- Genes, Tumor Suppressor/physiology
- Stem Cells/cytology
- Protein Tyrosine Phosphatases/genetics/physiology
- Hamartoma Syndrome, Multiple/genetics
- Phosphoric Monoester Hydrolases
- Adenocarcinoma/pathology
- Colonic Neoplasms/pathology
- Teratocarcinoma/pathology
- Testicular Neoplasms/pathology
- Thyroid Neoplasms/pathology
1970: Westerheide et al. (2009) "Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1." Science 323(5917):1063-1066 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Transfection
- Amino Acid Sequence
- Molecular Sequence Data
- DNA/metabolism
- HeLa Cells
- Homeostasis
- Cell Aging/physiology
- Transcription Factors/metabolism
- DNA-Binding Proteins/metabolism
- Promoter Regions, Genetic
- Acetylation
- Down-Regulation
- Sirtuin 1
- Sirtuins/genetics/metabolism
- RNA, Small Interfering
- HSP70 Heat-Shock Proteins/genetics
- Heat-Shock Response
- Stress, Psychological
- Chromatin Immunoprecipitation
2408: Bahadorani et al. (2010) "Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity." Neurobiol. Aging 31(7):1215-1226 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mutation
- Superoxide Dismutase/genetics/metabolism
- Transcription Factors/biosynthesis/genetics
- DNA-Binding Proteins/biosynthesis/genetics
- Longevity/drug effects/genetics
- Oxidative Stress/drug effects/genetics
- Neurons/drug effects/metabolism
- Gene Knockout Techniques
- Cadmium/metabolism/toxicity
- Drosophila melanogaster/drug effects/genetics
- Nervous System/drug effects/metabolism
- Stress, Physiological/drug effects/genetics
- Zinc/metabolism/toxicity
756: Laroia et al. (1999) "Control of mRNA decay by heat shock-ubiquitin-proteasome pathway." Science 284(5413):499-502 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Transfection
- Protein Binding
- RNA, Messenger/genetics/metabolism
- HeLa Cells
- Cell Nucleus/metabolism
- Multienzyme Complexes/metabolism
- Carrier Proteins/metabolism
- Cytoplasm/metabolism
- Heat-Shock Response
- Cysteine Endopeptidases/metabolism
- Proteasome Endopeptidase Complex
- Ubiquitins/metabolism
- HSP70 Heat-Shock Proteins/metabolism
- Granulocyte-Macrophage Colony-Stimulating Factor/genetics
- 3' Untranslated Regions
- Cysteine Proteinase Inhibitors/pharmacology
- Eukaryotic Initiation Factor-4G
- HSC70 Heat-Shock Proteins
- Heterogeneous-Nuclear Ribonucleoprotein D
- Leupeptins/pharmacology
- Peptide Initiation Factors/metabolism
- Poly(A)-Binding Proteins
- RNA-Binding Proteins/metabolism
4183: Edwards et al. (2015) "Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans." BMC Genet. 16:8 (PubMed)

134 citations in connected databases
- Tags:
- Animals
- Longevity
- Transcription Factors/genetics/metabolism
- DNA-Binding Proteins/genetics
- Mitochondria/metabolism
- Caenorhabditis elegans/physiology
- Models, Animal
- Caenorhabditis elegans Proteins/genetics/metabolism
- Diet
- Heat-Shock Response
- Forkhead Transcription Factors/metabolism
- Autophagy
- Electron Transport Complex I/genetics
- Endoplasmic Reticulum Stress
- Amino Acids/administration & dosage/chemistry
- Electron Transport Complex II/genetics
1256: Kojima et al. (2004) "Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways." Exp. Gerontol. 39(11-12):1595-1598 (PubMed)

9 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Adult
- Middle Aged
- Linkage Disequilibrium
- Signal Transduction/genetics
- Aged
- Aged, 80 and over
- Case-Control Studies
- Japan
- Polymorphism, Single Nucleotide
- Insulin-Like Growth Factor I/genetics
- Insulin/genetics
- Haplotypes
3222: Takata et al. (1987) "Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians." Lancet 2(8563):824-826 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity
- Phenotype
- Adult
- Middle Aged
- Aged
- Aged, 80 and over
- Japan
- HLA-DR Antigens/genetics
- HLA Antigens/genetics
- HLA-D Antigens/genetics
3233: Honnen et al. (2012) "C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling." PLoS ONE 7(2):e32183 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Insulin-Like Growth Factor I/metabolism
- Longevity
- Oxidative Stress
- Signal Transduction
- Transcription Factors
- Caenorhabditis elegans Proteins/genetics/physiology
- Insulin/metabolism
- RNA, Small Interfering/pharmacology
- Heat-Shock Response
- Caenorhabditis elegans/genetics/metabolism
- Receptor, Insulin
- Cell Polarity
- Phosphoproteins/genetics/physiology
3362: Fink et al. (2011) "53BP1 contributes to a robust genomic stability in human fibroblasts." Aging (Albany NY) 3(9):836-845 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Aging/physiology
- DNA-Binding Proteins/genetics/metabolism
- DNA Damage
- Cell Line
- Life Expectancy
- Cell Cycle/physiology
- Fibroblasts/cytology/physiology
- Antigens, Nuclear/metabolism
- Genomic Instability
- Intracellular Signaling Peptides and Proteins/genetics/metabolism
- Chromosomal Proteins, Non-Histone/genetics/metabolism
- Cell Cycle Checkpoints
- Micronuclei, Chromosome-Defective
3786: Li et al. (2008) "Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts." Mol. Cancer Res. 6(5):770-784 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Cell Line
- Cell Aging
- Reverse Transcriptase Polymerase Chain Reaction
- Gene Expression Regulation
- Fibroblasts/metabolism
- DNA Methylation
- Cell Proliferation
- Interferon-alpha/metabolism
- Epigenesis, Genetic
- Interferon Regulatory Factor-7/metabolism
- Interferon Regulatory Factors/metabolism
- Interferons/metabolism
- Li-Fraumeni Syndrome/metabolism
231: Kamei et al. (2003) "Association analysis of the SHC1 gene locus with longevity in the Japanese population." J. Mol. Med. 81(11):724-728 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Longevity/genetics
- Shc Signaling Adaptor Proteins
- DNA/genetics
- Linkage Disequilibrium
- Aged
- Aged, 80 and over
- Adaptor Proteins, Signal Transducing/genetics
- Japan
- Polymorphism, Single Nucleotide/genetics
566: Wen et al. (1990) "Molecular analysis of human acatalasemia. Identification of a splicing mutation." J. Mol. Biol. 211(2):383-393 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mutation
- Transfection
- Reference Values
- Base Sequence
- Cell Line
- Molecular Sequence Data
- Genes
- Exons
- Leukocytes/enzymology
- Blotting, Southern
- Acatalasia
- RNA Splicing
- Restriction Mapping
- Japan
- Catalase/blood/genetics
- DNA/blood/genetics