Entries tagged Interferon-beta/pharmacology (52)

  4634: Akhoon et al. (2016) "Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans." Exp. Gerontol. 78:47-56 (PubMed)

  1608: Masternak et al. (2006) "Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart." Exp. Gerontol. 41(4):417-429 (PubMed)

  1776: Qin et al. (2006) "Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction." J. Biol. Chem. 281(31):21745-21754 (PubMed)

  1900: Kanfi et al. (2008) "Regulation of SIRT6 protein levels by nutrient availability." FEBS Lett. 582(5):543-548 (PubMed)

  654: Kitao et al. (1999) "Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome." Nat. Genet. 22(1):82-84 (PubMed)

  249: Tohyama et al. (2004) "Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides." J. Biol. Chem. 279(11):9777-9784 (PubMed)

  422: Winkler et al. (2000) "Requirement of the prolyl isomerase Pin1 for the replication checkpoint." Science 287(5458):1644-1647 (PubMed)

  4616: Qi et al. (2017) "The ω-3 fatty acid α-linolenic acid extends Caenorhabditis elegans lifespan via NHR-49/PPARα and oxidation to oxylipins." Aging Cell 16(5):1125-1135 (PubMed)

  1511: Hirai et al. (2005) "WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus." Diabetes Res. Clin. Pract. 69(3):287-292 (PubMed)

  2072: Guan et al. (2009) "HDAC2 negatively regulates memory formation and synaptic plasticity." Nature 459(7243):55-60 (PubMed)

  2098: Osorio et al. (2010) "Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease." Aging Cell 9(6):947-957 (PubMed)

  2181: Liu et al. (2008) "Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling." Pigment Cell Melanoma Res 21(5):545-558 (PubMed)

  1795: Shumaker et al. (2006) "Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging." Proc. Natl. Acad. Sci. U.S.A. 103(23):8703-8708 (PubMed)

  1808: Pruitt et al. (2006) "Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation." PLoS Genet. 2(3):e40 (PubMed)

  1896: Li et al. (2008) "Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation." J. Biol. Chem. 283(12):7590-7598 (PubMed)

  3524: Ryu et al. (2014) "Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells." Biochem. Biophys. Res. Commun. 446(1):113-118 (PubMed)

  3720: Hsu et al. (2010) "Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts." J. Biol. Chem. 285(29):22630-22638 (PubMed)

  3786: Li et al. (2008) "Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts." Mol. Cancer Res. 6(5):770-784 (PubMed)

  3811: Feng et al. (2009) "The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence." FEBS J. 276(15):4197-4206 (PubMed)

  1251: Sung et al. (2004) "Modulation of PPAR in aging, inflammation, and calorie restriction." J. Gerontol. A Biol. Sci. Med. Sci. 59(10):997-991006 (PubMed)