You can search for any reference by title, author, date, editor, journal and publisher. Searching is case insensitive, and allows for only partial terms (e.g. seq with pickup both RNA-Seq and sequencing) matching. You can also use advanced queries that are detailed here.

Entries tagged Papilloma/chemically induced/genetics/metabolism/pathology (58)

3564: Okuyama et al. (2010) "The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans." J. Biol. Chem. 285(39):30274-30281 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Longevity/physiology
- DNA-Binding Proteins/genetics/metabolism
- Transcription Factors/genetics/metabolism
- Receptor, Insulin/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- MAP Kinase Signaling System/physiology
- Caenorhabditis elegans/genetics/metabolism
- Active Transport, Cell Nucleus/physiology
- Cell Nucleus/genetics/metabolism
- Phosphorylation/physiology
- Mitogen-Activated Protein Kinase 1/genetics/metabolism
- Epistasis, Genetic/physiology
- Insulin/genetics/metabolism
- raf Kinases/genetics/metabolism
4014: Ching et al. (2011) "Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity." Aging Cell 10(3):506-519 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity
- Signal Transduction
- Forkhead Transcription Factors
- Transcription Factors/metabolism
- Insulin/metabolism
- Structure-Activity Relationship
- Anti-Inflammatory Agents, Non-Steroidal/pharmacology
- Caenorhabditis elegans Proteins/metabolism
- Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism
- Insulin-Like Growth Factor I/antagonists & inhibitors/metabolism
- Caenorhabditis elegans/drug effects/genetics/growth & development
- 3-Phosphoinositide-Dependent Protein Kinases
- Cyclooxygenase 2/metabolism
- Celecoxib
- Cyclooxygenase 2 Inhibitors/pharmacology
- Pyrazoles
- Sulfonamides
1079: Kauffmann-Zeh et al. (1997) "Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB." Nature 385(6616):544-548 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Signal Transduction
- Proto-Oncogene Proteins c-akt
- Rats
- Fibroblasts
- Point Mutation
- Cell Line
- Androstadienes/pharmacology
- Enzyme Inhibitors/pharmacology
- ras Proteins/metabolism
- Phosphatidylinositol 3-Kinases
- Apoptosis/drug effects
- Chromones/pharmacology
- Morpholines/pharmacology
- Ribosomal Protein S6 Kinases
- Tamoxifen/analogs & derivatives/pharmacology
- Phosphotransferases (Alcohol Group Acceptor)/genetics/metabolism
- Polyenes/pharmacology
- Protein-Serine-Threonine Kinases/antagonists & inhibitors/genetics/metabolism
- Proto-Oncogene Proteins/antagonists & inhibitors/genetics/metabolism
- Proto-Oncogene Proteins c-myc/antagonists & inhibitors/physiology
- Sirolimus
1375: Saura et al. (2004) "Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration." Neuron 42(1):23-36 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Carrier Proteins/genetics/metabolism
- Disease Models, Animal
- Mice
- Mice, Knockout
- Protein-Serine-Threonine Kinases/metabolism
- Transcription Factors/genetics/metabolism
- DNA-Binding Proteins
- Age Factors
- Blotting, Western/methods
- Reverse Transcriptase Polymerase Chain Reaction/methods
- Gene Expression Regulation
- Time Factors
- Viral Proteins/metabolism
- RNA, Messenger/biosynthesis
- Activating Transcription Factor 1
- Cyclin-Dependent Kinases/metabolism
- Behavior, Animal
- Membrane Proteins/genetics/metabolism/physiology
- Neurodegenerative Diseases/metabolism
- Patch-Clamp Techniques
- Presenilin-1
- Immunohistochemistry/methods
- Excitatory Amino Acid Agonists/pharmacology
- Neuronal Plasticity/physiology
- Fear/physiology
- Proto-Oncogene Proteins c-fos/genetics/metabolism
- Brain/anatomy & histology/metabolism
- N-Methylaspartate/pharmacology
- Antibodies, Monoclonal/metabolism
- Association Learning/physiology
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Cyclin-Dependent Kinase 5
- Gene Products, gag/metabolism
- Lamin Type B/genetics/metabolism
- Long-Term Potentiation/genetics/physiology
- Membrane Potentials/physiology
- Memory Disorders/metabolism
- Microtubule-Associated Proteins/metabolism
- Precipitin Tests/methods
- Reaction Time/genetics/physiology
- Receptors, N-Methyl-D-Aspartate/drug effects/metabolism
- alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
- gag Gene Products, Human Immunodeficiency Virus
1537: Thorslund et al. (2005) "Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress." Mol. Cell. Biol. 25(17):7625-7636 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Oxidative Stress
- Protein Binding
- Cell Line
- DNA Repair Enzymes
- Active Transport, Cell Nucleus
- Mutation/genetics
- Substrate Specificity
- DNA Helicases/deficiency/genetics/metabolism
- Poly(ADP-ribose) Polymerases/antagonists & inhibitors/genetics/metabolism
- Cell Nucleus/genetics/metabolism
- Cockayne Syndrome
2000: Marcheva et al. (2010) "Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes." Nature 466(7306):627-631 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Phenotype
- Glucose Tolerance Test
- Aging/genetics/pathology
- Cell Survival
- Gene Expression Profiling
- Cell Size
- Islets of Langerhans/metabolism/pathology/secretion
- Cell Proliferation
- Diabetes Mellitus/genetics/metabolism
- Insulin/blood/metabolism/secretion
- Glucose Intolerance/genetics
- Circadian Rhythm/genetics/physiology
- ARNTL Transcription Factors/deficiency/genetics/metabolism
- Blood Glucose/analysis/metabolism
- CLOCK Proteins/deficiency/genetics/metabolism
- Period Circadian Proteins/genetics/metabolism
- Sleep/genetics/physiology
- Synaptic Vesicles/metabolism
- Wakefulness/genetics/physiology
2095: Murga et al. (2009) "A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging." Nat. Genet. 41(8):891-898 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- DNA Damage
- Alleles
- Phenotype
- Syndrome
- Cell Cycle Proteins/metabolism
- DNA Repair/drug effects
- DNA-Binding Proteins/metabolism
- DNA Replication/drug effects
- Nuclear Proteins/metabolism
- Apoptosis/drug effects
- Protein-Serine-Threonine Kinases/deficiency/metabolism
- Tumor Suppressor Protein p53/deficiency/metabolism
- Brain/enzymology/pathology
- DNA-Activated Protein Kinase/metabolism
- Abnormalities, Multiple/enzymology/genetics/pathology
- Aging/drug effects/genetics/pathology
- Embryo, Mammalian/drug effects/enzymology/metabolism/pathology
- Fibroblasts/drug effects/enzymology/pathology
- Progeria/embryology/enzymology/pathology
- Protein Kinase Inhibitors/pharmacology
- Stress, Physiological/drug effects
- Ataxia Telangiectasia Mutated Proteins
2165: Poulopoulou et al. (2010) "Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease." Neurobiol. Dis. 37(2):339-348 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Cells, Cultured
- Aged
- Aged, 80 and over
- Mitogens/pharmacology
- Patch-Clamp Techniques
- Excitatory Amino Acid Agonists/pharmacology
- Cell Proliferation/drug effects
- Excitatory Amino Acid Antagonists/pharmacology
- Alzheimer Disease/immunology/metabolism/physiopathology
- Brain Infarction/immunology/metabolism/physiopathology
- Cell Membrane/drug effects/metabolism
- Glutamic Acid/metabolism/pharmacology
- Ion Channel Gating/drug effects/physiology
- Kv1.3 Potassium Channel/drug effects/metabolism
- Lymphocyte Activation/drug effects/physiology
- Membrane Potentials/drug effects/physiology
- Neuroimmunomodulation/physiology
- Phytohemagglutinins/pharmacology
- Receptors, Metabotropic Glutamate/agonists/metabolism
- T-Lymphocytes/drug effects/immunology/metabolism
4298: Barakat et al. (2015) "CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells." Oncogene 34(48):5912-5922 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Fluorescent Antibody Technique
- Tumor Cells, Cultured
- RNA, Messenger/genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Blotting, Western
- Flow Cytometry
- Cell Aging/drug effects
- Gene Expression Regulation, Neoplastic/drug effects
- Promoter Regions, Genetic/genetics
- Apoptosis/drug effects
- Transcription, Genetic/drug effects
- Immunoenzyme Techniques
- Cell Proliferation/drug effects
- Chromatin Immunoprecipitation
- Real-Time Polymerase Chain Reaction
- Androgens/deficiency/pharmacology
- CCAAT-Enhancer-Binding Protein-beta/genetics/metabolism
- Prostatic Neoplasms/drug therapy/metabolism/pathology
4304: Li et al. (2014) "Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78." Oncol. Rep. 31(6):2525-2534 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Aging/genetics
- Gene Expression Regulation, Neoplastic/drug effects
- Apoptosis/drug effects
- Heat-Shock Proteins/biosynthesis/genetics
- Endoplasmic Reticulum/metabolism
- Cell Line, Tumor
- Chromosomal Proteins, Non-Histone/biosynthesis
- Cisplatin/administration & dosage
- Drug Resistance, Neoplasm/genetics
- Ovarian Neoplasms/drug therapy/genetics/pathology
1230: Trougakos et al. (2002) "Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction." Exp. Gerontol. 37(10-11):1175-1187 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Cell Aging
- Analysis of Variance
- Immunoblotting
- Clusterin
- Coronary Disease/blood/etiology
- Diabetes Mellitus, Type 2/blood
- Diabetic Angiopathies/blood/etiology
- Enzyme-Linked Immunosorbent Assay/methods/standards
- Glycoproteins/blood
- Molecular Chaperones/blood
- Myocardial Infarction/blood/etiology
1275: Lin et al. (2004) "Cytoplasmic PML function in TGF-beta signalling." Nature 431(7005):205-211 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Carrier Proteins/genetics/metabolism
- Humans
- Mice
- DNA-Binding Proteins/genetics/metabolism
- Protein Binding
- Fibroblasts
- Tumor Suppressor Proteins
- Cell Line
- Mutation/genetics
- Cell Aging/drug effects
- Cell Division/drug effects
- Transforming Growth Factor beta/pharmacology
- Signal Transduction/drug effects
- Apoptosis/drug effects
- Protein Transport
- Transcription, Genetic/drug effects
- Trans-Activators/genetics/metabolism
- Nuclear Proteins/deficiency/genetics/metabolism
- Cell Line, Tumor
- B-Lymphocytes/cytology/drug effects
- Cytoplasm/drug effects/metabolism
- Endosomes/drug effects/metabolism
- Leukemia, Promyelocytic, Acute/metabolism/pathology
- Neoplasm Proteins/deficiency/genetics/metabolism
- Oncogene Proteins, Fusion/metabolism
- Receptors, Transforming Growth Factor beta/metabolism
- Smad2 Protein
- Smad3 Protein
- Transcription Factors/deficiency/genetics/metabolism
2133: Yu et al. (2011) "Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration." Hum. Mol. Genet. 20(18):3699-3709 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Cohort Studies
- Case-Control Studies
- Genetic Variation
- European Continental Ancestry Group/genetics
- Polymorphism, Single Nucleotide
- Neoplasm Proteins/genetics
- Protein-Tyrosine Kinases/genetics
- Vascular Endothelial Growth Factor A/genetics
- Macular Degeneration/genetics
- Genome-Wide Association Study
- Collagen Type X/genetics
2492: Kimura et al. (2007) "Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans." J. Biol. Chem. 282(8):5910-5918 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Female
- Male
- Longevity/genetics
- Phenotype
- Animals, Genetically Modified
- Progeria/genetics/metabolism
- Mitochondria/metabolism/pathology
- Adenosine Triphosphate/biosynthesis
- Motor Activity/genetics
- Caenorhabditis elegans Proteins/biosynthesis/genetics
- Caenorhabditis elegans/cytology/genetics/metabolism
- Chaperonin 60/biosynthesis/genetics
- HSP70 Heat-Shock Proteins/deficiency/metabolism
- Mitochondrial Proteins/deficiency/metabolism
- Oogenesis/genetics
2507: Almeida et al. (2008) "Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis." Mol. Biol. Cell 19(3):865-876 (PubMed)

1 citation in connected databases
- Tags:
- Hydrogen Peroxide/pharmacology
- Mutation
- Models, Biological
- Antioxidants/metabolism
- Time Factors
- Caspases/metabolism
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Apoptosis/drug effects
- Saccharomyces cerevisiae Proteins/genetics/metabolism
- Oxidative Stress/drug effects
- Iron/metabolism
- Oxidation-Reduction/drug effects
- Intracellular Space/drug effects/metabolism
- Biological Markers/metabolism
- Gene Expression Regulation, Fungal/drug effects
- Saccharomyces cerevisiae/cytology/drug effects/genetics/metabolism
- Type C Phospholipases/deficiency/metabolism
1660: Miyauchi et al. (2004) "Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway." EMBO J. 23(1):212-220 (PubMed)

4 citations in connected databases
- Tags:
- Humans
- Cyclin-Dependent Kinase Inhibitor p21
- Signal Transduction
- Forkhead Transcription Factors
- Proto-Oncogene Proteins c-akt
- Reactive Oxygen Species/metabolism
- Luciferases/metabolism
- Tumor Suppressor Protein p53/metabolism
- Endothelium, Vascular/cytology
- Immunohistochemistry
- Cell Line
- Cell Aging
- Superoxide Dismutase/metabolism
- Blotting, Western
- Gene Expression Regulation
- Retroviridae/genetics
- Genes, Reporter
- Insulin/metabolism
- Cyclins/metabolism
- Aorta/cytology
- Proto-Oncogene Proteins/antagonists & inhibitors/metabolism
- Arteries/pathology
- Breast/blood supply
- Coronary Vessels/pathology
- DNA-Binding Proteins/antagonists & inhibitors
- Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism
- Transcription Factors/antagonists & inhibitors
- Umbilical Veins/cytology
1717: McLean et al. (2004) "Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression." Genes Dev. 18(24):2998-3003 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Gene Deletion
- Genotype
- Immunohistochemistry
- Mice, Transgenic
- Fluorescent Antibody Technique
- 9,10-Dimethyl-1,2-benzanthracene/toxicity
- Blotting, Western
- Flow Cytometry
- DNA Primers
- Apoptosis/genetics/physiology
- Skin Neoplasms/chemically induced/genetics
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Receptors, Estrogen/metabolism
- Keratin-14
- Protein-Tyrosine Kinases/genetics
- Hydroxytestosterones/metabolism
- Integrases/metabolism
- Keratinocytes/physiology
- Keratins/metabolism
- Neoplasm Metastasis/genetics/prevention & control
- Tamoxifen/analogs & derivatives/metabolism/pharmacology
1893: Bayes-Genis et al. (2001) "Pregnancy-associated plasma protein A as a marker of acute coronary syndromes." N. Engl. J. Med. 345(14):1022-1029 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Middle Aged
- Aged
- Case-Control Studies
- Myocardium/pathology
- Insulin-Like Growth Factor I/analysis
- Regression Analysis
- Prognosis
- Coronary Vessels/pathology
- Angina Pectoris/blood
- Angina, Unstable/blood/diagnosis
- Biological Markers/analysis/blood
- C-Reactive Protein/analysis
- Coronary Artery Disease/diagnosis/pathology
- Death, Sudden, Cardiac
- Myocardial Infarction/blood/diagnosis
- Pregnancy-Associated Plasma Protein-A/analysis
1896: Li et al. (2008) "Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation." J. Biol. Chem. 283(12):7590-7598 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Longevity/physiology
- Tumor Suppressor Protein p53/genetics/metabolism
- Transcription Factors/genetics/metabolism
- Cell Line
- Cell Aging/physiology
- Neoplasms/genetics/metabolism
- Exodeoxyribonucleases/genetics/metabolism
- Tumor Suppressor Proteins/genetics/metabolism
- Acetylation
- Sirtuin 1
- Sirtuins/genetics/metabolism
- Down-Regulation/physiology
- DNA Damage/physiology
- Caenorhabditis elegans/genetics/metabolism
- Nuclear Proteins/genetics/metabolism
- Neoplasm Proteins/genetics/metabolism
- Aging, Premature/genetics/metabolism
- Cell Nucleus/genetics/metabolism
- Genomic Instability/physiology
- E1A-Associated p300 Protein/genetics/metabolism
- RecQ Helicases/genetics/metabolism
1985: Qiang et al. (2010) "Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization." J. Biol. Chem. 285(35):27396-27401 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Hydrogen Peroxide/pharmacology
- Cell Line
- Oxidants/pharmacology
- Insulin/metabolism
- Cell Nucleus/genetics/metabolism
- Acetylation/drug effects
- Forkhead Transcription Factors/genetics/metabolism
- Sirtuin 1/genetics/metabolism
- Active Transport, Cell Nucleus/drug effects/physiology
- Oxidative Stress/drug effects/physiology
- Phosphorylation/drug effects/physiology
- Proto-Oncogene Proteins c-akt/genetics/metabolism