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Entries tagged Skin/enzymology/pathology/radiation effects (47)

3175: Zeng et al. (2010) "Effects of FOXO genotypes on longevity: a biodemographic analysis." J. Gerontol. A Biol. Sci. Med. Sci. 65(12):1285-1299 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Heterozygote
- Longevity/genetics
- Proportional Hazards Models
- Survival Analysis
- Middle Aged
- Cohort Studies
- Aged, 80 and over
- Sex Factors
- Asian Continental Ancestry Group/genetics
- Longitudinal Studies
- Likelihood Functions
- Probability
- Forkhead Transcription Factors/genetics
3228: Reiner et al. (2013) "Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults." Arterioscler. Thromb. Vasc. Biol. 33(1):158-164 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Phenotype
- Chromosomes, Human, Pair 5
- Proportional Hazards Models
- Genetic Predisposition to Disease
- Age Factors
- Time Factors
- Risk Factors
- Aged
- Membrane Proteins/genetics
- European Continental Ancestry Group/genetics
- Polymorphism, Single Nucleotide
- Prospective Studies
- Linear Models
- United States/epidemiology
- Biological Markers/blood
- Multivariate Analysis
- Haplotypes
- Incidence
- Logistic Models
- Risk Assessment
- Prognosis
- Genome-Wide Association Study
- Principal Component Analysis
- African Americans/genetics
- Antigens, CD14/blood/genetics
- Cardiovascular Diseases/ethnology/genetics/immunology/mortality
- Hexosyltransferases/genetics
- Inflammation Mediators/blood
3268: Satoh et al. (2013) "Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH." Cell Metab. 18(3):416-430 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Aging
- Longevity
- Signal Transduction
- Up-Regulation
- Mice, Transgenic
- Phenotype
- Transcription, Genetic
- Promoter Regions, Genetic
- RNA Interference
- Muscle, Skeletal/metabolism
- Motor Activity
- Nuclear Proteins/antagonists & inhibitors/genetics/metabolism
- RNA, Small Interfering/metabolism
- Mitochondria/metabolism/pathology
- Body Temperature
- Transcription Factors/antagonists & inhibitors/genetics/metabolism
- Hypothalamus/metabolism
- Orexin Receptors/antagonists & inhibitors/genetics/metabolism
- Sirtuin 1/antagonists & inhibitors/genetics/metabolism
1842: Antoch et al. (2008) "Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis." Cell Cycle 7(9):1197-1204 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Phenotype
- Mutation/genetics
- Cell Transformation, Neoplastic/genetics/metabolism
- Trans-Activators/genetics
- Genetic Predisposition to Disease/genetics
- CLOCK Proteins
- Aging, Premature/genetics/metabolism
- Cell Proliferation/radiation effects
- Circadian Rhythm/genetics
- Aging/genetics/metabolism/radiation effects
- Apoptosis/genetics/radiation effects
- Chronobiology Disorders/genetics/metabolism/physiopathology
- Down-Regulation/genetics/radiation effects
- Gamma Rays/adverse effects
- Gene Expression Regulation, Neoplastic/genetics/radiation effects
- Immunity, Innate/genetics/radiation effects
- Lymphoid Tissue/metabolism/radiation effects
1936: Fu et al. (2006) "Hormonal control of androgen receptor function through SIRT1." Mol. Cell. Biol. 26(21):8122-8135 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Male
- Transcription, Genetic
- Amino Acid Sequence
- Cell Line
- Molecular Sequence Data
- Cell Cycle Proteins/metabolism
- Transcription Factors/metabolism
- Gene Expression Regulation
- Models, Molecular
- Signal Transduction/physiology
- Genes, Reporter
- Acetylation
- Sirtuin 1
- Sirtuins/genetics/metabolism
- p300-CBP Transcription Factors
- Lysine/metabolism
- Receptors, Androgen/genetics/metabolism
- Cell Proliferation
- Histone Acetyltransferases/metabolism
- Dihydrotestosterone/metabolism
- Peptides/genetics/metabolism
- Prostatic Neoplasms
1938: Imura et al. (2007) "alpha-Klotho as a regulator of calcium homeostasis." Science 316(5831):1615-1618 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- HeLa Cells
- Homeostasis
- Enzyme Inhibitors/pharmacology
- Feedback, Physiological
- Endoplasmic Reticulum/metabolism
- Golgi Apparatus/metabolism
- Calcium/cerebrospinal fluid/metabolism
- Cell Membrane/enzymology/metabolism
- Choroid Plexus/metabolism
- Cytoplasm/enzymology/metabolism
- Endosomes/metabolism
- Glucuronidase/genetics/metabolism/physiology
- Ion Transport
- Kidney/enzymology/metabolism
- Ouabain/pharmacology
- Parathyroid Glands/enzymology/metabolism
- Parathyroid Hormone/secretion
- Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors/metabolism
465: Lee et al. (1996) "Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)." Science 273(5279):1219-1221 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Female
- Male
- Transfection
- Base Sequence
- Cell Line
- Molecular Sequence Data
- DNA-Binding Proteins/genetics
- Gene Expression Regulation
- Promoter Regions, Genetic
- Transcription Factors/genetics
- Immediate-Early Proteins
- Early Growth Response Protein 1
- Infertility, Female/genetics
- Pituitary Gland/metabolism
- Receptors, Cytoplasmic and Nuclear
- Homeodomain Proteins
- Follicle Stimulating Hormone/genetics
- Follicle Stimulating Hormone, beta Subunit
- Fushi Tarazu Transcription Factors
- Gonadotropins/pharmacology
- Luteinizing Hormone/analysis/deficiency/genetics
- Ovary/drug effects/physiology
- Steroidogenic Factor 1
- Uterus/drug effects
- Zinc Fingers
3106: Li et al. (2009) "Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations." Hum. Mol. Genet. 18(24):4897-4904 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Aged, 80 and over
- Sex Factors
- Asian Continental Ancestry Group/genetics
- Polymorphism, Single Nucleotide
- China
- Forkhead Transcription Factors/genetics
3134: Donlon et al. (2012) "FOXO3 gene variants and human aging: coding variants may not be key players." J. Gerontol. A Biol. Sci. Med. Sci. 67(11):1132-1139 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Aging/genetics
- Alleles
- Chromosome Mapping
- Middle Aged
- Cohort Studies
- Aged
- Aged, 80 and over
- Case-Control Studies
- Genetic Variation
- European Continental Ancestry Group/genetics
- Polymorphism, Single Nucleotide
- Sensitivity and Specificity
- Forkhead Transcription Factors/genetics
- Asian Americans/genetics
- Open Reading Frames/genetics
3494: Maoz et al. (2015) "The yeast forkhead HCM1 controls life span independent of calorie restriction." J. Gerontol. A Biol. Sci. Med. Sci. 70(4):444-453 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity/genetics
- Saccharomyces cerevisiae/genetics
- Antioxidants/metabolism
- Catalase/genetics
- RNA, Messenger/genetics
- Caloric Restriction
- Saccharomyces cerevisiae Proteins/genetics
- Biological Markers/metabolism
- Forkhead Transcription Factors/genetics
2756: Kong et al. (2012) "Rate of de novo mutations and the importance of father's age to disease risk." Nature 488(7412):471-475 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Pedigree
- Genetic Predisposition to Disease
- Middle Aged
- Sequence Analysis, DNA
- Risk Factors
- Polymorphism, Single Nucleotide/genetics
- Mothers
- Young Adult
- Autistic Disorder/epidemiology/etiology/genetics
- Chromosomes, Human/genetics
- Genome, Human/genetics
- Iceland/epidemiology
- Mutation Rate
- Ovum/metabolism
- Paternal Age
- Schizophrenia/epidemiology/etiology/genetics
- Selection, Genetic/genetics
- Spermatozoa/metabolism
2761: Pang et al. (2011) "Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age." Proc. Natl. Acad. Sci. U.S.A. 108(50):20012-20017 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Aging/physiology
- Adult
- Cell Differentiation
- Middle Aged
- Gene Expression Regulation
- Aged
- Aged, 80 and over
- Gene Expression Profiling
- Cell Count
- Bone Marrow Cells/cytology
- Hematopoietic Stem Cells/cytology/metabolism
- Myeloid Cells/cytology/metabolism
- Young Adult
- Cell Lineage/genetics
4030: Schriner et al. (2012) "Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat." Biogerontology 13(2):105-117 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Female
- Male
- Reactive Oxygen Species/metabolism
- Time Factors
- Down-Regulation
- Hot Temperature
- Sex Factors
- Longevity/drug effects
- Drosophila Proteins/genetics/metabolism
- Hydrogen Peroxide/toxicity
- Heat-Shock Proteins/genetics/metabolism
- Paraquat/toxicity
- Oxidative Stress/drug effects
- HSP70 Heat-Shock Proteins/genetics/metabolism
- Mitochondria/drug effects/metabolism
- Drosophila melanogaster/drug effects/genetics/metabolism
- Oxidants/toxicity
- Antioxidants/isolation & purification/pharmacology
- Ferric Compounds/toxicity
- Flowers
- Heat-Shock Response/drug effects
- Nitrilotriacetic Acid/analogs & derivatives/toxicity
- Plant Extracts/isolation & purification/pharmacology
- Polyphenols/isolation & purification/pharmacology
- Rosa/chemistry
4404: Kumar et al. (2016) "Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span." PLoS Genet. 12(2):e1005866 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Longevity
- Mutation
- Animals, Genetically Modified
- Phosphatidylinositol 3-Kinases/genetics
- RNA Interference
- Stress, Physiological/genetics
- Sirtuins/genetics
- Caenorhabditis elegans/drug effects/physiology
- Receptor, Insulin/genetics
- Forkhead Transcription Factors/genetics
- Aging/drug effects/genetics
- Electron Transport Complex III/genetics
- Angiotensin-Converting Enzyme Inhibitors/pharmacology
- Caenorhabditis elegans Proteins/antagonists & inhibitors/genetics
- Captopril/pharmacology
4685: Urban et al. (2017) "Non-linear impact of glutathione depletion on C. elegans life span and stress resistance." Redox Biol 11:502-515 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Oxidation-Reduction
- Oxidative Stress/genetics
- Caenorhabditis elegans/genetics/physiology
- DNA-Binding Proteins/genetics
- Tumor Suppressor Protein p53/genetics
- Transcription Factors/genetics
- Gene Expression Regulation, Developmental
- Repressor Proteins/genetics
- Dipeptides/metabolism
- Cell Death/genetics
- Glutamate-Cysteine Ligase/genetics
- Caenorhabditis elegans Proteins/genetics
- Forkhead Transcription Factors/genetics
- Gene Knockdown Techniques
- Glutathione/biosynthesis/genetics
- Maleates/metabolism
- Sulfhydryl Compounds/metabolism
1562: Masuda et al. (2005) "Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice." Mech. Ageing Dev. 126(12):1274-1283 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Male
- Mice, Inbred C57BL
- Aging
- Mice, Inbred C3H
- Mice, Mutant Strains
- Mutation
- Arteriosclerosis/genetics
- Immunohistochemistry
- Mice, Transgenic
- Phenotype
- Crosses, Genetic
- Gene Expression
- Time Factors
- Models, Genetic
- Tissue Distribution
- Glucuronidase
- Membrane Proteins/genetics/metabolism
- Bone Diseases, Metabolic/genetics
- Genetic Techniques
- Hypogonadism/genetics
- Ribonucleases/metabolism
- Testosterone/metabolism
1983: Flachsbart et al. (2009) "Association of FOXO3A variation with human longevity confirmed in German centenarians." Proc. Natl. Acad. Sci. U.S.A. 106(8):2700-2705 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Longevity/genetics
- Adult
- Adolescent
- Middle Aged
- Aged
- Aged, 80 and over
- Case-Control Studies
- Genetic Variation
- Polymorphism, Single Nucleotide
- Forkhead Transcription Factors/genetics
2150: Van Hee et al. (2010) "Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis." Environ. Health Perspect. 118(7):962-969 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Middle Aged
- Aged
- Aged, 80 and over
- Genetic Variation
- Genetic Predisposition to Disease/genetics
- Polymorphism, Single Nucleotide/genetics
- Linear Models
- Cross-Sectional Studies
- Magnetic Resonance Imaging
- Haplotypes/genetics
- Air Pollution/statistics & numerical data
- Environmental Exposure
- Hypertrophy, Left Ventricular/epidemiology/genetics/pathology
- Vehicle Emissions
3138: Pawlikowska et al. (2009) "Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity." Aging Cell 8(4):460-472 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Signal Transduction
- Aged
- Aged, 80 and over
- Genome, Human
- Insulin-Like Growth Factor I/genetics/metabolism
- Polymorphism, Single Nucleotide
- Follow-Up Studies
- Forkhead Transcription Factors/genetics
- Insulin/genetics/metabolism
- Osteoporosis/epidemiology/genetics
- Proto-Oncogene Proteins c-akt/genetics
3147: Deelen et al. (2011) "Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited." Aging Cell 10(4):686-698 (PubMed)

5 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Adult
- Genetic Predisposition to Disease
- Middle Aged
- Linkage Disequilibrium
- Cohort Studies
- Aged
- Aged, 80 and over
- Apolipoproteins E/genetics
- Case-Control Studies
- Genome, Human
- Polymorphism, Single Nucleotide
- Alzheimer Disease/genetics
- Longitudinal Studies
- Forkhead Transcription Factors/genetics
- Genome-Wide Association Study
- Proto-Oncogene Proteins c-akt/genetics
- Genetic Loci