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Entries tagged Neoplasm Proteins/analysis (65)

3304: Bojesen et al. (2013) "Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer." Nat. Genet. 45(4):371-84, 384e1 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Luciferases/metabolism
- Telomerase/genetics
- Telomere/genetics
- Genetic Predisposition to Disease
- RNA, Messenger/genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Risk Factors
- Case-Control Studies
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide/genetics
- DNA Methylation
- Alternative Splicing
- Genome-Wide Association Study
- Chromatin/genetics
- Genetic Loci/genetics
- Real-Time Polymerase Chain Reaction
- Breast Neoplasms/etiology/pathology
- Ovarian Neoplasms/etiology/pathology
- Tumor Markers, Biological/genetics
3417: Chu et al. (2013) "Novel locus including FGF21 is associated with dietary macronutrient intake." Hum. Mol. Genet. 22(9):1895-1902 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Dietary Fats/administration & dosage
- Genetic Predisposition to Disease
- Cohort Studies
- Obesity/genetics
- Polymorphism, Single Nucleotide
- NF-kappa B/genetics/metabolism
- Linear Models
- Energy Intake
- Body Mass Index
- Diabetes Mellitus, Type 2/genetics
- Fibroblast Growth Factors/genetics/metabolism
- Genome-Wide Association Study
- Genetic Loci
- Dietary Carbohydrates/administration & dosage
- Dietary Fiber/administration & dosage
- Dietary Proteins/administration & dosage
4034: Luciani et al. (2011) "Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans." Nat. Chem. Biol. 7(12):891-893 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Enzyme Activation/drug effects
- Longevity/drug effects
- Structure-Activity Relationship
- Molecular Structure
- Cytochrome P-450 Enzyme System/metabolism
- Larva/drug effects
- Caenorhabditis elegans Proteins/antagonists & inhibitors/metabolism
- Caenorhabditis elegans/drug effects/growth & development/metabolism
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors/chemistry/pharmacology
- Isoxazoles/chemistry/pharmacology
- Piperidines/chemistry/pharmacology
- Pyridines/chemistry/pharmacology
- Stereoisomerism
1328: Cohen et al. (2004) "Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase." Science 305(5682):390-392 (PubMed)

6 citations in connected databases
- Tags:
- Animals
- Humans
- Male
- Apoptosis
- Mutation
- Proto-Oncogene Proteins/metabolism
- Rats
- Alleles
- Cell Line
- Cell Survival
- DNA-Binding Proteins/metabolism
- Mitochondria/metabolism
- Rats, Inbred F344
- Acetylation
- Adipose Tissue/metabolism
- Sirtuin 1
- Sirtuins/genetics/metabolism
- Caloric Restriction
- Histone Deacetylases/genetics/metabolism
- Kidney/metabolism
- Liver/metabolism
- Proto-Oncogene Proteins c-bcl-2
- bcl-2-Associated X Protein
- Insulin/metabolism/pharmacology
- RNA, Small Interfering
- Antigens, Nuclear/metabolism
- Insulin-Like Growth Factor I/metabolism/pharmacology
2125: Pollin et al. (2008) "A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection." Science 322(5908):1702-1705 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Heterozygote
- Mutation
- Dietary Fats/administration & dosage
- Lipids/blood
- Adult
- Pedigree
- Middle Aged
- Linkage Disequilibrium
- Risk Factors
- Polymorphism, Single Nucleotide
- Haplotypes
- Cholesterol/blood
- Triglycerides/blood
- Fasting
- Cholesterol, HDL/blood
- Cholesterol, LDL/blood
- Genome-Wide Association Study
- Apolipoprotein C-III/blood/genetics
- Christianity
- Coronary Artery Disease/genetics/prevention & control
- Pennsylvania
2161: Yap et al. (2009) "Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation." Oncogene 28(27):2524-2534 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Adaptor Proteins, Signal Transducing
- Up-Regulation
- Cells, Cultured
- Immunohistochemistry
- Reverse Transcriptase Polymerase Chain Reaction
- Blotting, Western
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- RNA Interference
- Cell Membrane/metabolism
- Cell Movement
- Cell Line, Tumor
- Intracellular Signaling Peptides and Proteins/genetics/metabolism
- Keratinocytes/cytology/metabolism
- Carcinoma, Squamous Cell/genetics/metabolism/pathology
- Antigens, Neoplasm/metabolism
- Integrins/metabolism
- Mouth Mucosa/cytology/metabolism
- Mouth Neoplasms/genetics/metabolism/pathology
- Neoplasm Invasiveness
- Receptors, Vitronectin/metabolism
- rac1 GTP-Binding Protein/genetics/metabolism
4603: Kim et al. (2017) "Selenocysteine modulates resistance to environmental stress and confers anti-aging effects in C. elegans." Clinics (Sao Paulo) 72(8):491-498 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Antioxidants/pharmacology
- Age Factors
- Time Factors
- Aging/drug effects
- Fertility/drug effects
- Longevity/drug effects
- Reproducibility of Results
- Oxidative Stress/drug effects
- Reproduction/drug effects
- Locomotion/drug effects
- Stress, Physiological/drug effects
- Caenorhabditis elegans/drug effects/physiology/radiation effects
- Selenocysteine/pharmacology
4642: Han et al. (2017) "Microbial Genetic Composition Tunes Host Longevity." Cell 169(7):1249-1262.e13 (PubMed)

26 citations in connected databases
- Tags:
- Animals
- Gene Deletion
- Longevity
- Transcription Factors/metabolism
- Aging/metabolism
- Models, Animal
- Amyloid beta-Peptides/metabolism
- Escherichia coli/genetics/metabolism
- Caenorhabditis elegans Proteins/metabolism
- Genome-Wide Association Study
- Polysaccharides/metabolism
- Unfolded Protein Response
- Bacterial Load
- Caenorhabditis elegans/metabolism/microbiology
- Mitochondrial Dynamics
4720: Holck et al. (1970) "Effects of disulfiram on growth, longevity, and reproduction of the albino rat." J Pharm Sci 59(9):1267-1270 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Female
- Male
- Rats
- Age Factors
- Xanthine Oxidase/metabolism
- Ascorbic Acid/pharmacology
- Sex Factors
- Longevity/drug effects
- Diet
- Liver/metabolism
- Body Weight/drug effects
- Oxygen Consumption/drug effects
- Blood Cell Count
- Growth/drug effects
- Reproduction/drug effects
- Disulfiram/pharmacology
- Molybdenum/metabolism
2935: Welch et al. (2012) "The origin and evolution of mutations in acute myeloid leukemia." Cell 150(2):264-278 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Mutation
- DNA Mutational Analysis
- Adult
- Middle Aged
- Aged
- Disease Progression
- Hematopoietic Stem Cells/metabolism
- Skin/metabolism
- Young Adult
- Genome-Wide Association Study
- Clonal Evolution
- Leukemia, Myeloid, Acute/genetics/physiopathology
- Oncogene Proteins, Fusion/genetics
- Recurrence
2133: Yu et al. (2011) "Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration." Hum. Mol. Genet. 20(18):3699-3709 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Cohort Studies
- Case-Control Studies
- Genetic Variation
- European Continental Ancestry Group/genetics
- Polymorphism, Single Nucleotide
- Neoplasm Proteins/genetics
- Protein-Tyrosine Kinases/genetics
- Vascular Endothelial Growth Factor A/genetics
- Macular Degeneration/genetics
- Genome-Wide Association Study
- Collagen Type X/genetics
1565: Chehab et al. (1997) "Early onset of reproductive function in normal female mice treated with leptin." Science 275(5296):88-90 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Mice, Inbred C57BL
- Recombinant Proteins/pharmacology
- Luteinizing Hormone/blood
- Body Weight/drug effects
- Estradiol/blood
- Eating/drug effects
- Leptin
- Organ Size/drug effects
- Estrus/drug effects
- Genitalia, Female/drug effects
- Proteins/analysis/pharmacology
- Reproduction/drug effects
- Sexual Maturation/drug effects
1658: Esposito et al. (2003) "A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling." J. Clin. Endocrinol. Metab. 88(4):1468-1475 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Male
- Signal Transduction
- Rats
- Transfection
- Amino Acid Sequence
- Phosphatidylinositol 3-Kinases/metabolism
- Middle Aged
- Mutation, Missense
- Insulin/metabolism/pharmacology
- Insulin Receptor Substrate Proteins
- 3T3 Cells
- Polymorphism, Single-Stranded Conformational
- Immunosorbent Techniques
- Insulin Resistance/genetics
- Diabetes Mellitus, Type 2/genetics
- Monosaccharide Transport Proteins/metabolism
- Adipocytes/metabolism
- Phosphoproteins/chemistry/genetics
- Glucose Transporter Type 4
- Muscle Proteins
1743: Altomonte et al. (2004) "Foxo1 mediates insulin action on apoC-III and triglyceride metabolism." J. Clin. Invest. 114(10):1493-1503 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Inbred C57BL
- Cells, Cultured
- Rats
- Transcription Factors/genetics/metabolism
- Luciferases/metabolism
- Alleles
- Mice, Transgenic
- Cell Line
- Dose-Response Relationship, Drug
- Mice, Inbred Strains
- Adenoviridae/genetics
- Promoter Regions, Genetic
- Genes, Reporter
- Hepatocytes/metabolism
- Binding Sites/genetics
- Insulin/metabolism/pharmacology
- Caco-2 Cells
- Mice, Inbred NOD
- Apolipoproteins C/blood/drug effects/genetics/metabolism
- Enterocytes/metabolism
- Hypertriglyceridemia/genetics
- Triglycerides/blood/metabolism
3139: Nebel et al. (2011) "A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals." Mech. Ageing Dev. 132(6-7):324-330 (PubMed)

4 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Alleles
- Aged, 80 and over
- Apolipoproteins E/genetics
- Case-Control Studies
- Polymorphism, Single Nucleotide
- Genome-Wide Association Study
- Germany
- Linkage Disequilibrium/genetics
- Genetic Loci
3177: Piaceri et al. (2011) "Implication of a genetic variant at PICALM in Alzheimer’s disease patients and centenarians." J. Alzheimers Dis. 24(3):409-413 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Genetic Predisposition to Disease
- Aged
- Aged, 80 and over
- Gene Frequency
- Alzheimer Disease/genetics
- Italy
- Genome-Wide Association Study
- Monomeric Clathrin Assembly Proteins/genetics
3322: Chung et al. (2008) "HSP72 protects against obesity-induced insulin resistance." Proc. Natl. Acad. Sci. U.S.A. 105(5):1739-1744 (PubMed)

5 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Insulin/blood
- Phosphorylation
- Mice, Transgenic
- Blood Glucose/analysis
- Obesity/complications
- Liver/metabolism
- Muscle, Skeletal/metabolism
- Insulin Resistance
- Adiponectin/blood
- Piperidines/pharmacology
- MAP Kinase Kinase 4/metabolism
- Hyperthermia, Induced
- I-kappa B Kinase/metabolism
- HSP72 Heat-Shock Proteins/genetics/metabolism
- Hyperinsulinism/etiology/metabolism/therapy
- Oximes/pharmacology
3991: Saul et al. (2010) "The longevity effect of tannic acid in Caenorhabditis elegans: Disposable Soma meets hormesis." J. Gerontol. A Biol. Sci. Med. Sci. 65(6):626-635 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Models, Biological
- Dose-Response Relationship, Drug
- Hot Temperature
- Longevity/drug effects
- Oxidative Stress/drug effects
- Reproduction/drug effects
- Stress, Physiological/drug effects
- MAP Kinase Kinase 4/metabolism
- Caenorhabditis elegans/drug effects/genetics/growth & development/physiology
- Pharynx/drug effects/physiology
- Mutation/drug effects
- Tannins/administration & dosage
2541: Unal et al. (2011) "Gametogenesis eliminates age-induced cellular damage and resets life span in yeast." Science 332(6037):1554-1557 (PubMed)

1 citation in connected databases
- Tags:
- Aging
- DNA-Binding Proteins/genetics/metabolism
- Transcription Factors/genetics/metabolism
- Cell Division
- Recombinant Fusion Proteins/metabolism
- Heat-Shock Proteins/metabolism
- Nuclear Proteins/genetics/metabolism
- Saccharomyces cerevisiae Proteins/genetics/metabolism
- Meiosis
- DNA, Circular/genetics/metabolism
- DNA, Fungal/genetics/metabolism
- DNA, Ribosomal/genetics/metabolism
- Cell Nucleolus/physiology/ultrastructure
- Saccharomyces cerevisiae/genetics/growth & development/physiology/ultrastructure
- Spores, Fungal/physiology
109: Counter et al. (1995) "Telomerase activity in normal leukocytes and in hematologic malignancies." Blood 85(9):2315-2320 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Cells, Cultured
- Models, Biological
- Cell Division
- Fibroblasts
- Base Sequence
- Molecular Sequence Data
- Adult
- Cell Aging/genetics
- Middle Aged
- DNA/analysis
- Skin
- Bone Marrow Cells
- Aged
- Aged, 80 and over
- Acute Disease
- DNA Nucleotidylexotransferase/analysis
- DNA, Neoplasm/analysis
- Disease Progression
- Fetal Blood/cytology
- Leukemia, Lymphocytic, Chronic, B-Cell/enzymology/genetics/pathology
- Leukemia, Myeloid/enzymology/genetics/pathology
- Leukocytes/enzymology
- Myelodysplastic Syndromes/enzymology/genetics/pathology
- Neoplasm Proteins/analysis
- Telomere/chemistry