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Entries tagged Arteriosclerosis/genetics/pathology (54)

3504: Demontis et al. (2014) "Intertissue control of the nucleolus via a myokine-dependent longevity pathway." Cell Rep 7(5):1481-1494 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Longevity
- Amino Acid Sequence
- Molecular Sequence Data
- Aging/metabolism
- p38 Mitogen-Activated Protein Kinases
- Drosophila Proteins/genetics/metabolism
- Muscle, Skeletal/metabolism
- Cell Nucleolus/metabolism
- Adipocytes/metabolism
- Transforming Growth Factor beta/genetics/metabolism
- Drosophila/growth & development/metabolism
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics/metabolism
- Myostatin/genetics/metabolism
- RNA, Ribosomal/genetics/metabolism
3519: Yizhak et al. (2013) "Model-based identification of drug targets that revert disrupted metabolism and its application to ageing." Nat Commun 4:2632 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Gene Expression Regulation, Fungal
- Computer Simulation
- Genome, Human
- Caloric Restriction
- Saccharomyces cerevisiae/genetics/metabolism
- Saccharomyces cerevisiae Proteins/genetics
- Algorithms
- Sirolimus/pharmacology
- Stilbenes/pharmacology
- Longevity/drug effects/genetics
- Aging/drug effects/genetics/metabolism
- Genome, Fungal
- Metabolic Networks and Pathways
- Alcohol Dehydrogenase/deficiency/genetics
- Alcohol Oxidoreductases/deficiency/genetics
- Eicosanoids/metabolism
- Hormesis
- Molecular Targeted Therapy
- Reactive Oxygen Species/antagonists & inhibitors/metabolism
4063: Spindler et al. (2012) "Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation." PLoS ONE 7(6):e39581 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Longevity
- Behavior, Animal
- Feeding Behavior
- Aging/drug effects
- Drosophila melanogaster
- Benzamides/pharmacology
- Ubiquinone/analogs & derivatives/pharmacology
- Cardiovascular Diseases/drug therapy
- Heart/drug effects
- Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
- Methionine/analogs & derivatives/pharmacology
- Simvastatin/pharmacology
535: Galve-Roperh et al. (1996) "Levels and activity of brain protein kinase C alpha and zeta during the aging of the medfly." Mech. Ageing Dev. 92(1):21-29 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Immunohistochemistry
- Brain/metabolism
- Aging/metabolism
- Diptera
- Protein Kinase C/metabolism
- Culture Techniques
949: Zhen et al. (1999) "Age-associated impairment in brain MAPK signal pathways and the effect of caloric restriction in Fischer 344 rats." J. Gerontol. A Biol. Sci. Med. Sci. 54(12):B539-B548 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Epidermal Growth Factor/pharmacology
- Phosphorylation
- Rats
- Cell Division/physiology
- Apoptosis/physiology
- Brain/enzymology
- Aging/metabolism
- Cytosol/enzymology
- Cell Differentiation/physiology
- Tetradecanoylphorbol Acetate/pharmacology
- Signal Transduction/physiology
- Rats, Inbred F344
- Mitogen-Activated Protein Kinases/metabolism
- p38 Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinase 1/metabolism
- Mitogen-Activated Protein Kinase 3
- Energy Intake
- Isoenzymes/metabolism
- Phospholipase C gamma
- Mitosis/physiology
- Cerebral Cortex/enzymology
- Neurons/enzymology
- Enzyme Activators/pharmacology
- Myelin Sheath/metabolism
- Phosphotransferases/metabolism
- Protein-Tyrosine Kinases/physiology
- Type C Phospholipases/metabolism
1264: Miskin et al. (2005) "AlphaMUPA mice: a transgenic model for longevity induced by caloric restriction." Mech. Ageing Dev. 126(2):255-261 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Mice
- Insulin-Like Growth Factor I/metabolism
- Female
- Aging
- Apoptosis
- Mice, Transgenic
- Phenotype
- Brain/metabolism
- RNA, Messenger/metabolism
- Time Factors
- Mitochondria/metabolism
- Transgenes
- Caloric Restriction
- Feeding Behavior
- Obesity/genetics
- Liver/metabolism
- Urokinase-Type Plasminogen Activator/genetics
- Antioxidants/chemistry
2090: Miller et al. (1997) "An accessory protein of DNA polymerase alpha declines in function with increasing age." Mutat. Res. 374(1):125-138 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Tumor Cells, Cultured
- Aging/metabolism
- Isoenzymes/metabolism
- DNA Polymerase II/metabolism
- Antigens, Polyomavirus Transforming/chemistry
- DNA Primase
- Luminescent Measurements
- RNA Nucleotidyltransferases/metabolism
- Simian virus 40/immunology
1676: Wooster et al. (1995) "Identification of the breast cancer susceptibility gene BRCA2." Nature 378(6559):789-792 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Molecular Sequence Data
- Frameshift Mutation
- Open Reading Frames
- Genetic Predisposition to Disease
- Sequence Deletion
- Transcription Factors/genetics
- Germ-Line Mutation
- Breast Neoplasms/genetics
- Neoplasm Proteins/genetics
- BRCA2 Protein
- Chromosomes, Human, Pair 13
- Chromosomes, Artificial, Yeast
- Breast Neoplasms, Male/genetics
- DNA, Neoplasm
1874: Turek et al. (2005) "Obesity and metabolic syndrome in circadian Clock mutant mice." Science 308(5724):1043-1045 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Insulin/blood
- Mice, Inbred C57BL
- Body Weight
- Leptin/blood
- Mutation
- Dietary Fats/administration & dosage
- Brain/metabolism
- Feeding Behavior
- Trans-Activators/genetics/physiology
- Circadian Rhythm
- Energy Intake
- Energy Metabolism
- Motor Activity
- CLOCK Proteins
- Obesity/genetics/physiopathology
- Hyperglycemia
- Neuropeptides/genetics/metabolism
- Adipocytes/pathology
- Hepatocytes/pathology
- Hyperlipidemias
- Metabolic Syndrome X/genetics/physiopathology
- Weight Gain
1998: Asher et al. (2010) "Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding." Cell 142(6):943-953 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Feeding Behavior
- Circadian Rhythm
- Liver/metabolism
- Biological Clocks
- Poly(ADP-ribose) Polymerases/genetics/metabolism
- Circadian Rhythm Signaling Peptides and Proteins/metabolism
4238: Zuo et al. (2012) "IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells." J. Cancer Res. Clin. Oncol. 138(6):1045-1055 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Signal Transduction
- Cell Aging/physiology
- Genes, Tumor Suppressor
- Gene Expression Regulation, Neoplastic
- Retinoblastoma Protein/genetics/metabolism
- Recombinant Fusion Proteins/genetics/metabolism
- Cell Cycle Proteins/genetics/metabolism
- G1 Phase/physiology
- Cell Line, Tumor
- Cell Growth Processes/physiology
- Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism
- Transfection/methods
- Breast Neoplasms/genetics/metabolism/pathology
- Insulin-Like Growth Factor Binding Proteins/genetics/metabolism
- Gene Knockdown Techniques/methods
- G0 Phase
- Cell Cycle Checkpoints/physiology
- Tumor Suppressor Protein p53/biosynthesis/genetics/metabolism
746: Martínez-Lara et al. (2003) "Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum." Neurobiol. Aging 24(3):501-509 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Aging/physiology
- Rats
- Immunohistochemistry
- Oxidative Stress/physiology
- Age Factors
- Tissue Distribution
- Rats, Wistar
- Glutathione Transferase/metabolism
- Carrier Proteins/metabolism
- Isoenzymes/metabolism
- Glutathione S-Transferase pi
- Astrocytes/enzymology
- Bacterial Proteins
- Cerebellum/enzymology
- Cerebral Cortex/enzymology
- Oligodendroglia/enzymology
769: Lev et al. (1995) "Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions." Nature 376(6543):737-745 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Adaptor Proteins, Signal Transducing
- Phosphorylation
- Tyrosine/metabolism
- Cells, Cultured
- PC12 Cells
- Rats
- Proteins/metabolism
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Molecular Sequence Data
- Enzyme Activation
- Protein Kinases/metabolism
- Brain/enzymology
- DNA Primers
- Calcium/metabolism
- Potassium Channels/metabolism
- 3T3 Cells
- GRB2 Adaptor Protein
- Protein Kinase C/metabolism
- GTP-Binding Proteins/metabolism
- Focal Adhesion Kinase 2
- Ion Channels/metabolism
- Kv1.2 Potassium Channel
- Potassium Channels, Voltage-Gated
- Protein-Tyrosine Kinases/drug effects/metabolism
20: Kuro-o et al. (1997) "Mutation of the mouse klotho gene leads to a syndrome resembling ageing." Nature 390(6655):45-51 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Female
- Male
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred C3H
- Mice, Transgenic
- Phenotype
- Amino Acid Sequence
- Cloning, Molecular
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Syndrome
- Aging/genetics/pathology
- Arteriosclerosis/genetics/pathology
- Atrophy
- Calcinosis/genetics/pathology
- Emphysema/genetics
- Genitalia/pathology
- Membrane Proteins/genetics/physiology
- Mutagenesis, Insertional
- Osteoporosis/genetics/pathology
- Pituitary Gland/pathology
- Skin/pathology
- Thymus Gland/pathology
387: Asghar et al. (2003) "Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats." Am. J. Physiol. Renal Physiol. 285(6):F1100-F1107 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Rats
- Aging/metabolism
- Rats, Inbred F344
- 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
- Dopamine Agonists/pharmacology
- Kidney Tubules, Proximal/enzymology
- Organ Culture Techniques
- Protein Kinase C/genetics/metabolism
- Protein Kinase C-delta
- Receptors, Dopamine D1/agonists/metabolism
- Sodium-Potassium-Exchanging ATPase/metabolism
- Protein Kinase C beta
868: Tsujii et al. (1998) "Cyclooxygenase regulates angiogenesis induced by colon cancer cells." Cell 93(5):705-716 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Up-Regulation
- Molecular Sequence Data
- Mice, Nude
- Antineoplastic Agents/pharmacology
- Coculture Techniques
- Cell Movement
- Isoenzymes/metabolism
- Membrane Proteins
- Cell Communication
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors/pharmacology
- Cyclooxygenase 1
- Anti-Inflammatory Agents, Non-Steroidal/pharmacology
- Caco-2 Cells
- Carcinoma/blood supply/pathology
- Colonic Neoplasms/blood supply/pathology
- Endothelium, Vascular/cytology/growth & development
- Growth Substances/biosynthesis
- Neoplasms, Experimental/blood supply
- Neovascularization, Pathologic
- Prostaglandin-Endoperoxide Synthases/metabolism
952: Undie et al. (1995) "Decreased phospholipase C-beta immunoreactivity, phosphoinositide metabolism, and protein kinase C activation in senescent F-344 rat brain." Neurobiol. Aging 16(1):19-28 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Rats
- Dose-Response Relationship, Drug
- Aging/metabolism
- Rats, Inbred F344
- Enzyme Activation/drug effects
- Isoenzymes/metabolism
- Protein Kinase C/metabolism
- Type C Phospholipases/metabolism
- Atropine/pharmacology
- Brain/drug effects/enzymology/metabolism
- Carbachol/antagonists & inhibitors/pharmacology
- Inositol/metabolism
- Phosphatidylinositols/metabolism
1099: Gueven et al. (2004) "Aprataxin, a novel protein that protects against genotoxic stress." Hum. Mol. Genet. 13(10):1081-1093 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Hydrogen Peroxide/pharmacology
- DNA Damage
- Protein Binding
- Tumor Suppressor Protein p53/metabolism
- DNA Repair
- Syndrome
- Radiation, Ionizing
- Poly(ADP-ribose) Polymerases/metabolism
- Chromatin/metabolism
- Mutation, Missense
- Mitomycin/pharmacology
- Protein Interaction Mapping
- Ataxia/genetics
- Apraxias/genetics
- Ataxia Telangiectasia/genetics/metabolism
- Cell Culture Techniques
- DNA-Binding Proteins/analysis/genetics/metabolism/physiology
- Fibroblasts/ultrastructure
- Mesylates/pharmacology
- Nuclear Localization Signals/genetics
- Nuclear Proteins/analysis/genetics/physiology
1210: Qian et al. (1998) "Increased leptin resistance as rats grow to maturity." Proc. Soc. Exp. Biol. Med. 219(2):160-165 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Aging/physiology
- Rats
- Feeding Behavior
- Rats, Sprague-Dawley
- Body Composition/drug effects
- Proteins/pharmacology
- Adipose Tissue/drug effects/physiopathology
- Blood Proteins/analysis
- Drug Resistance/physiology
- Leptin
- Organ Size/drug effects
2987: Meier et al. (2008) "Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans." Diabetes 57(6):1584-1594 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Aging/physiology
- Organ Size
- Adult
- Child
- Cell Division/physiology
- Adolescent
- Child, Preschool
- Infant
- Infant, Newborn
- Insulin-Secreting Cells/cytology
- Pancreas/cytology/growth & development