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Entries tagged Electrophoretic Mobility Shift Assay/methods (25)

3375: Wheatcroft et al. (2007) "IGF-binding protein-2 protects against the development of obesity and insulin resistance." Diabetes 56(2):285-294 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Mice
- Insulin-Like Growth Factor I/metabolism
- Leptin/blood
- Cells, Cultured
- Mice, Transgenic
- Phenotype
- Aging/metabolism
- Insulin Resistance/physiology
- Adipocytes/metabolism
- Blood Pressure/physiology
- Fatty Liver/metabolism
- Adiposity/physiology
- 3T3-L1 Cells/drug effects
- Insulin-Like Growth Factor Binding Protein 2/metabolism/pharmacology
- Obesity/metabolism/prevention & control
- Thinness/metabolism
3909: Anisimov et al. (2001) "Melatonin increases both life span and tumor incidence in female CBA mice." J. Gerontol. A Biol. Sci. Med. Sci. 56(7):B311-B323 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Brain/metabolism
- Longevity/drug effects
- Liver/metabolism
- Neoplasms/chemically induced
- Aging/drug effects/physiology
- Incidence
- Mice, Inbred CBA
- Body Weight/drug effects
- Estrus/drug effects
- Locomotion/drug effects
- Free Radicals/blood/metabolism
- Melatonin/adverse effects/pharmacology/physiology
- Models, Theoretical
1478: Navarro et al. (2004) "Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy." Hum. Mol. Genet. 13(20):2493-2503 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Mutation
- Exons/genetics
- Lamin Type A/analysis/genetics
- Syndrome
- Skin/pathology
- Infant, Newborn
- Membrane Proteins/genetics
- Fibroblasts/pathology
- RNA Splicing/genetics
- Lipoproteins/genetics
- Metalloendopeptidases
- Metalloproteases/genetics
- Bone and Bones/abnormalities/radiography
- Cell Nucleus/chemistry/ultrastructure
- Fetus/pathology
- Nuclear Lamina/pathology
- Skin Abnormalities/genetics/mortality/pathology
2057: Martínez et al. (2009) "Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice." Genes Dev. 23(17):2060-2075 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Tumor Suppressor Protein p53/metabolism
- Cell Line
- Telomere/genetics
- Aging/metabolism
- DNA Damage/genetics
- Mutation/genetics
- Gene Expression Regulation
- Cell Cycle/physiology
- Neoplasms/genetics
- Fibroblasts/cytology/metabolism
- Neoplasm Proteins/metabolism
- E2F1 Transcription Factor/metabolism
- Cyclin-Dependent Kinase Inhibitor p21/metabolism
- Chromosome Fragility
- Epidermis/cytology/pathology
- Hyperpigmentation/etiology/genetics
- Protein Deficiency/complications
- Skin Diseases/etiology/genetics
- Skin Neoplasms/etiology/genetics
- Stem Cells/pathology
- Telomeric Repeat Binding Protein 1/deficiency/genetics/metabolism
627: Brunet et al. (1999) "Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor." Cell 96(6):857-868 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Apoptosis
- Phosphorylation
- Protein-Serine-Threonine Kinases/metabolism
- DNA-Binding Proteins/genetics/metabolism
- Forkhead Transcription Factors
- Proto-Oncogene Proteins/metabolism
- Proto-Oncogene Proteins c-akt
- Transcription Factors/genetics/metabolism
- Proteins/metabolism
- Binding Sites
- Cell Survival
- Cell Line, Transformed
- Recombinant Fusion Proteins/genetics/metabolism
- Membrane Glycoproteins/metabolism
- Cytoplasm/metabolism
- Fas Ligand Protein
- 14-3-3 Proteins
- Tyrosine 3-Monooxygenase
875: Xiao et al. (1999) "Induction of G(1) checkpoint in the gastric mucosa of aged rats." Am. J. Physiol. 277(5 Pt 1):G929-G934 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Male
- Aging/physiology
- Cyclin-Dependent Kinase Inhibitor p21
- Rats
- Tumor Suppressor Protein p53/metabolism
- Enzyme Activation/physiology
- Blotting, Western
- Rats, Inbred F344
- CDC2-CDC28 Kinases
- Cyclin-Dependent Kinase 2
- G1 Phase/physiology
- Cyclin D1/analysis/metabolism
- Cyclin E/analysis/metabolism
- Cyclin-Dependent Kinases/analysis/metabolism
- Cyclins/analysis/metabolism
- Gastric Mucosa/cytology/enzymology
- Protein-Serine-Threonine Kinases/analysis/metabolism
- Retinoblastoma Protein/analysis/metabolism
- S Phase/physiology
876: Konishi et al. (2002) "Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery." Mol. Cell 9(5):1005-1016 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Apoptosis
- Phosphorylation
- Cells, Cultured
- Protein Binding
- Serine/metabolism
- Carrier Proteins/metabolism
- Neurons/cytology
- Cerebellum/cytology
- Rabbits
- 14-3-3 Proteins
- CDC2 Protein Kinase/metabolism
- Tyrosine 3-Monooxygenase/metabolism
- bcl-Associated Death Protein
59: Silhol et al. (2005) "Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats." Neuroscience 132(3):613-624 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Rats
- RNA, Messenger/metabolism
- Aging/metabolism
- Age Factors
- Animals, Newborn
- Blotting, Western/methods
- Brain-Derived Neurotrophic Factor/genetics/metabolism
- Cloning, Molecular/methods
- Electrophoretic Mobility Shift Assay/methods
- Enzyme-Linked Immunosorbent Assay/methods
- Gene Expression Regulation, Developmental/physiology
- Hippocampus/growth & development/metabolism
- Hypothalamus/growth & development/metabolism
- Pregnancy
- Protein Isoforms/metabolism
- Receptor Protein-Tyrosine Kinases/genetics/metabolism
- Receptor, trkB/genetics/metabolism
- Reverse Transcriptase Polymerase Chain Reaction/methods
236: Diderich et al. (2003) "Accelerated bone aging in the trichothiodystrophy mouse model." J. Gerontol. A Biol. Sci. Med. Sci. 58(11):969 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Mice
- Proteins/genetics
- Phenotype
- DNA-Binding Proteins
- Point Mutation
- Transcription Factors
- Xeroderma Pigmentosum Group D Protein
- Time Factors
- DNA Helicases
- Aging, Premature/etiology/physiopathology
- Bone and Bones/metabolism/physiopathology
- Hair Diseases/complications
997: Yaffe et al. (1997) "The structural basis for 14-3-3:phosphopeptide binding specificity." Cell 91(7):961-971 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Phosphorylation
- Protein Binding
- Molecular Sequence Data
- Protein Conformation
- Phosphoserine/metabolism
- Models, Molecular
- Substrate Specificity
- Crystallography, X-Ray
- 14-3-3 Proteins
- Tyrosine 3-Monooxygenase
- Proteins/chemistry/metabolism
- Enzyme Inhibitors/chemistry/metabolism
- Peptide Library
- Phosphopeptides/metabolism
1118: Couëdel et al. (2004) "Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells." Genes Dev. 18(11):1293-1304 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Mutant Strains
- Cells, Cultured
- DNA-Binding Proteins/genetics/metabolism
- Aging/genetics
- Survival Rate
- Radiation, Ionizing
- Recombination, Genetic
- DNA Damage/genetics
- Animals, Newborn
- Fetal Death/genetics
- DNA Repair/physiology
- DNA Helicases
- Brain/pathology
- Testis/pathology
- Nuclear Proteins/genetics/metabolism
- Antigens, Nuclear/genetics/metabolism
- Histones/genetics/metabolism
- Fibroblasts/physiology/radiation effects
4318: Iwagami et al. (2016) "Aspartate β-hydroxylase modulates cellular senescence through glycogen synthase kinase 3β in hepatocellular carcinoma." Hepatology 63(4):1213-1226 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Female
- Phosphorylation
- Tumor Cells, Cultured
- Mice, Nude
- Cell Aging/physiology
- Membrane Proteins/metabolism
- Sensitivity and Specificity
- Cell Proliferation
- Random Allocation
- Glycogen Synthase Kinase 3/metabolism
- Muscle Proteins/metabolism
- Calcium-Binding Proteins/metabolism
- Heterografts
- Carcinoma, Hepatocellular/enzymology/pathology
- Liver Neoplasms/enzymology/pathology
- Mixed Function Oxygenases/metabolism
3405: Welford et al. (2006) "HIF1alpha delays premature senescence through the activation of MIF." Genes Dev. 20(24):3366-3371 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Transcription, Genetic
- Cell Aging/physiology
- Gamma Rays
- Gene Expression Regulation
- Cell Hypoxia
- Fibroblasts/physiology/radiation effects
- Aerobiosis
- Hypoxia-Inducible Factor 1, alpha Subunit/physiology
- Intramolecular Oxidoreductases/genetics/physiology
- Macrophage Migration-Inhibitory Factors/genetics/physiology
1759: Peled-Kamar et al. (1995) "Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome." EMBO J. 14(20):4985-4993 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Male
- Apoptosis
- Oxidative Stress
- Mice, Transgenic
- Superoxide Dismutase/genetics
- Lipid Peroxidation
- Hydrogen Peroxide/metabolism
- Flow Cytometry
- Tumor Necrosis Factor-alpha/pharmacology
- T-Lymphocytes/pathology
- Bone Marrow/drug effects/growth & development/pathology
- Down Syndrome/etiology
- Granulocytes
- Hematopoietic Stem Cells/pathology
- Macrophages
- Thymus Gland/abnormalities
1116: Haussmann et al. (2004) "Telomerase expression is differentially regulated in birds of differing life span." Ann. N. Y. Acad. Sci. 1019:186-190 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Aging
- Longevity
- Telomere/ultrastructure
- Species Specificity
- Time Factors
- Tissue Distribution
- Bone Marrow Cells/metabolism
- Birds
- Songbirds
- Telomerase/biosynthesis
1181: Chakraborty et al. (2003) "Age-related changes in estrogen receptor beta in rat hypothalamus: a quantitative analysis." Endocrinology 144(9):4164-4171 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Rats
- Aging/metabolism
- Cell Count
- Rats, Sprague-Dawley
- Estrogen Receptor beta
- Estrogens/physiology
- Hypothalamus/cytology/metabolism
- Neurons/chemistry/metabolism
- Ovariectomy
- Receptors, Estrogen/metabolism
- Receptors, N-Methyl-D-Aspartate/analysis
- Septal Nuclei/cytology/metabolism
3367: Lombard et al. (2007) "Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation." Mol. Cell. Biol. 27(24):8807-8814 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Sequence Homology, Amino Acid
- Acetylation
- Histone Deacetylases/metabolism
- Feeding Behavior
- Sirtuin 2
- Lysine/metabolism
- Solubility
- Food Deprivation
- Thermogenesis
- Sirtuins/deficiency/metabolism
- Mitochondria, Liver/enzymology/metabolism
- Sirtuin 3
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/metabolism
- Mitochondrial Proteins/deficiency/metabolism
- Adipose Tissue, Brown/cytology
- Glutamate Dehydrogenase/metabolism
- Mammals/metabolism
3810: Schultz et al. (2009) "14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence." Mol. Cancer 8:53 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Gene Expression
- Cell Aging/genetics
- Gene Expression Regulation, Neoplastic
- Disease Progression
- RNA, Messenger/biosynthesis/genetics
- Antineoplastic Agents/pharmacology
- Down-Regulation
- Gene Silencing
- DNA Methylation
- Cell Movement/genetics
- 14-3-3 Proteins
- Cell Line, Tumor
- CpG Islands
- Neoplasm Metastasis
- Cell Cycle/drug effects/genetics
- Melanoma/genetics/metabolism/pathology
- Azacitidine/analogs & derivatives/pharmacology
- Biomarkers, Tumor/biosynthesis/genetics
- Exonucleases/biosynthesis/genetics
- Exoribonucleases
- Neoplasm Proteins/biosynthesis/genetics
- Phenylbutyrates/pharmacology
2831: Cartwright et al. (2007) "Aging in adipocytes: potential impact of inherent, depot-specific mechanisms." Exp. Gerontol. 42(6):463-471 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Male
- Rats
- Models, Biological
- Adult
- Transcription Factors/metabolism
- Middle Aged
- Cell Differentiation/physiology
- Aged
- Aging/pathology/physiology
- Adipogenesis/physiology
- Adult Stem Cells/cytology
- Adipocytes/cytology/physiology
- Adiposity/physiology
- Mesenchymal Stromal Cells/cytology
415: Yu et al. (2002) "Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor." Science 297(5579):259-263 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Apoptosis
- Hydrogen Peroxide/pharmacology
- Oxidative Stress
- Cells, Cultured
- Cytochrome c Group/metabolism
- Enzyme Inhibitors/pharmacology
- Enzyme Activation
- Active Transport, Cell Nucleus
- Cell Nucleus/metabolism
- Caspases/metabolism
- NAD/metabolism
- Proto-Oncogene Proteins c-bcl-2/metabolism
- Antibodies/immunology
- Apoptosis Inducing Factor
- Caspase Inhibitors
- Flavoproteins/immunology/metabolism
- Membrane Potentials
- Membrane Proteins/immunology/metabolism
- Methylnitronitrosoguanidine/pharmacology
- Mitochondria/metabolism/physiology
- N-Methylaspartate/metabolism/pharmacology
- Neurons/cytology/physiology
- Poly(ADP-ribose) Polymerases/antagonists & inhibitors/genetics/metabolism
- Receptors, N-Methyl-D-Aspartate/metabolism