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Entries tagged Enzyme Activation/genetics/physiology (24)

3519: Yizhak et al. (2013) "Model-based identification of drug targets that revert disrupted metabolism and its application to ageing." Nat Commun 4:2632 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Models, Biological
- Gene Expression Regulation, Fungal
- Computer Simulation
- Genome, Human
- Caloric Restriction
- Saccharomyces cerevisiae/genetics/metabolism
- Saccharomyces cerevisiae Proteins/genetics
- Algorithms
- Sirolimus/pharmacology
- Stilbenes/pharmacology
- Longevity/drug effects/genetics
- Aging/drug effects/genetics/metabolism
- Genome, Fungal
- Metabolic Networks and Pathways
- Alcohol Dehydrogenase/deficiency/genetics
- Alcohol Oxidoreductases/deficiency/genetics
- Eicosanoids/metabolism
- Hormesis
- Molecular Targeted Therapy
- Reactive Oxygen Species/antagonists & inhibitors/metabolism
2165: Poulopoulou et al. (2010) "Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease." Neurobiol. Dis. 37(2):339-348 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Cells, Cultured
- Aged
- Aged, 80 and over
- Mitogens/pharmacology
- Patch-Clamp Techniques
- Excitatory Amino Acid Agonists/pharmacology
- Cell Proliferation/drug effects
- Excitatory Amino Acid Antagonists/pharmacology
- Alzheimer Disease/immunology/metabolism/physiopathology
- Brain Infarction/immunology/metabolism/physiopathology
- Cell Membrane/drug effects/metabolism
- Glutamic Acid/metabolism/pharmacology
- Ion Channel Gating/drug effects/physiology
- Kv1.3 Potassium Channel/drug effects/metabolism
- Lymphocyte Activation/drug effects/physiology
- Membrane Potentials/drug effects/physiology
- Neuroimmunomodulation/physiology
- Phytohemagglutinins/pharmacology
- Receptors, Metabotropic Glutamate/agonists/metabolism
- T-Lymphocytes/drug effects/immunology/metabolism
116: Iwama et al. (1998) "Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals." Hum. Genet. 102(4):397-402 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Aging/genetics
- Adult
- Child
- Age Factors
- Adolescent
- Child, Preschool
- Middle Aged
- Aged
- Aged, 80 and over
- Enzyme Activation/genetics/physiology
- Leukocytes, Mononuclear/enzymology
- Telomerase/blood/genetics/physiology
- Telomere/chemistry/genetics
296: Maki et al. (1996) "Interleukin 7 receptor-deficient mice lack gammadelta T cells." Proc. Natl. Acad. Sci. U.S.A. 93(14):7172-7177 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Polymerase Chain Reaction
- Crosses, Genetic
- Base Sequence
- Molecular Sequence Data
- Mice, Inbred Strains
- Flow Cytometry
- DNA Primers
- Restriction Mapping
- Genomic Library
- Lymphocytes/immunology
- Spleen/immunology
- Receptors, Interleukin-7
- Antigens, CD/genetics/physiology
- B-Lymphocytes/immunology
- Embryo, Mammalian
- Immunologic Deficiency Syndromes/genetics/immunology
- Intestines/immunology
- Killer Cells, Natural/immunology
- Liver/immunology
- Receptors, Antigen, T-Cell, gamma-delta
- Receptors, Interleukin/genetics/physiology
- Skin/immunology
- Stem Cells
- T-Lymphocytes/immunology
4626: Zhang et al. (2016) "The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans." Food Funct 7(4):1975-1984 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Superoxide Dismutase/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Longevity/drug effects
- Oxidative Stress/drug effects
- Aging/drug effects/genetics/metabolism
- Caenorhabditis elegans/drug effects/genetics/growth & development/metabolism
- Dipeptides/administration & dosage
- Plant Proteins/administration & dosage/chemistry
- Zea mays/chemistry
2837: Der et al. (2012) "Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?" PLoS ONE 7(9):e45166 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Aging/genetics
- Adult
- Biological Markers
- Adolescent
- Middle Aged
- Aged
- Telomere/chemistry/genetics
- Cross-Sectional Studies
- Cognition/physiology
- Longitudinal Studies
- Predictive Value of Tests
- Scotland
- Principal Component Analysis
- Telomere Homeostasis/genetics
1275: Lin et al. (2004) "Cytoplasmic PML function in TGF-beta signalling." Nature 431(7005):205-211 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Carrier Proteins/genetics/metabolism
- Humans
- Mice
- DNA-Binding Proteins/genetics/metabolism
- Protein Binding
- Fibroblasts
- Tumor Suppressor Proteins
- Cell Line
- Mutation/genetics
- Cell Aging/drug effects
- Cell Division/drug effects
- Transforming Growth Factor beta/pharmacology
- Signal Transduction/drug effects
- Apoptosis/drug effects
- Protein Transport
- Transcription, Genetic/drug effects
- Trans-Activators/genetics/metabolism
- Nuclear Proteins/deficiency/genetics/metabolism
- Cell Line, Tumor
- B-Lymphocytes/cytology/drug effects
- Cytoplasm/drug effects/metabolism
- Endosomes/drug effects/metabolism
- Leukemia, Promyelocytic, Acute/metabolism/pathology
- Neoplasm Proteins/deficiency/genetics/metabolism
- Oncogene Proteins, Fusion/metabolism
- Receptors, Transforming Growth Factor beta/metabolism
- Smad2 Protein
- Smad3 Protein
- Transcription Factors/deficiency/genetics/metabolism
2053: Houlihan et al. (2009) "Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936." Genes Brain Behav. 8(2):238-247 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Phenotype
- Child
- Reverse Transcriptase Polymerase Chain Reaction
- Cohort Studies
- Aged
- Gene Frequency
- Polymorphism, Single Nucleotide/genetics
- Cognition/physiology
- Aging/psychology
- Neuropsychological Tests
- Intelligence Tests
- Intelligence/genetics/physiology
- Scotland
1573: Masternak et al. (2005) "Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice." J. Gerontol. A Biol. Sci. Med. Sci. 60(10):1238-1245 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Receptors, Somatotropin/genetics
- Polymerase Chain Reaction
- Blotting, Western
- Insulin/physiology
- Caloric Restriction
- Insulin Resistance/physiology
- Muscle, Skeletal/chemistry
- Cholesterol/analysis
- Fats/metabolism
- Fatty Acids, Nonesterified/analysis
- PPAR alpha/genetics
- PPAR gamma/genetics
- PPAR-beta/genetics
- Peroxisome Proliferator-Activated Receptors/analysis/genetics
- Retinoid X Receptors/genetics
- Triglycerides/analysis
4040: Peng et al. (2012) "Blueberry extract prolongs lifespan of Drosophila melanogaster." Exp. Gerontol. 47(2):170-178 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Up-Regulation
- Catalase/genetics/metabolism
- Superoxide Dismutase/deficiency/genetics/metabolism
- Blotting, Western
- Gene Expression Regulation, Enzymologic
- Down-Regulation
- Longevity/drug effects
- Drosophila Proteins/genetics/metabolism
- Hydrogen Peroxide/toxicity
- Paraquat/toxicity
- Drosophila melanogaster/genetics
- Receptors, G-Protein-Coupled/genetics/metabolism
- Chromatography, High Pressure Liquid
- Oxidants/toxicity
- Real-Time Polymerase Chain Reaction
- Endopeptidases/genetics/metabolism
- Plant Extracts/pharmacology
- Blueberry Plant/metabolism
- Herbicides/toxicity
716: Beharka et al. (2001) "Interleukin-6 production does not increase with age." J. Gerontol. A Biol. Sci. Med. Sci. 56(2):B81-B88 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Male
- Mice, Inbred C57BL
- Cells, Cultured
- Adult
- Aging/metabolism
- Aged
- Recombinant Proteins/pharmacology
- Dinoprostone/biosynthesis
- Interleukin-6/biosynthesis/blood/pharmacology
- Macrophages/drug effects/metabolism
- Monocytes/metabolism
- Nitric Oxide/biosynthesis
970: Trinchese et al. (2004) "Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice." Ann. Neurol. 55(6):801-814 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Inbred C57BL
- Aging
- Mice, Transgenic
- Analysis of Variance
- Age Factors
- Animals, Newborn
- Time Factors
- Disease Progression
- Membrane Proteins/genetics
- Enzyme-Linked Immunosorbent Assay
- Amyloid beta-Protein Precursor/genetics/metabolism
- Brain Chemistry
- Alzheimer Disease/metabolism/pathology/physiopathology
- Amyloid beta-Peptides/analysis/blood
- Cognition Disorders/etiology/metabolism/physiopathology
- Electric Stimulation/methods
- Excitatory Postsynaptic Potentials/physiology/radiation effects
- Hippocampus/pathology/physiopathology
- Long-Term Potentiation/physiology/radiation effects
- Memory, Short-Term/physiology
- Mitochondrial Proteins/genetics
- Peptide Fragments/analysis/blood
2080: et al. (2011) "Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes." Nat. Genet. 43(2):117-120 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Rats
- Protein Kinases/metabolism
- Dose-Response Relationship, Drug
- Cell Cycle Proteins/genetics
- DNA-Binding Proteins/genetics
- Polymorphism, Single Nucleotide
- Hypoglycemic Agents/pharmacology
- Protein-Serine-Threonine Kinases/genetics
- Liver Neoplasms/genetics/metabolism
- Tumor Suppressor Proteins/genetics
- Genome-Wide Association Study
- Scotland
- Carcinoma, Hepatocellular/genetics/metabolism
- Diabetes Mellitus, Type 2/drug therapy/genetics
- Metformin/pharmacology
- Ataxia Telangiectasia Mutated Proteins
2967: Fülöp et al. (1985) "Age-dependent alterations of Fc gamma receptor-mediated effector functions of human polymorphonuclear leucocytes." Clin. Exp. Immunol. 61(2):425-432 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Aging
- Adult
- Middle Aged
- Aged
- Sex Factors
- Neutrophils/immunology/metabolism
- Phagocytosis
- Immunoglobulin G/immunology
- Cytotoxicity, Immunologic
- Antibody-Dependent Cell Cytotoxicity
- Cyclic AMP/blood
- Cyclic GMP/blood
- Receptors, Fc/immunology
- Receptors, IgG
3899: Kaeberlein et al. (2005) "Substrate-specific activation of sirtuins by resveratrol." J. Biol. Chem. 280(17):17038-17045 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Antioxidants/pharmacology
- Protein Binding
- Tumor Suppressor Protein p53/metabolism
- Transcription, Genetic
- Telomere/metabolism
- Kinetics
- Dose-Response Relationship, Drug
- Recombination, Genetic
- Time Factors
- Substrate Specificity
- Models, Chemical
- Binding, Competitive
- Histone Deacetylase Inhibitors
- Sirtuin 1
- Sirtuin 2
- Gene Silencing
- Fungal Proteins/chemistry
- Peptides/chemistry
- Stilbenes/pharmacology
- DNA, Ribosomal/chemistry/metabolism
- Histone Deacetylases/chemistry
- Niacinamide/chemistry
- Silent Information Regulator Proteins, Saccharomyces cerevisiae/antagonists & inhibitors/metabolism
- Sirtuins/antagonists & inhibitors/chemistry
- In Vitro Techniques
4049: Zarse et al. (2012) "L-Theanine extends lifespan of adult Caenorhabditis elegans." Eur J Nutr 51(6):765-768 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity
- Dose-Response Relationship, Drug
- Survival Analysis
- Osmolar Concentration
- Paraquat/toxicity
- Oxidative Stress/drug effects
- Drug Resistance/drug effects
- Oxidants/toxicity
- Caenorhabditis elegans/drug effects/growth & development
- Herbicides/toxicity
- Antioxidants/administration & dosage/pharmacokinetics
- Camellia sinensis/chemistry
- Glutamates/administration & dosage/pharmacology
- Larva/drug effects/growth & development
- Neuroprotective Agents/administration & dosage/pharmacology
- Plant Leaves/chemistry
3487: Ohtsuka et al. (2013) "Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe." Mol. Genet. Genomics 288(5-6):285-295 (PubMed)

1 citation in connected databases
- Tags:
- Gene Deletion
- DNA-Binding Proteins/genetics/metabolism
- Cloning, Molecular
- Genetic Complementation Test
- Gene Expression Regulation, Fungal
- Protein Kinases/genetics
- Saccharomyces cerevisiae Proteins/genetics
- Schizosaccharomyces pombe Proteins/genetics/metabolism
- Saccharomyces cerevisiae/drug effects/genetics
- Caffeine/pharmacology
- Canavanine/pharmacology
- Drug Resistance, Fungal/genetics
- G-Quadruplexes
- Schizosaccharomyces/drug effects/physiology
2051: Semba et al. (2011) "Plasma klotho and mortality risk in older community-dwelling adults." J. Gerontol. A Biol. Sci. Med. Sci. 66(7):794-800 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Longevity/physiology
- Male
- Proportional Hazards Models
- Time Factors
- Risk Factors
- Aged
- Aging/blood
- Enzyme-Linked Immunosorbent Assay
- Motor Activity/physiology
- Biological Markers/blood
- Follow-Up Studies
- Confidence Intervals
- Retrospective Studies
- Italy/epidemiology
- Cause of Death/trends
- Geriatric Assessment/methods
- Glucuronidase/blood
- Survival Rate/trends
1853: Razzaque et al. (2006) "Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process." FASEB J. 20(6):720-722 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Gene Deletion
- Phenotype
- Gene Expression Regulation
- T-Lymphocytes/metabolism
- Lung/metabolism
- Intestines/metabolism
- Cell Proliferation
- Glucuronidase/genetics/metabolism
- Fibroblast Growth Factors/deficiency/genetics/metabolism
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics/metabolism
- Aging, Premature/metabolism
- Atherosclerosis
- Lymphatic System/metabolism
- Skin/metabolism
- Vitamin D/metabolism
2052: Massip et al. (2010) "Vitamin C restores healthy aging in a mouse model for Werner syndrome." FASEB J. 24(1):158-172 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Oxidative Stress
- Base Sequence
- Gene Expression Profiling
- DNA, Mitochondrial/genetics
- Microscopy, Electron, Scanning
- Longevity/drug effects/genetics
- PPAR alpha/genetics
- Adipose Tissue/drug effects/pathology
- Aging/drug effects/genetics/metabolism
- Ascorbic Acid/therapeutic use
- Glutathione/blood/metabolism
- Liver/drug effects/metabolism/pathology
- RecQ Helicases/genetics
- Werner Syndrome/drug therapy/genetics/metabolism/pathology