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Entries tagged Immune System/physiology (54)

3144: Soerensen et al. (2012) "Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis." Aging Cell 11(2):223-227 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity
- RNA/genetics
- Telomerase/genetics
- Telomere/genetics
- Aged
- Genetic Variation
- Longitudinal Studies
- Leukocytes/metabolism
3358: Difilippantonio et al. (2008) "53BP1 facilitates long-range DNA end-joining during V(D)J recombination." Nature 456(7221):529-533 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Apoptosis
- DNA-Binding Proteins
- Recombination, Genetic
- Models, Genetic
- DNA/genetics/metabolism
- Thymus Gland/cytology
- Chromosomal Proteins, Non-Histone
- Genomic Instability
- Sequence Homology
- DNA Breaks
- Gene Rearrangement, T-Lymphocyte/genetics
- Genes, T-Cell Receptor alpha/genetics
- Intracellular Signaling Peptides and Proteins/deficiency/genetics/metabolism
- Lymphopenia/genetics/pathology
- Receptors, Antigen, T-Cell/genetics/metabolism
- T-Lymphocytes/cytology/metabolism
3359: Dimitrova et al. (2008) "53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility." Nature 456(7221):524-528 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Signal Transduction
- Cells, Cultured
- DNA Damage
- Protein Binding
- DNA-Binding Proteins
- DNA Repair
- Telomere/genetics/metabolism
- Movement
- Chromatin/genetics/metabolism
- Chromosomal Proteins, Non-Histone
- Sequence Homology
- DNA Breaks, Double-Stranded
- Intracellular Signaling Peptides and Proteins/deficiency/genetics/metabolism
- Telomeric Repeat Binding Protein 2/deficiency/genetics/metabolism
1576: Ma et al. (2004) "mRNA level of alpha-2-macroglobulin as an aging biomarker of human fibroblasts in culture." Exp. Gerontol. 39(3):415-421 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Cell Line
- Cell Aging/physiology
- RNA, Messenger/analysis
- Biological Markers/analysis
- Reverse Transcriptase Polymerase Chain Reaction
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- alpha-Macroglobulins/genetics
- Fibroblasts/physiology
- Lung/embryology
- Blotting, Northern/methods
- Leukocytes/metabolism
1756: Atzmon et al. (2006) "Lipoprotein genotype and conserved pathway for exceptional longevity in humans." PLoS Biol. 4(4):e113 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Carrier Proteins/genetics
- Longevity/genetics
- Aged
- Aged, 80 and over
- Glycoproteins/genetics
- Polymorphism, Genetic/genetics
- Apolipoproteins C/genetics
- Apolipoproteins A/genetics
- Cholesterol Ester Transfer Proteins
1932: Conti et al. (2006) "Transgenic mice with a reduced core body temperature have an increased life span." Science 314(5800):825-828 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Aging
- Body Weight
- Longevity
- Mice, Transgenic
- Eating
- Circadian Rhythm
- Energy Metabolism
- Neurons/metabolism
- Body Temperature
- Neuropeptides/metabolism
- Intracellular Signaling Peptides and Proteins/metabolism
- Thermogenesis
- Body Temperature Regulation
- Drinking
- Hypothalamic Area, Lateral/cytology/metabolism
- Ion Channels/genetics/physiology
- Mitochondrial Proteins/genetics/physiology
- Preoptic Area/cytology/physiology
1999: Ramsey et al. (2009) "Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis." Science 324(5927):651-654 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Protein Binding
- Transcription, Genetic
- Cell Line
- Enzyme Inhibitors/pharmacology
- Nuclear Proteins/genetics
- Cell Cycle Proteins/genetics
- Gene Expression Regulation
- Transcription Factors/genetics
- Sirtuin 1
- Hepatocytes/metabolism
- Sirtuins/metabolism
- Circadian Rhythm
- Liver/metabolism
- Feedback, Physiological
- Trans-Activators/genetics/metabolism
- Cell Line, Tumor
- ARNTL Transcription Factors
- Biological Clocks
- CLOCK Proteins
- Period Circadian Proteins
- Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism
- Acrylamides/pharmacology
- Adipose Tissue, White/metabolism
- Cytokines/antagonists & inhibitors/genetics/metabolism
- NAD/biosynthesis
- Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors/genetics/metabolism
- Piperidines/pharmacology
2001: Nakahata et al. (2009) "Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1." Science 324(5927):654-657 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Male
- Mice, Inbred BALB C
- Transcription, Genetic
- Cell Line
- Enzyme Inhibitors/pharmacology
- Gene Expression Regulation
- Promoter Regions, Genetic
- NAD/metabolism
- Sirtuin 1
- Sirtuins/metabolism
- Circadian Rhythm
- Feedback, Physiological
- Trans-Activators/genetics/metabolism
- ARNTL Transcription Factors
- Biological Clocks
- CLOCK Proteins
- Acrylamides/pharmacology
- Cytokines/antagonists & inhibitors/genetics/metabolism
- Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors/genetics/metabolism
- Piperidines/pharmacology
- Basic Helix-Loop-Helix Transcription Factors/metabolism
- Chromatin Assembly and Disassembly
- Niacinamide/metabolism
230: Russell-Aulet et al. (2001) "Aging-related growth hormone (GH) decrease is a selective hypothalamic GH-releasing hormone pulse amplitude mediated phenomenon." J. Gerontol. A Biol. Sci. Med. Sci. 56(2):M124-M129 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Middle Aged
- Aged
- Aged, 80 and over
- Human Growth Hormone/blood
- Aging/blood
- Circadian Rhythm
- Growth Hormone-Releasing Hormone/secretion
- Hypothalamus/secretion
- Insulin-Like Growth Factor I/analysis
- Osmolar Concentration
3209: Walston et al. (2009) "Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults." Exp. Gerontol. 44(5):350-355 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Aging/genetics
- Phenotype
- Risk Factors
- Aged
- Aged, 80 and over
- Case-Control Studies
- Genetic Variation
- Poly(ADP-ribose) Polymerases/blood/genetics
- Interleukin-6/blood/genetics
- Cardiovascular Diseases/blood/genetics/mortality
- Inflammation/blood/genetics/mortality
3305: Codd et al. (2013) "Identification of seven loci affecting mean telomere length and their association with disease." Nat. Genet. 45(4):422-7, 427e1 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Telomerase/genetics
- Telomere/genetics
- Genetic Predisposition to Disease
- Risk Factors
- Case-Control Studies
- Leukocytes/metabolism
- Genome-Wide Association Study
- Meta-Analysis as Topic
- Genetic Loci/genetics
- Tumor Markers, Biological/genetics
- Disease/genetics
3420: Goo et al. (2013) "HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA." Biochim. Biophys. Acta 1833(8):1866-1875 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mutation
- Reactive Oxygen Species/metabolism
- DNA Damage
- Brain/metabolism
- DNA Repair
- HeLa Cells
- Nucleic Acid Conformation
- Cell Line, Tumor
- DNA, Mitochondrial/genetics/metabolism
- Mitochondrial Proteins/deficiency/genetics/metabolism
- Serine Endopeptidases/deficiency/genetics/metabolism
3016: Merched et al. (1998) "Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease." Neurosci. Lett. 242(2):117-119 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Aging/genetics
- Alleles
- Point Mutation
- Middle Aged
- Polymorphism, Genetic
- Aged
- Aged, 80 and over
- Gene Frequency
- Alzheimer Disease/genetics
- Genetic Markers
- Apolipoproteins A/genetics
3079: Pepe et al. (1998) "In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians." Atherosclerosis 137(2):407-417 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Polymerase Chain Reaction
- Adult
- Middle Aged
- DNA/analysis
- Polymorphism, Genetic
- Aged
- Aged, 80 and over
- Gene Frequency
- Enzyme-Linked Immunosorbent Assay
- DNA Primers/chemistry
- Lipoproteins/blood
- Apolipoproteins A/genetics
- Aging/blood/genetics
- Lipoprotein(a)/blood
1065: Christiansen et al. (2004) "Modest implication of interleukin-6 promoter polymorphisms in longevity." Mech. Ageing Dev. 125(5):391-395 (PubMed)

3 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Child
- Adolescent
- Child, Preschool
- Middle Aged
- Infant
- Aged
- Aged, 80 and over
- Longevity/genetics/immunology
- Aging/genetics/immunology/pathology
- Inflammation/genetics/immunology/mortality/pathology
- Interleukin-6/genetics/immunology
- Polymorphism, Single Nucleotide/genetics/immunology
- Promoter Regions, Genetic/genetics/immunology
4140: Tam et al. (2014) "Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans." J. Gerontol. A Biol. Sci. Med. Sci. 69(7):810-820 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Models, Biological
- Animals, Genetically Modified
- Recombinant Fusion Proteins/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Longevity/drug effects
- Adenosine Triphosphate/metabolism
- Lithium/pharmacology
- Microtubule-Associated Proteins/genetics/metabolism
- DNA, Mitochondrial/genetics/metabolism
- Energy Metabolism/drug effects
- Locomotion/drug effects
- Autophagy/drug effects
- Aging/drug effects/genetics/physiology
- Caenorhabditis elegans/drug effects/genetics/physiology
- Green Fluorescent Proteins/genetics/metabolism
- DNA Copy Number Variations/drug effects
- Mitochondria/drug effects/physiology
4580: Zhang et al. (2016) "NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice." Science 352(6292):1436-1443 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Disease Models, Animal
- Mice
- Mice, Inbred C57BL
- Oxidative Stress
- Longevity/drug effects/physiology
- Mitochondria/drug effects/physiology
- Unfolded Protein Response/drug effects
- Cellular Reprogramming
- Cellular Senescence/drug effects/physiology
- Melanocytes/cytology/drug effects/physiology
- Mice, Inbred mdx
- Muscular Dystrophies/therapy
- Myoblasts, Skeletal/cytology/drug effects/physiology
- NAD/metabolism/pharmacology
- Neural Stem Cells/cytology/drug effects/physiology
- Niacinamide/analogs & derivatives/metabolism
- Repressor Proteins/biosynthesis
1867: Kondratov et al. (2003) "BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system." Genes Dev. 17(15):1921-1932 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Mice
- Mice, Inbred C57BL
- Phosphorylation
- Mutation
- Transfection
- Protein Binding
- Transcriptional Activation
- Models, Biological
- Cell Line
- Blotting, Western
- Transcription Factors/physiology
- Cell Nucleus/metabolism
- Time Factors
- Plasmids/metabolism
- Trans-Activators/metabolism
- Fibroblasts/metabolism
- Dimerization
- Circadian Rhythm
- Cytoplasm/metabolism
- 3T3 Cells
- Protein Processing, Post-Translational
- Basic Helix-Loop-Helix Transcription Factors
- ARNTL Transcription Factors
- CLOCK Proteins
- Oscillometry
1062: Kapsa et al. (1998) "mtDNA replicative potential remains constant during ageing: polymerase gamma activity does not correlate with age related cytochrome oxidase activity decline in platelets." Nucleic Acids Res. 26(19):4365-4373 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Aging/genetics
- Adult
- Enzyme Activation
- Middle Aged
- DNA Replication
- Electron Transport Complex IV/genetics/metabolism
- DNA-Directed DNA Polymerase/genetics/metabolism
- DNA, Mitochondrial/genetics/metabolism
1316: Sonntag et al. (2005) "Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span." Endocrinology 146(7):2920-2932 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Male
- Heterozygote
- Homozygote
- Aging
- Rats
- Dwarfism/genetics
- Reproduction
- Longevity/drug effects
- Circadian Rhythm
- Insulin-Like Growth Factor I/deficiency
- Motor Activity
- Maze Learning
- Body Composition
- Body Temperature
- Hand Strength
- Growth Hormone/deficiency/pharmacology
- Neoplasms/prevention & control
- Rats, Inbred Lew
- Steroid Metabolism, Inborn Errors/pathology/physiopathology