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Entries tagged beta-Galactosidase/biosynthesis/genetics (31)

3161: Zhao et al. (2012) "Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity." Aging Cell 11(6):1094-1101 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Longevity/genetics
- Transfection
- Aging/genetics/metabolism
- Linkage Disequilibrium
- Aged, 80 and over
- Genes, Reporter
- Case-Control Studies
- Protein Biosynthesis
- Asian Continental Ancestry Group/genetics
- Polymorphism, Single Nucleotide
- Follow-Up Studies
- Haplotypes
- Questionnaires
- HEK293 Cells
- Mitogen-Activated Protein Kinase 1/genetics/metabolism
- Adenylate Cyclase/genetics/metabolism
- Luciferases, Renilla
- Receptors, Adrenergic, beta-1/genetics/metabolism
- Receptors, Adrenergic, beta-2/genetics/metabolism
4014: Ching et al. (2011) "Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity." Aging Cell 10(3):506-519 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity
- Signal Transduction
- Forkhead Transcription Factors
- Transcription Factors/metabolism
- Insulin/metabolism
- Structure-Activity Relationship
- Anti-Inflammatory Agents, Non-Steroidal/pharmacology
- Caenorhabditis elegans Proteins/metabolism
- Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism
- Insulin-Like Growth Factor I/antagonists & inhibitors/metabolism
- Caenorhabditis elegans/drug effects/genetics/growth & development
- 3-Phosphoinositide-Dependent Protein Kinases
- Cyclooxygenase 2/metabolism
- Celecoxib
- Cyclooxygenase 2 Inhibitors/pharmacology
- Pyrazoles
- Sulfonamides
4102: Zhang et al. (2014) "Rapamycin extends life and health in C57BL/6 mice." J. Gerontol. A Biol. Sci. Med. Sci. 69(2):119-130 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred C57BL
- Myocardium/pathology
- Brain/pathology
- Sex Factors
- Longevity/drug effects
- Body Composition/drug effects
- Kidney/pathology
- Liver/pathology
- Sirolimus/pharmacology
- Energy Metabolism/drug effects
- Motor Activity/drug effects
- Sleep/drug effects
- Rotarod Performance Test
- Autophagy/drug effects
- Immunosuppressive Agents/pharmacology
- TOR Serine-Threonine Kinases/drug effects/metabolism
1608: Masternak et al. (2006) "Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart." Exp. Gerontol. 41(4):417-429 (PubMed)

9 citations in connected databases
- Tags:
- Animals
- Carrier Proteins/genetics/metabolism
- Mice
- Mice, Knockout
- Receptors, Somatotropin/genetics/metabolism
- Male
- Mice, Transgenic
- Receptor, IGF Type 1/genetics/metabolism
- Myocardium/metabolism
- Gene Expression
- RNA, Messenger/analysis
- Aging/metabolism
- Reverse Transcriptase Polymerase Chain Reaction/methods
- Blotting, Western
- Signal Transduction/physiology
- Insulin/metabolism
- Caloric Restriction
- Receptor, Insulin/genetics/metabolism
- Insulin-Like Growth Factor I/genetics/metabolism
- Insulin Resistance
- PPAR alpha/genetics/metabolism
- PPAR gamma/genetics/metabolism
- Growth Hormone/genetics/metabolism
- Retinoid X Receptors/genetics/metabolism
- Glucose Transporter Type 4/genetics/metabolism
- PPAR delta/genetics/metabolism
- PPAR-beta/genetics/metabolism
2165: Poulopoulou et al. (2010) "Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease." Neurobiol. Dis. 37(2):339-348 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Cells, Cultured
- Aged
- Aged, 80 and over
- Mitogens/pharmacology
- Patch-Clamp Techniques
- Excitatory Amino Acid Agonists/pharmacology
- Cell Proliferation/drug effects
- Excitatory Amino Acid Antagonists/pharmacology
- Alzheimer Disease/immunology/metabolism/physiopathology
- Brain Infarction/immunology/metabolism/physiopathology
- Cell Membrane/drug effects/metabolism
- Glutamic Acid/metabolism/pharmacology
- Ion Channel Gating/drug effects/physiology
- Kv1.3 Potassium Channel/drug effects/metabolism
- Lymphocyte Activation/drug effects/physiology
- Membrane Potentials/drug effects/physiology
- Neuroimmunomodulation/physiology
- Phytohemagglutinins/pharmacology
- Receptors, Metabotropic Glutamate/agonists/metabolism
- T-Lymphocytes/drug effects/immunology/metabolism
750: Menegon et al. (1998) "Parkinson's disease, pesticides, and glutathione transferase polymorphisms." Lancet 352(9137):1344-1346 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Middle Aged
- Polymorphism, Genetic
- Aged
- Case-Control Studies
- Logistic Models
- Australia
- Blood-Brain Barrier/drug effects
- Environmental Exposure/adverse effects
- Glutathione Transferase/classification/genetics
- Parkinson Disease, Secondary/chemically induced/genetics
- Pesticides/adverse effects
- Questionnaires
2774: Raguso et al. (2006) "A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise." Clin Nutr 25(4):573-580 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Male
- Aging/physiology
- Aged
- Aged, 80 and over
- Cross-Sectional Studies
- Body Composition/physiology
- Questionnaires
- Longitudinal Studies
- Absorptiometry, Photon/methods
- Adipose Tissue/anatomy & histology/metabolism/pathology
- Exercise/physiology
- Geriatric Assessment
- Leisure Activities
- Muscular Atrophy/epidemiology/pathology
- Patient Compliance
2491: Araiz et al. (2008) "14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans." Exp. Gerontol. 43(6):505-519 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Insulin-Like Growth Factor I/metabolism
- Longevity/physiology
- Aging/physiology
- Oxidative Stress
- Transcription Factors/genetics/metabolism
- Genes, Helminth
- Reverse Transcriptase Polymerase Chain Reaction
- Gene Expression Regulation, Developmental
- Caenorhabditis elegans/physiology
- Insulin/metabolism
- RNA Interference
- Transgenes
- RNA, Small Interfering/pharmacology
- Receptor, Insulin/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- 14-3-3 Proteins/genetics/physiology
- Bacteria/genetics
2492: Kimura et al. (2007) "Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans." J. Biol. Chem. 282(8):5910-5918 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Female
- Male
- Longevity/genetics
- Phenotype
- Animals, Genetically Modified
- Progeria/genetics/metabolism
- Mitochondria/metabolism/pathology
- Adenosine Triphosphate/biosynthesis
- Motor Activity/genetics
- Caenorhabditis elegans Proteins/biosynthesis/genetics
- Caenorhabditis elegans/cytology/genetics/metabolism
- Chaperonin 60/biosynthesis/genetics
- HSP70 Heat-Shock Proteins/deficiency/metabolism
- Mitochondrial Proteins/deficiency/metabolism
- Oogenesis/genetics
3544: Jurk et al. (2014) "Chronic inflammation induces telomere dysfunction and accelerates ageing in mice." Nat Commun 2:4172 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Reactive Oxygen Species/metabolism
- Feedback, Physiological
- Chronic Disease
- Inflammation/genetics/immunology
- Cell Aging/genetics/immunology
- Aging, Premature/genetics/immunology
- Cyclooxygenase 2/metabolism
- DNA Damage/genetics/immunology
- Fibroblasts/immunology/metabolism
- Liver Regeneration/genetics/immunology
- NF-kappa B/genetics/immunology
- NF-kappa B p50 Subunit/genetics/immunology
- Regeneration/genetics/immunology
- Telomere Homeostasis/genetics/immunology
344: Smith et al. (2003) "Telomerase modulates expression of growth-controlling genes and enhances cell proliferation." Nat. Cell Biol. 5(5):474-479 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Cells, Cultured
- Molecular Sequence Data
- Telomerase/genetics/metabolism
- Cell Aging/drug effects/genetics
- Breast/enzymology
- Cell Transformation, Neoplastic/genetics/metabolism
- Mitogens/pharmacology
- Cell Division/drug effects/genetics
- DNA Replication/drug effects/genetics
- Epithelial Cells/drug effects/enzymology
- Gene Expression Regulation, Neoplastic/drug effects/genetics
- Growth Substances/biosynthesis/genetics
- Neoplasms/enzymology/genetics
- RNA/analysis/genetics
- Receptor, Epidermal Growth Factor/genetics/metabolism
- Repressor Proteins/genetics/metabolism
- Up-Regulation/drug effects/genetics
319: Tischler et al. (1993) "Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro." J. Neurosci. 13(4):1533-1542 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Rats
- Cell Aging
- Growth Substances/pharmacology
- Cell Division/drug effects
- Nerve Growth Factors/pharmacology
- Cell Differentiation/drug effects
- Chromaffin System/cytology/drug effects
- Fibroblast Growth Factors/pharmacology
- Mitogens/pharmacology
- Neurons/cytology
- Sympathetic Nervous System/cytology
1641: Friedman et al. (2005) "Social relationships, sleep quality, and interleukin-6 in aging women." Proc. Natl. Acad. Sci. U.S.A. 102(51):18757-18762 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Middle Aged
- Aged
- Aged, 80 and over
- Questionnaires
- Aging/blood/physiology
- Interleukin-6/blood
- Interpersonal Relations
- Sleep/physiology
1888: Enerbäck et al. (1997) "Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese." Nature 387(6628):90-94 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Gene Targeting
- Mice
- Female
- Male
- Proteins/genetics/physiology
- Mice, Transgenic
- Carrier Proteins/genetics/physiology
- Diet
- Stem Cells
- Cold Temperature
- Mitochondria/physiology
- Membrane Proteins/deficiency/genetics/physiology
- Mitochondrial Proteins
- Ion Channels
- Oxygen Consumption/drug effects
- Adrenergic beta-Agonists/pharmacology
- Membrane Transport Proteins
- Dioxoles/pharmacology
- Adipose Tissue, Brown/anatomy & histology/physiology
- Body Temperature Regulation/genetics/physiology
- Body Weight/genetics/physiology
- Obesity/etiology/genetics
- Uncoupling Agents
2202: Reversade et al. (2009) "Mutations in PYCR1 cause cutis laxa with progeroid features." Nat. Genet. 41(9):1016-1021 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Gene Deletion
- Male
- Homozygote
- Mutation
- Base Sequence
- Molecular Sequence Data
- Frameshift Mutation
- Pedigree
- Genes, Recessive
- Child, Preschool
- Infant
- Case-Control Studies
- Infant, Newborn
- Fibroblasts/metabolism
- Consanguinity
- Mutation, Missense
- Polymorphism, Single Nucleotide
- Genetic Markers
- Chromosomes, Human, Pair 17
- Intellectual Disability/genetics
- Skin/cytology/metabolism/ultrastructure
- Agenesis of Corpus Callosum
- Cutis Laxa/etiology/genetics/metabolism
- Physical Chromosome Mapping
- Pyrroline Carboxylate Reductases/genetics/metabolism
2754: Berger et al. (2008) "Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents." CMAJ 178(13):1660-1668 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Adult
- Age Factors
- Middle Aged
- Time Factors
- Aged
- Aged, 80 and over
- Disease Progression
- Follow-Up Studies
- Incidence
- Questionnaires
- Prognosis
- Canada/epidemiology
- Retrospective Studies
- Absorptiometry, Photon
- Lumbar Vertebrae/radiography
- Bone Density/drug effects/physiology
- Bone Density Conservation Agents/therapeutic use
- Osteoporosis/epidemiology/metabolism
- Rural Population
3022: Schwanke et al. (2002) "Analysis of the association between apolipoprotein E polymorphism and cardiovascular risk factors in an elderly population with longevity." Arq. Bras. Cardiol. 78(6):561-579 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Genotype
- Polymerase Chain Reaction
- Alleles
- Chi-Square Distribution
- Risk Factors
- Polymorphism, Genetic
- Aged
- Aged, 80 and over
- Polymorphism, Restriction Fragment Length
- Cross-Sectional Studies
- Odds Ratio
- Cholesterol/blood
- Apolipoproteins E/blood/genetics
- Brazil/epidemiology
- Cardiovascular Diseases/blood/genetics/mortality
3954: Wiegant et al. (2009) "Plant adaptogens increase lifespan and stress resistance in C. elegans." Biogerontology 10(1):27-42 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Ultraviolet Rays
- Forkhead Transcription Factors
- Mutation
- Dose-Response Relationship, Drug
- Transcription Factors/metabolism
- Heat-Shock Proteins/metabolism
- Time Factors
- Caenorhabditis elegans Proteins/genetics/metabolism
- Hot Temperature
- Paraquat/toxicity
- Oxidative Stress/drug effects
- Succinate Dehydrogenase/genetics/metabolism
- Rhodiola
- Plant Extracts/pharmacology
- Caenorhabditis elegans/drug effects/genetics/metabolism/radiation effects
- Eleutherococcus
- Longevity/drug effects/radiation effects
- Plant Roots
- Stress, Physiological/drug effects/radiation effects
493: Marino et al. (1997) "Characterization of tumor necrosis factor-deficient mice." Proc. Natl. Acad. Sci. U.S.A. 94(15):8093-8098 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Hot Temperature
- Interleukins/blood
- Lipopolysaccharides/pharmacology/toxicity
- Propionibacterium acnes
- Recombinant Proteins/biosynthesis/genetics/toxicity
- Tumor Necrosis Factor-alpha/biosynthesis/genetics/toxicity
3209: Walston et al. (2009) "Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults." Exp. Gerontol. 44(5):350-355 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Female
- Genotype
- Male
- Longevity/genetics
- Aging/genetics
- Phenotype
- Risk Factors
- Aged
- Aged, 80 and over
- Case-Control Studies
- Genetic Variation
- Poly(ADP-ribose) Polymerases/blood/genetics
- Interleukin-6/blood/genetics
- Cardiovascular Diseases/blood/genetics/mortality
- Inflammation/blood/genetics/mortality