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Entries tagged Protein-Serine-Threonine Kinases/drug effects/metabolism (24)

486: Kanters et al. (2003) "Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice." J. Clin. Invest. 112(8):1176-1185 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Cell Differentiation
- Protein-Serine-Threonine Kinases/physiology
- Arteriosclerosis/etiology
- Lipoproteins, LDL/metabolism
- I-kappa B Kinase
- Bone Marrow Transplantation
- Lipopolysaccharides/toxicity
- Macrophages/physiology
- NF-kappa B/antagonists & inhibitors/physiology
- Phagocytosis
- Receptors, LDL/physiology
2331: Vartanian et al. (2006) "The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase." Proc. Natl. Acad. Sci. U.S.A. 103(6):1864-1869 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Female
- Gene Deletion
- Male
- Mice, Inbred C57BL
- Leptin/blood
- DNA Damage
- Pedigree
- DNA, Mitochondrial/genetics
- Obesity/genetics/metabolism
- DNA Glycosylases/deficiency/genetics/metabolism
- Fatty Liver/metabolism
- Hyperinsulinism/genetics/metabolism
- Hyperlipidemias/genetics/metabolism
- Kidney/blood supply/metabolism
- Metabolic Syndrome X/genetics/metabolism
1595: Kalitsis et al. (2000) "Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis." Genes Dev. 14(18):2277-2282 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Inbred C57BL
- Proteins/genetics/metabolism
- Cell Cycle Proteins
- Mutagenesis, Insertional
- Mitosis
- Embryonic and Fetal Development
- Chimera
- Nocodazole/pharmacology
- Mitotic Spindle Apparatus/genetics/metabolism
- Spindle Apparatus/genetics/metabolism
3428: Song et al. (2011) "Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients." Neurochem. Res. 36(8):1558-1565 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Male
- Aging/physiology
- Oxidative Stress/physiology
- Aged
- Aged, 80 and over
- Alzheimer Disease/physiopathology
- Guanine/analogs & derivatives/metabolism
- Phosphoric Monoester Hydrolases/genetics/metabolism
- Hippocampus/anatomy & histology/metabolism
- RNA/chemistry/metabolism
- Random Allocation
- DNA Repair Enzymes/genetics/metabolism
127: Herrera et al. (1996) "TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein." Mol. Biol. Cell 7(9):1335-1342 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Mutant Strains
- Cyclin-Dependent Kinase Inhibitor p21
- Cells, Cultured
- Mutation
- Cell Cycle Proteins
- Tumor Suppressor Proteins
- Transcription, Genetic
- Fibroblasts/drug effects/metabolism
- Cell Division/drug effects
- CDC2-CDC28 Kinases
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin-Dependent Kinases/drug effects/metabolism
- Cyclins/drug effects/genetics/metabolism
- Embryo, Mammalian/cytology
- Growth Substances/metabolism
- Microtubule-Associated Proteins/drug effects/metabolism
- Protein-Serine-Threonine Kinases/drug effects/metabolism
- Proteins
- Proto-Oncogene Proteins
- Retinoblastoma Protein/drug effects/genetics
- Transforming Growth Factor beta/pharmacology
999: Ichijo et al. (1997) "Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways." Science 275(5296):90-94 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Apoptosis
- Phosphorylation
- Signal Transduction
- Transfection
- Polymerase Chain Reaction
- Cell Division
- Amino Acid Sequence
- Cell Line
- Molecular Sequence Data
- Cell Survival
- Recombinant Proteins/metabolism
- Enzyme Activation
- Tumor Necrosis Factor-alpha/pharmacology
- p38 Mitogen-Activated Protein Kinases
- Calcium-Calmodulin-Dependent Protein Kinases/metabolism
- JNK Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 6
- MAP Kinase Kinase Kinases
- Protein-Tyrosine Kinases/metabolism
- COS Cells
- Mitogen-Activated Protein Kinase Kinases
- Protein-Serine-Threonine Kinases/chemistry/metabolism
- Saccharomyces cerevisiae/genetics/growth & development/metabolism
744: Shi et al. (1996) "Mutations in the glutathione synthetase gene cause 5-oxoprolinuria." Nat. Genet. 14(3):361-365 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Heterozygote
- Mutation
- Polymerase Chain Reaction
- Genetic Complementation Test
- Molecular Sequence Data
- Pedigree
- Binding Sites
- Sequence Analysis, DNA
- Recombinant Proteins/genetics/metabolism
- RNA Splicing
- Amino Acid Metabolism, Inborn Errors/complications/genetics
- Anemia/complications/genetics
- Erythrocytes/pathology
- Escherichia coli/genetics/metabolism
- Glutathione Synthase/genetics/metabolism
- Pyrrolidonecarboxylic Acid/metabolism
- Schizosaccharomyces/genetics/metabolism
1300: Rodgers et al. (2005) "Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1." Nature 434(7029):113-118 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Mice
- Longevity
- Rats
- Protein Binding
- RNA, Messenger/genetics/metabolism
- Transcription Factors
- Homeostasis
- Glucose/metabolism
- NAD/metabolism
- Trans-Activators/metabolism
- Insulin/pharmacology
- Acetylation
- Sirtuin 1
- Sirtuins/genetics/metabolism
- Caloric Restriction
- Gene Expression Regulation/drug effects
- Fasting/metabolism
- Lysine/metabolism
- Nutritional Status
- Cyclic AMP/pharmacology
- Gluconeogenesis/drug effects/genetics
- Glycolysis/drug effects/genetics
- Hepatocytes/drug effects/metabolism
- Lactic Acid/metabolism
- Liver/cytology/drug effects/metabolism
- Pyruvic Acid/metabolism/pharmacology
1880: Yoon et al. (2001) "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1." Nature 413(6852):131-138 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Male
- Rats
- DNA-Binding Proteins
- RNA, Messenger/metabolism
- Cell Line
- Tumor Cells, Cultured
- Phosphoproteins/metabolism
- Insulin/physiology
- Rats, Wistar
- Receptor, Insulin/genetics/metabolism
- Liver/metabolism
- Blood Glucose/metabolism
- 3T3 Cells
- Cyclic AMP/metabolism
- Amino Acid Motifs
- Transcription Factors/genetics/metabolism/physiology
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Obesity/genetics/metabolism
- Response Elements
- Fasting
- Gluconeogenesis
- Phosphoenolpyruvate Carboxykinase (GTP)/genetics/metabolism
- Receptors, Glucocorticoid/metabolism
- Diabetes Mellitus, Experimental/blood/metabolism
- Hepatocyte Nuclear Factor 4
- Hormones/metabolism
3791: Lin et al. (1998) "Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling." Genes Dev. 12(19):3008-3019 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Mice
- Protein-Serine-Threonine Kinases/metabolism
- Signal Transduction
- Cells, Cultured
- Cell Transformation, Neoplastic
- Cell Aging
- Tumor Suppressor Protein p53/physiology
- Cell Cycle
- Calcium-Calmodulin-Dependent Protein Kinases/metabolism
- ras Proteins/metabolism
- Protein-Tyrosine Kinases/metabolism
- MAP Kinase Kinase 1
- Microinjections
- Cyclin-Dependent Kinase Inhibitor p16/physiology
- Fibroblasts/physiology
- Mitogen-Activated Protein Kinase Kinases
- MAP Kinase Kinase 2
4081: Kayashima et al. (2012) "Freeze-dried royal jelly maintains its developmental and physiological bioactivity in Drosophila melanogaster." Biosci. Biotechnol. Biochem. 76(11):2107-2111 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Female
- Male
- Insulin/metabolism
- Somatomedins/metabolism
- Longevity/drug effects
- Gene Expression Regulation/drug effects
- Signal Transduction/drug effects
- TOR Serine-Threonine Kinases/genetics
- Oviposition/drug effects
- Bees
- Drosophila melanogaster/drug effects/genetics/growth & development/physiology
- Fatty Acids/administration & dosage/pharmacology
- Freeze Drying
436: van Leeuwen et al. (2002) "+1 Proteins and aging." Int. J. Biochem. Cell Biol. 34(11):1502-1505 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Aging/physiology
- RNA, Messenger/genetics/metabolism
- Frameshift Mutation
- Alzheimer Disease/physiopathology
- Ubiquitin/genetics/metabolism
2184: Huai et al. (2008) "Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice." Proc. Natl. Acad. Sci. U.S.A. 105(13):5177-5182 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Mice
- Mice, Knockout
- Gene Deletion
- Cells, Cultured
- Tumor Suppressor Protein p53/metabolism
- Phenotype
- Fibroblasts
- NF-kappa B/metabolism
- Aging/immunology
- Apoptosis/immunology
- Cell Differentiation/immunology
- T-Lymphocytes/cytology/enzymology/immunology
- Aminopeptidases
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Lymphopenia/enzymology/genetics/pathology
- Serine Endopeptidases/deficiency/genetics/metabolism
- Thymus Gland/cytology/enzymology/immunology
2332: Lazakovitch et al. (2005) "nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival." BMC Dev. Biol. 5:24 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Longevity
- Phenotype
- Caenorhabditis elegans/genetics/physiology
- DNA Replication
- Gene Expression Regulation, Developmental
- Behavior, Animal
- Alternative Splicing
- Caenorhabditis elegans Proteins/physiology
- Survival
- NFI Transcription Factors/physiology
2902: Arora et al. (1989) "Effect of age on tests of intestinal and hepatic function in healthy humans." Gastroenterology 96(6):1560-1565 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Male
- Reference Values
- Adult
- Aging/metabolism
- Middle Aged
- Aged
- Aged, 80 and over
- Intestinal Absorption
- Aminopyrine/diagnostic use
- Breath Tests
- Creatinine/metabolism
- Fats/analysis
- Feces/analysis
- Glycocholic Acid/diagnostic use
- Microsomes, Liver/enzymology
- Xylose/diagnostic use
3001: Berry et al. (1984) "The development of human benign prostatic hyperplasia with age." J. Urol. 132(3):474-479 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Male
- Aging
- Organ Size
- Reference Values
- Adult
- Child
- Adolescent
- Middle Aged
- Aged
- Autopsy
- Prostate/growth & development/pathology/surgery
- Prostatectomy
- Prostatic Hyperplasia/pathology/surgery
3055: Cipriano et al. (2006) "Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population." Biogerontology 7(5-6):357-365 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Female
- Longevity/genetics
- Open Reading Frames
- Aging/genetics/metabolism
- Aged
- Aged, 80 and over
- Gene Frequency
- Polymorphism, Single Nucleotide
- Haplotypes
- Interleukin-6/blood
- Italy
- Fluorescent Dyes
- Flow Cytometry/methods
- Fluoresceins
- Hydrazines
- Metallothionein/genetics/metabolism
- Nitric Oxide Donors
- Spectrophotometry, Atomic
- Zinc/blood/metabolism
2955: Holt and Balint (1993) "Effects of aging on intestinal lipid absorption." Am. J. Physiol. 264(1 Pt 1):G1-G6 (PubMed)

2 citations in connected databases
- Tags:
- Animals
- Humans
- Reference Values
- Aging/metabolism
- Lipid Metabolism
- Lipolysis
- Intestinal Mucosa/metabolism
- Intestinal Absorption
2940: Davison (1987) "Pathophysiology of ageing brain." Gerontology 33(3-4):129-135 (PubMed)

1 citation in connected databases
- Tags:
- Humans
- Aging/physiology
- Alzheimer Disease/physiopathology
- Brain/physiopathology
- Brain Diseases/physiopathology
312: Gasparini and Xu (2003) "Potential roles of insulin and IGF-1 in Alzheimer's disease." Trends Neurosci. 26(8):404-406 (PubMed)

2 citations in connected databases
- Tags:
- Humans
- Insulin-Like Growth Factor I/metabolism
- Aging/physiology
- Phosphorylation
- Signal Transduction
- Insulin/metabolism
- Alzheimer Disease/physiopathology
- Amyloidosis/physiopathology
- Neurofibrillary Tangles/metabolism
- tau Proteins/metabolism